PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18492949-4 2008 In vitro autoradiography of DAT binding with [125I]2-carbomethoxy-3-(4-iodophenyl)tropane (RTI-55) on brain sections obtained 24 h after injection showed a highly localized blockade of binding in striatum, with maximal blockade of binding by 1 to 3 nmol HD-205. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 91-97 solute carrier family 6 member 3 Rattus norvegicus 28-31 23758882-8 2013 RESULTS: The striatal uptake of [123I]beta-CIT differed significantly between the lesion groups and the results were highly correlated to both striatal DAT- and TH-immunoreactive fiber densities and to TH-immunoreactive cell numbers in the rat SNpc. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 38-46 solute carrier family 6 member 3 Rattus norvegicus 152-155 19453722-7 2009 The interaction between CBZ and 125I beta-CIT binding to SERT and DAT was investigated using in vitro autoradiography. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 37-45 solute carrier family 6 member 3 Rattus norvegicus 66-69 10607889-4 1999 [3H]beta-CIT is proposed as a useful, high-affinity DAT radioprobe. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 4-12 solute carrier family 6 member 3 Rattus norvegicus 52-55 17307129-6 2007 Because [(131)I]beta-CIT binds unselectively both to DAT and serotonin transporters, no definite conclusion about the selectivity of the new compounds is possible. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 16-24 solute carrier family 6 member 3 Rattus norvegicus 53-56 10607889-0 1999 [3H]beta-CIT: a radioligand for dopamine transporters in rat brain tissue. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 4-12 solute carrier family 6 member 3 Rattus norvegicus 32-53 10607889-2 1999 With rat forebrain tissue, [3H]beta-CIT showed high affinity for dopamine transporters (DAT), with selectivity for DAT over norepinephrine transporters, but not serotonin transporters, as well as DAT-stereoselectivity with beta-CIT, amphetamine and methylphenidate. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 31-39 solute carrier family 6 member 3 Rattus norvegicus 65-86 10607889-2 1999 With rat forebrain tissue, [3H]beta-CIT showed high affinity for dopamine transporters (DAT), with selectivity for DAT over norepinephrine transporters, but not serotonin transporters, as well as DAT-stereoselectivity with beta-CIT, amphetamine and methylphenidate. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 31-39 solute carrier family 6 member 3 Rattus norvegicus 88-91 10607889-2 1999 With rat forebrain tissue, [3H]beta-CIT showed high affinity for dopamine transporters (DAT), with selectivity for DAT over norepinephrine transporters, but not serotonin transporters, as well as DAT-stereoselectivity with beta-CIT, amphetamine and methylphenidate. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 31-39 solute carrier family 6 member 3 Rattus norvegicus 115-118 10607889-2 1999 With rat forebrain tissue, [3H]beta-CIT showed high affinity for dopamine transporters (DAT), with selectivity for DAT over norepinephrine transporters, but not serotonin transporters, as well as DAT-stereoselectivity with beta-CIT, amphetamine and methylphenidate. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 31-39 solute carrier family 6 member 3 Rattus norvegicus 115-118 8612664-1 1996 Iodine-123-labelled 3beta-(4-iodophenyl)tropane-2beta-carboxylic acid ([123I]beta-CIT) labels both the dopamine transporter (DAT) and the serotonin transporter (5-HTT) and this ligand is able to clarify pathological changes in both dopaminergic and serotonergic systems. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 77-85 solute carrier family 6 member 3 Rattus norvegicus 103-123 9074541-2 1997 METHODS: The amounts of the dopamine transporter (DAT) and dopamine D1 and D2 receptors in the brain were assessed by in vitro autoradiography with the ligands [125I] beta-CIT, [125I]SCH23982 and [125I]iodospiperone, respectively. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 167-175 solute carrier family 6 member 3 Rattus norvegicus 50-53 9074541-4 1997 RESULTS: The beta-CIT binding for the DAT was increased significantly in the caudate-putamen (CPu) of SH rats compared with that of Wistar-Kyoto (WKY) rats at both pre- and posthypertensive stages. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 13-21 solute carrier family 6 member 3 Rattus norvegicus 38-41 8804721-3 1996 To clarify this mechanism, we examined the expression of DAT in the caudate putamen (CPu) by in situ hybridization histochemistry (mRNA) and autoradiography (using the ligand [125I] beta-CIT, which labels DAT) and compared them with the recovery of motor disturbance revealed with methamphetamine-induced rotation. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 182-190 solute carrier family 6 member 3 Rattus norvegicus 57-60 8612664-1 1996 Iodine-123-labelled 3beta-(4-iodophenyl)tropane-2beta-carboxylic acid ([123I]beta-CIT) labels both the dopamine transporter (DAT) and the serotonin transporter (5-HTT) and this ligand is able to clarify pathological changes in both dopaminergic and serotonergic systems. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 77-85 solute carrier family 6 member 3 Rattus norvegicus 125-128 8612664-2 1996 However, the differential kinetics of beta-CIT binding to DAT and 5-HTT has not been clarified fully. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 38-46 solute carrier family 6 member 3 Rattus norvegicus 58-61 8612664-11 1996 Therefore binding kinetics of [123i]beta-cit in the region rich in dat is apparently different from that in the region rich in 5-HTT. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 36-44 solute carrier family 6 member 3 Rattus norvegicus 67-70 8612664-12 1996 These results will provide fundamental data to image both DAT and 5-HTT in one series of examinations with [123I]beta-CIT. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 113-121 solute carrier family 6 member 3 Rattus norvegicus 58-61 7802967-8 1994 Therefore, radiolabelled RTI-55, combined with unlabelled clomipramine, which displaces its binding to 5HTT, also appears to be suitable for the selective imaging of DAT in vivo. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 25-31 solute carrier family 6 member 3 Rattus norvegicus 166-169 8558525-1 1996 This report concerns the synthesis and chemical characterization of novel series of N-substituted 2 beta-carbomethoxy-3 beta-(4"-iodophenyl)tropane (beta-CIT, 2) analogs and their neuropharmacological evaluation for affinity at dopamine (DAT), serotonin (5-HTT), and norepinephrine membrane transporters in rat brain tissue. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 149-157 solute carrier family 6 member 3 Rattus norvegicus 238-241 8558525-2 1996 N-Substituted analogs of beta-CIT with a 2 beta-carbomethoxy ester moiety showed lower DAT affinity than beta-CIT for the DAT, and some were more selective for the 5-HTT over the DAT. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 25-33 solute carrier family 6 member 3 Rattus norvegicus 87-90 8558525-2 1996 N-Substituted analogs of beta-CIT with a 2 beta-carbomethoxy ester moiety showed lower DAT affinity than beta-CIT for the DAT, and some were more selective for the 5-HTT over the DAT. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 25-33 solute carrier family 6 member 3 Rattus norvegicus 122-125 8558525-2 1996 N-Substituted analogs of beta-CIT with a 2 beta-carbomethoxy ester moiety showed lower DAT affinity than beta-CIT for the DAT, and some were more selective for the 5-HTT over the DAT. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 25-33 solute carrier family 6 member 3 Rattus norvegicus 122-125 8558525-2 1996 N-Substituted analogs of beta-CIT with a 2 beta-carbomethoxy ester moiety showed lower DAT affinity than beta-CIT for the DAT, and some were more selective for the 5-HTT over the DAT. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 105-113 solute carrier family 6 member 3 Rattus norvegicus 122-125 8558525-2 1996 N-Substituted analogs of beta-CIT with a 2 beta-carbomethoxy ester moiety showed lower DAT affinity than beta-CIT for the DAT, and some were more selective for the 5-HTT over the DAT. 2beta-carbomethoxy-3beta-(4-iodophenyl)tropane 105-113 solute carrier family 6 member 3 Rattus norvegicus 122-125