PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30334401-0	2018	Azithromycin influences airway remodeling in asthma via the PI3K/Akt/MTOR/HIF-1alpha/VEGF pathway.	Azithromycin	0-12	AKT serine/threonine kinase 1	Homo sapiens	65-68	
30348950-0	2018	Azithromycin promotes alternatively activated macrophage phenotype in systematic lupus erythematosus via PI3K/Akt signaling pathway.	Azithromycin	0-12	AKT serine/threonine kinase 1	Homo sapiens	110-113	
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	Azithromycin	0-12	AKT serine/threonine kinase 1	Homo sapiens	79-82	
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	Azithromycin	0-12	AKT serine/threonine kinase 1	Homo sapiens	136-139	
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	Azithromycin	238-250	AKT serine/threonine kinase 1	Homo sapiens	136-139	
30348950-9	2018	Azithromycin showed the same effect in imitated SLE macrophages, with distinct Akt phosphorylation at 30 min and 12 h. After inhibiting Akt phosphorylation by LY294002, the down-regulation of CD80, IL-1beta, IL-6, and TNF-alpha caused by azithromycin raised again, meanwhile, the up-regulation of CD206, Arg-1, Fizz-1, and IL-10 due to azithromycin was abolished.	Azithromycin	336-348	AKT serine/threonine kinase 1	Homo sapiens	136-139	
30334401-8	2018	In this study, we investigated the protective effect of azithromycin on airway remodeling through the phosphoinositol-3 kinase/Akt/mechanistic target of rapamycin kinase/hypoxia-inducible factor 1alpha (HIF-1alpha)/vascular endothelial growth factor (VEGF) pathway.	Azithromycin	56-68	AKT serine/threonine kinase 1	Homo sapiens	127-130	
33098839-7	2020	The best core hub protein drug targets involved in QT interval prolongation were identified as HSP90AA1 exclusively associated with HCQ, while AKT1 exclusively associated with AZM on the basis of node degree value.	Azithromycin	176-179	AKT serine/threonine kinase 1	Homo sapiens	143-147	
28693139-8	2017	Notably, the inhibitory effects of azithromycin on angiogenesis are associated with its ability to suppress VEGF-induced activation of VEGF receptor 2 (VEGFR2), phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt), focal adhesion kinase, and disruption of focal adhesion assembly and actin stress fiber formation in HLT-ECs.	Azithromycin	35-47	AKT serine/threonine kinase 1	Homo sapiens	212-215	
28693139-9	2017	The present study identifies that azithromycin targets VEGFR2-mediated focal adhesion and PI3K/Akt signaling pathways in HLT-ECs, leading to the suppression of angiogenesis and lung tumor growth.	Azithromycin	34-46	AKT serine/threonine kinase 1	Homo sapiens	95-98