PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30085341-6 2018 Pretreatment with the HO-1 inhibitor, protoporphyrin IX zinc (II), exacerbated double strand break formation following exposure to fusion radiation. protoporphyrin IX 38-55 heme oxygenase 1 Homo sapiens 22-26 33831425-8 2021 Mechanistic assessment of HMOX1 in cefotaxime-mediated ferroptosis was tested with Protoporphyrin IX zinc. protoporphyrin IX 83-100 heme oxygenase 1 Homo sapiens 26-31 32163836-7 2020 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase (FECH) and heme oxygenase-1 (HO-1) and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 21-25 heme oxygenase 1 Homo sapiens 154-170 32163836-7 2020 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase (FECH) and heme oxygenase-1 (HO-1) and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 21-25 heme oxygenase 1 Homo sapiens 172-176 32163836-7 2020 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase (FECH) and heme oxygenase-1 (HO-1) and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 111-115 heme oxygenase 1 Homo sapiens 154-170 32163836-7 2020 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase (FECH) and heme oxygenase-1 (HO-1) and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 111-115 heme oxygenase 1 Homo sapiens 172-176 32163836-7 2020 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase (FECH) and heme oxygenase-1 (HO-1) and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 111-115 heme oxygenase 1 Homo sapiens 154-170 32163836-7 2020 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase (FECH) and heme oxygenase-1 (HO-1) and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 111-115 heme oxygenase 1 Homo sapiens 172-176 31734545-7 2019 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase and heme oxygenase-1 and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 21-25 heme oxygenase 1 Homo sapiens 147-163 31734545-7 2019 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase and heme oxygenase-1 and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 111-115 heme oxygenase 1 Homo sapiens 147-163 31734545-7 2019 We hypothesized that PpIX fluorescence intensity results from the interplay between the metabolic clearance of PpIX mediated by ferrochelatase and heme oxygenase-1 and the cellular efflux of PpIX through the ATP-binding cassette subfamily G member 2 (ABCG2). protoporphyrin IX 111-115 heme oxygenase 1 Homo sapiens 147-163 28704474-6 2017 In these animals the catalytic activity of heme oxygenase 1 contributed to the release of elemental iron from the protoporphyrin ring of heme within enterocytes, which may then be transported by the strongly expressed ferroportin across the basolateral membrane to the circulation. protoporphyrin IX 114-128 heme oxygenase 1 Homo sapiens 43-59 30048241-4 2018 METHODS AND RESULTS: Upregulation of HO-1 by Hemin or adenovirus infection reversed H2O2-induced senescence in human umbilical vein endothelial cells (HUVECs); whereas depletion of HO-1 by siRNA or HO-1 inhibitor protoporphyrin IX zinc (II) (ZnPP) triggered HUVEC senescence. protoporphyrin IX 213-230 heme oxygenase 1 Homo sapiens 37-41 29307774-7 2018 5-aminolevulinate synthase 1 (ALAS1), Ferrochelatase (FECH), hemeoxygenase 1 (HO-1) and ATP binding cassette subfamily G member 2 (ABCG2)) which affect production of PpIX was assessed. protoporphyrin IX 166-170 heme oxygenase 1 Homo sapiens 61-82 28684418-7 2017 The HO-1 inducer cobalt protoporphyrin IX more efficiently attenuated PGE2 and IL-6 release in HG+IL-1beta-treated cells than in NG+IL-1beta-treated cells. protoporphyrin IX 24-41 heme oxygenase 1 Homo sapiens 4-8 28286125-4 2017 The inhibition of the HO-1 activity by treatment with zinc (II) protoporphyrin IX (ZnPP) or by knockdown of the HO-1 expression with small interference RNA significantly reversed the inhibitory effect of n-Propyl gallate on activations of nuclear factor-kappaB (NF-kappaB) and inducible nitric oxide synthase (iNOS) induced by lipopolysaccharide (LPS). protoporphyrin IX 64-81 heme oxygenase 1 Homo sapiens 22-26 26655464-3 2016 In the present study, we demonstrate here that PB increased heme oxygenase-1 (HO-1) expression, which conferred protection against MPP(+)-induced cytotoxicity, because the inhibitor of HO-1 zinc protoporphyrin-IX attenuated the neuroprotection of PB. protoporphyrin IX 195-212 heme oxygenase 1 Homo sapiens 60-76 26655464-3 2016 In the present study, we demonstrate here that PB increased heme oxygenase-1 (HO-1) expression, which conferred protection against MPP(+)-induced cytotoxicity, because the inhibitor of HO-1 zinc protoporphyrin-IX attenuated the neuroprotection of PB. protoporphyrin IX 195-212 heme oxygenase 1 Homo sapiens 78-82 26655464-3 2016 In the present study, we demonstrate here that PB increased heme oxygenase-1 (HO-1) expression, which conferred protection against MPP(+)-induced cytotoxicity, because the inhibitor of HO-1 zinc protoporphyrin-IX attenuated the neuroprotection of PB. protoporphyrin IX 195-212 heme oxygenase 1 Homo sapiens 185-189 25483558-10 2015 Whereas, treatment with zinc protoporphyrin IX (a HO-1 inhibitor) into the IPC+ischemia-operated groups did not preserve the IPC-mediated increase of HO-1 and lost beneficial effects of IPC by inhibiting ischemia-induced DNA damage and lipid peroxidation. protoporphyrin IX 29-46 heme oxygenase 1 Homo sapiens 50-54 21352351-7 2012 The HO-1 inhibitor protoporphyrin IX zinc (II) abolished the inhibitory effect of puerarin on HG-induced calpain and caspase-3 activation, as well as apoptosis. protoporphyrin IX 19-36 heme oxygenase 1 Homo sapiens 4-8 24003391-10 2013 In addition, HO-1 induction by the HO activator copper protoporphyrin suppressed LPS-induced COX-2 expression, which was restored by the addition of exogenous PGE2. protoporphyrin IX 55-69 heme oxygenase 1 Homo sapiens 13-17 23535229-6 2013 The autophagy inhibitor 3-methyladenine significantly inhibited HO-1 up-regulation and increased the rate of cell death in cells treated with P-VO2, while the HO-1 inhibitor protoporphyrin IX zinc (II) (ZnPP) enhanced the occurrence of cell death in the P-VO2-treated cells while having no effect on the autophagic response induced by P-VO2. protoporphyrin IX 174-191 heme oxygenase 1 Homo sapiens 159-163 23861314-6 2014 Interestingly, protoporphyrin-IX, a competitive inhibitor of HO-1 activity, partly attenuated the inhibitory effects of Res and Pic (but not TMS) on TNF-alpha and IL-1beta production, suggesting that suppression of TNF-alpha and IL-1beta production correlates at least in part with HO-1 expression. protoporphyrin IX 15-32 heme oxygenase 1 Homo sapiens 61-65 23861314-6 2014 Interestingly, protoporphyrin-IX, a competitive inhibitor of HO-1 activity, partly attenuated the inhibitory effects of Res and Pic (but not TMS) on TNF-alpha and IL-1beta production, suggesting that suppression of TNF-alpha and IL-1beta production correlates at least in part with HO-1 expression. protoporphyrin IX 15-32 heme oxygenase 1 Homo sapiens 282-286 23649692-4 2013 Cox-2 inhibitor NS398 suppressed the upregulation of HO-1, whereas HO-1 inhibitor protoporphyrin IX zinc (II) stimulated the expression of Cox-2. protoporphyrin IX 82-99 heme oxygenase 1 Homo sapiens 67-71 21668870-6 2011 The ALA-dependent accumulation of protoporphyrin was decreased in HeLa cells by transfection with HO-1 and HO-2 cDNA. protoporphyrin IX 34-48 heme oxygenase 1 Homo sapiens 98-111 22492492-8 2012 The cytotoxicity of arsenite was augmented by p38 MAP kinase inhibitor SB202190 and HO-1 inhibitor tin protoporphyrin IX (SnPP), whereas p38 MAP kinase inhibitor SB202190 also inhibited HO-1 induction by NaAsO(2) . protoporphyrin IX 103-120 heme oxygenase 1 Homo sapiens 84-88 22848562-10 2012 Furthermore, treatment with HO-1 siRNA and the specific HO-1 inhibitor zinc-protoporphyrin produced an increase in the G(0)/G(1) phase of the cell cycle in crotonaldehyde-stimulated HepG2 cells. protoporphyrin IX 76-90 heme oxygenase 1 Homo sapiens 28-32 22848562-10 2012 Furthermore, treatment with HO-1 siRNA and the specific HO-1 inhibitor zinc-protoporphyrin produced an increase in the G(0)/G(1) phase of the cell cycle in crotonaldehyde-stimulated HepG2 cells. protoporphyrin IX 76-90 heme oxygenase 1 Homo sapiens 56-60 20875851-9 2010 The HO-1 inhibitor Sn(IV) protoporphyrin-IX also inhibited the PST/PNU protecting effects. protoporphyrin IX 26-43 heme oxygenase 1 Homo sapiens 4-8 18435907-5 2008 Interestingly, the effects of tranilast on LPS-induced PGE(2), NO, TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor tin protoporphyrin, suggesting that tranilast-induced HO-1 expression is at least partly responsible for the resulting anti-inflammatory effects of the drug. protoporphyrin IX 152-166 heme oxygenase 1 Homo sapiens 133-137 19036700-5 2009 In contrast, HO-1 agonists hemin and cobalt protoporphyrin IX significantly increased DAF protein expression, reflecting an increase in transcription and steady-state mRNA. protoporphyrin IX 44-61 heme oxygenase 1 Homo sapiens 13-17 20668435-5 2010 The inhibitory effect of DHA on nitric oxide production was abolished by HO-1 inhibitor zinc protoporphyrin IX. protoporphyrin IX 93-110 heme oxygenase 1 Homo sapiens 73-77 19320847-5 2009 Targeted knockdown of HO-1 leads to decreased intracellular PpIX accumulation, resulting in a failure to enhance ALA-PDT effect in four cell lines. protoporphyrin IX 60-64 heme oxygenase 1 Homo sapiens 22-26 19508729-6 2009 HO-1 expression and activity was regulated by zinc (inhibition) and cobalt (induction) protoporphyrin. protoporphyrin IX 85-101 heme oxygenase 1 Homo sapiens 0-4 18435907-5 2008 Interestingly, the effects of tranilast on LPS-induced PGE(2), NO, TNF-alpha, and IL-1beta production were partially reversed by the HO-1 inhibitor tin protoporphyrin, suggesting that tranilast-induced HO-1 expression is at least partly responsible for the resulting anti-inflammatory effects of the drug. protoporphyrin IX 152-166 heme oxygenase 1 Homo sapiens 202-206 18771089-4 2008 When HepG2 cells were incubated with non-toxic concentrations of delta-aminolevulinic acid, protoporphyrin IX, or pheophorbide a and then exposed to visible light for 90 min, the mRNA level of HO-1 began increasing markedly, reaching the maximal level in 4 h. Following the transient induction of HO-1, the mRNA level of ABCG2 gradually increased in a time-dependent manner, whereas the ABCB6 mRNA level was little affected. protoporphyrin IX 92-109 heme oxygenase 1 Homo sapiens 193-197 18483307-3 2008 Elevation of HO-1 gene expression by ferric protoporphyrin IX inhibited TPA-induced invasion of MCF-7 cells, which was blocked by adding the heme oxygenase inhibitor, tin protoporphyrin IX, or transfection of cells with HO-1 short hairpin RNA. protoporphyrin IX 44-61 heme oxygenase 1 Homo sapiens 13-17 18483307-3 2008 Elevation of HO-1 gene expression by ferric protoporphyrin IX inhibited TPA-induced invasion of MCF-7 cells, which was blocked by adding the heme oxygenase inhibitor, tin protoporphyrin IX, or transfection of cells with HO-1 short hairpin RNA. protoporphyrin IX 44-61 heme oxygenase 1 Homo sapiens 220-224 8897897-3 1996 SNAP (300 microM) caused a transient increase in heme oxygenase-1 (HO-1) mRNA associated with a fivefold increase in HO activity that was completely blocked by the competitive HO inhibitor, tin protoporphyrin IX (SnPP). protoporphyrin IX 194-211 heme oxygenase 1 Homo sapiens 49-65 17982681-5 2007 Thus, the production and degradation of PPIX (via heme by HO-1) were simultaneously enhanced, leading to a reduced intracellular concentration of the photodynamically active substance PPIX. protoporphyrin IX 40-44 heme oxygenase 1 Homo sapiens 58-62 17927807-7 2007 HO-1 inhibition, with small interfering RNA (siRNA) or zinc protoporphyrin IX, abrogated atorvastatin-mediated cytoprotection. protoporphyrin IX 60-77 heme oxygenase 1 Homo sapiens 0-4 17108707-6 2007 Interestingly, pre-induction of heme oxygenase (HO)-1 by hemin prevented dialysis membrane-induced monocyte apoptosis, whereas inhibition of HO-1 activity (treatment with tin protoporphyrin, SN-P) enhanced dialysis membrane-induced monocyte apoptosis. protoporphyrin IX 175-189 heme oxygenase 1 Homo sapiens 141-145 17982681-5 2007 Thus, the production and degradation of PPIX (via heme by HO-1) were simultaneously enhanced, leading to a reduced intracellular concentration of the photodynamically active substance PPIX. protoporphyrin IX 184-188 heme oxygenase 1 Homo sapiens 58-62 17982681-6 2007 Diminishing HO-1 activity by the HO-1 inhibitor tin protoporphyrin IX (SnPPIX) significantly enhanced the formation of PPIX up to 1.8 fold. protoporphyrin IX 73-77 heme oxygenase 1 Homo sapiens 12-16 17982681-6 2007 Diminishing HO-1 activity by the HO-1 inhibitor tin protoporphyrin IX (SnPPIX) significantly enhanced the formation of PPIX up to 1.8 fold. protoporphyrin IX 73-77 heme oxygenase 1 Homo sapiens 33-37