PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31041744-1 2019 Increases in levels of protoporphyrin IX (PPIX; a heme precursor) may be driven by xenobiotic induction of aminolevulinic acid synthase 1 (ALAS1) expression. protoporphyrin IX 23-40 5'-aminolevulinate synthase 1 Homo sapiens 107-137 10522552-7 1999 Because the 5"-untranslated region of the erythroid-specific ALA-S2 mRNA contains the iron-responsive element, a cis-acting sequence responsible for translational induction of erythroid ALA-S2 by iron, the availability of iron controls protoporphyrin IX levels in hemoglobin-synthesizing cells. protoporphyrin IX 236-253 5'-aminolevulinate synthase 1 Homo sapiens 61-66 34249128-1 2021 Background: The accumulation of the hepatotoxic substance protoporphyrin IX (PPIX) induced by aminolevulinate synthase 1 (ALAS1) activation is one of the important mechanisms of antituberculosis drug-induced hepatotoxicity (ATDH). protoporphyrin IX 58-75 5'-aminolevulinate synthase 1 Homo sapiens 94-120 34249128-1 2021 Background: The accumulation of the hepatotoxic substance protoporphyrin IX (PPIX) induced by aminolevulinate synthase 1 (ALAS1) activation is one of the important mechanisms of antituberculosis drug-induced hepatotoxicity (ATDH). protoporphyrin IX 58-75 5'-aminolevulinate synthase 1 Homo sapiens 122-127 34249128-1 2021 Background: The accumulation of the hepatotoxic substance protoporphyrin IX (PPIX) induced by aminolevulinate synthase 1 (ALAS1) activation is one of the important mechanisms of antituberculosis drug-induced hepatotoxicity (ATDH). protoporphyrin IX 77-81 5'-aminolevulinate synthase 1 Homo sapiens 94-120 34249128-1 2021 Background: The accumulation of the hepatotoxic substance protoporphyrin IX (PPIX) induced by aminolevulinate synthase 1 (ALAS1) activation is one of the important mechanisms of antituberculosis drug-induced hepatotoxicity (ATDH). protoporphyrin IX 77-81 5'-aminolevulinate synthase 1 Homo sapiens 122-127 31041744-1 2019 Increases in levels of protoporphyrin IX (PPIX; a heme precursor) may be driven by xenobiotic induction of aminolevulinic acid synthase 1 (ALAS1) expression. protoporphyrin IX 23-40 5'-aminolevulinate synthase 1 Homo sapiens 139-144 31041744-1 2019 Increases in levels of protoporphyrin IX (PPIX; a heme precursor) may be driven by xenobiotic induction of aminolevulinic acid synthase 1 (ALAS1) expression. protoporphyrin IX 42-46 5'-aminolevulinate synthase 1 Homo sapiens 107-137 31041744-1 2019 Increases in levels of protoporphyrin IX (PPIX; a heme precursor) may be driven by xenobiotic induction of aminolevulinic acid synthase 1 (ALAS1) expression. protoporphyrin IX 42-46 5'-aminolevulinate synthase 1 Homo sapiens 139-144 31041744-3 2019 Therefore, a high-throughput fluorescence spectroscopy method that detects PPIX would enable the screening of drugs that increase ALAS1 through nuclear hormone receptor-mediated induction of transcription that may cause toxicity or even provide utility in the diagnosis or treatment of cancers that have elevated cellular PPIX levels. protoporphyrin IX 75-79 5'-aminolevulinate synthase 1 Homo sapiens 130-135 29307774-7 2018 5-aminolevulinate synthase 1 (ALAS1), Ferrochelatase (FECH), hemeoxygenase 1 (HO-1) and ATP binding cassette subfamily G member 2 (ABCG2)) which affect production of PpIX was assessed. protoporphyrin IX 166-170 5'-aminolevulinate synthase 1 Homo sapiens 0-28 29307774-7 2018 5-aminolevulinate synthase 1 (ALAS1), Ferrochelatase (FECH), hemeoxygenase 1 (HO-1) and ATP binding cassette subfamily G member 2 (ABCG2)) which affect production of PpIX was assessed. protoporphyrin IX 166-170 5'-aminolevulinate synthase 1 Homo sapiens 30-35 28874591-8 2017 The presence of low-activity CLPX increases the posttranslational stability of ALAS, causing increased ALAS protein and ALA levels, leading to abnormal accumulation of PPIX. protoporphyrin IX 168-172 5'-aminolevulinate synthase 1 Homo sapiens 79-83 28874591-8 2017 The presence of low-activity CLPX increases the posttranslational stability of ALAS, causing increased ALAS protein and ALA levels, leading to abnormal accumulation of PPIX. protoporphyrin IX 168-172 5'-aminolevulinate synthase 1 Homo sapiens 103-107 24718052-0 2014 Expression of murine 5-aminolevulinate synthase variants causes protoporphyrin IX accumulation and light-induced mammalian cell death. protoporphyrin IX 64-81 5'-aminolevulinate synthase 1 Homo sapiens 21-47 27838491-11 2017 These results, taken together, permit us to further an INH inhibition kinetic mechanism for ALAS, which suggests the possible use of INH-derived drugs in treating patients with XLPP and potentially other protoporphyrin-accumulating porphyrias. protoporphyrin IX 204-218 5'-aminolevulinate synthase 1 Homo sapiens 92-96 28118809-4 2017 Aminolevulinic acid synthase1 (ALAS1), ferrochelatase (FECH) and breast cancer resistance protein (BCRP) play crucial roles in PPIX synthesis, metabolism and transport, respectively. protoporphyrin IX 127-131 5'-aminolevulinate synthase 1 Homo sapiens 0-29 26300302-2 2015 Mutations in the C-terminal region of human erythroid-specific ALAS (hALAS2) are associated with X-linked protoporphyria (XLPP), a disease characterized by extreme photosensitivity, with elevated blood concentrations of free protoporphyrin IX and zinc protoporphyrin. protoporphyrin IX 225-242 5'-aminolevulinate synthase 1 Homo sapiens 63-67 15134506-4 2004 When applied topically or systemically, ALA bypasses the negative feedback control that haem exerts on the enzyme ALA synthase (ALAS), which catalyses the natural production of this delta-amino acid, thereby temporarily boosting the generation of PpIX, the direct precursor of haem. protoporphyrin IX 247-251 5'-aminolevulinate synthase 1 Homo sapiens 114-126 15134506-4 2004 When applied topically or systemically, ALA bypasses the negative feedback control that haem exerts on the enzyme ALA synthase (ALAS), which catalyses the natural production of this delta-amino acid, thereby temporarily boosting the generation of PpIX, the direct precursor of haem. protoporphyrin IX 247-251 5'-aminolevulinate synthase 1 Homo sapiens 128-132