PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32857620-0 2020 Azithromycin Downregulates Gene Expression of IL-1beta and Pathways Involving TMPRSS2 and TMPRSS11D Required by SARS-CoV-2. Azithromycin 0-12 transmembrane serine protease 2 Homo sapiens 78-85 32857620-8 2020 RESULTS: Cell cultures treated with 10microg of azithromycin significantly downregulated receptor-mediated endocytosis canonical pathways involving TMPRSS2 and TMPRSS11D genes. Azithromycin 48-60 transmembrane serine protease 2 Homo sapiens 148-155 32857620-11 2020 CONCLUSIONS: This proof of concept demonstrates azithromycin downregulates pathways involving serine proteases TMPRSS2 and TMPRSS11D required for SARS-CoV-2 activation and its cell-to-cell transmission while downregulating pro-inflammatory cytokine IL-1beta, NDST-1 and their associated pathways. Azithromycin 48-60 transmembrane serine protease 2 Homo sapiens 111-118