PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24393660-0 2014 Pro- and anti-inflammatory effects of histamine on tissue factor and TNFalpha expression in monocytes of human blood. Histamine 38-47 tumor necrosis factor Homo sapiens 69-77 24488273-3 2014 Histamine suppresses tumor necrosis factor (TNF) production by human myeloid cells and is a product of L-histidine decarboxylation, which is a proton-facilitated reaction. Histamine 0-9 tumor necrosis factor Homo sapiens 21-42 24488273-3 2014 Histamine suppresses tumor necrosis factor (TNF) production by human myeloid cells and is a product of L-histidine decarboxylation, which is a proton-facilitated reaction. Histamine 0-9 tumor necrosis factor Homo sapiens 44-47 24333719-5 2014 Histamine augmented the TNF-alpha effect, leading to a high number of arrested breast cancer cells under both static and shear flow conditions. Histamine 0-9 tumor necrosis factor Homo sapiens 24-33 24393660-9 2014 Contrary to the effect of histamine on LPS plus PMA induced TF activity, histamine caused a significant reduction in TNFalpha albeit less than in the absence of PMA. Histamine 73-82 tumor necrosis factor Homo sapiens 117-125 24393660-11 2014 CONCLUSION: Our study shows that histamine has an anti-inflammatory effect on LPS and LPS/TNFalpha stimulated monocytes of whole blood. Histamine 33-42 tumor necrosis factor Homo sapiens 90-98 25170632-9 2014 RESULTS: We found that the neuromediators histamine and substance P were able to stimulate microglial activation and the subsequent production of ROS and proinflammatory factors TNF-alpha and IL-6. Histamine 42-51 tumor necrosis factor Homo sapiens 178-187 21115236-0 2011 Histamine modulates the responsiveness of keratinocytes to IL-17 and TNF-alpha through the H1-receptor. Histamine 0-9 tumor necrosis factor Homo sapiens 69-78 24648846-4 2014 Histamine reduced IL-1 beta /TNF- alpha -induced CXCL10 protein, but not mRNA, levels independent of H1 and H2 receptor activation, whereas tryptase and MC 2 h supernatants reduced all cytokine-induced CXCL10. Histamine 0-9 tumor necrosis factor Homo sapiens 29-39 23053728-1 2013 The histamine level is high during allergic attacks, and patients with allergy may have chronic inflammatory conditions at which tumor necrosis factor (TNF)-alpha is extensively released by macrophages. Histamine 4-13 tumor necrosis factor Homo sapiens 129-162 23053728-3 2013 In a static assay, histamine stimulation of TNF-alpha-activated HUVEC elevated the number of attached THP-1 cells. Histamine 19-28 tumor necrosis factor Homo sapiens 44-53 23053728-4 2013 In a flow assay, the number of crawling and firmly adherent THP-1 cells was higher on TNF-alpha + histamine activated HUVEC than on HUVEC activated by TNF-alpha alone. Histamine 98-107 tumor necrosis factor Homo sapiens 86-95 23053728-6 2013 Since the exposure of TNF-alpha-activated endothelium to histamine favors monocyte recruitment, it may be a serious risk factor for atherosclerosis and other inflammatory disorders. Histamine 57-66 tumor necrosis factor Homo sapiens 22-31 23465664-7 2013 Histamine also suppressed LPS-induced myeloid dendritic cell TNF-alpha secretion and suppressed CpG-induced plasmacytoid dendritic cell IFN-alpha gene expression. Histamine 0-9 tumor necrosis factor Homo sapiens 61-70 23465664-9 2013 Lactobacillus rhamnosus, which secretes histamine, significantly suppressed Peyer patch IL-2, IL-4, IL-5, IL-12, TNF-alpha, and GM-CSF secretion in wild-type but not H2R-deficient animals. Histamine 40-49 tumor necrosis factor Homo sapiens 113-122 23260446-0 2013 Histamine reduces GPIbalpha-mediated adhesion of platelets to TNF-alpha-activated vascular endothelium. Histamine 0-9 tumor necrosis factor Homo sapiens 62-71 23260446-5 2013 However, the application of histamine to endothelium pre-activated by TNF-alpha inhibited GP Ibalpha-mediated platelet adhesion. Histamine 28-37 tumor necrosis factor Homo sapiens 70-79 22674155-8 2012 In combination with tumor necrosis factor alpha, histamine significantly promoted cartilage proteoglycan depletion and release. Histamine 49-58 tumor necrosis factor Homo sapiens 20-47 21645239-1 2012 Upon stimulation by histamine, human vascular endothelial cells (EC) shed a soluble form of tumour necrosis factor receptor 1 (sTNFR1) that binds up free TNF, dampening the inflammatory response. Histamine 20-29 tumor necrosis factor Homo sapiens 128-131 21803870-10 2011 In fura 2-loaded ASM cells, [Ca(2+)](i) responses to 1 muM ACh, 10 muM histamine, or 10 nM bradykinin were all exaggerated by TNF-alpha as well as IL-13 exposure. Histamine 71-80 tumor necrosis factor Homo sapiens 126-135 21324712-5 2011 Histamine suppressed tumor necrosis factor alpha (TNF-alpha)- and interferon-gamma (IFN-gamma)-induced production of CC chemokine ligand 17(CCL17), a type 2 T-helper (Th2) chemokine, by HaCaT KCs. Histamine 0-9 tumor necrosis factor Homo sapiens 21-48 21324712-5 2011 Histamine suppressed tumor necrosis factor alpha (TNF-alpha)- and interferon-gamma (IFN-gamma)-induced production of CC chemokine ligand 17(CCL17), a type 2 T-helper (Th2) chemokine, by HaCaT KCs. Histamine 0-9 tumor necrosis factor Homo sapiens 50-59 21324712-7 2011 In contrast, histamine enhanced the production of CXC chemokine ligand 10 (CXCL10), a Th1 chemokine, by TNF-alpha- and IFN-gamma-stimulated HaCaT KCs and NHKs. Histamine 13-22 tumor necrosis factor Homo sapiens 104-113 21324712-8 2011 TNF-alpha- and IFN-gamma-induced CXCL10 production was upregulated by suppression of p38 MAP kinase or NF-kappaB activity, which could explain histamine involvement. Histamine 143-152 tumor necrosis factor Homo sapiens 0-9 20977504-7 2011 In conjunctival fibroblast cultures, Smad-3 and PIP were stimulated by histamine, IL-4, -13 and TGF-beta1 exposure, while PIP was reduced by IFN-gamma, and TNF-alpha mRNA expression of Smad-3 was increased by histamine, while Smad-7 was reduced by IL-4. Histamine 209-218 tumor necrosis factor Homo sapiens 156-165 19213875-6 2009 Exposure to TNF-alpha enhanced [Ca2+](i) responses to agonist (acetylcholine, histamine). Histamine 78-87 tumor necrosis factor Homo sapiens 12-21 17928537-12 2007 These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma-induced hBD-2 production dependent on NF-kappaB, AP-1, or STAT1 in human keratinocytes. Histamine 27-36 tumor necrosis factor Homo sapiens 76-85 18257926-7 2008 Furthermore, TNF-alpha-sensitive ME-180 carcinoma cells were also resistant to the combination effect of TNF-alpha and histamine. Histamine 119-128 tumor necrosis factor Homo sapiens 13-22 17928537-4 2007 Histamine enhanced TNF-alpha- or IFN-gamma-induced hBD-2 secretion and mRNA expression. Histamine 0-9 tumor necrosis factor Homo sapiens 19-28 17716784-4 2008 Under certain conditions, however, stress hormones, substance P, ATP and the activation of the corticotropin-releasing hormone/substance P-histamine axis may actually facilitate inflammation, through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor (TNF)-alpha and CRP production. Histamine 139-148 tumor necrosis factor Homo sapiens 252-285 17928537-5 2007 Histamine alone enhanced transcriptional activities of NF-kappaB and activator protein-1 (AP-1) and potentiated TNF-alpha-induced NF-kappaB and AP-1 activities or IFN-gamma-induced NF-kappaB and STAT1 activities. Histamine 0-9 tumor necrosis factor Homo sapiens 112-121 17928537-6 2007 Antisense oligonucleotides against NF-kappaB components p50 and p65, AP-1 components c-Jun and c-Fos, or H1 antagonist pyrilamine suppressed hBD-2 production induced by histamine plus TNF-alpha or IFN-gamma. Histamine 169-178 tumor necrosis factor Homo sapiens 184-193 17928537-8 2007 Histamine induced serine phosphorylation of inhibitory NF-kappaBalpha (IkappaBalpha) alone or together with TNF-alpha or IFN-gamma. Histamine 0-9 tumor necrosis factor Homo sapiens 108-117 17928537-9 2007 Histamine induced c-Fos mRNA expression alone or together with TNF-alpha, whereas it did not further increase c-Jun mRNA levels enhanced by TNF-alpha. Histamine 0-9 tumor necrosis factor Homo sapiens 63-72 15481160-2 2004 Human nasal mucosal mast cells contain and secrete tumour necrosis factor (TNF)-alpha, which in turn can stimulate histamine secretion by these cells. Histamine 115-124 tumor necrosis factor Homo sapiens 51-85 17269555-5 2006 DHA and CLA significantly decreased the production of IL-8 in response to stimulation by TNF-alpha [2907 +/- 970 (DHA) and 6471 +/- 1203 (CLA) vs. 12,287 +/- 2309 (control) pg/mL; P < or = 0.05, mean +/- SEM], whereas both EPA and DHA reduced histamine-stimulated RANTES (regulation on activation, T cell-expressed and -secreted) production [2314 +/- 861 (EPA) and 877 +/- 326 (DHA) vs. 8526 +/- 1118 (control) pg/mL; P < or = 0.03]. Histamine 246-255 tumor necrosis factor Homo sapiens 89-98 16938121-0 2006 Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: the role of c-Jun NH2-terminal kinase. Histamine 0-9 tumor necrosis factor Homo sapiens 40-67 16938121-3 2006 OBJECTIVES: This study examined the effect of histamine on tumor necrosis factor-alpha- (TNF-alpha-) vs. thrombin-induced endothelial TF expression. Histamine 46-55 tumor necrosis factor Homo sapiens 59-86 16938121-3 2006 OBJECTIVES: This study examined the effect of histamine on tumor necrosis factor-alpha- (TNF-alpha-) vs. thrombin-induced endothelial TF expression. Histamine 46-55 tumor necrosis factor Homo sapiens 89-99 16938121-5 2006 Although TF expression by TNF-alpha and thrombin was identical, histamine augmented TNF-alpha-induced expression 7.0-fold, but thrombin-induced expression only 2.6-fold. Histamine 64-73 tumor necrosis factor Homo sapiens 84-93 16938121-9 2006 Histamine-induced p38 activation preceded a weak second activation to both TNF-alpha and thrombin. Histamine 0-9 tumor necrosis factor Homo sapiens 75-84 16938121-10 2006 Histamine-induced c-Jun NH2-terminal kinase (JNK) activation was followed by a strong second activation to TNF-alpha, and less to thrombin. Histamine 0-9 tumor necrosis factor Homo sapiens 107-116 16938121-12 2006 Histamine augmented TNF-alpha- and thrombin-induced vascular cell adhesion molecule 1 (VCAM-1) expression to a similar extent. Histamine 0-9 tumor necrosis factor Homo sapiens 20-29 16938121-14 2006 CONCLUSIONS: Histamine differentially augments TNF-alpha- vs. thrombin-induced TF expression and activity, which is mediated by the H1-receptor, occurs at the mRNA level, and is related to differential JNK activation. Histamine 13-22 tumor necrosis factor Homo sapiens 47-56 16491014-11 2006 Histamine also augmented the IL-8 production caused by IL-4 or tumor necrosis factor-alpha. Histamine 0-9 tumor necrosis factor Homo sapiens 63-90 16575470-10 2006 Tumor promotor PMA and histamine down-regulated specific binding of [125I]TNF- alpha on HeLa cells. Histamine 23-32 tumor necrosis factor Homo sapiens 74-84 15378360-4 2004 On incubation with histamine, HACs showed increased production of MMP-3, MMP-13, TNFalpha and PGE(2) (statistical significance P=0.02, 0.005, 0.008 and 0.03, respectively, student"s t-test), but MMP-1 expression was unaffected. Histamine 19-28 tumor necrosis factor Homo sapiens 81-89 17891168-5 2007 KEY RESULTS: Addition of histamine to TNFalpha-stimulated BEAS-2B cells maximally potentiated NF-kappaB-dependent transcription 1.8 fold, whereas IL-6 and IL-8 protein release were enhanced 7.3- and 2.7-fold respectively. Histamine 25-34 tumor necrosis factor Homo sapiens 38-46 17959901-4 2007 Stimulation of gingival fibroblasts with tumor necrosis factor-alpha, IL-1alpha, and lipopolysaccharide markedly induced IL-8 production, and the IL-8 production was synergistically augmented in the presence of or pre-treatment with histamine. Histamine 233-242 tumor necrosis factor Homo sapiens 41-68 17412405-10 2007 The histamine-induced CTGF expression was mediated through the histamine receptor (HR1) and could be completely abolished by TNF-alpha. Histamine 4-13 tumor necrosis factor Homo sapiens 125-134 17523945-9 2007 Long-term anti-TNF-alpha treatment significantly increased circulating levels of histamine in RA patients. Histamine 81-90 tumor necrosis factor Homo sapiens 15-24 17470620-6 2007 However, histamine increased IL-1beta-induced GM-CSF release and markedly reduced TNF-alpha-induced RANTES release by both asthmatic and nonasthmatic cells to a similar extent, but did not modulate PGE(2) release. Histamine 9-18 tumor necrosis factor Homo sapiens 82-91 16996482-12 2006 The anti-histamine azelastine inhibited TNF-alpha release dose dependently. Histamine 9-18 tumor necrosis factor Homo sapiens 40-49 14499251-7 2003 The pretreatment with histamine partially inhibited the LPS-induced TNF-alpha production in human peripheral blood mononuclear cells (PBMC). Histamine 22-31 tumor necrosis factor Homo sapiens 68-77 12538815-4 2003 Histamine also inhibited the responses of TNF-alpha production induced by LPS. Histamine 0-9 tumor necrosis factor Homo sapiens 42-51 12594246-3 2003 In this study, we show that human plasmacytoid DC, activated by either CpG oligodeoxynucleotides or viral infection, also respond to histamine through H2 receptors, leading to a marked down-regulation of IFN-alpha and TNF-alpha and a moderate switch in their capacity to polarize naive T cells. Histamine 133-142 tumor necrosis factor Homo sapiens 218-227 12646554-0 2003 Histamine antagonizes tumor necrosis factor (TNF) signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool. Histamine 0-9 tumor necrosis factor Homo sapiens 22-43 12646554-0 2003 Histamine antagonizes tumor necrosis factor (TNF) signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool. Histamine 0-9 tumor necrosis factor Homo sapiens 45-48 12646554-7 2003 Histamine-induced shedding is blocked by TNF-alpha protease inhibitor, an inhibitor of TNF-alpha-converting enzyme, and through the H1 receptor via a MEK-1/p42 and p44 mitogen-activated protein kinase pathway. Histamine 0-9 tumor necrosis factor Homo sapiens 41-50 12646554-7 2003 Histamine-induced shedding is blocked by TNF-alpha protease inhibitor, an inhibitor of TNF-alpha-converting enzyme, and through the H1 receptor via a MEK-1/p42 and p44 mitogen-activated protein kinase pathway. Histamine 0-9 tumor necrosis factor Homo sapiens 87-96 12646554-8 2003 Cultured EC with histamine-induced surface receptor loss become transiently refractory to TNF. Histamine 17-26 tumor necrosis factor Homo sapiens 90-93 12538815-7 2003 These results as a whole indicated that histamine via H2-receptor inhibited the LPS-induced TNF-alpha production through the regulation of ICAM-1 and B7.1 expression, leading to the reduction of innate immune response stimulated by LPS. Histamine 40-49 tumor necrosis factor Homo sapiens 92-101 12527821-10 2002 RESULTS: NAAGA was found to totally inhibit adhesion of unstimulated leukocytes, or leukocytes activated with C5a, TNFalpha, or histamine, to TNFalpha-stimulated HUVECs (P=0.0001). Histamine 128-137 tumor necrosis factor Homo sapiens 142-150 11472381-7 2001 Histamine plasma levels are chronically elevated in migraineurs, and interictally decreased lymphocyte phagocytotic function and increased plasma tumor necrosis factor alpha (TNFalpha) levels were found, and may be related to increased infection susceptibility. Histamine 0-9 tumor necrosis factor Homo sapiens 175-183 11839707-3 2002 In this study, the effect of TNF-alpha on ion secretion induced by the mast cell mediator histamine in HT29cl.19A cells and mouse distal colon was investigated and the possible second messengers involved were studied. Histamine 90-99 tumor necrosis factor Homo sapiens 29-38 11839707-6 2002 RESULTS: In both experimental systems TNF-alpha was found to potentiate ion secretion induced by histamine. Histamine 97-106 tumor necrosis factor Homo sapiens 38-47 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 tumor necrosis factor Homo sapiens 183-192 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 tumor necrosis factor Homo sapiens 183-192 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 tumor necrosis factor Homo sapiens 183-192 12013412-0 2002 Histamine (HA) suppresses the production of tumor necrosis factor alpha (TNFalpha) in cultured astroglial cells. Histamine 0-9 tumor necrosis factor Homo sapiens 44-71 12013412-0 2002 Histamine (HA) suppresses the production of tumor necrosis factor alpha (TNFalpha) in cultured astroglial cells. Histamine 0-9 tumor necrosis factor Homo sapiens 73-81 12013412-0 2002 Histamine (HA) suppresses the production of tumor necrosis factor alpha (TNFalpha) in cultured astroglial cells. Histamine 11-13 tumor necrosis factor Homo sapiens 44-71 12013412-0 2002 Histamine (HA) suppresses the production of tumor necrosis factor alpha (TNFalpha) in cultured astroglial cells. Histamine 11-13 tumor necrosis factor Homo sapiens 73-81 11342615-7 2001 In addition, histamine induces a potent production of IL-6, IL-8, monocyte chemoattractant protein 1, and macrophage-inflammatory protein 1alpha by immature DC and also up-regulates IL-1beta, RANTES, and macrophage-inflammatory protein 1beta but not TNF-alpha and IL-12 mRNA expression. Histamine 13-22 tumor necrosis factor Homo sapiens 250-259 11336536-0 2001 Histamine-induced production of interleukin-6 and interleukin-8 by human coronary artery endothelial cells is enhanced by endotoxin and tumor necrosis factor-alpha. Histamine 0-9 tumor necrosis factor Homo sapiens 136-163 11336536-7 2001 In the presence of all stimulatory concentrations of LPS and TNF-alpha tested, histamine was shown to further enhance IL-6 and IL-8 production. Histamine 79-88 tumor necrosis factor Homo sapiens 61-70 11174198-3 2001 OBJECTIVE: The objective of this study was to examine whether histamine can alter the expression of the 4 genes encoding H1 receptor, IL-8, TNF-alpha, and ZO-1 tight-junction protein in cultured nasal epithelial cells. Histamine 62-71 tumor necrosis factor Homo sapiens 140-149 11336536-10 2001 Since both LPS and TNF-alpha potentiated histamine-induced cytokine production, it is possible that these activators stimulate H-1 receptor expression and/or augment the signal transduction pathways leading to the expression of IL-6 and IL-8. Histamine 41-50 tumor necrosis factor Homo sapiens 19-28 10818238-1 2000 It is known that histamine suppresses gene expression and synthesis of tumor necrosis factor alpha (TNF-alpha) induced by lipopolysaccharide (LPS) in human peripheral blood mononuclear monocytes (HPM) or alveolar macrophages via histamine H2 receptors. Histamine 17-26 tumor necrosis factor Homo sapiens 71-98 10818238-1 2000 It is known that histamine suppresses gene expression and synthesis of tumor necrosis factor alpha (TNF-alpha) induced by lipopolysaccharide (LPS) in human peripheral blood mononuclear monocytes (HPM) or alveolar macrophages via histamine H2 receptors. Histamine 17-26 tumor necrosis factor Homo sapiens 100-109 10818238-2 2000 We investigated the effect of histamine and differentiation in macrophages on the expression and secretion of TNF-alpha, TNF-alpha-converting enzyme (TACE), and histamine H1 and H2 receptors by use of a leukemia cell line, U937, and HPM. Histamine 30-39 tumor necrosis factor Homo sapiens 110-119 10818238-3 2000 Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE. Histamine 195-204 tumor necrosis factor Homo sapiens 241-250 10805372-2 2000 Therefore, we have studied whether recombinant human TNF-alpha (rHuTNF-alpha) can cause histamine secretion from rat peritoneal MC. Histamine 88-97 tumor necrosis factor Homo sapiens 53-62 11268424-3 2000 Recent evidence indicates that glucocorticoids, norepinephrine, epinephrine, histamine, and adenosine inhibit the production of human IL-12 and TNF-alpha, whereas they do not affect or even stimulate the production of IL-10. Histamine 77-86 tumor necrosis factor Homo sapiens 144-153 10706683-2 2000 Thus, we tested the hypothesis that histamine inhibits the release of a proinflammatory cytokine, namely TNF, by stimulating the release of an anti-inflammatory cytokine, IL-10. Histamine 36-45 tumor necrosis factor Homo sapiens 105-108 10706683-6 2000 Interestingly, treatment of AMs with anti-IL-10, anti-PGE2, or a NO synthase inhibitor (Nomega-nitro-l -arginine methyl ester) before the addition of histamine abrogated the inhibitory effect of the latter on TNF release. Histamine 150-159 tumor necrosis factor Homo sapiens 209-212 9500521-4 1998 Mast cells cocultured with activated T cells released histamine and beta-hexosaminidase and produced tumor necrosis factor alpha (TNF-alpha), an effect that peaked at 20 h. Kinetics of histamine release paralleled the formation of heterotypic aggregates. Histamine 185-194 tumor necrosis factor Homo sapiens 101-128 9500521-4 1998 Mast cells cocultured with activated T cells released histamine and beta-hexosaminidase and produced tumor necrosis factor alpha (TNF-alpha), an effect that peaked at 20 h. Kinetics of histamine release paralleled the formation of heterotypic aggregates. Histamine 185-194 tumor necrosis factor Homo sapiens 130-139 8859220-12 1996 These findings strongly suggest that histamine upregulates VCAM-1 expression at the transcriptional level through newly generated of mRNA in endothelial cells stimulated with IL-4 and TNF-alpha. Histamine 37-46 tumor necrosis factor Homo sapiens 184-193 9419020-0 1997 Tumor necrosis factor alpha (TNF-alpha) activates human adenoidal and cutaneous mast cells to histamine secretion. Histamine 94-103 tumor necrosis factor Homo sapiens 0-27 9419020-0 1997 Tumor necrosis factor alpha (TNF-alpha) activates human adenoidal and cutaneous mast cells to histamine secretion. Histamine 94-103 tumor necrosis factor Homo sapiens 29-38 9419020-2 1997 Therefore, we have studied whether TNF-alpha can cause histamine secretion from human adenoidal and cutaneous mast cells. Histamine 55-64 tumor necrosis factor Homo sapiens 35-44 9419020-5 1997 TNF-alpha-induced histamine release was concentration- and time-dependent. Histamine 18-27 tumor necrosis factor Homo sapiens 0-9 9419020-6 1997 Moreover, the release of histamine evoked by TNF-alpha was also dependent on reaction temperature and on glycolytic and oxidative cellular metabolism. Histamine 25-34 tumor necrosis factor Homo sapiens 45-54 9419020-7 1997 We have concluded that TNF-alpha is a potent stimulus for mast cells to release histamine and that it induces histamine release via an active, secretory process. Histamine 80-89 tumor necrosis factor Homo sapiens 23-32 9419020-7 1997 We have concluded that TNF-alpha is a potent stimulus for mast cells to release histamine and that it induces histamine release via an active, secretory process. Histamine 110-119 tumor necrosis factor Homo sapiens 23-32 9271310-0 1997 Inability of histamine to regulate TNF-alpha production by human alveolar macrophages. Histamine 13-22 tumor necrosis factor Homo sapiens 35-44 9271310-2 1997 Histamine, a mediator important in pulmonary inflammation, has been demonstrated to regulate the production of TNF-alpha by monocytes. Histamine 0-9 tumor necrosis factor Homo sapiens 111-120 9271310-4 1997 Whereas histamine suppressed lipopolysaccharide (LPS)-stimulated TNF-alpha production by monocytes through a cAMP-dependent mechanism, it had no effect on either cAMP levels or TNF-alpha production by AM. Histamine 8-17 tumor necrosis factor Homo sapiens 65-74 9271310-6 1997 The lack of response of AM to histamine appears unique, as histamine suppressed LPS-stimulated TNF-alpha production by mononuclear cells isolated from sites of acute and chronic inflammation, as well as from noninflammatory tissues, and by macrophages differentiated in vitro. Histamine 59-68 tumor necrosis factor Homo sapiens 95-104 9164635-5 1997 LP skin mast cells and healthy skin mast cells showed similar sensitivity to stimulation with TNF-alpha at a concentration of 10(-7) M (15.2% histamine release, as a proportion of total cellular content vs 15.9%) and to stimulation with anti-IgE at a dilution of 1:100) (38.8% vs 37.0%). Histamine 142-151 tumor necrosis factor Homo sapiens 94-103 8859220-0 1996 Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells. Histamine 0-9 tumor necrosis factor Homo sapiens 50-59 8859220-4 1996 Histamine, significantly augmented (p < 0.05 to p < 0.01) VCAM-1 expression in both IL-4- and TNF-alpha-stimulated endothelial cells. Histamine 0-9 tumor necrosis factor Homo sapiens 100-109 8859220-5 1996 IL-4 and TNF-alpha were found to have a synergistic effect on endothelial cell VCAM-1 expression, when compared with the effect of stimulation with each of these cytokines separately, and the addition of histamine further increased VCAM-1 expression. Histamine 204-213 tumor necrosis factor Homo sapiens 9-18 8780164-12 1996 Upon activation, mast cells released histamine and TNF-alpha, as was detected in cytotoxicity assays with TNF-alpha-sensitive target cells (WEHI). Histamine 37-46 tumor necrosis factor Homo sapiens 106-115 8806799-0 1996 Histamine enhanced the TNF-alpha-induced expression of E-selectin and ICAM-1 on vascular endothelial cells. Histamine 0-9 tumor necrosis factor Homo sapiens 23-32 8806799-4 1996 In this report, we show that histamine concentration-dependently enhances the TNF-alpha-induced expression of E-selectin and ICAM-1 on HUVEC. Histamine 29-38 tumor necrosis factor Homo sapiens 78-87 8806799-8 1996 These data indicate that histamine induces the expression of E-selectin and ICAM-1 synergistically with TNF-alpha through histamine H1 receptors. Histamine 25-34 tumor necrosis factor Homo sapiens 104-113 8535096-2 1995 We investigated whether TNF alpha induced histamine release from mast cells in human chopped lung tissue and whether it modulated antigen-induced release of histamine and leukotrienes C4/D4/E4 from passively sensitized lung tissue. Histamine 42-51 tumor necrosis factor Homo sapiens 24-33 7553243-5 1995 In a subsequent study of seven atopic subjects, nasal allergen challenge produced increases in lavage levels of histamine and albumin, which was associated with significant release of TNF alpha as early as 2 min post-allergen when compared with the saline control day (P = 0.05). Histamine 112-121 tumor necrosis factor Homo sapiens 184-193 8535096-3 1995 Spontaneous histamine release in the presence of 1 nM TNF alpha for up to 4 h at 37 degrees C was not significantly different from spontaneous histamine release alone (6.1 +/- 1.3% and 6.1 +/- 1.5% of total tissue histamine at 4h respectively; n = 3). Histamine 12-21 tumor necrosis factor Homo sapiens 54-63 8535096-6 1995 These results suggest that TNF alpha may be involved in potentiation of histamine release in allergic asthma, particularly in the presence of low antigen concentrations. Histamine 72-81 tumor necrosis factor Homo sapiens 27-36 8335573-4 1993 TNF-alpha (0.00417, 0.0417, 0.417, and 1.25 micrograms/ml) incubated with BPA for 60 min inhibited EDR of the BPA to ACh, BK, and histamine. Histamine 130-139 tumor necrosis factor Homo sapiens 0-9 7541148-2 1995 We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-alpha (TNF-alpha) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. Histamine 212-221 tumor necrosis factor Homo sapiens 132-141 8102141-0 1993 Histamine and cis-urocanic acid augment tumor necrosis factor-alpha mediated induction of keratinocyte intercellular adhesion molecule-1 expression. Histamine 0-9 tumor necrosis factor Homo sapiens 40-67 8102141-8 1993 These results demonstrate that 1) KCs can be induced to express ICAM-1 by exposure to histamine and cis-UCA, 2) histamine and cis-UCA can also augment TNF-alpha inducible ICAM-1 mRNA and cell surface protein expression, 3) this augmentation does not directly involve changes in KC TNF-alpha receptor number, affinity, or TNF-alpha production and, 4) KCs possess a type 2 histamine receptor which is not the photoreceptor for UCA. Histamine 112-121 tumor necrosis factor Homo sapiens 151-160 8102141-8 1993 These results demonstrate that 1) KCs can be induced to express ICAM-1 by exposure to histamine and cis-UCA, 2) histamine and cis-UCA can also augment TNF-alpha inducible ICAM-1 mRNA and cell surface protein expression, 3) this augmentation does not directly involve changes in KC TNF-alpha receptor number, affinity, or TNF-alpha production and, 4) KCs possess a type 2 histamine receptor which is not the photoreceptor for UCA. Histamine 112-121 tumor necrosis factor Homo sapiens 281-290 8102141-8 1993 These results demonstrate that 1) KCs can be induced to express ICAM-1 by exposure to histamine and cis-UCA, 2) histamine and cis-UCA can also augment TNF-alpha inducible ICAM-1 mRNA and cell surface protein expression, 3) this augmentation does not directly involve changes in KC TNF-alpha receptor number, affinity, or TNF-alpha production and, 4) KCs possess a type 2 histamine receptor which is not the photoreceptor for UCA. Histamine 112-121 tumor necrosis factor Homo sapiens 281-290 8387095-3 1993 This contrasted with the mechanism involving histamine type 2 receptors by which the UCA structural analogue, histamine, suppressed monocyte TNF-alpha production. Histamine 45-54 tumor necrosis factor Homo sapiens 141-150 7955543-6 1994 Tumour necrosis factor-alpha (TNF-alpha)-induced IL-6 production was also potentiated in a dose-dependent manner by histamine, without modification of the time course of IL-6 secretion. Histamine 116-125 tumor necrosis factor Homo sapiens 30-39 7919340-5 1994 Histamine-induced IL-8 production was (1) dose-dependent (at a dose > or = 10(-6) mol/L), (2) potentialized by costimulation with tumor necrosis factor (TNF)-alpha, (3) inhibited by H1 or H2 histamine receptor antagonists, and (4) significantly increased 4 hours after the initial stimulation. Histamine 0-9 tumor necrosis factor Homo sapiens 133-166 8335573-10 1993 The effect of TNF-alpha was specific for release of NO from the endothelium of BPA because TNF-alpha did not affect 1) EDR of BPV to ACh, BK, or ATP; 2) EIR of BPA or BPV to nitroprusside; and 3) contraction of either BPA or BPV to KCl, U-46619, histamine, norepinephrine, or serotonin. Histamine 246-255 tumor necrosis factor Homo sapiens 14-23 1575548-3 1992 A significant correlation was found between plasma TNF-alpha and plasma histamine concentrations in atopic dermatitis. Histamine 72-81 tumor necrosis factor Homo sapiens 51-60 1575548-4 1992 The data suggest that the overproduction of TNF-alpha is associated with increased plasma histamine concentration, and might play a part in the pathophysiological mechanism of atopic dermatitis. Histamine 90-99 tumor necrosis factor Homo sapiens 44-53 1937930-0 1991 Effect of histamine on tumor necrosis factor production by human monocytes. Histamine 10-19 tumor necrosis factor Homo sapiens 23-44 1937930-4 1991 In conclusion, histamine causes, in vitro, a depression of TNF alpha secretion by human monocytes through activation of H2 receptors. Histamine 15-24 tumor necrosis factor Homo sapiens 59-68 2056280-0 1991 Histamine suppresses gene expression and synthesis of tumor necrosis factor alpha via histamine H2 receptors. Histamine 0-9 tumor necrosis factor Homo sapiens 54-81 2056280-2 1991 We now report the effect of histamine on gene expression and total cellular synthesis of TNF-alpha. Histamine 28-37 tumor necrosis factor Homo sapiens 89-98 2056280-3 1991 Lipopolysaccharide (LPS)-induced synthesis of TNF-alpha in peripheral blood mononuclear cells (PBMC) from 18 healthy donors was suppressed by histamine concentrations from 10(-6) to 10(-4) M, levels comparable with those measured in tissues after mast cell degranulation. Histamine 142-151 tumor necrosis factor Homo sapiens 46-55 2056280-4 1991 Histamine (10(-5) M) markedly suppressed LPS-induced synthesis of TNF-alpha in both unfractionated PBMC (83% inhibition, p less than 0.001) and monocytes purified by positive selection of LeuM3+ cells (62% inhibition, p less than 0.05). Histamine 0-9 tumor necrosis factor Homo sapiens 66-75 2056280-5 1991 The suppressive effect of histamine on TNF-alpha synthesis did not require the presence of T cells. Histamine 26-35 tumor necrosis factor Homo sapiens 39-48 2056280-6 1991 The histamine-mediated decrease in TNF-alpha synthesis was not affected by indomethacin, nor by diphenhydramine, an H1 receptor antagonist, but was reversed by cimetidine or ranitidine, H2 receptor antagonists, in a dose-dependent manner. Histamine 4-13 tumor necrosis factor Homo sapiens 35-44 2056280-7 1991 Suppression of TNF-alpha synthesis by histamine is likely to be a transcriptional event, since histamine (10(-5) M) reduced TNF-alpha mRNA levels fourfold. Histamine 38-47 tumor necrosis factor Homo sapiens 15-24 2056280-7 1991 Suppression of TNF-alpha synthesis by histamine is likely to be a transcriptional event, since histamine (10(-5) M) reduced TNF-alpha mRNA levels fourfold. Histamine 38-47 tumor necrosis factor Homo sapiens 124-133 2056280-7 1991 Suppression of TNF-alpha synthesis by histamine is likely to be a transcriptional event, since histamine (10(-5) M) reduced TNF-alpha mRNA levels fourfold. Histamine 95-104 tumor necrosis factor Homo sapiens 15-24 2056280-7 1991 Suppression of TNF-alpha synthesis by histamine is likely to be a transcriptional event, since histamine (10(-5) M) reduced TNF-alpha mRNA levels fourfold. Histamine 95-104 tumor necrosis factor Homo sapiens 124-133 1937930-1 1991 This study was aimed at evaluating the effect of histamine on tumor necrosis factor (TNF alpha) secretion by purified human blood monocytes. Histamine 49-58 tumor necrosis factor Homo sapiens 62-83 1937930-1 1991 This study was aimed at evaluating the effect of histamine on tumor necrosis factor (TNF alpha) secretion by purified human blood monocytes. Histamine 49-58 tumor necrosis factor Homo sapiens 85-94 1937930-3 1991 Histamine caused a dose-dependent inhibition of lipopolysaccharide-induced TNF alpha production from human blood monocytes, averaging maximally 50% at 10(-5) M. Preincubation of mononuclear cells with an H2 antagonist (cimetidine), but not with an H1 antagonist (promethazine) prevented this inhibitory effect of histamine. Histamine 0-9 tumor necrosis factor Homo sapiens 75-84 32748974-0 2020 Histamine- or vascular endothelial growth factor-induced tissue factor expression and gap formation between vascular endothelial cells are synergistically enhanced by lipopolysaccharide, tumor necrosis factor-alpha, interleukin (IL)-33 or IL-1beta. Histamine 0-9 tumor necrosis factor Homo sapiens 187-214 2290027-3 1990 In addition to short acting stimuli like thrombin and histamine an increased prostanoid release occurs in the presence of endotoxin, interleukin 1 or tumor necrosis factor (TNF). Histamine 54-63 tumor necrosis factor Homo sapiens 173-176 1695452-2 1990 Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). Histamine 103-112 tumor necrosis factor Homo sapiens 166-193 1695452-2 1990 Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). Histamine 103-112 tumor necrosis factor Homo sapiens 195-204 34228141-6 2021 RESULTS: Histamine elevated gene expression of tumor necrosis factor under control conditions and in combination with pressure application. Histamine 9-18 tumor necrosis factor Homo sapiens 47-68 33673529-7 2021 Neutralization of upstream histamine by histamine-conjugated normal human immunoglobulin has been demonstrated to inhibit the nuclear translocation of NF-kappaB, thereby preventing the release of pro-inflammatory cytokines Interleukin (IL) 1beta, TNF-alpha, and IL-6 and IL-10 in a safer manner. Histamine 27-36 tumor necrosis factor Homo sapiens 247-256 33673529-7 2021 Neutralization of upstream histamine by histamine-conjugated normal human immunoglobulin has been demonstrated to inhibit the nuclear translocation of NF-kappaB, thereby preventing the release of pro-inflammatory cytokines Interleukin (IL) 1beta, TNF-alpha, and IL-6 and IL-10 in a safer manner. Histamine 40-49 tumor necrosis factor Homo sapiens 247-256 32748974-5 2020 The expression of TF mRNA and surface protein of TF on HUVEC in response to histamine or VEGF were synergistically enhanced by the treatment with LPS, TNF-alpha, IL-33 or IL-1beta. Histamine 76-85 tumor necrosis factor Homo sapiens 151-160 32748974-6 2020 Moreover, the activation of the extrinsic coagulation pathway and intercellular gap formation of HUVEC in response to histamine or VEGF were also synergistically increased in the presence of TNF-alpha and LPS. Histamine 118-127 tumor necrosis factor Homo sapiens 191-200 31018959-8 2019 IL-23 and TNF from the CD14+ population could be downregulated by a PDE4I and other agents (histamine and 8-Bromo-cAMP) which elevate cAMP. Histamine 92-101 tumor necrosis factor Homo sapiens 10-13 31165327-10 2019 In conclusion, combination of resveratrol and silymarin could significantly inhibit inflammatory effects of histamine on cultured HGFs by reduction of IL-6, IL-8, TPA-1, and TNF-alpha. Histamine 108-117 tumor necrosis factor Homo sapiens 174-183 29433511-8 2018 Histamine also dose-dependently stimulated astrocyte activation and subsequent production of glial cell-derived neurotrophic factor (GDNF), whereas it suppressed the secretion of the proinflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Histamine 0-9 tumor necrosis factor Homo sapiens 207-234 30540489-5 2019 Sensitivity to histamine was enhanced by pretreatment with the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). Histamine 15-24 tumor necrosis factor Homo sapiens 85-112 30540489-5 2019 Sensitivity to histamine was enhanced by pretreatment with the inflammatory cytokine tumor necrosis factor-alpha (TNF-alpha). Histamine 15-24 tumor necrosis factor Homo sapiens 114-123 30540489-11 2019 Our results indicate that inflammatory conditions with elevated levels of TNF-alpha might enhance histamine-induced serotonin release from intestinal neuroendocrine cells. Histamine 98-107 tumor necrosis factor Homo sapiens 74-83 29433511-8 2018 Histamine also dose-dependently stimulated astrocyte activation and subsequent production of glial cell-derived neurotrophic factor (GDNF), whereas it suppressed the secretion of the proinflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta). Histamine 0-9 tumor necrosis factor Homo sapiens 236-245 24752587-4 2014 Histamine can also dose-dependently stimulate microglia activation and subsequently production of proinflammatory factors tumor necrosis factor (TNF)-alpha and interleukin-6 (IL-6). Histamine 0-9 tumor necrosis factor Homo sapiens 122-155 27027966-8 2016 Compared with untreated cells, calcitriol blunted the heightened effect of TNF-alpha on [Ca(2+)]i response to histamine in ASM. Histamine 110-119 tumor necrosis factor Homo sapiens 75-84 25723478-10 2015 H1R and H2R, but not H3R or H4R, were constitutively expressed by primary and immortalized cells, and epithelial histamine stimulation induced GM-CSF, TNFalpha, and IL-8, but not TSLP or eotaxin-3 secretion. Histamine 113-122 tumor necrosis factor Homo sapiens 151-159 25723478-11 2015 Epithelial priming with the TLR3 ligand poly (I:C) induced H1R and H2R expression, and enhanced histamine-induced GM-CSF, TNFalpha, and IL-8 secretion. Histamine 96-105 tumor necrosis factor Homo sapiens 122-130 24752587-5 2014 The antagonists of H1R and H4R but not H2R and H3R reduced histamine-induced TNF-alpha and IL-6 production, MAPK and PI3K/AKT pathway activation, and mitochondrial membrane potential loss in microglia, suggesting that the actions of histamine are via H1R and H4R. Histamine 59-68 tumor necrosis factor Homo sapiens 77-86 24752587-6 2014 On the other hand, inhibitors of JNK, p38, or PI3K suppressed histamine-induced TNF-alpha and IL-6 release from microglia. Histamine 62-71 tumor necrosis factor Homo sapiens 80-89 24752587-7 2014 Histamine also activated NF-kappa B and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF-kappa B, and reduced histamine-induced TNF-alpha and IL-6 release. Histamine 0-9 tumor necrosis factor Homo sapiens 135-144 24752587-7 2014 Histamine also activated NF-kappa B and ammonium pyrrolidinedithiocarbamate, an inhibitor of NF-kappa B, and reduced histamine-induced TNF-alpha and IL-6 release. Histamine 117-126 tumor necrosis factor Homo sapiens 135-144 24752587-9 2014 We also demonstrate that histamine induced TNF-alpha and IL-6 release from activated microglia via H1R and H4R-MAPK and PI3K/AKT-NF-kappa B signaling pathway, which will deepen the understanding of microglia-mediated neuroinflammatory symptoms of chronic neurodegenerative disease. Histamine 25-34 tumor necrosis factor Homo sapiens 43-52