PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31578565-7	2020	The Pb-infected mice treated with AZT/CMX exhibited decreased pulmonary concentrations of OH-proline associated with lower levels of TGF-beta1, and higher levels of IL-10 compared controls.	Azithromycin	34-37	transforming growth factor, beta 1	Mus musculus	133-142	
34803671-7	2021	In addition, this study found that AZM significantly inhibits the TGF-beta1/Smad and JNK/c-Jun signaling pathways in vivo, and expression of a-SMA, type I collagen, LOX and LOXL-2 in the lung tissue of mice treated with AZM was significantly lower than that in the BLM group.	Azithromycin	35-38	transforming growth factor, beta 1	Mus musculus	66-75	
34803671-7	2021	In addition, this study found that AZM significantly inhibits the TGF-beta1/Smad and JNK/c-Jun signaling pathways in vivo, and expression of a-SMA, type I collagen, LOX and LOXL-2 in the lung tissue of mice treated with AZM was significantly lower than that in the BLM group.	Azithromycin	220-223	transforming growth factor, beta 1	Mus musculus	66-75	
34803671-8	2021	In vitro, AZM also effectively inhibited type I collagen, LOX, LOXL-2 and JNK-c-Jun signaling pathways in TGF-beta1-stimulated primary mouse fibroblasts, and this effect was similar to that of a JNK-specific inhibitor (SP600125).	Azithromycin	10-13	transforming growth factor, beta 1	Mus musculus	106-115	
34803671-9	2021	In conclusion, AZM effectively attenuated BLM-induced PF in mice, which may play a role by partially inhibiting the JNK/c-Jun and TGF-beta1/Smad signaling pathways and reducing production of LOX and LOXL2.	Azithromycin	15-18	transforming growth factor, beta 1	Mus musculus	130-139	
29567590-2	2018	In this study, we hypothesized that azithromycin (35 mg/kg orally) alleviated airway remodeling through suppression of epithelial-to-mesenchymal transition (EMT) via downregulation of transforming growth factor-beta 1 (TGF-beta1)/receptor for activated C-kinase1 (RACK1)/snail in mice.	Azithromycin	36-48	transforming growth factor, beta 1	Mus musculus	184-217	
29567590-2	2018	In this study, we hypothesized that azithromycin (35 mg/kg orally) alleviated airway remodeling through suppression of epithelial-to-mesenchymal transition (EMT) via downregulation of transforming growth factor-beta 1 (TGF-beta1)/receptor for activated C-kinase1 (RACK1)/snail in mice.	Azithromycin	36-48	transforming growth factor, beta 1	Mus musculus	219-228	
29567590-7	2018	Moreover, the increasing mRNA and protein expressions of TGF-beta1 and RACK1 and mRNA level of Snail in lung tissue were all significantly decreased in azithromycin-treated mice (P < 0.05).	Azithromycin	152-164	transforming growth factor, beta 1	Mus musculus	57-66	
29567590-8	2018	Taken together, our results suggest that azithromycin has the greatest effects on reducing airway remodeling by inhibiting TGF-beta1/RACK1/Snail signal and improving the EMT in airway epithelium.	Azithromycin	41-53	transforming growth factor, beta 1	Mus musculus	123-132