PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10946577-8 2000 PBGD activity seemed to play a minor role for the differential accumulation of PPIX in urothelial cells. protoporphyrin IX 79-83 hydroxymethylbilane synthase Homo sapiens 0-4 9675887-2 1998 BACKGROUND AND AIMS: Uroporphyrin and protoporphyrin produce alterations on 5-aminolevulinic acid dehydratase and porphobilinogen deaminase, as a result of a direct effect of porphyrins on the protein structure. protoporphyrin IX 38-52 hydroxymethylbilane synthase Homo sapiens 114-139 10483361-0 1999 Effect of delta-aminolevulinic acid on protoporphyrin IX accumulation in tumor cells transfected with plasmids containing porphobilinogen deaminase DNA. protoporphyrin IX 39-56 hydroxymethylbilane synthase Homo sapiens 122-147 10483361-1 1999 Recently, we reported that the delta-aminolevulinic acid (delta-ALA)-induced increase in porphobilinogen deaminase (PBGD) activity was closely correlated with an increase in the accumulation of protoporphyrin IX (PPIX), resulting in augmented phototoxicity. protoporphyrin IX 194-211 hydroxymethylbilane synthase Homo sapiens 89-114 10483361-1 1999 Recently, we reported that the delta-aminolevulinic acid (delta-ALA)-induced increase in porphobilinogen deaminase (PBGD) activity was closely correlated with an increase in the accumulation of protoporphyrin IX (PPIX), resulting in augmented phototoxicity. protoporphyrin IX 194-211 hydroxymethylbilane synthase Homo sapiens 116-120 10483361-1 1999 Recently, we reported that the delta-aminolevulinic acid (delta-ALA)-induced increase in porphobilinogen deaminase (PBGD) activity was closely correlated with an increase in the accumulation of protoporphyrin IX (PPIX), resulting in augmented phototoxicity. protoporphyrin IX 213-217 hydroxymethylbilane synthase Homo sapiens 116-120 10483361-2 1999 In this report, we asked whether increasing the cellular expression of PBGD by use of gene transfection techniques in vitro would further enhance delta-ALA-induced PPIX accumulation and hence, phototoxicity. protoporphyrin IX 164-168 hydroxymethylbilane synthase Homo sapiens 71-75 19789817-2 2009 Two key enzymes that were described as affecting PpIX accumulation during ALA treatment are porphobilinogen deaminase (PBGD) and ferrochelatase. protoporphyrin IX 49-53 hydroxymethylbilane synthase Homo sapiens 92-117 21655622-6 2011 This feedback mechanism enabled partial PpIX synthesis under PBGD silencing, whereas ALAD silencing reduced PpIX production to a minimum. protoporphyrin IX 40-44 hydroxymethylbilane synthase Homo sapiens 61-65 21655622-8 2011 Thus, only ALAD-silenced cells were not affected by ALA+ irradiation, while following PBGD silencing, the accumulated PpIX, though decreased, was sufficient for successful ALA-PDT. protoporphyrin IX 118-122 hydroxymethylbilane synthase Homo sapiens 86-90 25809721-4 2015 PBGS and PBGD are the first two cytosolic enzymes involved in PpIX biosynthesis, and FECH is the enzyme responsible for converting PpIX to heme. protoporphyrin IX 62-66 hydroxymethylbilane synthase Homo sapiens 9-13 25809721-4 2015 PBGS and PBGD are the first two cytosolic enzymes involved in PpIX biosynthesis, and FECH is the enzyme responsible for converting PpIX to heme. protoporphyrin IX 131-135 hydroxymethylbilane synthase Homo sapiens 9-13 25809721-7 2015 Silencing PBGS or PBGD significantly reduced ALA-stimulated PpIX fluorescence, whereas silencing FECH elevated basal and ALA-stimulated PpIX fluorescence. protoporphyrin IX 60-64 hydroxymethylbilane synthase Homo sapiens 18-22 21509470-4 2012 The active moieties accelerated biosynthesis of protoporphyrin IX (PpIX) due to upregulated porphobilinogen deaminase (PBGD) activity. protoporphyrin IX 48-65 hydroxymethylbilane synthase Homo sapiens 92-117 21509470-4 2012 The active moieties accelerated biosynthesis of protoporphyrin IX (PpIX) due to upregulated porphobilinogen deaminase (PBGD) activity. protoporphyrin IX 48-65 hydroxymethylbilane synthase Homo sapiens 119-123 21509470-4 2012 The active moieties accelerated biosynthesis of protoporphyrin IX (PpIX) due to upregulated porphobilinogen deaminase (PBGD) activity. protoporphyrin IX 67-71 hydroxymethylbilane synthase Homo sapiens 92-117 21509470-4 2012 The active moieties accelerated biosynthesis of protoporphyrin IX (PpIX) due to upregulated porphobilinogen deaminase (PBGD) activity. protoporphyrin IX 67-71 hydroxymethylbilane synthase Homo sapiens 119-123 19789817-2 2009 Two key enzymes that were described as affecting PpIX accumulation during ALA treatment are porphobilinogen deaminase (PBGD) and ferrochelatase. protoporphyrin IX 49-53 hydroxymethylbilane synthase Homo sapiens 119-123 12462647-5 2002 The tumor-preferential PPIX accumulation is strongly influenced, but not solely determined, by activity differences between the PPIX-producing PBGD and the PPIX-converting FC, when compared with fibroblasts. protoporphyrin IX 23-27 hydroxymethylbilane synthase Homo sapiens 143-147 12462647-5 2002 The tumor-preferential PPIX accumulation is strongly influenced, but not solely determined, by activity differences between the PPIX-producing PBGD and the PPIX-converting FC, when compared with fibroblasts. protoporphyrin IX 128-132 hydroxymethylbilane synthase Homo sapiens 143-147 12462647-5 2002 The tumor-preferential PPIX accumulation is strongly influenced, but not solely determined, by activity differences between the PPIX-producing PBGD and the PPIX-converting FC, when compared with fibroblasts. protoporphyrin IX 128-132 hydroxymethylbilane synthase Homo sapiens 143-147