PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19716840-0	2009	Enlightened protein: Fhit tumor suppressor protein structure and function and its role in the toxicity of protoporphyrin IX-mediated photodynamic reaction.	protoporphyrin IX	106-123	fragile histidine triad diadenosine triphosphatase	Homo sapiens	21-25	
19286306-3	2009	Additionally, Fhit production enhances the overall response of cells to PpIX-mediated photodynamic reaction.	protoporphyrin IX	72-76	fragile histidine triad diadenosine triphosphatase	Homo sapiens	14-18	
19286306-1	2009	The tumor suppressor Fhit protein lost in many human pre-malignant tissues, possesses diadenosine triphosphate activity regulated by a photosensitizer, protoporphyrin IX (PpIX) in vitro.	protoporphyrin IX	152-169	fragile histidine triad diadenosine triphosphatase	Homo sapiens	21-25	
19286306-1	2009	The tumor suppressor Fhit protein lost in many human pre-malignant tissues, possesses diadenosine triphosphate activity regulated by a photosensitizer, protoporphyrin IX (PpIX) in vitro.	protoporphyrin IX	171-175	fragile histidine triad diadenosine triphosphatase	Homo sapiens	21-25	
19286306-6	2009	Moreover, according to our findings, substitution at histidine94 in Fhit active site induces the vulnerability of HeLa cells to PpIX-PDT in a similar manner to that caused by wild-type Fhit protein.	protoporphyrin IX	128-132	fragile histidine triad diadenosine triphosphatase	Homo sapiens	68-72	
17310323-0	2007	Expression and simple, one-step purification of fragile histidine triad (Fhit) tumor suppressor mutant forms in Escherichia coli and their interaction with protoporphyrin IX.	protoporphyrin IX	156-173	fragile histidine triad diadenosine triphosphatase	Homo sapiens	73-77	
17310323-10	2007	Importantly, purified mutant forms of Fhit also interact with a photosensitizer, protoporphyrin IX in vitro.	protoporphyrin IX	81-98	fragile histidine triad diadenosine triphosphatase	Homo sapiens	38-42	
16990010-0	2007	Tumor suppressor Fhit protein interacts with protoporphyrin IX in vitro and enhances the response of HeLa cells to photodynamic therapy.	protoporphyrin IX	45-62	fragile histidine triad diadenosine triphosphatase	Homo sapiens	17-21	
16990010-3	2007	We demonstrate here for the first time that the photosensitizer, protoporphyrin IX (which is a natural precursor of heme) binds to Fhit protein and its mutants in the active site in vitro.	protoporphyrin IX	65-82	fragile histidine triad diadenosine triphosphatase	Homo sapiens	131-135	
16990010-4	2007	Furthermore, PpIX inhibits the enzymatic activity of Fhit.	protoporphyrin IX	13-17	fragile histidine triad diadenosine triphosphatase	Homo sapiens	53-57	
16990010-5	2007	Simultaneously, PpIX shows lower binding capacity to mutant Fhit-H96N of highly reduced hydrolase activity.	protoporphyrin IX	16-20	fragile histidine triad diadenosine triphosphatase	Homo sapiens	60-64	
16990010-6	2007	In cell-based assay PpIX induced HeLa cell death in Fhit and Fhit-H96N-dependent manner which was measured by means of MTT assay.	protoporphyrin IX	20-24	fragile histidine triad diadenosine triphosphatase	Homo sapiens	52-56	
16990010-6	2007	In cell-based assay PpIX induced HeLa cell death in Fhit and Fhit-H96N-dependent manner which was measured by means of MTT assay.	protoporphyrin IX	20-24	fragile histidine triad diadenosine triphosphatase	Homo sapiens	61-65	
16990010-7	2007	Moreover, HeLa cells stably expressing Fhit or mutant Fhit-H96N were more susceptible to protoporphyrin IX-mediated photodynamic therapy (2J/cm(2)) than parental cells.	protoporphyrin IX	89-106	fragile histidine triad diadenosine triphosphatase	Homo sapiens	39-43	
16990010-7	2007	Moreover, HeLa cells stably expressing Fhit or mutant Fhit-H96N were more susceptible to protoporphyrin IX-mediated photodynamic therapy (2J/cm(2)) than parental cells.	protoporphyrin IX	89-106	fragile histidine triad diadenosine triphosphatase	Homo sapiens	54-58