PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14570773-5 2003 In contrast to microsomes, the oxidation of rofecoxib to 5-hydroxyrofecoxib by S9 fractions followed two pathways, one NADPH-dependent and one NAD+-dependent (non-cytochrome P450), with the latter accounting for about 40% of total activity. 5-hydroxyrofecoxib 57-75 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 163-178