PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30967525-12 2019 CONCLUSIONS Treatment with MSCs overexpressed Nrf2 gene and activated downstream antioxidant HO-1, leading to inhibit oxidative stress, cell apoptosis and inflammatory response in lung tissue, thereby significantly improving PQ-induced acute lung injury in rats. Paraquat 225-227 NFE2 like bZIP transcription factor 2 Rattus norvegicus 46-50 30112919-0 2019 Sodium tanshinone IIA sulfate protects myocardium against paraquat-induced toxicity through activating the Nrf2 signaling pathway in rats. Paraquat 58-66 NFE2 like bZIP transcription factor 2 Rattus norvegicus 107-111 30112919-12 2019 The expression of phosphorylated Nrf2 and heme oxygenase 1 in PQ + STS group was significantly increased compared with PQ and control groups ( p < 0.05 or 0.01). Paraquat 62-64 NFE2 like bZIP transcription factor 2 Rattus norvegicus 33-37 26598004-0 2015 Compensatory role of the Nrf2-ARE pathway against paraquat toxicity: Relevance of 26S proteasome activity. Paraquat 50-58 NFE2 like bZIP transcription factor 2 Rattus norvegicus 25-29 29285131-0 2017 Effects of water extracts of Rehmannia glutinosa on antioxidant system of Nrf2 in paraquat-induced insulin resistance diabetic rat model. Paraquat 82-90 NFE2 like bZIP transcription factor 2 Rattus norvegicus 74-78 29151408-13 2017 CONCLUSIONS: 5-ASA attenuates the damage of acute renal injury (AKI) caused by PQ, which mechanism may be related with the activation of Nrf2-antioxidant response element (ARE) signaling pathway. Paraquat 79-81 NFE2 like bZIP transcription factor 2 Rattus norvegicus 137-141 26598004-6 2015 Consequently, paraquat induced expression of Nrf2-dependent ARE-driven genes, such as gamma-glutamylcysteine synthetase, catalase, and hemeoxygenase-1. Paraquat 14-22 NFE2 like bZIP transcription factor 2 Rattus norvegicus 45-49 26598004-7 2015 Knockdown of Nrf2 or inhibition of gamma-glutamylcysteine synthetase and catalase exacerbated paraquat-induced toxicity, whereas suppression of hemeoxygenase-1 did not. Paraquat 94-102 NFE2 like bZIP transcription factor 2 Rattus norvegicus 13-17 24812154-1 2015 OBJECTIVE: To investigate the effects of overexpression of nuclear factor E2-related factor-2 (NRF2) on lung injury in rats exposed to paraquat (PQ) poisoning. Paraquat 135-143 NFE2 like bZIP transcription factor 2 Rattus norvegicus 95-99 26173462-0 2015 Silymarin attenuates paraquat-induced lung injury via Nrf2-mediated pathway in vivo and in vitro. Paraquat 21-29 NFE2 like bZIP transcription factor 2 Rattus norvegicus 54-58 24812154-1 2015 OBJECTIVE: To investigate the effects of overexpression of nuclear factor E2-related factor-2 (NRF2) on lung injury in rats exposed to paraquat (PQ) poisoning. Paraquat 145-147 NFE2 like bZIP transcription factor 2 Rattus norvegicus 95-99 24812154-7 2015 However, pretreatment with Ad-RUNRF2 and RU486 strongly enhanced the expression levels of NRF2, HO-1, NQO-1, CAT and GSH-Px in the lungs of PQ intoxicated rats, with increased GSH and decreased MDA (p < 0.05). Paraquat 140-142 NFE2 like bZIP transcription factor 2 Rattus norvegicus 32-36 24812154-10 2015 CONCLUSION: RU486-induced overexpression of NRF2 in lungs transfected with Ad-RUNRF2 can ameliorate PQ-induced lung injury by the activation of the NRF2-antioxidant response element (ARE) pathway. Paraquat 100-102 NFE2 like bZIP transcription factor 2 Rattus norvegicus 44-48 24812154-10 2015 CONCLUSION: RU486-induced overexpression of NRF2 in lungs transfected with Ad-RUNRF2 can ameliorate PQ-induced lung injury by the activation of the NRF2-antioxidant response element (ARE) pathway. Paraquat 100-102 NFE2 like bZIP transcription factor 2 Rattus norvegicus 80-84 25511395-10 2014 RESULTS: After inducing acute lung injury with paraquat for 24 h, Xuebijing was observed to block lung p-p38 MAPK, NF-kappaB65, HIF-1alpha, p-IkappaB-alpha and TGF-beta1 expression, and increased Nrf2 and IkB expression. Paraquat 47-55 NFE2 like bZIP transcription factor 2 Rattus norvegicus 196-200 22983789-5 2012 The dual-luciferase reporter gene also revealed that the transcriptional activation of HO-1 gene expression of the antioxidant responsive element via Nrf2 occurred as a consequence of 100 and 300 muM PQ exposure. Paraquat 200-202 NFE2 like bZIP transcription factor 2 Rattus norvegicus 150-154 24771067-2 2014 The study aimed to investigate the role of CYP2E1 in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes (PMNs) and its crosstalk with iNOS-mediated nitrosative stress and GSTA4-4-linked protective effect, if any and their consequent links with the nuclear factor erythoid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression. Paraquat 64-72 NFE2 like bZIP transcription factor 2 Rattus norvegicus 278-320 24771067-2 2014 The study aimed to investigate the role of CYP2E1 in maneb- and paraquat-induced oxidative stress in rat polymorphonuclear leukocytes (PMNs) and its crosstalk with iNOS-mediated nitrosative stress and GSTA4-4-linked protective effect, if any and their consequent links with the nuclear factor erythoid 2-related factor 2 (Nrf2) activation and heme oxygenase-1 (HO-1) expression. Paraquat 64-72 NFE2 like bZIP transcription factor 2 Rattus norvegicus 322-326 24771067-8 2014 CYP2E1 inhibitor, DAS noticeably alleviated maneb- and paraquat-induced ROS, LPO, 4-HNE, SOD, Nrf2 and HO-1, GST, GSH, and GST-pi while iNOS, nitrite content and GSTA4-4 levels were unchanged. Paraquat 55-63 NFE2 like bZIP transcription factor 2 Rattus norvegicus 94-98 24771067-10 2014 The results demonstrate that CYP2E1 induces iNOS-independent free radical generation and subsequently modulates the Nrf2-dependent HO-1 and 4-HNE-mediated GST expression in maneb- and paraquat-treated PMNs. Paraquat 184-192 NFE2 like bZIP transcription factor 2 Rattus norvegicus 116-120 25169090-9 2014 Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P < 0.05 for all except HO-1 activity in paraquat group on day 7). Paraquat 5-13 NFE2 like bZIP transcription factor 2 Rattus norvegicus 209-213 25169090-9 2014 Both paraquat group and curcumin intervention group showed increase in MDA content, decreases in SOD and CAT activities, increases in HO-1 and NQO-1 activities, and increases in the protein and mRNA levels of Nrf2, in comparison with the control group (P < 0.05 for all except HO-1 activity in paraquat group on day 7). Paraquat 297-305 NFE2 like bZIP transcription factor 2 Rattus norvegicus 209-213 23933652-11 2013 CONCLUSION: Pretreatment with rosiglitazone protects rats against PQ-induced acute lung injury by activating PPAR-gamma, inducing Nrf2 expression and inhibiting NF-kappaB activation. Paraquat 66-68 NFE2 like bZIP transcription factor 2 Rattus norvegicus 130-134 22983789-6 2012 Collectively, these results clearly indicated for the first time that the Nrf2/HO-1 pathway in the substantia nigra was activated by PQ, and pretreatment with tBHQ conferred neuroprotection against PQ-induced Parkinsonism presumably by increasing Nrf2 and HO-1 expression. Paraquat 198-200 NFE2 like bZIP transcription factor 2 Rattus norvegicus 247-251 22983789-6 2012 Collectively, these results clearly indicated for the first time that the Nrf2/HO-1 pathway in the substantia nigra was activated by PQ, and pretreatment with tBHQ conferred neuroprotection against PQ-induced Parkinsonism presumably by increasing Nrf2 and HO-1 expression. Paraquat 133-135 NFE2 like bZIP transcription factor 2 Rattus norvegicus 74-78 22983789-6 2012 Collectively, these results clearly indicated for the first time that the Nrf2/HO-1 pathway in the substantia nigra was activated by PQ, and pretreatment with tBHQ conferred neuroprotection against PQ-induced Parkinsonism presumably by increasing Nrf2 and HO-1 expression. Paraquat 198-200 NFE2 like bZIP transcription factor 2 Rattus norvegicus 74-78 33544450-9 2021 Our findings showed that nanocurcumin had better hepatoprotective effect than curcumin in liver damage after PQ exposure most likely through modulation of oxidative stress and genes expression of Nrf2 pathway. Paraquat 109-111 NFE2 like bZIP transcription factor 2 Rattus norvegicus 196-200 34635711-8 2021 Finally, the differentially expressed genes were analysed in the PQ + AH2QDS group and the PQ group by NextGen sequencing, and we verified that Nrf2"s expression in the PQ + AH2QDS group was significantly higher than that in the PQ group. Paraquat 229-231 NFE2 like bZIP transcription factor 2 Rattus norvegicus 144-148 35128959-8 2022 It was found that silymarin treatment improved renal function, decreased injury score in kidney tissues, and inhibited the apoptosis and oxidative stress in PQ-induced acute kidney injury through the activating the signaling pathway of Nrf2 and promoting its nuclear translocation. Paraquat 157-159 NFE2 like bZIP transcription factor 2 Rattus norvegicus 236-240 33544450-3 2021 The aim of this study is to evaluate and compare the hepatoprotective effects of curcumin and nanocurcumin against liver damage caused by sub-acute exposure with PQ via modulation of oxidative stress and genes expression of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Paraquat 162-164 NFE2 like bZIP transcription factor 2 Rattus norvegicus 224-267 33544450-3 2021 The aim of this study is to evaluate and compare the hepatoprotective effects of curcumin and nanocurcumin against liver damage caused by sub-acute exposure with PQ via modulation of oxidative stress and genes expression of nuclear factor erythroid 2-related factor 2 (Nrf2) pathway. Paraquat 162-164 NFE2 like bZIP transcription factor 2 Rattus norvegicus 269-273 33544450-7 2021 PQ significantly increased malondialdehyde, alanine transaminase, aspartate aminotransferase, alkaline phosphatase levels, and Kelch-like ECH-associated protein 1 gene expression and also decreased total antioxidant capacity, total thiol group levels, Glutathione S-transferases, heme oxygenase 1, Nrf2, and NAD(P)H:quinone oxidoreductase 1 genes expression, causing histological damages to liver tissue. Paraquat 0-2 NFE2 like bZIP transcription factor 2 Rattus norvegicus 298-302 22185821-3 2012 By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway. Paraquat 116-124 NFE2 like bZIP transcription factor 2 Rattus norvegicus 21-25 22185821-3 2012 By knocking down the Nrf2 gene, we confirmed that cyclo(His-Pro) inhibits NF-kappaB nuclear accumulation induced by paraquat in rat pheochromocytoma PC12 cells via the Nrf2/heme oxygenase-1 pathway. Paraquat 116-124 NFE2 like bZIP transcription factor 2 Rattus norvegicus 168-172 35236239-4 2022 In addition, PQ reduced the expression of anti-apoptotic protein Bcl-2, HMOX1 mRNA and protein, and nuclear factor-erythroid factor 2-related factor 2 (Nrf2) protein and the activity of superoxide dismutase 1 (SOD1) and PC12 cells. Paraquat 13-15 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-150 35236239-4 2022 In addition, PQ reduced the expression of anti-apoptotic protein Bcl-2, HMOX1 mRNA and protein, and nuclear factor-erythroid factor 2-related factor 2 (Nrf2) protein and the activity of superoxide dismutase 1 (SOD1) and PC12 cells. Paraquat 13-15 NFE2 like bZIP transcription factor 2 Rattus norvegicus 152-156 32064027-12 2020 The antioxidative effect of H2S in PQ-induced liver injury can at least partly be attributed to the promotion of Nrf2-driven antioxidant enzymes via Keap1 S-sulfhydration and regulation of SIRT3/IDH2 signaling via Nrf2-dependent SIRT3 gene transcription as well as SIRT3 S-sulfhydration. Paraquat 35-37 NFE2 like bZIP transcription factor 2 Rattus norvegicus 113-117 32064027-8 2020 When hepatocytes were subjected to PQ-induced oxidative stress, H2S markedly enhanced nuclear translocation of Nrf2 via S-sulfhydration of Keap1 and resulted in the increase in IDH2 activity by regulating S-sulfhydration of SIRT3. Paraquat 35-37 NFE2 like bZIP transcription factor 2 Rattus norvegicus 111-115 32064027-10 2020 Moreover, H2S cannot reverse the decrease in SIRT3 and activation of the NLRP3 inflammasome caused by PQ in Nrf2-knockdown hepatocytes. Paraquat 102-104 NFE2 like bZIP transcription factor 2 Rattus norvegicus 108-112 32064027-12 2020 The antioxidative effect of H2S in PQ-induced liver injury can at least partly be attributed to the promotion of Nrf2-driven antioxidant enzymes via Keap1 S-sulfhydration and regulation of SIRT3/IDH2 signaling via Nrf2-dependent SIRT3 gene transcription as well as SIRT3 S-sulfhydration. Paraquat 35-37 NFE2 like bZIP transcription factor 2 Rattus norvegicus 214-218