PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11956509-9 2002 In vitro, the activity of acetylcholinesterase was inhibited by 100-micromol/L irinotecan (-24.8%) and markedly reduced by 1-micromol/L physostigmine (-86.7%), whereas neither SN-38 nor camptothecin had an effect. Physostigmine 136-149 acetylcholinesterase (Cartwright blood group) Homo sapiens 26-46 11979423-0 2002 Inhibition of acetylcholinesterase by physostigmine analogs: conformational mobility of cysteine loop due to the steric effect of the alkyl chain. Physostigmine 38-51 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 11979423-1 2002 The effect of a series of physostigmine analogs on acetylcholinesterase activity was investigated. Physostigmine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 51-71 11176277-1 2001 [11C]physostigmine, an acetylcholinesterase inhibitor, has been shown to be a promising positron emission tomography ligand to quantify the cerebral concentration of the enzyme in animals and humans in vivo. Physostigmine 5-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-43 11893059-2 2001 The earliest known AChE inhibitors, namely, physostigmine and tacrine, performed poorly in clinical trials (e.g., poor oral activity, brain penetration, and hepatotoxic liability). Physostigmine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 11405996-2 2001 Physostigmine is an AChE inhibitor originally extracted from calabar beans. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 9675107-0 1998 Kinetics of human erythrocyte acetylcholinesterase inhibition by a novel derivative of physostigmine: phenserine. Physostigmine 87-100 acetylcholinesterase (Cartwright blood group) Homo sapiens 30-50 10718513-1 2000 Previously, we have shown that physostigmine, an acetylcholinesterase inhibitor, improved performance on a working memory for faces task, as reflected by reduced reaction time (RT), and reduced task-specific regional cerebral blood flow (rCBF) in right prefrontal cortex and, further, that these reductions in RT and right frontal rCBF were significantly correlated. Physostigmine 31-44 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 9742217-1 1998 The role of the functional architecture of the human acetylcholinesterase (HuAChE) active centre in accommodating the non-covalent inhibitors tacrine and huperzine A, or the carbamates pyridostigmine and physostigmine, was analysed using 16 mutants of residues lining the active-centre gorge. Physostigmine 204-217 acetylcholinesterase (Cartwright blood group) Homo sapiens 53-73 11256231-4 2000 The order of inhibitory potency (IC50) towards AChE activity under optimal assay conditions for each ChE inhibitor was: physostigmine (0.67 nM) > rivastigmine (4.3 nM) > donepezil (6.7 nM) > TAK-147 (12 nM) > tacrine (77 nM) > ipidacrine (270 nM). Physostigmine 120-133 acetylcholinesterase (Cartwright blood group) Homo sapiens 47-51 10976649-3 2000 After physostigmine, acetylcholinesterase inhibition averaged 52% in normal cerebral cortex. Physostigmine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 21-41 10637365-3 2000 These data are summarised from nearly all therapeutically important chemical classes of reversible AChE inhibitors, e.g., derivatives of physostigmine, tacrine, donepezil and huperzine A. Interactions observed from X-ray crystallography between these inhibitors and AChE have also been incorporated and compared with modelling and QSAR results. Physostigmine 137-150 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-103 10637367-3 2000 The earliest known AChE inhibitors, namely, physostigmine and tacrine, showed modest improvement in the cognitive function of Alzheimer"s patients. Physostigmine 44-57 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-23 11139819-4 1999 Early acetylcholinesterase inhibitors, such as tacrine and physostigmine, are poorly tolerated and have a short duration of action. Physostigmine 59-72 acetylcholinesterase (Cartwright blood group) Homo sapiens 6-26 9568379-1 1998 Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 63-83 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Physostigmine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 71-91 9568379-0 1998 Effects of hexamethonium, phenothiazines, propranolol and ephedrine on acetylcholinesterase carbamylation by physostigmine, aldicarb and carbaryl: interaction between the active site and the functionally distinct peripheral sites in acetylcholinesterase. Physostigmine 109-122 acetylcholinesterase (Cartwright blood group) Homo sapiens 233-253 9568379-1 1998 Physostigmine, aldicarb and carbaryl were potent inhibitors of acetylcholinesterase (AChE). Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 85-89 9568379-2 1998 The physostigmine-inhibited AChE fluoresced at 300 nm excitation and 500 nm emission wavelengths, but the aldicarb and carbaryl inhibited enzyme did not. Physostigmine 4-17 acetylcholinesterase (Cartwright blood group) Homo sapiens 28-32 9568379-4 1998 The fluorescence intensity of physostigmine-inhibited AChE decreased with increasing the substrate (acetylthiocholine) concentration, thus indicating that physostigmine binding to the active site is essential for the development of fluorescence. Physostigmine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9568379-4 1998 The fluorescence intensity of physostigmine-inhibited AChE decreased with increasing the substrate (acetylthiocholine) concentration, thus indicating that physostigmine binding to the active site is essential for the development of fluorescence. Physostigmine 155-168 acetylcholinesterase (Cartwright blood group) Homo sapiens 54-58 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. Physostigmine 10-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. Physostigmine 10-23 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. Physostigmine 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 34-38 9568379-5 1998 Thus, the physostigmine-inhibited AChE fluoresces due to the binding of trimethylpyrrolo[2,3-b]indol (TMPI) moiety, formed by the hydrolysis of physostigmine, to a peripheral site in AChE. Physostigmine 144-157 acetylcholinesterase (Cartwright blood group) Homo sapiens 183-187 9568379-12 1998 Hexamethonium protected AChE from inhibition by carbamates and decreased the fluorescence intensity of the physostigmine-inhibited AChE. Physostigmine 107-120 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 8784921-1 1996 A method for preparing various forms of acetylcholinesterase (AChE) from human erythrocyte has been established and they have been characterized in terms of kinetic parameters such as K(m), rate constant (k), turnover number (kcat), specificity constant (ksp), Vmax, half-life (t1/2), IC50 and Ki for tetrabutylammonium hydroxide, procaine and physostigmine in the present study. Physostigmine 344-357 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 9062656-2 1997 AChE inhibitors, including physostigmine, E-2020, amiridin, tetrahydroaminoacridine (THA) and Nicergoline had a poor effect on AChE present in the senile plaque-rich fraction isolated from Alzheimer brain than that either in the soluble fraction of Alzheimer brain or in the control brain. Physostigmine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 9030907-4 1997 Acetylcholinesterase activity of adrenal homogenates was inhibited by tacrine and physostigmine in a concentration-dependent manner. Physostigmine 82-95 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 8764619-2 1996 The study was carried out in eight healthy human volunteers using as a tracer [11C]-physostigmine ([11C]PHY), an inhibitor of AChE. Physostigmine 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 9428657-0 1997 Long chain analogs of physostigmine as potential drugs for Alzheimer"s disease: new insights into the mechanism of action in the inhibition of acetylcholinesterase. Physostigmine 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 143-163 9279214-7 1997 Physostigmine (0.1 mumol/L), an acetylcholinesterase inhibitor, reduced A23187-evoked histamine release by 58%. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 9365431-3 1997 She improved with a combination of benzodiazepines and the acetylcholinesterase inhibitor physostigmine. Physostigmine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 8784921-1 1996 A method for preparing various forms of acetylcholinesterase (AChE) from human erythrocyte has been established and they have been characterized in terms of kinetic parameters such as K(m), rate constant (k), turnover number (kcat), specificity constant (ksp), Vmax, half-life (t1/2), IC50 and Ki for tetrabutylammonium hydroxide, procaine and physostigmine in the present study. Physostigmine 344-357 acetylcholinesterase (Cartwright blood group) Homo sapiens 62-66 1552502-4 1992 The most active AChE inhibitors were N,N"-disubstituted derivatives of 2-nitro-1,1-ethenediamine and 4,6-dinitro-1,3-benzenediamine, with compound 8 demonstrating activity greater than physostigmine. Physostigmine 185-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-20 8846227-4 1995 AChE inhibitors, physostigmine and Tacrine can slow the decline of cognitive function and memory in some patients with mild or moderate AD, if given for at least 3-6 months in sufficient doses to inhibit brain AChE. Physostigmine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 210-214 8846227-6 1995 Newer, less toxic AChE inhibitors, with selective central activity, formulations of physostigmine, selective Ml and nicotinic agonists are becoming available with improved bioavailability and pharmacokinetics. Physostigmine 84-97 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 7536306-5 1994 The acetylcholinesterase inhibitor, physostigmine, exerts a similar modulatory influence on the ACh current and on its extinction, and also prevents the manifestation of the effects of amiridin and tacrine. Physostigmine 36-49 acetylcholinesterase (Cartwright blood group) Homo sapiens 4-24 7970904-6 1994 Dose-response curves to locally applied Ach were obtained before and after the intravenous administration of the AChE inhibitor physostigmine (Phys). Physostigmine 128-141 acetylcholinesterase (Cartwright blood group) Homo sapiens 113-117 7681755-4 1993 Intravenous administration of physostigmine, an acetylcholinesterase inhibitor, evoked a spatial frequency-dependent change in VEP amplitude. Physostigmine 30-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-68 7636741-5 1995 The purpose of this study was to determine the selectivity of physostigmine, metrifonate, methanesulfonyl fluoride and tetrahydroaminoacridine (tacrine) toward AChE as compared with butyrylcholinesterase (BChE) in human cortex. Physostigmine 62-75 acetylcholinesterase (Cartwright blood group) Homo sapiens 160-164 7636741-7 1995 Physostigmine inhibited AChE more than BChE. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 8185877-5 1994 Physostigmine plasma concentrations were relatively stable (0.56 +/- 0.10 ng/ml) and correlated well with blood acetylcholinesterase inhibition. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 112-132 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Physostigmine 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Physostigmine 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 8421706-2 1993 We previously reported that traditional acetylcholinesterase inhibitors such as BW284C51, tacrine, and physostigmine were more potent inhibitors of the acetylcholinesterase in normal axons and cell bodies than of the acetylcholinesterase in plaques and tangles. Physostigmine 103-116 acetylcholinesterase (Cartwright blood group) Homo sapiens 152-172 1494302-1 1992 Heptylphysostigmine (HPTL), a derivative of the AChE inhibitor physostigmine (PHY), is under investigation as a therapeutic agent in Alzheimer"s disease. Physostigmine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 48-52 1787292-2 1991 Although refractory to precordial thump, synchronous cardioversion, and lidocaine, the ventricular tachycardia was reversed by intravenous administration of the tertiary acetylcholinesterase inhibitor physostigmine. Physostigmine 201-214 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-190 1955905-6 1991 These data suggest that the doses of physostigmine used were insufficient to produce marked inhibition of AChE within the central nervous system. Physostigmine 37-50 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-110 1954303-0 1991 Inhibition of acetylcholinesterase activity in human brain tissue and erythrocytes by galanthamine, physostigmine and tacrine. Physostigmine 100-113 acetylcholinesterase (Cartwright blood group) Homo sapiens 14-34 1954303-2 1991 Acetylcholinesterase activity was most effectively inhibited in all tissues by physostigmine, followed by tacrine and galanthamine. Physostigmine 79-92 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 1954303-5 1991 While physostigmine and tacrine acted equally on acetylcholinesterase from different sources, galanthamine was 10-fold less potent in inhibiting the enzyme activity from human brain that from human erythrocytes. Physostigmine 6-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 49-69 1676644-0 1991 Correlation between plasma physostigmine concentrations and percentage of acetylcholinesterase inhibition over time after controlled release of physostigmine in volunteer subjects. Physostigmine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 74-94 1907148-7 1991 The rate of recovery of red cell AChE and plasma ChE activities, following incubation of whole blood with physostigmine (1 x 10(-7) M), was in the order human greater than rhesus monkey greater than marmoset greater than guinea-pig. Physostigmine 106-119 acetylcholinesterase (Cartwright blood group) Homo sapiens 33-37 1676644-3 1991 Plasma physostigmine concentrations correlated with percentage of AChE inhibition across time by dose and across all doses and subjects tested. Physostigmine 7-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 66-70 1676644-4 1991 These data should be helpful to physicians in adjusting physostigmine dosing, enabling them to use the relatively simple and widely available AChE assay to approximate plasma physostigmine concentrations. Physostigmine 56-69 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 1676644-4 1991 These data should be helpful to physicians in adjusting physostigmine dosing, enabling them to use the relatively simple and widely available AChE assay to approximate plasma physostigmine concentrations. Physostigmine 175-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 142-146 3685073-3 1987 A rate-decreasing dose of physostigmine, an acetylcholinesterase inhibitor, was studied in combination with the range of atropine doses. Physostigmine 26-39 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-64 2294657-0 1990 Effects of tacrine, aminopyridines, and physostigmine on acetylcholinesterase, acetylcholine release, and potassium currents. Physostigmine 40-53 acetylcholinesterase (Cartwright blood group) Homo sapiens 57-77 33478277-2 2021 In the present study, we used three docking-based virtual screening approaches to screen both ZINC15 and MolPort databases for synthetic analogs of physostigmine and donepezil, two highly potent AChE inhibitors. Physostigmine 148-161 acetylcholinesterase (Cartwright blood group) Homo sapiens 195-199 3185960-3 1988 IC50 values (the concentration required to reduce enzyme activity by 50%) for the inhibition of total tissue AChE were 7.9 x 10(-7) M and 4.5 x 10(-8) M for THA and physostigmine, respectively, and similar values were also obtained for individual molecular forms of AChE (monomer G1, dimer G2 and tetramer G4) separated by sucrose density gradient centrifugation. Physostigmine 165-178 acetylcholinesterase (Cartwright blood group) Homo sapiens 109-113 1825627-11 1991 If the effects of the nondepolarizing neuromuscular blocking agents must be reversed more rapidly, acetylcholinesterase-inhibiting agents such as physostigmine, neostigmine, pyridostigmine, and edrophonium can be used. Physostigmine 146-159 acetylcholinesterase (Cartwright blood group) Homo sapiens 99-119 2326327-4 1990 Intraventricular administration of the acetylcholinesterase inhibitor, physostigmine (10 micrograms bilaterally), activated lordosis of short duration in ovariectomized hamsters primed only with estrogen. Physostigmine 71-84 acetylcholinesterase (Cartwright blood group) Homo sapiens 39-59 3694255-3 1987 The effects of acetylcholine (ACh), the muscarinic antagonist scopolamine (Sco), the nicotinic antagonist dihydro-beta-erythroidine (DBE), and the acetylcholinesterase inhibitor physostigmine (Phy) on maintained and light-evoked ganglion cell discharge was examined using iontophoresis techniques. Physostigmine 178-191 acetylcholinesterase (Cartwright blood group) Homo sapiens 147-167 4077467-2 1985 The inhibition of eel acetylcholinesterase by physostigmine at 20 degrees and 25 degrees C have been investigated. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 22-42 3575379-1 1987 A series of analogues of physostigmine were prepared with the aim of investigating their inhibitory effects on acetylcholinesterase in the treatment of Alzheimer"s disease. Physostigmine 25-38 acetylcholinesterase (Cartwright blood group) Homo sapiens 111-131 6661467-4 1983 Greater than 90% of AChE activity in CSF could be inhibited by 10(-3) M eserine. Physostigmine 72-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 20-24 7096782-0 1982 [Effect of intraperitoneal physostigmine administration on the multiple forms of acetylcholinesterase in different brain structures]. Physostigmine 27-40 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 16-36 6289994-3 1982 Exposure to the acetylcholinesterase (AChe) inhibitor physostigmine (1 microM) resulted in a 50% increase in electrically evoked [3H]dopamine release. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 38-42 14099400-0 1963 [ON THE INHIBITION OF THE HISTOCHEMICAL ACETYLCHOLINESTERASE REACTION ON MOTOR END-PLATES BY INJECTIONS OF NEOSTIGMINE AND PHYSOSTIGMINE]. Physostigmine 123-136 acetylcholinesterase (Cartwright blood group) Homo sapiens 40-60 7092918-0 1982 Reversible inhibition of acetylcholinesterase by eseroline, an opioid agonist structurally related to physostigmine (eserine) and morphine. Physostigmine 102-115 acetylcholinesterase (Cartwright blood group) Homo sapiens 25-45 1151640-1 1975 NMR was used to study the binding of acetylcholine, atropine, and physostigmine to acetylcholinesterase. Physostigmine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 1151640-4 1975 The dissociation constant, KD and the linewidth of the acetylcholinesterase-inhibitor complex, increment v bound, for atropine and physostigmine can be estimated from the linewidth changes of the N-methyl and phenyl group resonances of atropine and from the N-methyl and C-methyl group resonances of physostigmine resulting from association with the enzyme. Physostigmine 131-144 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 1151640-4 1975 The dissociation constant, KD and the linewidth of the acetylcholinesterase-inhibitor complex, increment v bound, for atropine and physostigmine can be estimated from the linewidth changes of the N-methyl and phenyl group resonances of atropine and from the N-methyl and C-methyl group resonances of physostigmine resulting from association with the enzyme. Physostigmine 300-313 acetylcholinesterase (Cartwright blood group) Homo sapiens 55-75 7217205-10 1981 As in the normal SCG, physostigmine-resistant staining, caused by noncholinesterase enzymes plus the possible presence of very low concentrations of AChE or BuChE, was noted at external mitochondrial membranes, elements of the endoplasmic reticulum of neurites and Schwann cells, and also in lysosomes. Physostigmine 22-35 acetylcholinesterase (Cartwright blood group) Homo sapiens 149-153 5873635-0 1965 [Acetylcholinesterase and the bioelectrical activity of the brain under the action of eserine and galanthamine in animals with premesencephalic section of the brain]. Physostigmine 86-93 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-21 31517530-2 2019 The structural properties and binding interactions of the AD drug physostigmine (-)-phy, and its analogues (-)-hex and (-)-phe and (+)-phe, were examined, as well as their impact on the conformational changes of two different AD target enzymes AChE and BChE. Physostigmine 66-79 acetylcholinesterase (Cartwright blood group) Homo sapiens 244-248 33357230-7 2020 Inhibition of this cancer-cell-intrinsic AChE via pyridostigmine and physostigmine, or administration of acetylcholine (ACh), diminished PCa cell viability and invasion in vitro and in vivo via suppression of pERK signaling, and reduced tumor-associated macrophage (TAM) infiltration and serum pro-inflammatory cytokine levels. Physostigmine 69-82 acetylcholinesterase (Cartwright blood group) Homo sapiens 41-45 31398669-12 2019 Physostigmine inhibited AChE activity with a sigmoidal concentration-response effect. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 28373858-3 2017 To determine if enhancing central cholinergic activity with the centrally acting acetylcholinesterase inhibitor, physostigmine would increase CBF when upright compared to the peripherally acting acetylcholinesterase inhibitor, neostigmine, or saline. Physostigmine 113-126 acetylcholinesterase (Cartwright blood group) Homo sapiens 81-101 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Physostigmine 239-246 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26902639-1 2016 Human serum albumin (HSA) induced modulation of acetylcholinesterase (AChE) inhibition activity of four well-known cholinergic inhibitors like tacrine hydrochloride (TAC), donepezil hydrochloride monohydrate (DON), (-) Huperzine A (HuPA), eserine (ESE) was monitored quantitatively by Ellman"s method. Physostigmine 248-251 acetylcholinesterase (Cartwright blood group) Homo sapiens 70-74 26200465-1 2015 BACKGROUND: Physostigmine, a centrally acting acetylcholinesterase inhibitor, is most commonly used by anesthesiologists in the postanesthetic setting to reverse confusion caused by central anticholinergic medication effects. Physostigmine 12-25 acetylcholinesterase (Cartwright blood group) Homo sapiens 46-66 23747570-4 2013 Furthermore, elevating extracellular ACh with the acetylcholinesterase inhibitor physostigmine had a larger effect on depolarizing versus hyperpolarizing responses. Physostigmine 81-94 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 25446352-3 2015 Using the pyrithiamine-induced thiamine deficiency (PTD) rat model of human Wernicke-Korsakoff syndrome, we tested the hypothesis that co-infusion of the acetylcholinesterase inhibitor physostigmine across the PFC and HPC would recover spatial alternation performance in PTD rats. Physostigmine 185-198 acetylcholinesterase (Cartwright blood group) Homo sapiens 154-174 23975732-6 2013 infusion of saline and the other during an infusion of the acetylcholinesterase inhibitor physostigmine. Physostigmine 90-103 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 19843075-0 2009 Ligand-based 3D-QSAR studies of physostigmine analogues as acetylcholinesterase inhibitors. Physostigmine 32-45 acetylcholinesterase (Cartwright blood group) Homo sapiens 59-79 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Physostigmine 51-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-4 23229229-3 2013 AChE inhibitors such as rivastigmine, galantamine, physostigmine and huperzine are obtained from plants, indicating that plants can serve as a potential source for novel AChE inhibitors. Physostigmine 51-64 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 22200647-4 2012 MATERIALS AND METHODS: AChE activity was evaluated utilizing reaction with Ellman"s reagent with physostigmine as a control. Physostigmine 97-110 acetylcholinesterase (Cartwright blood group) Homo sapiens 23-27 22461927-5 2012 DISCUSSION: Atropine causes anticholinergic toxicity; physostigmine reverses this by inhibiting acetylcholinesterase. Physostigmine 54-67 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 21414391-0 2011 In vitro kinetic interactions of pyridostigmine, physostigmine and soman with erythrocyte and muscle acetylcholinesterase from different species. Physostigmine 49-62 acetylcholinesterase (Cartwright blood group) Homo sapiens 101-121 21402092-0 2011 Pre- and post-treatment effect of physostigmine on soman-inhibited human erythrocyte and muscle acetylcholinesterase in vitro. Physostigmine 34-47 acetylcholinesterase (Cartwright blood group) Homo sapiens 96-116 21402092-5 2011 The present study was performed to investigate a possible pre- and post-treatment effect of physostigmine on soman-inhibited human AChE given at different time intervals before or after perfusion with soman by using a well-established dynamically working in vitro model for real-time analysis of erythrocyte and muscle AChE. Physostigmine 92-105 acetylcholinesterase (Cartwright blood group) Homo sapiens 131-135 21402092-6 2011 The major findings were that prophylactic physostigmine prevented complete inhibition of AChE by soman and resulted in partial spontaneous recovery of the enzyme by de-carbamylation. Physostigmine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 89-93 21402092-7 2011 Physostigmine given as post-treatment resulted in a time-dependent reduction of the protection from soman inhibition and recovery of AChE. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 133-137 20737911-2 2010 Alkaloids, such as physostigmine, galanthamine, and huperzine A, play an important role as AChE inhibitors. Physostigmine 19-32 acetylcholinesterase (Cartwright blood group) Homo sapiens 91-95 19843075-1 2009 Natural alkaloid Physostigmine is one of the most potent pseudo-irreversible inhibitor of Acetylcholinesterase. Physostigmine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 90-110 19843075-7 2009 Furthermore, the analysis of comparative molecular field analysis and comparative molecular similarity indices analysis contour maps within the active site of AChE were conducted in order to understand the interactions between the receptor and the Physostigmine derivatives. Physostigmine 248-261 acetylcholinesterase (Cartwright blood group) Homo sapiens 159-163 18729824-0 2009 Accommodation of physostigmine and its analogues by acetylcholinesterase is dominated by hydrophobic interactions. Physostigmine 17-30 acetylcholinesterase (Cartwright blood group) Homo sapiens 52-72 19416629-6 2009 In addition, McN-A-343, by activating the facilitatory M(1) receptors and physostigmine by inhibiting the acetylcholinesterase may induce the release of this factor through endogenous acetylcholine in the coaxial bioassay system. Physostigmine 74-87 acetylcholinesterase (Cartwright blood group) Homo sapiens 106-126 18729824-1 2009 The role of the functional architecture of the HuAChE (human acetylcholinesterase) in reactivity toward the carbamates pyridostigmine, rivastigmine and several analogues of physostigmine, that are currently used or considered for use as drugs for Alzheimer"s disease, was analysed using over 20 mutants of residues that constitute the interaction subsites in the active centre. Physostigmine 173-186 acetylcholinesterase (Cartwright blood group) Homo sapiens 61-81 18844288-8 2008 Spasm of the gut induced by the acetylcholinesterase inhibitor, physostigmine, was antagonized by ascorbigen with an IC50 of 286 microM. Physostigmine 64-77 acetylcholinesterase (Cartwright blood group) Homo sapiens 32-52 17134713-7 2007 Moreover, noteworthy results were obtained in the application of the AChE-CIM-IMER to the characterization of the carbamoylation and decarbamoylation steps in pseudo-irreversible binding of carbamate derivatives (physostigmine and rivastigmine). Physostigmine 213-226 acetylcholinesterase (Cartwright blood group) Homo sapiens 69-73 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Physostigmine 215-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 103-107 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Physostigmine 215-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18281016-7 2008 Therefore we studied the effects of the oximes obidoxime, HI 6 and MMB-4 on the rate of decarbamylation for physostigmine- and pyridostigmine-inhibited human erythrocyte AChE both in a dynamically working in vitro model and a static cuvette system. Physostigmine 108-121 acetylcholinesterase (Cartwright blood group) Homo sapiens 170-174 16971898-4 2007 Here, we tested whether the muscarinic antagonist scopolamine would disrupt LI and whether such disruption would be reversed by APDs and by the acetylcholinesterase inhibitor physostigmine. Physostigmine 175-188 acetylcholinesterase (Cartwright blood group) Homo sapiens 144-164 18304715-3 2008 Recently, by using a dynamically working in vitro model with real-time determination of membrane-bound AChE activity, we were able to demonstrate that pre-inhibition of human erythrocyte AChE with pyridostigmine or physostigmine resulted in a markedly higher residual AChE activity after inhibition by soman or paraoxon than in the absence of reversible inhibitors. Physostigmine 215-228 acetylcholinesterase (Cartwright blood group) Homo sapiens 187-191 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 18-22 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 18304715-7 2008 Pre-inhibition of AChE with pyridostigmine or physostigmine resulted in a concentration-dependent increase in carbamylation, residual activity after soman inhibition and fraction of decarbamylation AChE after discontinuation of the inhibitors without differences between human erythrocyte and muscle AChE. Physostigmine 46-59 acetylcholinesterase (Cartwright blood group) Homo sapiens 198-202 16797163-3 2006 Acetylcholinesterase inhibitors, such as Physostigmine and Rivastigmine, are considered effective treatments for cognitive decline in Alzheimer"s Disease, where the loss of cholinergic neurons is thought to be responsible for various cognitive deficits. Physostigmine 41-54 acetylcholinesterase (Cartwright blood group) Homo sapiens 0-20 17979787-4 2007 [(11)C]physostigmine, [(11)C]CP126,998 and 2-[(18)F]fluoro-CP118,954 were distributed corresponding well to the regional AChE activity in animals, and also former two probes were successfully applied to clinical PET trial. Physostigmine 7-20 acetylcholinesterase (Cartwright blood group) Homo sapiens 121-125 15803498-2 2005 Physostigmine, a potent AChE inhibitor, and galantamine, an allosteric modulator of nAChRs, are widely used for the treatment of Alzheimer"s disease. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 24-28 15803498-12 2005 The effects of physostigmine, a more potent AChE inhibitor than galantamine, could be interpreted as a desensitization of nAChRs, due to a prolonged exposure to high synaptic concentration of acetylcholine or as a competition with acetylcholine. Physostigmine 15-28 acetylcholinesterase (Cartwright blood group) Homo sapiens 44-48 15351315-10 2004 Physostigmine (PHY), a carbamate compound similar to PB, consistently showed inhibition of T-cell activation, but only at concentrations in excess of those required to inhibit AChE. Physostigmine 0-13 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 15892689-1 2005 The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. Physostigmine 182-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 93-124 15892689-1 2005 The Electronic-Topological (ETM) and Neural Network methods were applied to the study of the "structure-acetylcholinesterase (AChE) inhibitor activity" relationships for a series of physostigmine and N-benzylpiperidine derivatives. Physostigmine 182-195 acetylcholinesterase (Cartwright blood group) Homo sapiens 126-130 15611638-0 2005 Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis. Physostigmine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 88-108 15611638-0 2005 Novel assay utilizing fluorochrome-tagged physostigmine (Ph-F) to in situ detect active acetylcholinesterase (AChE) induced during apoptosis. Physostigmine 42-55 acetylcholinesterase (Cartwright blood group) Homo sapiens 110-114 15611638-2 2005 To obtain a marker of active AChE that could assay this enzyme in live intact cells and be applicable to fluorescence microscopy and cytometry, the fluorescein-tagged physostigmine (Ph-F), high affinity ligand (inhibitor) reactive with the active center of AChE, was constructed and tested for its ability to in situ label AChE and measure its induction during apoptosis. Physostigmine 167-180 acetylcholinesterase (Cartwright blood group) Homo sapiens 29-33 15351315-10 2004 Physostigmine (PHY), a carbamate compound similar to PB, consistently showed inhibition of T-cell activation, but only at concentrations in excess of those required to inhibit AChE. Physostigmine 15-18 acetylcholinesterase (Cartwright blood group) Homo sapiens 176-180 12840078-1 2003 Application of the acetylcholinesterase inhibitor physostigmine to conventional hippocampal slices caused a significant reduction of field excitatory postsynaptic potentials (EPSPs) elicited by single pulse stimulation to the medial perforant path. Physostigmine 50-63 acetylcholinesterase (Cartwright blood group) Homo sapiens 19-39 15038335-2 2004 Myoclonus and delirium improved dramatically with the intravenous injection of the acetylcholinesterase inhibitor physostigmine, and this improvement was maintained during the administration of donepezil, an oral medication with similar pharmacodynamic properties. Physostigmine 114-127 acetylcholinesterase (Cartwright blood group) Homo sapiens 83-103 15134572-3 2004 PET studies with [(11)C]physostigmine and [(11)C]CP-126,998 in the brain of healthy subjects have shown a radioactivity distribution corresponding to the regional distribution of AChE activity measured in postmortem human brains. Physostigmine 24-37 acetylcholinesterase (Cartwright blood group) Homo sapiens 179-183