PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30689946-5 2019 In the present work, structure optimizations guided by a binding model led to the identification of the lead compound 2-hydroxy-4-((4-(naphthalen-2-yl)thiazol-2-yl)amino)benzoic acid (27), showing a submicromolar potency against purified CK2alpha (IC50 = 0.6 muM). 2-hydroxy-4-((4-(naphthalen-2-yl)thiazol-2-yl)amino)benzoic acid 118-182 casein kinase 2 alpha 2 Homo sapiens 238-246