PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30248777-8	2018	Conclusion: Apoptosis and TNF-alpha, NF-kappa B and Caspase-3 play an important role in lung injury of paraquat-induced rats.	Paraquat	103-111	caspase 3	Rattus norvegicus	52-61	
33592258-8	2021	In vitro, A549 cells were treated with 250 microM PQ for 24 h. Incubation of A549 cells with PQ led to apoptosis, and increased the level of superoxide anions, reactive oxygen species (ROS), malondialdehyde and the activity of caspase-3 and up-regulation of phosphorylated p38-MAPK, reduced mitochondrial membrane potential (DeltaPsim) and the activity of SOD.	Paraquat	50-52	caspase 3	Rattus norvegicus	227-236	
33592258-8	2021	In vitro, A549 cells were treated with 250 microM PQ for 24 h. Incubation of A549 cells with PQ led to apoptosis, and increased the level of superoxide anions, reactive oxygen species (ROS), malondialdehyde and the activity of caspase-3 and up-regulation of phosphorylated p38-MAPK, reduced mitochondrial membrane potential (DeltaPsim) and the activity of SOD.	Paraquat	93-95	caspase 3	Rattus norvegicus	227-236	
30284226-8	2018	Our results showed that PQ has significantly increased brain LPO, DNA damage, and caspase-3 levels and further reduced TAC and TTM contents, as well as expression levels of Nestin and Neurod1, compared with the control group (injection of saline).	Paraquat	24-26	caspase 3	Rattus norvegicus	82-91	
30284226-9	2018	CeNPs (15- and 30-mg/kg doses) in groups co-administered with PQ significantly ameliorated the LPO, DNA damage, and caspase-3 levels while increasing TAC and TTM contents as well as enhancing Nestin and Neurod1 mRNA expression levels in the brain samples (P < 0.05).	Paraquat	62-64	caspase 3	Rattus norvegicus	116-125	
18235974-6	2008	In addition, our data provide direct evidence that MnTDM suppressed PQ-induced caspase-3 cleavage, possibly a key event of PQ neurotoxicity.	Paraquat	68-70	caspase 3	Rattus norvegicus	79-88	
26653232-0	2015	[The effect of paraquat on voltage-dependent anion channel and caspase-3, 8, 9 in the mitochondria of rat lung].	Paraquat	15-23	caspase 3	Rattus norvegicus	63-72	
26653232-9	2015	CONCLUSION: PQ poisoning can up-regulate the expression of VDAC and caspase-3, -8, and -9 in mitochondria of rat lung tissue to induce acute lung injury.	Paraquat	12-14	caspase 3	Rattus norvegicus	68-89	
25230871-12	2014	Western Blot results showed: compared with the control group, the protein expressions of LC3-II and caspase-3 were significantly increased in PQ poisoning group [LC3-II (A value): 0.22 +- 0.05 vs. 0.14 +- 0.03, caspase-3 (A value): 0.115 +- 0.013 vs. 0.023 +- 0.006, both P<0.05].	Paraquat	142-144	caspase 3	Rattus norvegicus	100-109	
25230871-12	2014	Western Blot results showed: compared with the control group, the protein expressions of LC3-II and caspase-3 were significantly increased in PQ poisoning group [LC3-II (A value): 0.22 +- 0.05 vs. 0.14 +- 0.03, caspase-3 (A value): 0.115 +- 0.013 vs. 0.023 +- 0.006, both P<0.05].	Paraquat	142-144	caspase 3	Rattus norvegicus	211-220	
24912633-15	2014	CONCLUSIONS: Paraquat can cause acute liver injury in rats, with caspase-3, -8, -9, -12 activities markedly enhanced, and liver injury may be associated with an early high expression of TNF-alpha, iNOS and p53 gene.	Paraquat	13-21	caspase 3	Rattus norvegicus	65-82	
25215081-4	2012	In this study, we observed the expression of caspase-3 and livin protein in rat renal tissue after PQ poisoning as well as the therapeutic effects of ulinastatin.	Paraquat	99-101	caspase 3	Rattus norvegicus	45-54	
18235974-6	2008	In addition, our data provide direct evidence that MnTDM suppressed PQ-induced caspase-3 cleavage, possibly a key event of PQ neurotoxicity.	Paraquat	123-125	caspase 3	Rattus norvegicus	79-88	
17561093-5	2007	PQ-exposed rats suffered a time-dependent increase of caspase-3 and caspase-8 and a decrease of caspase-1 activities in lungs compared to the control group.	Paraquat	0-2	caspase 3	Rattus norvegicus	54-63	
17509817-4	2007	Moreover, EGb761 pretreatment evidently increased the numbers of tyrosine hydroxylase (TH) positive and bcl-2 positive cells and degraded the number of caspase-3 positive cells in PQ-injured PC12 cells, in comparison to the treatment with PQ alone.	Paraquat	180-182	caspase 3	Rattus norvegicus	152-161	
34655599-10	2021	NAR treatment significantly modulated PQ-induced mRNA expressions of DRD2, DAT, LRRK2, SNCA, beta-catenin, caspase-3, BDNF genes.	Paraquat	38-40	caspase 3	Rattus norvegicus	107-116	
34446195-7	2021	Paraquat poisoning led to lung tissue apoptosis as was evidenced by higher Caspase-3 and Bax/Bcl2 expressions in rats subjected to paraquat inhalation instead of normal saline or free nanoparticles.	Paraquat	0-8	caspase 3	Rattus norvegicus	75-84	
34446195-7	2021	Paraquat poisoning led to lung tissue apoptosis as was evidenced by higher Caspase-3 and Bax/Bcl2 expressions in rats subjected to paraquat inhalation instead of normal saline or free nanoparticles.	Paraquat	131-139	caspase 3	Rattus norvegicus	75-84	
35236239-3	2022	Results showed that PQ dose-dependently increased the expression of miR-136-5p, the apoptosis of PC12 cells, the activities of reactive oxygen species (ROS), and the levels of lactate dehydrogenase (LDH), malondialdehyde (MDA), caspase-3, and pro-apoptotic protein Bax.	Paraquat	20-22	caspase 3	Rattus norvegicus	228-237