PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24534490-10	2014	In conclusion, azithromycin significantly attenuated P. intermedia LPS-induced production of IL-6 in murine macrophages via inhibition of NF-kappaB, STAT1 and STAT3 activation, which is possibly related to the activation of SOCS1 signaling.	Azithromycin	15-27	toll-like receptor 4	Mus musculus	67-70	
27449383-2	2016	The macrolide antibiotic azithromycin (AZM) had been demonstrated to inhibit the TLR4 agonist-induced maturation and activation of murine bone marrow-derived DCs (BMDCs).	Azithromycin	25-37	toll-like receptor 4	Mus musculus	81-85	
27449383-2	2016	The macrolide antibiotic azithromycin (AZM) had been demonstrated to inhibit the TLR4 agonist-induced maturation and activation of murine bone marrow-derived DCs (BMDCs).	Azithromycin	39-42	toll-like receptor 4	Mus musculus	81-85	
24534490-3	2014	The present study was designed to investigate the effect of the macrolide antibiotic azithromycin on IL-6 generation in murine macrophages treated with lipopolysaccharide (LPS) from Prevotella intermedia, a pathogen implicated in inflammatory periodontal disease, and its mechanisms of action.	Azithromycin	85-97	toll-like receptor 4	Mus musculus	172-175	
24534490-4	2014	Azithromycin significantly suppressed IL-6 production as well as its mRNA expression in P. intermedia LPS-activated RAW264.7 cells.	Azithromycin	0-12	toll-like receptor 4	Mus musculus	102-105	
24534490-7	2014	Instead, azithromycin significantly diminished nuclear translocation and DNA binding activity of NF-kappaB p50 subunit induced with LPS.	Azithromycin	9-21	toll-like receptor 4	Mus musculus	132-135	
24534490-8	2014	Azithromycin inhibited P. intermedia LPS-induced STAT1 and STAT3 phosphorylation.	Azithromycin	0-12	toll-like receptor 4	Mus musculus	37-40	
24534490-9	2014	In addition, azithromycin up-regulated the mRNA level of SOCS1 in cells treated with LPS.	Azithromycin	13-25	toll-like receptor 4	Mus musculus	85-88	
23099154-6	2012	Therefore, impairment of lysosomal functions by azithromycin and chloroquine deregulate TLR4 recycling and signaling and phospholipases activation and lead to anti-inflammatory phenotype in LPS-stimulated J774A.1 cells.	Azithromycin	48-60	toll-like receptor 4	Mus musculus	88-92