PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2898328-1 1988 Halothane is reduced to 2-chloro-1,1,1-trifluoroethane (CTE) and 2-chloro-1,1-difluoroethene (CDE) by cytochrome P-450. Halothane 0-9 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 102-118 3404442-8 1988 The cytochrome P-450 in microsomes from a single human subject metabolized halothane at a rate comparable to that found in microsomes from phenobarbital- and imidazole-pretreated rabbits. Halothane 75-84 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 4-20 3404442-11 1988 Antibodies to cytochrome P-450 3a inhibited halothane metabolism by 90% in microsomes from imidazole-pretreated rabbits, suggesting that isozyme 3a catalyzes halothane metabolism in imidazole-pretreated rabbits. Halothane 44-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-30 3404442-11 1988 Antibodies to cytochrome P-450 3a inhibited halothane metabolism by 90% in microsomes from imidazole-pretreated rabbits, suggesting that isozyme 3a catalyzes halothane metabolism in imidazole-pretreated rabbits. Halothane 158-167 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 14-30 2680385-1 1989 A variety of organic compounds such as carbon tetrachloride, halothane, gentian violet, and benznidazole are reductively metabolized to free radicals by liver microsomal cytochrome P-450. Halothane 61-70 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 170-186 3566799-0 1987 Stabilization of the reduced halocarbon-cytochrome P-450 complex of halothane by N-alkanes. Halothane 68-77 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 40-56 3566799-2 1987 Previous studies have shown that halothane forms such a complex with cytochrome P-450, and the result is a strong absorption at 470 nm. Halothane 33-42 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 69-85 3566799-4 1987 Data are presented which show that several organic solvents (C5-C7N-alkanes) will stabilize the complex formed between halothane and cytochrome P-450. Halothane 119-128 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 133-149 3566799-7 1987 Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450. Halothane 21-30 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 121-137 3566799-7 1987 Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450. Halothane 21-30 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 202-218 3566799-7 1987 Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450. Halothane 111-120 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 121-137 3566799-7 1987 Stabilization of the halothane complex in a biological system may facilitate studies to identify precisely the halothane-cytochrome P-450 complex and to clarify the mechanisms of halothane reduction by cytochrome P-450. Halothane 111-120 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 121-137 909072-0 1977 The in vitro metabolism of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by hepatic microsomal cytochrome P-450. Halothane 27-36 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 100-116 6696254-2 1984 In previous studies they have shown that the halothane-free radical produced by UV-irradiation is identical to that produced during reductive metabolism of halothane by hepatic cytochrome P-450. Halothane 45-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 177-193 6696254-2 1984 In previous studies they have shown that the halothane-free radical produced by UV-irradiation is identical to that produced during reductive metabolism of halothane by hepatic cytochrome P-450. Halothane 156-165 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 177-193 6796087-0 1981 1-Chloro-2,2,2-trifluoroethyl radical: Formation from halothane by human cytochrome P-450 in reconstituted vesicles and binding to phospholipids. Halothane 54-63 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 73-89 909072-0 1977 The in vitro metabolism of halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) by hepatic microsomal cytochrome P-450. Halothane 38-76 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 100-116 10805064-1 2000 OBJECTIVE: Halothane undergoes both oxidative and reductive metabolism by cytochrome P450 (CYP), respectively causing rare immune-mediated hepatic necrosis and common, mild subclinical hepatic toxicity. Halothane 11-20 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 74-89 10805064-1 2000 OBJECTIVE: Halothane undergoes both oxidative and reductive metabolism by cytochrome P450 (CYP), respectively causing rare immune-mediated hepatic necrosis and common, mild subclinical hepatic toxicity. Halothane 11-20 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 91-94 10805064-15 2000 CYP2A6-mediated, like CYP2E1-mediated human halothane oxidation, can be inhibited in vivo by mechanism-based CYP inhibitors. Halothane 44-53 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 0-3 1594531-0 1992 Suicidal inactivation of human cytochrome P-450 by carbon tetrachloride and halothane in vitro. Halothane 76-85 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 31-47 1594531-1 1992 A significant loss of human cytochrome P-450 was observed during the anaerobic incubation of NADPH-reduced human liver microsomes obtained from surgical samples, in presence of carbon tetrachloride or halothane. Halothane 201-210 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 28-44 1594531-5 1992 The results indicate that human liver cytochrome P-450 can be inactivated reductively in vitro by CCl4 and halothane reactive metabolites and suggest that a suicide type of mechanism, similar to that which was recently demonstrated to occur, for both substrates, with rat liver microsomes (Manno et al. Halothane 107-116 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 38-54