PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29970185-0 2018 Azithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo. Azithromycin 0-12 TNF receptor superfamily member 10a Homo sapiens 115-120 29970185-13 2018 Azithromycin increased the expressions of DR4, DR5, p62 and LC-3B proteins and potentiated induction of apoptosis by TRAIL. Azithromycin 0-12 TNF receptor superfamily member 10a Homo sapiens 42-45 29970185-16 2018 CONCLUSION: The synergistic antitumor effect of azithromycin and TRAIL mainly relies on the up-regulations of DR4 and DR5, which in turn result from LC-3B-involved autophagy inhibition. Azithromycin 48-60 TNF receptor superfamily member 10a Homo sapiens 110-113 29970185-14 2018 Knockdown of DR4 and DR5 with siRNAs increased cell survival rate and decreased the expression of cleaved-PARP induced by the combination of azithromycin and TRAIL. Azithromycin 141-153 TNF receptor superfamily member 10a Homo sapiens 13-16