PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3137235-3 1988 We now report that histamine, bradykinin, and the calcium ionophore A23187 exhibit the same fatty acid specificity as does thrombin. Histamine 19-28 coagulation factor II, thrombin Homo sapiens 123-131 7136728-0 1982 Possible regulatory role of histamine in human platelet function examined by thrombin-induced serotonin release. Histamine 28-37 coagulation factor II, thrombin Homo sapiens 77-85 2438330-5 1987 A similar pretreatment with PT inhibited thrombin-induced histamine release from BMMC and N-formyl-L-methionyl-L-leucyl-L-phenylalanine-induced histamine release from human basophils in a similar dose-dependent fashion. Histamine 58-67 coagulation factor II, thrombin Homo sapiens 41-49 2417488-4 1986 Increases in staining, as determined by the spectrophotometric quantitation of the dye after extraction from the microcarriers with formamide, occurred after treatment of human umbilical vein endothelium with histamine (10(-5) M) or thrombin (0.1 U/ml). Histamine 209-218 coagulation factor II, thrombin Homo sapiens 233-241 2417488-8 1986 Monolayer response to histamine was characterized morphologically by small openings which occurred randomly along the cell junctions; while with thrombin, the spaces, which had developed at junctions, occurred to a greater extent. Histamine 22-31 coagulation factor II, thrombin Homo sapiens 145-153 2416681-4 1985 Extracellular 45Ca2+ uptake of thrombin-stimulated cells is saturable within 90 seconds and corresponds to the kinetics of histamine release, whereas that of IgE-antigen exposed cells continues unabated for over 5 min. Histamine 123-132 coagulation factor II, thrombin Homo sapiens 31-39 7136728-1 1982 The influence of histamine on human platelet function was studied by thrombin-induced serotonin release. Histamine 17-26 coagulation factor II, thrombin Homo sapiens 69-77 10828481-5 2000 Histamine formation and liberation induced with thrombin and A23187 were not affected by chloroquine. Histamine 0-9 coagulation factor II, thrombin Homo sapiens 48-56 30243238-2 2018 Thrombin mediates adhesion of mast cell, a type of cell abundantly found in connective tissue and releasing histamine and other substances during inflammatory and allergic reactions, through phosphoinositol 3-kinase pathway. Histamine 108-117 coagulation factor II, thrombin Homo sapiens 0-8 24673528-3 2014 Tissue factor expressed by eosinophils can induce activation of blood coagulation generating thrombin which in turn can increase vascular permeability both directly, acting on endothelial cells, and indirectly, inducing degranulation of mast cells with release of histamine, as demonstrated in experimental models. Histamine 264-273 coagulation factor II, thrombin Homo sapiens 93-101 14686920-6 2004 Subcellular fractionation and immunofluorescence studies showed that following stimulation with histamine, thrombin or the calcium ionophore A23187, cPLA2-alpha relocated to intracellular membranes. Histamine 96-105 coagulation factor II, thrombin Homo sapiens 107-115 17472573-5 2007 Secretion in response to thrombin, a protease-activated receptor-1 agonist peptide, histamine, forskolin and adrenaline (epinephrine) was inhibited. Histamine 84-93 coagulation factor II, thrombin Homo sapiens 25-33 16938121-0 2006 Histamine differentially interacts with tumor necrosis factor-alpha and thrombin in endothelial tissue factor induction: the role of c-Jun NH2-terminal kinase. Histamine 0-9 coagulation factor II, thrombin Homo sapiens 72-80 16938121-9 2006 Histamine-induced p38 activation preceded a weak second activation to both TNF-alpha and thrombin. Histamine 0-9 coagulation factor II, thrombin Homo sapiens 89-97 16938121-10 2006 Histamine-induced c-Jun NH2-terminal kinase (JNK) activation was followed by a strong second activation to TNF-alpha, and less to thrombin. Histamine 0-9 coagulation factor II, thrombin Homo sapiens 130-138 16938121-12 2006 Histamine augmented TNF-alpha- and thrombin-induced vascular cell adhesion molecule 1 (VCAM-1) expression to a similar extent. Histamine 0-9 coagulation factor II, thrombin Homo sapiens 35-43 16938121-14 2006 CONCLUSIONS: Histamine differentially augments TNF-alpha- vs. thrombin-induced TF expression and activity, which is mediated by the H1-receptor, occurs at the mRNA level, and is related to differential JNK activation. Histamine 13-22 coagulation factor II, thrombin Homo sapiens 62-70 10749718-3 2000 Stimulation of endothelial cells with thrombin (1 U/ml) resulted in an immediate, P-selectin-dependent increase in neutrophil rolling and adhesion that was comparable in magnitude to optimal levels of histamine (the classical inducer of P-selectin). Histamine 201-210 coagulation factor II, thrombin Homo sapiens 38-46 9831706-13 1998 These data indicate that in endothelial cell monolayers that respond to histamine in a physiological way, thrombin induces a prolonged increase in permeability by "calcium sensitization," which involves protein tyrosine phosphorylation and RhoA activation. Histamine 72-81 coagulation factor II, thrombin Homo sapiens 106-114 16793702-2 1998 The maximum rise was 90% , while in the presence of thrombin (0.01-1 NIH U/ml) or phorbol 12-myristate 13-acetate (PMA) (10-100 nmol/l) histamine content rose maximally by 40%. Histamine 136-145 coagulation factor II, thrombin Homo sapiens 52-60 9657253-10 1998 The exposure of platelets to thrombin (10-60 mUml(-1)) produced a progressive aggregation, associated with histamine release. Histamine 107-116 coagulation factor II, thrombin Homo sapiens 29-37 9657253-13 1998 In resting platelets cytosolic calcium level (207 +/- 4.2 nM/10(8) platelets) is increased by thrombin as well as by anti-IgE; this effect is potentiated by 10(-5) M histamine. Histamine 166-175 coagulation factor II, thrombin Homo sapiens 94-102 1769377-2 1991 The purpose of the present study was to determine the relation between the intensity of a first thrombin stimulus and the subsequent response to a repeat thrombin, histamine, ionophore A23187 or aluminium fluoride (AlF4) stimulation and to determine possible targets of desensitization. Histamine 164-173 coagulation factor II, thrombin Homo sapiens 96-104 7523332-6 1994 Their exposure to varying concentrations of thrombin produces a progressive aggregation which runs parallel to histamine release. Histamine 111-120 coagulation factor II, thrombin Homo sapiens 44-52 1320036-5 1992 One micromolar histamine, like alpha-thrombin, produces sustained phosphorylation of MARCKS (plateau 3-5 min). Histamine 15-24 coagulation factor II, thrombin Homo sapiens 37-45 1320036-7 1992 HUVEC treated with 100 microM histamine for 5 min can be restimulated by alpha-thrombin but not fresh histamine, suggesting that the histamine receptor was desensitized. Histamine 30-39 coagulation factor II, thrombin Homo sapiens 79-87 1320036-8 1992 MARCKS phosphorylation can also be induced by several exogenous protein kinase C (PKC) activators and both alpha-thrombin- and histamine-induced MARCKS phosphorylation are inhibited by the PKC antagonist staurosporine. Histamine 127-136 coagulation factor II, thrombin Homo sapiens 113-121 7529999-0 1995 Possible involvement of protein kinase C and low molecular weight GTP-binding proteins in thrombin-induced histamine secretion in human platelets. Histamine 107-116 coagulation factor II, thrombin Homo sapiens 90-98 7529999-1 1995 Thrombin and 12-O-tetradecanoylphorbol 13-acetate (TPA) caused histamine secretion from human platelets. Histamine 63-72 coagulation factor II, thrombin Homo sapiens 0-8 1962329-3 1991 RESULTS: Arteries contracted to thrombin in a concentration-dependent manner; freshly obtained human platelets (8.5 x 10(8) cells/ml) activated with 10 micrograms/ml collagen increased the arteries" sensitivity to thrombin by threefold while augmenting the maximal response from 40 +/- 11% to 66 +/- 12% of the maximal response to 0.3 mM histamine. Histamine 338-347 coagulation factor II, thrombin Homo sapiens 214-222 1985891-7 1991 Phosphorylation induced by thrombin and histamine occurred within 1 min, peaked between 5 and 10 min, and returned to control levels by 1 h. DiC8-induced phosphorylation occurred more slowly but was also reduced by 1 h while phorbol ester treatment prolonged phosphorylation for at least 4 h. Treatment of these cells with thrombin or histamine for 1 h desensitized P29 to further phosphorylation by the homologous agonist although secondary phosphorylation could occur with heterologous compounds. Histamine 40-49 coagulation factor II, thrombin Homo sapiens 323-331 1900287-0 1991 Thrombin attenuates the stimulatory effect of histamine on Ca2+ entry in confluent human umbilical vein endothelial cell cultures. Histamine 46-55 coagulation factor II, thrombin Homo sapiens 0-8 1985891-7 1991 Phosphorylation induced by thrombin and histamine occurred within 1 min, peaked between 5 and 10 min, and returned to control levels by 1 h. DiC8-induced phosphorylation occurred more slowly but was also reduced by 1 h while phorbol ester treatment prolonged phosphorylation for at least 4 h. Treatment of these cells with thrombin or histamine for 1 h desensitized P29 to further phosphorylation by the homologous agonist although secondary phosphorylation could occur with heterologous compounds. Histamine 335-344 coagulation factor II, thrombin Homo sapiens 27-35 1900287-3 1991 Furthermore, the addition of thrombin after ionomycin or histamine lowered the raised Ca2+ back to near control levels. Histamine 57-66 coagulation factor II, thrombin Homo sapiens 29-37 1900287-7 1991 The mechanism by which thrombin lowers cytoplasmic Ca2+ is due mainly to inhibition of Ca2+ entry since thrombin prevented the stimulated influx of Mn2+ caused by histamine or ionomycin. Histamine 163-172 coagulation factor II, thrombin Homo sapiens 23-31 1900287-7 1991 The mechanism by which thrombin lowers cytoplasmic Ca2+ is due mainly to inhibition of Ca2+ entry since thrombin prevented the stimulated influx of Mn2+ caused by histamine or ionomycin. Histamine 163-172 coagulation factor II, thrombin Homo sapiens 104-112 1900287-8 1991 It may therefore be that in vivo under certain physiological or pathological conditions, thrombin"s effects on intracellular Ca2+ are more transient than those of histamine, and thrombin also may induce transience in histamine"s actions. Histamine 217-226 coagulation factor II, thrombin Homo sapiens 89-97 1900287-8 1991 It may therefore be that in vivo under certain physiological or pathological conditions, thrombin"s effects on intracellular Ca2+ are more transient than those of histamine, and thrombin also may induce transience in histamine"s actions. Histamine 217-226 coagulation factor II, thrombin Homo sapiens 178-186 1718891-3 1991 Histamine increases also cytosolic calcium concentration in platelets stimulated with thrombin, and binding sites for [3H]-mepyramine are present on platelet membranes. Histamine 0-9 coagulation factor II, thrombin Homo sapiens 86-94 1985891-12 1991 These data suggest that multiple and independent thrombin/histamine-induced events are susceptible to receptor occupancy-dependent homologous down-regulation. Histamine 58-67 coagulation factor II, thrombin Homo sapiens 49-57 2536373-2 1989 Incubation of HUVEC with either thrombin or histamine, agonists known to induce rapid transient increases in intracellular calcium levels in HUVEC, caused a rapid reversible increase in the phosphorylation of a protein with a Mr = 100,000 independent of the presence of extracellular calcium. Histamine 44-53 coagulation factor II, thrombin Homo sapiens 32-40 2105325-3 1990 Alpha thrombin (10 nM) produced levels of 6-keto PGF1 alpha approximating responses with 1 microM gamma-thrombin, 5 microM arachidonate, or 10 microM histamine. Histamine 150-159 coagulation factor II, thrombin Homo sapiens 6-14 1697456-2 1990 The histamine release by hrIL-3 significantly correlated with those by anti-IgE, thrombin, and f-met. Histamine 4-13 coagulation factor II, thrombin Homo sapiens 81-89