PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33592258-8 2021 In vitro, A549 cells were treated with 250 microM PQ for 24 h. Incubation of A549 cells with PQ led to apoptosis, and increased the level of superoxide anions, reactive oxygen species (ROS), malondialdehyde and the activity of caspase-3 and up-regulation of phosphorylated p38-MAPK, reduced mitochondrial membrane potential (DeltaPsim) and the activity of SOD. Paraquat 50-52 caspase 3 Rattus norvegicus 227-236 33592258-8 2021 In vitro, A549 cells were treated with 250 microM PQ for 24 h. Incubation of A549 cells with PQ led to apoptosis, and increased the level of superoxide anions, reactive oxygen species (ROS), malondialdehyde and the activity of caspase-3 and up-regulation of phosphorylated p38-MAPK, reduced mitochondrial membrane potential (DeltaPsim) and the activity of SOD. Paraquat 93-95 caspase 3 Rattus norvegicus 227-236 26653232-0 2015 [The effect of paraquat on voltage-dependent anion channel and caspase-3, 8, 9 in the mitochondria of rat lung]. Paraquat 15-23 caspase 3 Rattus norvegicus 63-72 30284226-8 2018 Our results showed that PQ has significantly increased brain LPO, DNA damage, and caspase-3 levels and further reduced TAC and TTM contents, as well as expression levels of Nestin and Neurod1, compared with the control group (injection of saline). Paraquat 24-26 caspase 3 Rattus norvegicus 82-91 30284226-9 2018 CeNPs (15- and 30-mg/kg doses) in groups co-administered with PQ significantly ameliorated the LPO, DNA damage, and caspase-3 levels while increasing TAC and TTM contents as well as enhancing Nestin and Neurod1 mRNA expression levels in the brain samples (P < 0.05). Paraquat 62-64 caspase 3 Rattus norvegicus 116-125 30248777-8 2018 Conclusion: Apoptosis and TNF-alpha, NF-kappa B and Caspase-3 play an important role in lung injury of paraquat-induced rats. Paraquat 103-111 caspase 3 Rattus norvegicus 52-61 26653232-9 2015 CONCLUSION: PQ poisoning can up-regulate the expression of VDAC and caspase-3, -8, and -9 in mitochondria of rat lung tissue to induce acute lung injury. Paraquat 12-14 caspase 3 Rattus norvegicus 68-89 24912633-15 2014 CONCLUSIONS: Paraquat can cause acute liver injury in rats, with caspase-3, -8, -9, -12 activities markedly enhanced, and liver injury may be associated with an early high expression of TNF-alpha, iNOS and p53 gene. Paraquat 13-21 caspase 3 Rattus norvegicus 65-82 25230871-12 2014 Western Blot results showed: compared with the control group, the protein expressions of LC3-II and caspase-3 were significantly increased in PQ poisoning group [LC3-II (A value): 0.22 +- 0.05 vs. 0.14 +- 0.03, caspase-3 (A value): 0.115 +- 0.013 vs. 0.023 +- 0.006, both P<0.05]. Paraquat 142-144 caspase 3 Rattus norvegicus 100-109 25230871-12 2014 Western Blot results showed: compared with the control group, the protein expressions of LC3-II and caspase-3 were significantly increased in PQ poisoning group [LC3-II (A value): 0.22 +- 0.05 vs. 0.14 +- 0.03, caspase-3 (A value): 0.115 +- 0.013 vs. 0.023 +- 0.006, both P<0.05]. Paraquat 142-144 caspase 3 Rattus norvegicus 211-220 25215081-4 2012 In this study, we observed the expression of caspase-3 and livin protein in rat renal tissue after PQ poisoning as well as the therapeutic effects of ulinastatin. Paraquat 99-101 caspase 3 Rattus norvegicus 45-54 17561093-5 2007 PQ-exposed rats suffered a time-dependent increase of caspase-3 and caspase-8 and a decrease of caspase-1 activities in lungs compared to the control group. Paraquat 0-2 caspase 3 Rattus norvegicus 54-63 18235974-6 2008 In addition, our data provide direct evidence that MnTDM suppressed PQ-induced caspase-3 cleavage, possibly a key event of PQ neurotoxicity. Paraquat 68-70 caspase 3 Rattus norvegicus 79-88 18235974-6 2008 In addition, our data provide direct evidence that MnTDM suppressed PQ-induced caspase-3 cleavage, possibly a key event of PQ neurotoxicity. Paraquat 123-125 caspase 3 Rattus norvegicus 79-88 17509817-4 2007 Moreover, EGb761 pretreatment evidently increased the numbers of tyrosine hydroxylase (TH) positive and bcl-2 positive cells and degraded the number of caspase-3 positive cells in PQ-injured PC12 cells, in comparison to the treatment with PQ alone. Paraquat 180-182 caspase 3 Rattus norvegicus 152-161 34446195-7 2021 Paraquat poisoning led to lung tissue apoptosis as was evidenced by higher Caspase-3 and Bax/Bcl2 expressions in rats subjected to paraquat inhalation instead of normal saline or free nanoparticles. Paraquat 0-8 caspase 3 Rattus norvegicus 75-84 34655599-10 2021 NAR treatment significantly modulated PQ-induced mRNA expressions of DRD2, DAT, LRRK2, SNCA, beta-catenin, caspase-3, BDNF genes. Paraquat 38-40 caspase 3 Rattus norvegicus 107-116 34446195-7 2021 Paraquat poisoning led to lung tissue apoptosis as was evidenced by higher Caspase-3 and Bax/Bcl2 expressions in rats subjected to paraquat inhalation instead of normal saline or free nanoparticles. Paraquat 131-139 caspase 3 Rattus norvegicus 75-84 35236239-3 2022 Results showed that PQ dose-dependently increased the expression of miR-136-5p, the apoptosis of PC12 cells, the activities of reactive oxygen species (ROS), and the levels of lactate dehydrogenase (LDH), malondialdehyde (MDA), caspase-3, and pro-apoptotic protein Bax. Paraquat 20-22 caspase 3 Rattus norvegicus 228-237