PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34803671-6 2021 Meanwhile, expression of lysyl oxidase (LOX) and lysyl oxidase-like protein (LOXL)-2 in the lung tissue of mice after AZM treatment was significantly lower than in the BLM group. Azithromycin 118-121 lysyl oxidase Mus musculus 25-38 34803671-0 2021 Azithromycin Attenuates Bleomycin-Induced Pulmonary Fibrosis Partly by Inhibiting the Expression of LOX and LOXL-2. Azithromycin 0-12 lysyl oxidase Mus musculus 100-103 34803671-6 2021 Meanwhile, expression of lysyl oxidase (LOX) and lysyl oxidase-like protein (LOXL)-2 in the lung tissue of mice after AZM treatment was significantly lower than in the BLM group. Azithromycin 118-121 lysyl oxidase Mus musculus 40-43 34803671-7 2021 In addition, this study found that AZM significantly inhibits the TGF-beta1/Smad and JNK/c-Jun signaling pathways in vivo, and expression of a-SMA, type I collagen, LOX and LOXL-2 in the lung tissue of mice treated with AZM was significantly lower than that in the BLM group. Azithromycin 35-38 lysyl oxidase Mus musculus 165-168 34803671-7 2021 In addition, this study found that AZM significantly inhibits the TGF-beta1/Smad and JNK/c-Jun signaling pathways in vivo, and expression of a-SMA, type I collagen, LOX and LOXL-2 in the lung tissue of mice treated with AZM was significantly lower than that in the BLM group. Azithromycin 220-223 lysyl oxidase Mus musculus 165-168 34803671-8 2021 In vitro, AZM also effectively inhibited type I collagen, LOX, LOXL-2 and JNK-c-Jun signaling pathways in TGF-beta1-stimulated primary mouse fibroblasts, and this effect was similar to that of a JNK-specific inhibitor (SP600125). Azithromycin 10-13 lysyl oxidase Mus musculus 58-61 34803671-9 2021 In conclusion, AZM effectively attenuated BLM-induced PF in mice, which may play a role by partially inhibiting the JNK/c-Jun and TGF-beta1/Smad signaling pathways and reducing production of LOX and LOXL2. Azithromycin 15-18 lysyl oxidase Mus musculus 191-194