PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28474156-0 2017 JNK Inhibitor SP600125 Attenuates Paraquat-Induced Acute Lung Injury: an In Vivo and In Vitro Study. Paraquat 34-42 mitogen-activated protein kinase 8 Homo sapiens 0-3 30317802-1 2018 Objective: To investigate the roles of p38 mitogen-activated protein kinases (p38 MAPK) , extracellular regulated protein kinases (ERK) and c-Jun N-tenninal kinases (JNK) of MAPK signaling pathway in Paraquat-induced epithelial to mesenchymal transition (EMT) of type II alveolarepithelial cells. Paraquat 200-208 mitogen-activated protein kinase 8 Homo sapiens 166-169 28474156-13 2017 JNK inhibitor SP600125 reduced JNK phosphorylation, downregulated cleaved caspase-3 protein level, decreased AP-1 transcriptional activity and ROS level, and reduced the transcription and expression of TNF-alpha and IL-6, which improved ALI and cell apoptosis after paraquat poisoning. Paraquat 266-274 mitogen-activated protein kinase 8 Homo sapiens 0-3 28474156-14 2017 Our results indicate that JNK/AP-1 mediates ALI as well as oxidative stress and inflammation deterioration secondary to paraquat poisoning. Paraquat 120-128 mitogen-activated protein kinase 8 Homo sapiens 26-29 25177032-8 2014 Furthermore, we observed that PQ activates NF-kappaB, while co-treatment with KM occludes its nuclear translocation, and additionally KM repressed the PQ phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in BEAS-2B cells. Paraquat 30-32 mitogen-activated protein kinase 8 Homo sapiens 173-196 26046590-6 2015 Surprisingly, PQ treatment led to inhibition of MTOR, activation of MAPK8/JNK1 and MAPK1/ERK2-MAPK3/ERK1 and upregulation of BECN1/Beclin 1 expression, all signals typically correlating with induction of autophagy. Paraquat 14-16 mitogen-activated protein kinase 8 Homo sapiens 68-73 26046590-6 2015 Surprisingly, PQ treatment led to inhibition of MTOR, activation of MAPK8/JNK1 and MAPK1/ERK2-MAPK3/ERK1 and upregulation of BECN1/Beclin 1 expression, all signals typically correlating with induction of autophagy. Paraquat 14-16 mitogen-activated protein kinase 8 Homo sapiens 74-78 25177032-8 2014 Furthermore, we observed that PQ activates NF-kappaB, while co-treatment with KM occludes its nuclear translocation, and additionally KM repressed the PQ phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in BEAS-2B cells. Paraquat 151-153 mitogen-activated protein kinase 8 Homo sapiens 173-196 25177032-8 2014 Furthermore, we observed that PQ activates NF-kappaB, while co-treatment with KM occludes its nuclear translocation, and additionally KM repressed the PQ phosphorylation of c-Jun N-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) in BEAS-2B cells. Paraquat 151-153 mitogen-activated protein kinase 8 Homo sapiens 198-201 17324951-0 2007 Activation of c-Jun N-terminal protein kinase is a common mechanism underlying paraquat- and rotenone-induced dopaminergic cell apoptosis. Paraquat 79-87 mitogen-activated protein kinase 8 Homo sapiens 14-45 20202476-4 2010 The relevance of these kinases in channeling PQ neurotoxicity was demonstrated with the use of interference RNA for ASK1 and two well-established pharmaceutical inhibitors for JNK and p38. Paraquat 45-47 mitogen-activated protein kinase 8 Homo sapiens 176-179 19735704-0 2009 Paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in human neuroblastoma SH-SY5Y cells. Paraquat 0-8 mitogen-activated protein kinase 8 Homo sapiens 33-36 19735704-8 2009 Paraquat activated inositol-requiring enzyme 1 (IRE1), apoptosis signal regulating kinase 1 (ASK1), and c-jun kinase (JNK). Paraquat 0-8 mitogen-activated protein kinase 8 Homo sapiens 118-121 19735704-11 2009 Therefore, current data indicate that paraquat activates the IRE1/ASK1/JNK cascade associated with apoptosis in SY5Y cells. Paraquat 38-46 mitogen-activated protein kinase 8 Homo sapiens 71-74 17324951-6 2007 The selective ability of paraquat and rotenone to induce apoptosis in different cell lines correlates with their ability to activate c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein kinases. Paraquat 25-33 mitogen-activated protein kinase 8 Homo sapiens 133-164 17324951-6 2007 The selective ability of paraquat and rotenone to induce apoptosis in different cell lines correlates with their ability to activate c-Jun N-terminal protein kinase (JNK) and p38 mitogen-activated protein kinases. Paraquat 25-33 mitogen-activated protein kinase 8 Homo sapiens 166-169 17324951-10 2007 However, JNK but not p38 plays a role in paraquat-induced loss of primary cultured dopaminergic neurons. Paraquat 41-49 mitogen-activated protein kinase 8 Homo sapiens 9-12 17324951-11 2007 Our data identify JNK activation as a common mechanism underlying dopaminergic cell death induced by both paraquat and rotenone in model cell lines and primary cultures. Paraquat 106-114 mitogen-activated protein kinase 8 Homo sapiens 18-21 16687388-0 2006 Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death. Paraquat 22-30 mitogen-activated protein kinase 8 Homo sapiens 124-151 16687388-0 2006 Low concentrations of paraquat induces early activation of extracellular signal-regulated kinase 1/2, protein kinase B, and c-Jun N-terminal kinase 1/2 pathways: role of c-Jun N-terminal kinase in paraquat-induced cell death. Paraquat 22-30 mitogen-activated protein kinase 8 Homo sapiens 124-147 16687388-4 2006 Low concentrations of paraquat stimulated very early increases in ERK1/2, JNK1/2, and PKB phosphorylation. Paraquat 22-30 mitogen-activated protein kinase 8 Homo sapiens 74-80 16687388-6 2006 Furthermore, early paraquat-mediated increases in ERK1/2 activation were sensitive to the mitogen-activated protein kinase kinase 1 (MEK1) inhibitor PD 98059 (2"-amino-3"-methoxyflavone), whereas JNK1/2 responses were blocked by the JNK1/2 inhibitor SP 600125 (anthra[1-9-cd]pyrazol-6(2H)-one). Paraquat 19-27 mitogen-activated protein kinase 8 Homo sapiens 196-202 16687388-6 2006 Furthermore, early paraquat-mediated increases in ERK1/2 activation were sensitive to the mitogen-activated protein kinase kinase 1 (MEK1) inhibitor PD 98059 (2"-amino-3"-methoxyflavone), whereas JNK1/2 responses were blocked by the JNK1/2 inhibitor SP 600125 (anthra[1-9-cd]pyrazol-6(2H)-one). Paraquat 19-27 mitogen-activated protein kinase 8 Homo sapiens 233-239 16687388-9 2006 In conclusion, we have shown that low concentrations of paraquat stimulate robust very early increases in ERK1/2, JNK1/2, and PKB phosphorylation in E18 cells. Paraquat 56-64 mitogen-activated protein kinase 8 Homo sapiens 114-120 16687388-10 2006 Furthermore, the data presented clearly suggest that inhibition of the JNK1/2 pathway protects E18 cells from paraquat-induced cell death and support the fact that inhibition of early activation of JNK1/2 can constitute a potential strategy in PD treatment. Paraquat 110-118 mitogen-activated protein kinase 8 Homo sapiens 71-77 16687388-10 2006 Furthermore, the data presented clearly suggest that inhibition of the JNK1/2 pathway protects E18 cells from paraquat-induced cell death and support the fact that inhibition of early activation of JNK1/2 can constitute a potential strategy in PD treatment. Paraquat 110-118 mitogen-activated protein kinase 8 Homo sapiens 198-204