PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27777144-3	2017	5-aminolevulinic acid synthase 2 (ALAS2) is the key enzyme upstream of protoporphyrin IX synthesis.	protoporphyrin IX	71-88	aminolevulinic acid synthase 2, erythroid	Mus musculus	0-32	
27777144-0	2017	Over expression of 5-aminolevulinic acid synthase 2 increased protoporphyrin IX in nonerythroid cells.	protoporphyrin IX	62-79	aminolevulinic acid synthase 2, erythroid	Mus musculus	19-51	
27777144-3	2017	5-aminolevulinic acid synthase 2 (ALAS2) is the key enzyme upstream of protoporphyrin IX synthesis.	protoporphyrin IX	71-88	aminolevulinic acid synthase 2, erythroid	Mus musculus	34-39	
27777144-8	2017	Overexpression ALAS2 in nonerythriod cells may become a novel approach to cause protoporphyrin IX accumulation.	protoporphyrin IX	80-97	aminolevulinic acid synthase 2, erythroid	Mus musculus	15-20	
24718052-2	2014	The erythroid-specific ALAS isozyme (ALAS2) is negatively regulated by heme at the level of mitochondrial import and, in its mature form, certain mutations of the murine ALAS2 active site loop result in increased production of protoporphyrin IX (PPIX), the precursor for heme.	protoporphyrin IX	227-244	aminolevulinic acid synthase 2, erythroid	Mus musculus	37-42	
24718052-2	2014	The erythroid-specific ALAS isozyme (ALAS2) is negatively regulated by heme at the level of mitochondrial import and, in its mature form, certain mutations of the murine ALAS2 active site loop result in increased production of protoporphyrin IX (PPIX), the precursor for heme.	protoporphyrin IX	227-244	aminolevulinic acid synthase 2, erythroid	Mus musculus	170-175	
24718052-2	2014	The erythroid-specific ALAS isozyme (ALAS2) is negatively regulated by heme at the level of mitochondrial import and, in its mature form, certain mutations of the murine ALAS2 active site loop result in increased production of protoporphyrin IX (PPIX), the precursor for heme.	protoporphyrin IX	246-250	aminolevulinic acid synthase 2, erythroid	Mus musculus	37-42	
24718052-2	2014	The erythroid-specific ALAS isozyme (ALAS2) is negatively regulated by heme at the level of mitochondrial import and, in its mature form, certain mutations of the murine ALAS2 active site loop result in increased production of protoporphyrin IX (PPIX), the precursor for heme.	protoporphyrin IX	246-250	aminolevulinic acid synthase 2, erythroid	Mus musculus	170-175	
24718052-8	2014	Transfection of HeLa cells with expression plasmids for murine ALAS2 variants, specifically for those with mutated mitochondrial presequences and a mutation in the active site loop, caused significant cellular accumulation of PPIX, particularly in the membrane.	protoporphyrin IX	226-230	aminolevulinic acid synthase 2, erythroid	Mus musculus	63-68	
26472512-0	2015	Over-expression 5-aminolevulinic acid synthase 2 in nonerythroid cell may causes protoporphyrin IX accumulation.	protoporphyrin IX	81-98	aminolevulinic acid synthase 2, erythroid	Mus musculus	16-48	
26472512-3	2015	5-aminolevulinic acid synthase 2 (ALAS2) is the key enzyme upstream of PpIX synthesis.	protoporphyrin IX	71-75	aminolevulinic acid synthase 2, erythroid	Mus musculus	0-32	
26472512-3	2015	5-aminolevulinic acid synthase 2 (ALAS2) is the key enzyme upstream of PpIX synthesis.	protoporphyrin IX	71-75	aminolevulinic acid synthase 2, erythroid	Mus musculus	34-39	
26472512-8	2015	Overexpression ALAS2 in nonerythriod cells may become a novel approach to cause PpIX accumulation.	protoporphyrin IX	80-84	aminolevulinic acid synthase 2, erythroid	Mus musculus	15-20	
15831703-7	2005	Marked overexpression of 5-aminolevulinic acid synthase 2 (Alas2) results from loss of IRP-dependent translational repression, and markedly increased levels of free protoporphyrin IX and zinc protoporphyrin are generated in IRP2-/- erythroid cells.	protoporphyrin IX	165-182	aminolevulinic acid synthase 2, erythroid	Mus musculus	59-64	
15831703-7	2005	Marked overexpression of 5-aminolevulinic acid synthase 2 (Alas2) results from loss of IRP-dependent translational repression, and markedly increased levels of free protoporphyrin IX and zinc protoporphyrin are generated in IRP2-/- erythroid cells.	protoporphyrin IX	165-179	aminolevulinic acid synthase 2, erythroid	Mus musculus	59-64