PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34463846-8	2022	In vitro, PQ exposure also increased the expressions of TLR4, NF-kappaB p65, and TGF-beta1 in A549 cells, but knocking down TNC gene expression obviously down-regulated the expressions of TLR4, NF-kappaB p65, NF-kappaB Pp65, and TGF-beta1.	Paraquat	10-12	transforming growth factor, beta 1	Mus musculus	229-238	
23603004-5	2013	Results showed that increase in leukocytes infiltration and overexpressions of TNF-alpha and TGF-beta1 caused by 8h of PQ exposure were dose-dependently ameliorated by naringin.	Paraquat	119-121	transforming growth factor, beta 1	Mus musculus	93-102	
23603004-8	2013	Results showed that naringin of 60 and 120 mg/kg significantly reduced PQ-induced upregulations of TNF-alpha, TGF-beta1, MMP-9 and TIMP-1, levels of pulmonary malonaldehyde and hydroxyproline, as well as pulmonary fibrosis deposition, while increased activities of SOD, GSH-Px and HO-1.	Paraquat	71-73	transforming growth factor, beta 1	Mus musculus	110-119	
34463846-8	2022	In vitro, PQ exposure also increased the expressions of TLR4, NF-kappaB p65, and TGF-beta1 in A549 cells, but knocking down TNC gene expression obviously down-regulated the expressions of TLR4, NF-kappaB p65, NF-kappaB Pp65, and TGF-beta1.	Paraquat	10-12	transforming growth factor, beta 1	Mus musculus	81-90	
25559956-14	2015	Immunohistochemical staining and Western blotting showed that RAPA treatment significantly down-regulated the enhanced levels of TGF-beta1 and alpha-SMA in lung tissues caused by PQ exposure.	Paraquat	179-181	transforming growth factor, beta 1	Mus musculus	129-138	
25559956-17	2015	CONCLUSIONS: This study demonstrates that RAPA treatment effectively suppresses PQ-induced alveolar collapse and collagen deposition in lung tissues through reducing the expression of TGF-beta1 and alpha-SMA.	Paraquat	80-82	transforming growth factor, beta 1	Mus musculus	184-193	
31177710-0	2019	[Doxycycline inhibits paraquat-induced pulmonary fibrosis via TGF-beta1/Smad pathway].	Paraquat	22-30	transforming growth factor, beta 1	Mus musculus	62-71	
31495108-15	2019	After 48 hours, the expression of TNF-alpha, TGF-beta1, and IL-1beta in peripheral blood significantly increased by 39%, 45%, and 38%, respectively, in the PQ group (P<0.05) , but they significantly decreased by 31%, 13%, and 22%, respectively, in the OPCs+PQ group as compared with the PQ group (P<0.05) .	Paraquat	156-158	transforming growth factor, beta 1	Mus musculus	45-54	
31177710-4	2019	The expression of TGF-beta1, a-SMA, Smad3 and Smad2 protein was detected by ELISA using 40 ml of paraquat 40 umol/L and 3 mg/L of oleic acid 10 mg/L.	Paraquat	97-105	transforming growth factor, beta 1	Mus musculus	18-27	
31177710-12	2019	Conclusion: Doxycycline inhibits paraquat-induced pulmonary fibrosis by inhibiting the expression of TGF-beta1, a-SMA and Smad3, Smad2 proteins.	Paraquat	33-41	transforming growth factor, beta 1	Mus musculus	101-110	
29852175-9	2018	PQ-induced fibrosis was also improved in Angptl2-/- mice by decreasing pulmonary transforming growth factor (TGF)-beta1 expressions.	Paraquat	0-2	transforming growth factor, beta 1	Mus musculus	81-119	
27507327-0	2016	Salvianolic acid B protects against paraquat-induced pulmonary injury by mediating Nrf2/Nox4 redox balance and TGF-beta1/Smad3 signaling.	Paraquat	36-44	transforming growth factor, beta 1	Mus musculus	111-120	
29195901-0	2018	Triptolide suppresses paraquat induced idiopathic pulmonary fibrosis by inhibiting TGFB1-dependent epithelial mesenchymal transition.	Paraquat	22-30	transforming growth factor, beta 1	Mus musculus	83-88	
29195901-8	2018	In summary, this study revealed the potential therapeutic effect of paraquat induced TPL in lung fibrosis by regulating TGFbeta-dependent EMT progression.	Paraquat	68-76	transforming growth factor, beta 1	Mus musculus	120-127	
31966703-0	2017	Bone morphogenetic protein 7 alleviates paraquat-induced pulmonary fibrosis via TGF-beta1/Erk1/2 pathway.	Paraquat	40-48	transforming growth factor, beta 1	Mus musculus	80-89