PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27372563-8 2016 The anti-hIgE vector, administered either before sensitization or after peanut sensitization and manifestation of the peanut-induced phenotype, blocked IgE-mediated alterations in peanut-induced histamine release, anaphylaxis scores, locomotor activity, and free IgE levels and protected animals from death caused by anaphylaxis. Histamine 195-204 immunoglobulin heavy constant epsilon Homo sapiens 152-155 28236656-5 2017 METHODS: Desensitization of IgE-mediated histamine release from human lung mast cells was explored by methods that partially replicate the pattern of treatment during clinical desensitization. Histamine 41-50 immunoglobulin heavy constant epsilon Homo sapiens 28-31 28441991-0 2017 In vitro impact of anti-immunoglobulin E monoclonal antibodies, including omalizumab on whole blood basophil histamine release: Assessment of direct induction of basophil histamine release and evaluation of modulation of allergen-induced basophil histamine release. Histamine 109-118 immunoglobulin heavy constant epsilon Homo sapiens 19-40 28441991-1 2017 AIM: The aim of this study was to evaluate the potential of anti-immunoglobulin E (IgE) and/or anti-IgE-IgE immune complexes to release histamine from peripheral blood basophils. Histamine 136-145 immunoglobulin heavy constant epsilon Homo sapiens 60-81 28441991-1 2017 AIM: The aim of this study was to evaluate the potential of anti-immunoglobulin E (IgE) and/or anti-IgE-IgE immune complexes to release histamine from peripheral blood basophils. Histamine 136-145 immunoglobulin heavy constant epsilon Homo sapiens 83-86 28441991-1 2017 AIM: The aim of this study was to evaluate the potential of anti-immunoglobulin E (IgE) and/or anti-IgE-IgE immune complexes to release histamine from peripheral blood basophils. Histamine 136-145 immunoglobulin heavy constant epsilon Homo sapiens 100-103 28441991-1 2017 AIM: The aim of this study was to evaluate the potential of anti-immunoglobulin E (IgE) and/or anti-IgE-IgE immune complexes to release histamine from peripheral blood basophils. Histamine 136-145 immunoglobulin heavy constant epsilon Homo sapiens 100-103 28441991-2 2017 In addition, a potential modulating effect of anti-IgE-IgE complexes on allergen-induced peripheral blood basophil histamine release was evaluated. Histamine 115-124 immunoglobulin heavy constant epsilon Homo sapiens 51-54 28441991-2 2017 In addition, a potential modulating effect of anti-IgE-IgE complexes on allergen-induced peripheral blood basophil histamine release was evaluated. Histamine 115-124 immunoglobulin heavy constant epsilon Homo sapiens 55-58 27372563-8 2016 The anti-hIgE vector, administered either before sensitization or after peanut sensitization and manifestation of the peanut-induced phenotype, blocked IgE-mediated alterations in peanut-induced histamine release, anaphylaxis scores, locomotor activity, and free IgE levels and protected animals from death caused by anaphylaxis. Histamine 195-204 immunoglobulin heavy constant epsilon Homo sapiens 9-13 27372563-8 2016 The anti-hIgE vector, administered either before sensitization or after peanut sensitization and manifestation of the peanut-induced phenotype, blocked IgE-mediated alterations in peanut-induced histamine release, anaphylaxis scores, locomotor activity, and free IgE levels and protected animals from death caused by anaphylaxis. Histamine 195-204 immunoglobulin heavy constant epsilon Homo sapiens 10-13 28414061-7 2017 However, IgE-dependent histamine release increased in washed cell preparations from omalizumab- but not placebo-treated subjects. Histamine 23-32 immunoglobulin heavy constant epsilon Homo sapiens 9-12 27097513-9 2016 Blood tests showed high serum histamine and tryptase levels, suggesting an Ig-E mediated allergic reaction. Histamine 30-39 immunoglobulin heavy constant epsilon Homo sapiens 75-79 27090936-5 2016 Subsequent studies revealed that IgE specifically bound to basophilic granulocytes and mast cells through the Fc portion of the molecules and that cross-linking of the cell-bound IgE antibody molecules by allergen induced the release of bioactive mediators, such as histamine and leukotrienes, which initiate allergic reactions. Histamine 266-275 immunoglobulin heavy constant epsilon Homo sapiens 179-182 27434218-6 2016 On re-exposure to relevant allergens, cross-linking of IgE on mast cells results in the release of mediators of hypersensitivity such as histamine and immediate nasal symptoms. Histamine 137-146 immunoglobulin heavy constant epsilon Homo sapiens 55-58 27090936-5 2016 Subsequent studies revealed that IgE specifically bound to basophilic granulocytes and mast cells through the Fc portion of the molecules and that cross-linking of the cell-bound IgE antibody molecules by allergen induced the release of bioactive mediators, such as histamine and leukotrienes, which initiate allergic reactions. Histamine 266-275 immunoglobulin heavy constant epsilon Homo sapiens 33-36 24179689-6 2013 It was observed how the IgE concentration affects the histamine release, FcepsilonRI density on the mast cell surface and the concentration of other mediators. Histamine 54-63 immunoglobulin heavy constant epsilon Homo sapiens 24-27 24953255-3 2015 Chronic autoimmune urticaria is caused by anti-FceR1beta and less frequently, by anti-IgE auto antibodies that lead to mast cell and basophil activation, thereby giving rise to the release of histamine and other proinflammatory mediators. Histamine 192-201 immunoglobulin heavy constant epsilon Homo sapiens 86-89 26541454-2 2015 The amounts of MGL_1304 and IgE against MGL_1304 are evaluated by the histamine release test using basophils or mast cells sensitized with serum containing IgE against MGL_1304, and enzyme linked sorbent assay (ELISA) using MGL_1304 and anti-MGL_1304 antibodies. Histamine 70-79 immunoglobulin heavy constant epsilon Homo sapiens 28-31 26541454-3 2015 Here, we identified a human monoclonal IgE (ABS-IgE) that binds to the high affinity IgE receptor (FcepsilonRI) and MGL_1304 with high affinity (KD = 1.99 nM) but does not release histamine from basophils and mast cells. Histamine 180-189 immunoglobulin heavy constant epsilon Homo sapiens 39-42 26541454-3 2015 Here, we identified a human monoclonal IgE (ABS-IgE) that binds to the high affinity IgE receptor (FcepsilonRI) and MGL_1304 with high affinity (KD = 1.99 nM) but does not release histamine from basophils and mast cells. Histamine 180-189 immunoglobulin heavy constant epsilon Homo sapiens 48-51 26541454-6 2015 Moreover, ABS-IgE prevented histamine release from mast cells and basophils by neutralizing MGL_1304 not only in a free form in solution, but also on FcepsilonRI expressed on the cell surface without cell activation. Histamine 28-37 immunoglobulin heavy constant epsilon Homo sapiens 10-17 25660404-8 2014 Stimulation of basophils with anti-IgE increased CD203c expression and histamine release, which was inhibited by ASM-024 (10(-5) to 10(-)(3) M, p < 0.05). Histamine 71-80 immunoglobulin heavy constant epsilon Homo sapiens 35-38 24179689-7 2013 RESULTS: A clear correlation between IgE concentration in culture medium and the release of histamine upon activation was observed. Histamine 92-101 immunoglobulin heavy constant epsilon Homo sapiens 37-40 24179689-10 2013 CONCLUSIONS: IgE in the culture medium during the last 10 days of mast cell maturation influences the release of the preformed mediator histamine after mast cell activation and the density of FcepsilonRI on the mast cell surface. Histamine 136-145 immunoglobulin heavy constant epsilon Homo sapiens 13-16 23541488-11 2013 This assay confirmed that plasma from animals identified as positive in the drug-specific IgE immunoassay contained biologically active IgE (i.e. could sensitize cultured mast cells), resulting in histamine release after exposure to the therapeutic antibody. Histamine 197-206 immunoglobulin heavy constant epsilon Homo sapiens 90-93 23541488-11 2013 This assay confirmed that plasma from animals identified as positive in the drug-specific IgE immunoassay contained biologically active IgE (i.e. could sensitize cultured mast cells), resulting in histamine release after exposure to the therapeutic antibody. Histamine 197-206 immunoglobulin heavy constant epsilon Homo sapiens 136-139 19917276-3 2010 The compound was shown to inhibit anti-IgE induced histamine release from human skin mast cells. Histamine 51-60 immunoglobulin heavy constant epsilon Homo sapiens 39-42 22374203-8 2012 Omalizumab significantly inhibited IgE-dependent enhancement of FcepsilonRI expression level and FcepsilonRI-mediated histamine release. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 35-38 22037448-0 2012 Histamine increases the level of IFNgamma produced by HIV-1 specific CTLs and this production depends on total IgE level. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 111-114 22037448-9 2012 CONCLUSIONS: We found an increase in IFNgamma production after the activation of HIV-1 specific CD8+ T lymphocytes by histamine (this elevation was blocked by cimetidine), furthermore, we demonstrated a negative correlation between the production of IFNgamma and levels of total IgE. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 279-282 22299028-9 2012 Finally, NVP-BEZ235 was found to inhibit IgE-dependent histamine release in BA and MC (IC(50) 0.5-1 microM) as well as anti-IgE-induced upregulation of CD203c in BA and IgE-dependent upregulation of CD63 in MC. Histamine 55-64 immunoglobulin heavy constant epsilon Homo sapiens 41-44 22762373-4 2012 Immunoglobulin E (IgE) mechanism was highly suggestive with significant increase in serum tryptase, positive basophil allergen threshold sensitivity (CD-sens) and histamine release tests towards fluorescein. Histamine 163-172 immunoglobulin heavy constant epsilon Homo sapiens 0-16 22762373-4 2012 Immunoglobulin E (IgE) mechanism was highly suggestive with significant increase in serum tryptase, positive basophil allergen threshold sensitivity (CD-sens) and histamine release tests towards fluorescein. Histamine 163-172 immunoglobulin heavy constant epsilon Homo sapiens 18-21 23070080-7 2012 Incubation with anti-human IgE antibodies or allergens produced a ninefold increase in histamine release in gastrointestinally mediated allergy (p<0.001), but anti-human IgE antibodies induced NO release in only 18% of the allergy patients. Histamine 87-96 immunoglobulin heavy constant epsilon Homo sapiens 27-30 22195688-9 2011 Subsequently, C-027 was shown to antagonize histamine- and serotonin-induced airway and vascular smooth muscle contraction, respectively, and histamine-released bronchocontraction mediated by IgE passive sensitization in human small airways. Histamine 142-151 immunoglobulin heavy constant epsilon Homo sapiens 192-195 21028948-7 2011 RESULTS: Exposure of small intestinal biopsy specimens of patients with food allergy to food allergens led to a significative increase of IgE-positive cells with a significative increase of histamine and tryptase release and an altered expression of tight junction proteins. Histamine 190-199 immunoglobulin heavy constant epsilon Homo sapiens 138-141 20066506-11 2010 The fastest rate of reduction in cat allergen-induced basophil histamine release following anti-IgE therapy was observed when the cat-specific IgE to total IgE ratio was <2.5%. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 96-99 20066506-11 2010 The fastest rate of reduction in cat allergen-induced basophil histamine release following anti-IgE therapy was observed when the cat-specific IgE to total IgE ratio was <2.5%. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 143-146 20066506-11 2010 The fastest rate of reduction in cat allergen-induced basophil histamine release following anti-IgE therapy was observed when the cat-specific IgE to total IgE ratio was <2.5%. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 143-146 19593978-8 2009 We found a strong inverse correlation between serum allergen-specific IgE and basophil histamine release (-0.789, p = 0.001). Histamine 87-96 immunoglobulin heavy constant epsilon Homo sapiens 70-73 19418203-8 2009 CONCLUSION: Using a strictly standardized flow cytometry protocol and a new dilution/succussion procedure, we have shown that low and high dilutions of histamine inhibit CD203c up-regulation in anti-IgE stimulated basophils. Histamine 152-161 immunoglobulin heavy constant epsilon Homo sapiens 199-202 20129176-6 2010 After over 20 years research trying to find out if high dilutions of histamine have a negative feedback effect on the activation of basophils by anti-IgE, what do we know? Histamine 69-78 immunoglobulin heavy constant epsilon Homo sapiens 150-153 19362683-3 2009 OBJECTIVE: To investigate the association between histamine releasibility, total serum IgE and expression of IgE receptor in releaser and non-releaser phenotypes in Indian population. Histamine 50-59 immunoglobulin heavy constant epsilon Homo sapiens 109-112 19302592-5 2009 KEY RESULTS: Diethylamine NONOate (DEA/NO) and MAHMA NONOate (NOC-9), both have rapid NO release rates, only inhibited anti-IgE-induced histamine release when added to HCMC at the time of activation. Histamine 136-145 immunoglobulin heavy constant epsilon Homo sapiens 124-127 19231594-2 2009 Even after its identity as the source of histamine released by blood cells in response to reaginic IgE, its role in allergic disease has largely been viewed as redundant to that of the tissue mast cell. Histamine 41-50 immunoglobulin heavy constant epsilon Homo sapiens 99-102 19379488-9 2009 RESULTS: Stimulations with anti-IgE on IgE-primed nasal tissue fragments lead to a concentration-dependent release of histamine, leukotrienes and PGD2. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 32-35 19379488-9 2009 RESULTS: Stimulations with anti-IgE on IgE-primed nasal tissue fragments lead to a concentration-dependent release of histamine, leukotrienes and PGD2. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 39-42 18588555-4 2008 The potency of IgE to induce mediator release was assessed by basophil histamine release and skin prick tests (SPTs). Histamine 71-80 immunoglobulin heavy constant epsilon Homo sapiens 15-18 18330729-4 2008 The mast cell pathway in which preformed mediators, such as histamine, rapidly formed mediators, leukotrienes and prostaglandins, are released from mast cells through IgE or direct activation. Histamine 60-69 immunoglobulin heavy constant epsilon Homo sapiens 167-170 18087163-3 2008 The aim of the study was to monitor the efficacy of anti-IgE treatment by ex vivo basophil histamine release. Histamine 91-100 immunoglobulin heavy constant epsilon Homo sapiens 57-60 18234322-1 2008 BACKGROUND: We have previously defined IgE+ as the IgE on basophils from a subset of highly allergic asthmatic subjects that release histamine after stimulation with histamine-releasing factor (HRF). Histamine 133-142 immunoglobulin heavy constant epsilon Homo sapiens 39-42 18234322-1 2008 BACKGROUND: We have previously defined IgE+ as the IgE on basophils from a subset of highly allergic asthmatic subjects that release histamine after stimulation with histamine-releasing factor (HRF). Histamine 133-142 immunoglobulin heavy constant epsilon Homo sapiens 51-54 18234322-5 2008 METHODS: IgE+ was defined as causing greater than 10% histamine release by using HRF as a stimulus of human basophils. Histamine 54-63 immunoglobulin heavy constant epsilon Homo sapiens 9-12 17877753-12 2007 CONCLUSION: Perfume induces a dose-dependent non-IgE-mediated release of histamine from human peripheral blood basophils. Histamine 73-82 immunoglobulin heavy constant epsilon Homo sapiens 49-52 17927691-5 2007 Histamine release was not observed on exposure to the glucans only, but in the presence of anti-immunoglobulin E (IgE) antibody or specific antigens, all the glucans investigated led to an enhancement of the IgE-mediated histamine release. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 114-117 17927691-5 2007 Histamine release was not observed on exposure to the glucans only, but in the presence of anti-immunoglobulin E (IgE) antibody or specific antigens, all the glucans investigated led to an enhancement of the IgE-mediated histamine release. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 208-211 17927691-5 2007 Histamine release was not observed on exposure to the glucans only, but in the presence of anti-immunoglobulin E (IgE) antibody or specific antigens, all the glucans investigated led to an enhancement of the IgE-mediated histamine release. Histamine 221-230 immunoglobulin heavy constant epsilon Homo sapiens 114-117 17927691-5 2007 Histamine release was not observed on exposure to the glucans only, but in the presence of anti-immunoglobulin E (IgE) antibody or specific antigens, all the glucans investigated led to an enhancement of the IgE-mediated histamine release. Histamine 221-230 immunoglobulin heavy constant epsilon Homo sapiens 208-211 17508965-9 2007 PGE(2) significantly enhanced anti-IgE induced histamine and PGD(2) release from mast cells of normal subjects but not those of ATA and AERD patients. Histamine 47-56 immunoglobulin heavy constant epsilon Homo sapiens 35-38 16937442-8 2006 Food antigens tolerated by oral provocation did not elicit mast cell degranulation 3.4 (0.4%-20.7%, P = 0.4), while anti-IgE and causative food allergens induced a significant histamine release of 5.4 (1.1%-25.6%, P = 0.04) and 8.1 (1.5%-57.9%, P = 0.008), respectively. Histamine 176-185 immunoglobulin heavy constant epsilon Homo sapiens 121-124 17128671-2 2006 During the IgE-mediated anaphylactic reaction mast cells release proteases such as tryptase, histamine and vasoactive mediators. Histamine 93-102 immunoglobulin heavy constant epsilon Homo sapiens 11-14 16895550-4 2006 The aim of the present study was to characterize pharmacologically the beta-adrenoceptors involved in the suppression of IgE-mediated release of mediators, including histamine, prostaglandin (PG) D2 and leukotriene (LT) C4 from cultured mast cells. Histamine 166-175 immunoglobulin heavy constant epsilon Homo sapiens 121-124 16110160-3 2006 Crosslinkage of IgE receptor I (Fc epsilonRI) on cord blood-derived mast cells by myeloma IgE and anti-human IgE is used to induce histamine release. Histamine 131-140 immunoglobulin heavy constant epsilon Homo sapiens 16-19 16512814-3 2006 AIMS: The present study was to characterize pharmacologically the prostanoid receptors by investigating the effects of prostanoid receptor agonists on the immunoglobulin E (IgE)-mediated histamine release from the cultured mast cells. Histamine 187-196 immunoglobulin heavy constant epsilon Homo sapiens 155-171 16512814-3 2006 AIMS: The present study was to characterize pharmacologically the prostanoid receptors by investigating the effects of prostanoid receptor agonists on the immunoglobulin E (IgE)-mediated histamine release from the cultured mast cells. Histamine 187-196 immunoglobulin heavy constant epsilon Homo sapiens 173-176 16512814-9 2006 CONCLUSIONS: The present results suggest that PGE2 potentiates the IgE-mediated histamine release from the cultured mast cell via EP3 and/or EP1 receptors. Histamine 80-89 immunoglobulin heavy constant epsilon Homo sapiens 67-70 16436135-6 2006 RESULTS: Preincubation of primary lung MCs with cerivastatin or atorvastatin (1-50 microM) for 24 h resulted in inhibition of anti-IgE-induced release of histamine. Histamine 154-163 immunoglobulin heavy constant epsilon Homo sapiens 131-134 16895550-10 2006 Both isoprenaline and salbutamol inhibited anti-IgE-induced release of histamine, PGD2 and LTC4 from cultured mast cells in a dose-dependent manner. Histamine 71-80 immunoglobulin heavy constant epsilon Homo sapiens 48-51 16322071-4 2006 Gallic acid attenuated compound 48/80- or immunoglobulin E (IgE)-induced histamine release from mast cells. Histamine 73-82 immunoglobulin heavy constant epsilon Homo sapiens 42-58 16322071-4 2006 Gallic acid attenuated compound 48/80- or immunoglobulin E (IgE)-induced histamine release from mast cells. Histamine 73-82 immunoglobulin heavy constant epsilon Homo sapiens 60-63 16630955-5 2006 Frequencies of filaria-specific IgE-producing cells and measures of filaria-specific IgE-mediated histamine and IL-4 release from basophils were measured in subsets of these patients. Histamine 98-107 immunoglobulin heavy constant epsilon Homo sapiens 85-88 16630955-10 2006 CONCLUSION: These results demonstrate that filaria-specific IgE production and filaria-specific IgE-mediated basophil release of histamine and IL-4 persist for years after treatment of human filarial infections. Histamine 129-138 immunoglobulin heavy constant epsilon Homo sapiens 96-99 16110160-3 2006 Crosslinkage of IgE receptor I (Fc epsilonRI) on cord blood-derived mast cells by myeloma IgE and anti-human IgE is used to induce histamine release. Histamine 131-140 immunoglobulin heavy constant epsilon Homo sapiens 90-93 15863643-6 2005 At concentrations experienced in vivo, monomeric IgE induced dose-dependent histamine release, LTC4 production and IL-8 synthesis. Histamine 76-85 immunoglobulin heavy constant epsilon Homo sapiens 49-52 16337471-4 2005 RESULTS: Exposure to IgE, but not IgG, at concentrations as low as 2.5 microg/mL significantly enhanced the release of IL-8 and monocyte chemoattractant protein 1, but not histamine or cysteinyl leukotrienes. Histamine 172-181 immunoglobulin heavy constant epsilon Homo sapiens 21-24 15842955-1 2005 Immunoglobulin E (IgE) is an important mediator in immediate hypersensitivity, as it facilitates mast cell degranulation and the release of immunomodulatory mediators, such as histamine, prostaglandins, and cytokines. Histamine 176-185 immunoglobulin heavy constant epsilon Homo sapiens 0-16 15842955-1 2005 Immunoglobulin E (IgE) is an important mediator in immediate hypersensitivity, as it facilitates mast cell degranulation and the release of immunomodulatory mediators, such as histamine, prostaglandins, and cytokines. Histamine 176-185 immunoglobulin heavy constant epsilon Homo sapiens 18-21 15863643-8 2005 Enhanced histamine release was still evident 1 week after initial exposure to IgE suggesting that continued exposure maintains enhanced secretion. Histamine 9-18 immunoglobulin heavy constant epsilon Homo sapiens 78-81 14680615-2 2004 Most hypersensitivity reactions are of immunologic origin (IgE-mediated) or are related to direct stimulation of histamine release. Histamine 113-122 immunoglobulin heavy constant epsilon Homo sapiens 59-62 15180766-0 2004 A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils. Histamine 91-100 immunoglobulin heavy constant epsilon Homo sapiens 36-39 15105971-6 2004 Anti-IgE induced histamine release was significantly inhibited by preincubation (15 min, 37 degrees C) with [-]-1-methyl-2-[3-pyridyl]pyrrolidine at the highest concentration tested 10(-)3 M (p<0.01). Histamine 17-26 immunoglobulin heavy constant epsilon Homo sapiens 5-8 15105971-7 2004 Preincubation (15 min, 37 degrees C) with (+)-nicotine di-p-toluoyltartrate salt significantly inhibited anti-IgE induced histamine release at 10(-3)M and 10(-5) M (p<0.05). Histamine 122-131 immunoglobulin heavy constant epsilon Homo sapiens 110-113 12956736-2 2003 The current review is focussed on IgE-dependent HRF that require the presence of certain types of IgE (designated IgE+) to induce histamine release. Histamine 130-139 immunoglobulin heavy constant epsilon Homo sapiens 34-37 14561149-2 2003 Mast cells are known to play a central role in the immediate phase reaction of allergic diseases through the IgE-mediated release of a variety of chemical mediators like histamine, leukotrienes, and prostaglandins. Histamine 170-179 immunoglobulin heavy constant epsilon Homo sapiens 109-112 12956736-2 2003 The current review is focussed on IgE-dependent HRF that require the presence of certain types of IgE (designated IgE+) to induce histamine release. Histamine 130-139 immunoglobulin heavy constant epsilon Homo sapiens 98-101 12956736-2 2003 The current review is focussed on IgE-dependent HRF that require the presence of certain types of IgE (designated IgE+) to induce histamine release. Histamine 130-139 immunoglobulin heavy constant epsilon Homo sapiens 114-118 12956744-10 2003 In the presence of increased tissue and organ susceptibility to histamine, minute amounts of specific IgE could have important biological consequences. Histamine 64-73 immunoglobulin heavy constant epsilon Homo sapiens 102-105 12430731-5 2002 However, the histamine release was impaired by removal of IgE on the basophils. Histamine 13-22 immunoglobulin heavy constant epsilon Homo sapiens 58-61 12776439-11 2003 The cross-linkage of two IgE molecules by allergen causes mast cells to degranulate, releasing histamine, leukotrienes, and other mediators that perpetuate the airway inflammation. Histamine 95-104 immunoglobulin heavy constant epsilon Homo sapiens 25-28 12641656-2 2003 Biological tests like leucocyte histamine release (LHR) and human basophil activation (HBA), frequently used in human allergy, reflect both the amount of IgE fixed on cells and the cellular reactivity. Histamine 32-41 immunoglobulin heavy constant epsilon Homo sapiens 154-157 12641658-0 2003 A correlation between migraine, histamine and immunoglobulin e. Histamine 32-41 immunoglobulin heavy constant epsilon Homo sapiens 46-62 12525568-0 2003 Cerivastatin and atorvastatin inhibit IL-3-dependent differentiation and IgE-mediated histamine release in human basophils and downmodulate expression of the basophil-activation antigen CD203c/E-NPP3. Histamine 86-95 immunoglobulin heavy constant epsilon Homo sapiens 73-76 12525568-4 2003 Preincubation of blood basophils with cerivastatin or atorvastatin (0.1-100 microM) for 24 h reduced their capacity to release histamine on immunoglobulin E (IgE)-dependent stimulation in a dose-dependent manner. Histamine 127-136 immunoglobulin heavy constant epsilon Homo sapiens 140-156 12525568-4 2003 Preincubation of blood basophils with cerivastatin or atorvastatin (0.1-100 microM) for 24 h reduced their capacity to release histamine on immunoglobulin E (IgE)-dependent stimulation in a dose-dependent manner. Histamine 127-136 immunoglobulin heavy constant epsilon Homo sapiens 158-161 12530543-8 2002 However, oligomeric forms might have a higher allergenic potential than monomers because larger molecules would have additional epitopes for IgE-mediated histamine release. Histamine 154-163 immunoglobulin heavy constant epsilon Homo sapiens 141-144 11984598-7 2002 It also showed dose- and time-dependent inhibition of antigen-driven IgE-mediated histamine release from fresh human basophils sensitized with IgE directed against NIP (4-hydroxy-3-iodo-5-nitrophenylacetyl). Histamine 82-91 immunoglobulin heavy constant epsilon Homo sapiens 69-72 11984598-7 2002 It also showed dose- and time-dependent inhibition of antigen-driven IgE-mediated histamine release from fresh human basophils sensitized with IgE directed against NIP (4-hydroxy-3-iodo-5-nitrophenylacetyl). Histamine 82-91 immunoglobulin heavy constant epsilon Homo sapiens 143-146 12569076-2 2003 2 The non-selective beta-adrenoceptor agonist, isoprenaline, and the selective beta(2)-adrenoceptor agonists, salbutamol and terbutaline, inhibited the IgE-mediated release of histamine from HLMC. Histamine 176-185 immunoglobulin heavy constant epsilon Homo sapiens 152-155 12385747-5 2002 Binding of a polyvalent allergen to the variable part of IgE leads to a cross-link of the receptor that triggers the cell to release histamine and pharmacological mediators of the symptomatic allergic response. Histamine 133-142 immunoglobulin heavy constant epsilon Homo sapiens 57-60 12383204-1 2002 It has been reported that serum immunoglobulin E (IgE) from certain atopic patients can sensitize basophils to release histamine in response to IgE-dependent histamine-releasing factors (HRFs). Histamine 119-128 immunoglobulin heavy constant epsilon Homo sapiens 32-54 12209627-5 2002 This antibody blocked the binding of grass pollen-allergic patients IgE (n=26; mean inhibition: 58%) to Phl p 2 and caused a 100-fold reduction of Phl p 2-induced basophil histamine release. Histamine 172-181 immunoglobulin heavy constant epsilon Homo sapiens 68-71 10887337-4 2000 IgE-sensitized mast cells were cocultured with fibroblasts from normal dermis and activated with anti-IgE to induce histamine release, after which proliferation and type I collagen synthesis by the fibroblasts were determined. Histamine 116-125 immunoglobulin heavy constant epsilon Homo sapiens 0-3 11518615-3 2001 To establish the specificity of the test model we used primary MC stimulated with immunoglobulin E (IgE), human recombinant stem cell factor (hrSCF), and anti-IgE antibodies to release significant amounts of histamine indicating the ability of MC to cause a hypersensitivity reaction of the immediate type. Histamine 208-217 immunoglobulin heavy constant epsilon Homo sapiens 82-98 11518615-3 2001 To establish the specificity of the test model we used primary MC stimulated with immunoglobulin E (IgE), human recombinant stem cell factor (hrSCF), and anti-IgE antibodies to release significant amounts of histamine indicating the ability of MC to cause a hypersensitivity reaction of the immediate type. Histamine 208-217 immunoglobulin heavy constant epsilon Homo sapiens 159-162 11422128-10 2001 CONCLUSIONS: These findings suggest that IL-10 might have anti-inflammatory effects on IgE/anti-IgE-challenged human MC by inhibiting their release of TNF-alpha, IL-8 and histamine. Histamine 171-180 immunoglobulin heavy constant epsilon Homo sapiens 87-90 11422128-10 2001 CONCLUSIONS: These findings suggest that IL-10 might have anti-inflammatory effects on IgE/anti-IgE-challenged human MC by inhibiting their release of TNF-alpha, IL-8 and histamine. Histamine 171-180 immunoglobulin heavy constant epsilon Homo sapiens 96-99 11513842-5 2001 However, haemoglobin was found to inhibit histamine release by anti-rat IgE or A23187 by ca. Histamine 42-51 immunoglobulin heavy constant epsilon Homo sapiens 72-75 11513842-7 2001 Alone of the NO donors, low concentrations of L-arginine produced a mild inhibition of histamine release induced by anti-IgE, compound 48/80 and A23187, but not other ligands, while sodium nitroprusside dose-dependently inhibited (by a maximum of ca. Histamine 87-96 immunoglobulin heavy constant epsilon Homo sapiens 121-124 11513842-8 2001 30%) histamine release by anti-rat IgE, sodium fluoride or A23187. Histamine 5-14 immunoglobulin heavy constant epsilon Homo sapiens 35-38 11467995-8 2001 In patients with low serum IgE current smoking is associated with increased bronchial responsiveness to histamine in vitro, which can be further enhanced by passive sensitization. Histamine 104-113 immunoglobulin heavy constant epsilon Homo sapiens 27-30 11152171-14 2000 One latex extract (Stallergene) with the widest IgE-reacting protein repertoire identified the majority of subjects (63%) as latex sensitive by leukocyte histamine release and also provided the best quantitative histamine release test results. Histamine 154-163 immunoglobulin heavy constant epsilon Homo sapiens 48-51 10887337-4 2000 IgE-sensitized mast cells were cocultured with fibroblasts from normal dermis and activated with anti-IgE to induce histamine release, after which proliferation and type I collagen synthesis by the fibroblasts were determined. Histamine 116-125 immunoglobulin heavy constant epsilon Homo sapiens 102-105 10853974-5 2000 Basophils from which IgE had been dissociated by brief exposure to lactic acid no longer released histamine in response to gp120 and anti-IgE. Histamine 98-107 immunoglobulin heavy constant epsilon Homo sapiens 21-24 10853974-5 2000 Basophils from which IgE had been dissociated by brief exposure to lactic acid no longer released histamine in response to gp120 and anti-IgE. Histamine 98-107 immunoglobulin heavy constant epsilon Homo sapiens 138-141 9647730-7 1998 In addition, IgE-mediated histamine release was observed, suggesting that the Fc epsilon RI induced by IL-4 was functional and was able to transduce a signal for degranulation. Histamine 26-35 immunoglobulin heavy constant epsilon Homo sapiens 13-16 10651776-7 2000 RESULTS: Histamine responsiveness was significantly increased in airways obtained from patients with IgE levels above 200 U/mL as compared with airways from patients with IgE levels below 10 U/mL (P < 0.05). Histamine 9-18 immunoglobulin heavy constant epsilon Homo sapiens 101-104 10651776-8 2000 Passive sensitization of bronchi from patients with low IgE significantly increased histamine responsiveness, as compared with non-sensitized controls from the same patients (P < 0.05). Histamine 84-93 immunoglobulin heavy constant epsilon Homo sapiens 56-59 10651776-11 2000 CONCLUSION: Our findings reveal that elevated levels of serum IgE predict airway hyperresponsiveness to histamine in vitro. Histamine 104-113 immunoglobulin heavy constant epsilon Homo sapiens 62-65 10359566-6 1999 Moreover, recombinant Cepsilon3 inhibited binding of natural IgE antibodies to alpha2, and preincubation of human IgE with alpha2 inhibited anti-IgE-triggered histamine release from human basophils. Histamine 159-168 immunoglobulin heavy constant epsilon Homo sapiens 114-117 10359566-6 1999 Moreover, recombinant Cepsilon3 inhibited binding of natural IgE antibodies to alpha2, and preincubation of human IgE with alpha2 inhibited anti-IgE-triggered histamine release from human basophils. Histamine 159-168 immunoglobulin heavy constant epsilon Homo sapiens 114-117 10200014-1 1999 BACKGROUND: We have previously shown that the human recombinant histamine releasing factor (HrHRF) caused histamine release from a subset of basophils from donors with allergy, and this release seemed to be dependent on the presence of a certain type of IgE, termed IgE+. Histamine 64-73 immunoglobulin heavy constant epsilon Homo sapiens 254-257 10200014-1 1999 BACKGROUND: We have previously shown that the human recombinant histamine releasing factor (HrHRF) caused histamine release from a subset of basophils from donors with allergy, and this release seemed to be dependent on the presence of a certain type of IgE, termed IgE+. Histamine 64-73 immunoglobulin heavy constant epsilon Homo sapiens 266-269 10200014-3 1999 However, subsequently we demonstrated that HrHRF primes anti-IgE-antibody-induced histamine release from all basophils, irrespective of the type of IgE on the cell surface. Histamine 82-91 immunoglobulin heavy constant epsilon Homo sapiens 61-64 10200014-9 1999 RESULTS: Mean anti-IgE-induced histamine release was 33% +/- 15%, and there was no difference between IgE+ sensitization (32% +/- 12%) and IgE- sensitization (34% +/- 18%). Histamine 31-40 immunoglobulin heavy constant epsilon Homo sapiens 19-22 10030852-5 1999 ATP (10(-4) M) enhanced anti-IgE-induced histamine release (10.9 +/- 2.7% to 19. Histamine 41-50 immunoglobulin heavy constant epsilon Homo sapiens 29-32 10030852-7 1999 The adenine nucleotides consistently enhanced anti-IgE-induced histamine release; the rank order for this action was: ATP > 2mSATP > alpha,betamATP > beta,gammamATP, suggesting mediation by a P2Y-purinoceptor subtype. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 51-54 10030852-9 1999 UTP, an agonist at P2Y-purinoceptors, also significantly enhanced anti-IgE-induced histamine release. Histamine 83-92 immunoglobulin heavy constant epsilon Homo sapiens 71-74 9824387-16 1998 Our study suggests an important role for IgE in the course of the disease, since a higher initial serum IgE level predicts a more favourable course with regard to annual decline of PC20 histamine. Histamine 186-195 immunoglobulin heavy constant epsilon Homo sapiens 41-44 9824387-16 1998 Our study suggests an important role for IgE in the course of the disease, since a higher initial serum IgE level predicts a more favourable course with regard to annual decline of PC20 histamine. Histamine 186-195 immunoglobulin heavy constant epsilon Homo sapiens 104-107 9824389-9 1998 RESULTS: The cultured mast cells released histamine, LTs and PGD2 following immunological stimulation through IgE. Histamine 42-51 immunoglobulin heavy constant epsilon Homo sapiens 110-113 9824389-14 1998 CONCLUSIONS: The present results indicate that cultured mast cells release histamine, LTs and PGD2 following IgE crosslinking. Histamine 75-84 immunoglobulin heavy constant epsilon Homo sapiens 109-112 10807498-10 2000 Histamine release from skin mast cells due to anti-IgE or A23187 was inhibited by epinastine in a dose-dependent fashion, whereas substance P-induced activation as well as stem cell factor priming were not. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 51-54 10228046-1 1999 Previously, infusions of an anti-IgE mAb (rhumAb-E25) in subjects decreased serum IgE levels, basophil IgE and FcepsilonRIalpha surface density, and polyclonal anti-IgE and Ag-induced basophil histamine release responses. Histamine 193-202 immunoglobulin heavy constant epsilon Homo sapiens 33-36 10030852-0 1999 ATP modulates anti-IgE-induced release of histamine from human lung mast cells. Histamine 42-51 immunoglobulin heavy constant epsilon Homo sapiens 19-22 9893198-12 1999 CONCLUSION: The carbohydrate moieties of allergenic glycoproteins can constitute significant determinants on the binding to IgE of the sera from patients who are hypersensitive and can be responsible for inducing histamine release from blood cells. Histamine 213-222 immunoglobulin heavy constant epsilon Homo sapiens 124-127 10374453-6 1997 (5) House dust mite and rabbit antihuman IgE induced histamine release from mast cell. Histamine 53-62 immunoglobulin heavy constant epsilon Homo sapiens 41-44 9491224-7 1998 In fact, SMC challenged by an optimal concentration of alpha-IgE could release histamine upon a second activation by 2 h after the first activation, if the cells had been presensitized before the second challenge. Histamine 79-88 immunoglobulin heavy constant epsilon Homo sapiens 61-64 9491224-10 1998 SMC can release histamine when reactivated with alpha-IgE antibodies after presensitization by 2 h after the first challenge, while they reacquire their susceptibility to reactivation with compound 48/80 in only 2-3 days. Histamine 16-25 immunoglobulin heavy constant epsilon Homo sapiens 54-57 9338607-9 1997 Significant histamine release was observed following treatment with anti-human IgE, calcium ionophore A23187, concanavalin A, compound 48/80 and morphine. Histamine 12-21 immunoglobulin heavy constant epsilon Homo sapiens 79-82 8939160-8 1996 RESULTS: Replacing IgE- on basophils with IgE+ serum decreased the correlation between monocyte chemotactic protein-1 and histamine release (rho = 0.80, n = 280 vs p = 0.12, n = 18; p for difference between p values; < 0.05). Histamine 122-131 immunoglobulin heavy constant epsilon Homo sapiens 19-22 9117014-1 1997 Incubation of airways from nonatopic patients with serum from patients with high IgE levels confers responsiveness to "specific" (allergen) and hyperresponsiveness to "nonspecific" (histamine) stimuli. Histamine 182-191 immunoglobulin heavy constant epsilon Homo sapiens 81-84 9117014-7 1997 The potency and magnitude of the maximal contraction to histamine was significantly (p < 0.05) increased in tissues sensitized using atopic serum with high total IgE concentrations compared with nonsensitized preparations, but was unchanged in tissues sensitized using chimeric IgE or serum with low total IgE levels. Histamine 56-65 immunoglobulin heavy constant epsilon Homo sapiens 165-168 9117014-7 1997 The potency and magnitude of the maximal contraction to histamine was significantly (p < 0.05) increased in tissues sensitized using atopic serum with high total IgE concentrations compared with nonsensitized preparations, but was unchanged in tissues sensitized using chimeric IgE or serum with low total IgE levels. Histamine 56-65 immunoglobulin heavy constant epsilon Homo sapiens 281-284 9117014-7 1997 The potency and magnitude of the maximal contraction to histamine was significantly (p < 0.05) increased in tissues sensitized using atopic serum with high total IgE concentrations compared with nonsensitized preparations, but was unchanged in tissues sensitized using chimeric IgE or serum with low total IgE levels. Histamine 56-65 immunoglobulin heavy constant epsilon Homo sapiens 281-284 9151531-2 1997 Immunoglobulin E (IgE)-mediated cell activation plays a crucial role in acute inflammation and leads to the release of proinflammatory mediators, such as histamine, eicosanoids, platelet-activating factor, oxygen-free radicals, neuropeptides and cytokines. Histamine 154-163 immunoglobulin heavy constant epsilon Homo sapiens 0-16 9151531-2 1997 Immunoglobulin E (IgE)-mediated cell activation plays a crucial role in acute inflammation and leads to the release of proinflammatory mediators, such as histamine, eicosanoids, platelet-activating factor, oxygen-free radicals, neuropeptides and cytokines. Histamine 154-163 immunoglobulin heavy constant epsilon Homo sapiens 18-21 9395919-3 1997 We have previously shown that murine IgE bound to tumor cells can activate murine mast cells to release TNF-alpha and histamine. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 37-40 9024994-3 1996 The histamine release following ConA, anti-IgE and anti-IgE + IL3 from those cells were evaluated before and following the addition of cromoline Na and nedocromil Na. Histamine 4-13 immunoglobulin heavy constant epsilon Homo sapiens 56-59 9137992-5 1997 Functional integrity of which was assessed by comparing the anti-IgE or calcium ionophore A23187 induced histamine release from basophils obtained from each enrichment step. Histamine 105-114 immunoglobulin heavy constant epsilon Homo sapiens 65-68 9137992-8 1997 Net histamine release from basophils stimulated with optimal concentrations of anti-human IgE was 39.1 +/- 6.5% after Ficoll centrifugation, 41.6 +/- 7.7% following elutriation and 35.7 +/- 6.8% from the final purified fraction. Histamine 4-13 immunoglobulin heavy constant epsilon Homo sapiens 90-93 9048527-4 1997 METHODS: IgE reactivity was measured in eight clinically codfish-allergic adult patients, confirmed by double-blind, placebo-controlled challenges with fresh raw codfish, and in 30 codfish-tolerant control subjects, by means of skin prick test, histamine release test, specific IgE tests, SDS-PAGE, and immunoblotting. Histamine 245-254 immunoglobulin heavy constant epsilon Homo sapiens 9-12 8939160-8 1996 RESULTS: Replacing IgE- on basophils with IgE+ serum decreased the correlation between monocyte chemotactic protein-1 and histamine release (rho = 0.80, n = 280 vs p = 0.12, n = 18; p for difference between p values; < 0.05). Histamine 122-131 immunoglobulin heavy constant epsilon Homo sapiens 42-45 8760789-0 1996 Histamine selectively enhances human immunoglobulin E (IgE) and IgG4 production induced by anti-CD58 monoclonal antibody. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 37-59 8760789-1 1996 We studied the effects of histamine on human immunoglobulin (IgE) and IgG4 production. Histamine 26-35 immunoglobulin heavy constant epsilon Homo sapiens 61-64 8760789-9 1996 These results indicate that histamine enhanced IgE and IgG4 production by increasing endogenous IL-6 and IL-10 production via H1 and H3 receptors, respectively. Histamine 28-37 immunoglobulin heavy constant epsilon Homo sapiens 47-50 8760789-2 1996 Histamine selectively enhanced IgE and IgG4 production in purified surface IgE and IgG4 negative (sIgE-sIgG4-) B cells from normal donors stimulated with interleukin (IL)-4 plus anti-CD58 or IL-13 plus anti-CD58 monoclonal antibody (mAb) without affecting production of IgG1, IgG2, IgG3, IgM, IgA1, or IgA2. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 31-34 8760789-2 1996 Histamine selectively enhanced IgE and IgG4 production in purified surface IgE and IgG4 negative (sIgE-sIgG4-) B cells from normal donors stimulated with interleukin (IL)-4 plus anti-CD58 or IL-13 plus anti-CD58 monoclonal antibody (mAb) without affecting production of IgG1, IgG2, IgG3, IgM, IgA1, or IgA2. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 75-78 8760789-3 1996 In cultures with IL-4 plus anti-CD58 mAb, histamine-induced enhancement of IgE and IgG4 production was specifically blocked by thioperamide (H3 receptor antagonist), and was inhibited by anti-IL-10 antibody (Ab). Histamine 42-51 immunoglobulin heavy constant epsilon Homo sapiens 75-78 8760789-5 1996 Histamine also enhanced IgE and IgG4 production by in vivo-generated sIgE+ and sIgG4+ B cells, respectively, from atopic patients; enhancement was blocked by dimaprit and thioperamide, and was inhibited by anti-IL-6 mAb and anti-IL-10 Ab. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 24-27 8688673-0 1996 Basophil histamine release and leukotriene production in response to anti-IgE and anti-IgE receptor antibodies. Histamine 9-18 immunoglobulin heavy constant epsilon Homo sapiens 74-77 8688673-0 1996 Basophil histamine release and leukotriene production in response to anti-IgE and anti-IgE receptor antibodies. Histamine 9-18 immunoglobulin heavy constant epsilon Homo sapiens 87-90 8645460-4 1996 All patients showed IgE-mediated histamine release when their peripheral leukocytes were incubated in vitro with the infecting species, indicating basophil-bound IgE directed against their own bacterium. Histamine 33-42 immunoglobulin heavy constant epsilon Homo sapiens 20-23 8534491-11 1996 Both CD29 and CD49d clustering significantly inhibited anti-IgE-induced histamine release from the human basophil. Histamine 72-81 immunoglobulin heavy constant epsilon Homo sapiens 60-63 8807505-21 1996 When comparing the diagnostic reliability of specific IgE with respect to other allergologic diagnostic methods, we find a significant and positive correlation of this technique with skin tests (but never greater than 90-95%) and with the histamine release test. Histamine 239-248 immunoglobulin heavy constant epsilon Homo sapiens 54-57 8645460-4 1996 All patients showed IgE-mediated histamine release when their peripheral leukocytes were incubated in vitro with the infecting species, indicating basophil-bound IgE directed against their own bacterium. Histamine 33-42 immunoglobulin heavy constant epsilon Homo sapiens 162-165 8821777-4 1996 Rabbit IgG anti-human IgE induced significant histamine release at all concentrations tested, maximum at 78 micrograms/ml. Histamine 46-55 immunoglobulin heavy constant epsilon Homo sapiens 22-25 8834823-4 1995 Additionally, the reactivity to Der p 1 was significantly correlated with that to anti-IgE (rs = 0.690, P = 0.0012), indicating that an intrinsic cellular property may be one of the contributing factors in immunologic histamine release. Histamine 218-227 immunoglobulin heavy constant epsilon Homo sapiens 87-90 8834823-9 1995 Taken together, our results suggest that an intrinsic cellular property, as well as specific IgE antibody levels on the cell surface, is an important factor in determining histamine release in response to IgE-dependent activation. Histamine 172-181 immunoglobulin heavy constant epsilon Homo sapiens 93-96 8834823-9 1995 Taken together, our results suggest that an intrinsic cellular property, as well as specific IgE antibody levels on the cell surface, is an important factor in determining histamine release in response to IgE-dependent activation. Histamine 172-181 immunoglobulin heavy constant epsilon Homo sapiens 205-208 8546845-7 1995 At lower concentrations of H. influenzae causing no histamine release the bacterium was found to enhance IgE-mediated histamine release triggered by anti-IgE antibody. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 105-108 8546845-7 1995 At lower concentrations of H. influenzae causing no histamine release the bacterium was found to enhance IgE-mediated histamine release triggered by anti-IgE antibody. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 154-157 7542803-3 1995 Both recombinant proteins caused histamine release from the human basophils of a subpopulation of donors, and this release was dependent on IgE. Histamine 33-42 immunoglobulin heavy constant epsilon Homo sapiens 140-143 8620953-7 1995 Similarly, anti-IgE released histamine from isolated lung mast cells sensitized with atopic serum up to 22.4 +/- 2% of total histamine measured within mast cells. Histamine 29-38 immunoglobulin heavy constant epsilon Homo sapiens 16-19 8620953-7 1995 Similarly, anti-IgE released histamine from isolated lung mast cells sensitized with atopic serum up to 22.4 +/- 2% of total histamine measured within mast cells. Histamine 125-134 immunoglobulin heavy constant epsilon Homo sapiens 16-19 8620953-8 1995 When isolated airways or mast cells were sensitized with human monoclonal IgE (1,000 IU.mL-1), response to anti-IgE in terms of contractile response or histamine release, respectively, were not significantly different from those obtained following passive sensitization with atopic serum. Histamine 152-161 immunoglobulin heavy constant epsilon Homo sapiens 74-77 7666875-9 1995 RESULTS: Serum total IgE levels were strongly correlated (r = 0.65, P < 0.01) in pairs of siblings concordant for bronchial hyperresponsiveness (defined as a > or = 20 percent decrease in the forced expiratory volume in one second produced by histamine [threshold dose, < or = 16 mg per milliliter]), suggesting that these traits are coinherited. Histamine 249-258 immunoglobulin heavy constant epsilon Homo sapiens 21-24 7542104-4 1995 Cells sensitized with 1 microgram/ml human IgE released 58.5% histamine and 1.55 ng tumor necrosis factor (TNF)-alpha per 10(6) cells when challenged with 1 microgram/ml antihuman IgE, whereas the control cells spontaneously released 3.7% histamine and 0.18 ng TNF-alpha. Histamine 62-71 immunoglobulin heavy constant epsilon Homo sapiens 43-46 7542104-4 1995 Cells sensitized with 1 microgram/ml human IgE released 58.5% histamine and 1.55 ng tumor necrosis factor (TNF)-alpha per 10(6) cells when challenged with 1 microgram/ml antihuman IgE, whereas the control cells spontaneously released 3.7% histamine and 0.18 ng TNF-alpha. Histamine 239-248 immunoglobulin heavy constant epsilon Homo sapiens 43-46 8198252-3 1994 This conclusion may be related to the known heterogeneity of autoanti-IgE antibodies in terms of their ability to trigger basophil histamine release. Histamine 131-140 immunoglobulin heavy constant epsilon Homo sapiens 70-73 7537937-0 1994 Effect of R59022, an inhibitor of diacylglycerol kinase, on IgE-mediated histamine release from human lung mast cells and basophils. Histamine 73-82 immunoglobulin heavy constant epsilon Homo sapiens 60-63 7537937-2 1994 At 1 microM the drug increased the IgE-dependent release of histamine from human basophils from 19 +/- 5% to 60 +/- 13% (n = 5, p < 0.01). Histamine 60-69 immunoglobulin heavy constant epsilon Homo sapiens 35-38 7537937-7 1994 As anticipated there was a strong negative correlation (r = 0.764, p < 0.05) between anti-IgE-induced histamine release and the percentage enhancement in the presence of 10 microM R59022. Histamine 105-114 immunoglobulin heavy constant epsilon Homo sapiens 93-96 7537937-9 1994 The data suggest that the R59022 increases the release of histamine induced by anti-IgE in human basophils but not in human lung mast cells. Histamine 58-67 immunoglobulin heavy constant epsilon Homo sapiens 84-87 7526643-2 1994 Calcium ionophore A23187 and anti-IgE caused histamine release from all bladder mast cells in a dose-related manner. Histamine 45-54 immunoglobulin heavy constant epsilon Homo sapiens 34-37 7526646-0 1994 Bacteria-induced IgE-mediated histamine release: examination of patients with chronic bronchitis (CB) during acute exacerbations. Histamine 30-39 immunoglobulin heavy constant epsilon Homo sapiens 17-20 7526646-2 1994 Bacteria, isolated from the expectorate caused an IgE-mediated histamine release from the patient"s own blood leukocytes, indicating that all were sensitized to their own bacteria. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 50-53 7526657-3 1994 Furosemide inhibited anti-IgE-induced histamine release. Histamine 38-47 immunoglobulin heavy constant epsilon Homo sapiens 26-29 7526657-5 1994 In contrast, bumetanide potentiated anti-IgE-induced histamine secretion from the rat peritoneal mast cell. Histamine 53-62 immunoglobulin heavy constant epsilon Homo sapiens 41-44 7526657-6 1994 Both diuretics were modest inhibitors of anti-IgE-mediated histamine release from human lung mast cells. Histamine 59-68 immunoglobulin heavy constant epsilon Homo sapiens 46-49 7510965-1 1994 The effect of the H1-antihistamine drug loratadine and its active metabolite descarboxyethoxyloratadine upon histamine release was examined on anti-immunoglobulin E (IgE) triggered human basophils and 2,4-dinitrophenyl (DNP) triggered rat basophilic leukemia (RBL-2H3) cells. Histamine 25-34 immunoglobulin heavy constant epsilon Homo sapiens 166-169 7897156-7 1995 The biologic activity of IgE in response to profilin was tested by in vitro histamine release and skin prick tests. Histamine 76-85 immunoglobulin heavy constant epsilon Homo sapiens 25-28 8640146-4 1995 In addition to the serum IgE and IgG4 the percentage of histamine, liberated by a-IgE and specific allergens, from peripheral blood basophils was determined. Histamine 56-65 immunoglobulin heavy constant epsilon Homo sapiens 82-85 7512434-4 1994 Isosmotic replacement of extracellular Na+ either with choline+, a non-permeant Na+ analogue, or glucose significantly increased spontaneous and anti-IgE-induced histamine release. Histamine 162-171 immunoglobulin heavy constant epsilon Homo sapiens 150-153 7512434-8 1994 The Na+/H+ exchanger monensin had a dose-dependent inhibitory effect on anti-IgE-induced histamine release, and the concentration inhibiting 50% of histamine release was 1.5 x 10(-7) M. When basophils were challenged in the presence of different Na+ and Ca2+ concentrations, it was shown that the two cations have antagonistic effects, which is to say that they down-regulate and upregulate histamine release, respectively. Histamine 89-98 immunoglobulin heavy constant epsilon Homo sapiens 77-80 7512434-8 1994 The Na+/H+ exchanger monensin had a dose-dependent inhibitory effect on anti-IgE-induced histamine release, and the concentration inhibiting 50% of histamine release was 1.5 x 10(-7) M. When basophils were challenged in the presence of different Na+ and Ca2+ concentrations, it was shown that the two cations have antagonistic effects, which is to say that they down-regulate and upregulate histamine release, respectively. Histamine 148-157 immunoglobulin heavy constant epsilon Homo sapiens 77-80 7512434-8 1994 The Na+/H+ exchanger monensin had a dose-dependent inhibitory effect on anti-IgE-induced histamine release, and the concentration inhibiting 50% of histamine release was 1.5 x 10(-7) M. When basophils were challenged in the presence of different Na+ and Ca2+ concentrations, it was shown that the two cations have antagonistic effects, which is to say that they down-regulate and upregulate histamine release, respectively. Histamine 148-157 immunoglobulin heavy constant epsilon Homo sapiens 77-80 7679683-1 1993 Within the atopic and nonatopic population, basophils display a wide variation in the extent of histamine release when challenged with an optimal concentration of polyclonal anti-IgE antibody. Histamine 96-105 immunoglobulin heavy constant epsilon Homo sapiens 179-182 7521712-12 1994 We conclude that salmeterol significantly inhibits IgE-mediated histamine release from human leukocytes in the micromolar range. Histamine 64-73 immunoglobulin heavy constant epsilon Homo sapiens 51-54 7505995-3 1993 In contrast, the frequency of positive skin reaction to HD and histamine release from peripheral basophils by anti-IgE were significantly lower in DIA than in non-DIA. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 115-118 7521712-0 1994 Influence of salmeterol, a long-acting beta 2-adrenoceptor agonist, on IgE-mediated histamine release from human basophils. Histamine 84-93 immunoglobulin heavy constant epsilon Homo sapiens 71-74 7690780-2 1993 In the current study, we investigated whether Staphylococcus aureus grown from affected skin of atopic dermatitis (AD) patients secreted identifiable toxins that could act as allergens to induce IgE-mediated basophil histamine release. Histamine 217-226 immunoglobulin heavy constant epsilon Homo sapiens 195-198 7690780-9 1993 Stripped basophils sensitized with three AD sera containing IgE to toxin released 15-41% of total basophil histamine only when exposed to the relevant toxin, but not to other toxins. Histamine 107-116 immunoglobulin heavy constant epsilon Homo sapiens 60-63 7683772-0 1993 Autoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. Histamine 68-77 immunoglobulin heavy constant epsilon Homo sapiens 41-44 8477156-0 1993 Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. Histamine 17-26 immunoglobulin heavy constant epsilon Homo sapiens 35-38 7679683-9 1993 In the IgE-mediated response one parameter is the maximum histamine release obtainable through IgE-mediated mechanisms, and the second parameter is basophil sensitivity as defined above. Histamine 58-67 immunoglobulin heavy constant epsilon Homo sapiens 7-10 1380984-8 1992 Using small tissue samples from polyps, histamine was released by anti-human IgE in allergic patients but not in non allergic patients. Histamine 40-49 immunoglobulin heavy constant epsilon Homo sapiens 77-80 8139217-4 1993 Intestinal mast cells release histamine in a dose-dependent manner after challenges with anti-IgE (1.875-240.0 U/ml). Histamine 30-39 immunoglobulin heavy constant epsilon Homo sapiens 94-97 1380985-2 1992 This study was performed to elucidate whether IgG4 antibody inhibits IgE-mediated histamine release from target cells after antigenic stimulation, and whether it has reaginic activity. Histamine 82-91 immunoglobulin heavy constant epsilon Homo sapiens 69-72 1380985-11 1992 After sensitization with 100 ngs of IgE, one showed high-grade histamine release after challenge with 0.5 micrograms/ml mite antigen and the other showed middle-grade release with 0.1 micrograms/ml mite. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 36-39 1372188-4 1992 IL-4 significantly inhibited IgE-mediated histamine release, while there was a trend for enhancement of IgE-mediated histamine release by IL-2. Histamine 42-51 immunoglobulin heavy constant epsilon Homo sapiens 29-32 1373172-2 1992 The nonselective PDE inhibitors, theophylline and 3-isobutyl-1-methylxanthine, inhibited anti-IgE-induced release of histamine and leukotriene C4 (LTC4) from basophils. Histamine 117-126 immunoglobulin heavy constant epsilon Homo sapiens 94-97 1372188-4 1992 IL-4 significantly inhibited IgE-mediated histamine release, while there was a trend for enhancement of IgE-mediated histamine release by IL-2. Histamine 117-126 immunoglobulin heavy constant epsilon Homo sapiens 104-107 1384867-2 1992 In the present study the effects of different nonselective and selective PKC inhibitors on IgE-mediated histamine release from human basophils were investigated. Histamine 104-113 immunoglobulin heavy constant epsilon Homo sapiens 91-94 1382368-0 1992 Modulation of IgE-mediated histamine release from human leukocytes by a new class of histamine H2-agonists. Histamine 27-36 immunoglobulin heavy constant epsilon Homo sapiens 14-17 1382368-1 1992 A new class of phenyl (pyridylalcyl) guanidines, acting as potent histamine H2-agonists, inhibits IgE-mediated human basophil histamine release in a nanomolar range. Histamine 66-75 immunoglobulin heavy constant epsilon Homo sapiens 98-101 1382368-1 1992 A new class of phenyl (pyridylalcyl) guanidines, acting as potent histamine H2-agonists, inhibits IgE-mediated human basophil histamine release in a nanomolar range. Histamine 126-135 immunoglobulin heavy constant epsilon Homo sapiens 98-101 1357857-3 1992 9/10 birch pollen-allergic patients proved positive in the histamine release test and the results correlated with specific IgE levels measured by RAST. Histamine 59-68 immunoglobulin heavy constant epsilon Homo sapiens 123-126 1382746-8 1992 After 3 days in culture mast cells released 16% of their histamine stores in response to A23187 and 10% in response to anti-human IgE. Histamine 57-66 immunoglobulin heavy constant epsilon Homo sapiens 130-133 1726056-1 1991 The relation between the amount of cell-bound IgE and the histamine "releasability" of peripheral leukocytes was studied in 28 patients with atopic diseases and 26 non-atopic controls after in vitro stimulation with anti-IgE. Histamine 58-67 immunoglobulin heavy constant epsilon Homo sapiens 46-49 1726056-2 1991 Cell-bound IgE was eluted in acid buffer (pH 3.7) and the amount of histamine released (HR) into supernatant at this pH was measured. Histamine 68-77 immunoglobulin heavy constant epsilon Homo sapiens 11-14 1726056-8 1991 It is concluded that the increased histamine releasability from leukocytes of atopic individuals after stimulation with anti-IgE is only in part due to an increased number of IgE molecules per basophil surface. Histamine 35-44 immunoglobulin heavy constant epsilon Homo sapiens 125-128 1726056-8 1991 It is concluded that the increased histamine releasability from leukocytes of atopic individuals after stimulation with anti-IgE is only in part due to an increased number of IgE molecules per basophil surface. Histamine 35-44 immunoglobulin heavy constant epsilon Homo sapiens 175-178 1705512-9 1991 By contrast, histamine and leukotrienes are released more rapidly in response to IgE-dependent stimulation after IL 3 priming. Histamine 13-22 immunoglobulin heavy constant epsilon Homo sapiens 81-84 1708341-4 1991 A variability in the extent of histamine release upon stimulation by either anti-IgE or fMLP was found between donors. Histamine 31-40 immunoglobulin heavy constant epsilon Homo sapiens 81-84 1708341-5 1991 Kinetic studies revealed that the histamine release induced by anti-IgE (t1/2 greater than 240 s) was more than 20-fold slower than the almost instantaneous release upon stimulation with fMLP (t1/2 less than 10 s). Histamine 34-43 immunoglobulin heavy constant epsilon Homo sapiens 68-71 1712675-0 1991 The inhibitory effect of 3,3",4,5"-tetrahydroxystilbene, a constituent of Cassia garrettiana, on anti-IgE-induced histamine release from human basophils in vitro. Histamine 114-123 immunoglobulin heavy constant epsilon Homo sapiens 102-105 1727011-5 1991 Basophils of atopic patients released more histamine with 1/5 anti-IgE dilution (p < 0.01), while non-atopic patients did so with the 1/25 dilution (p < 0.05). Histamine 43-52 immunoglobulin heavy constant epsilon Homo sapiens 67-70 1727011-9 1991 As for the effect of age on IgE-dependent histamine release, the group of patients who presented greater releasability corresponded to those older than 6 years of age. Histamine 42-51 immunoglobulin heavy constant epsilon Homo sapiens 28-31 1727011-10 1991 The discrepancies observed between the clinical history, skin tests, serum IgE and antigen-dependent histamine release in some patients could be related to the individual basophil ability to release histamine. Histamine 199-208 immunoglobulin heavy constant epsilon Homo sapiens 75-78 1716311-8 1991 Prolonged exposure to 100 ng/ml of TPA reduced IgE-mediated histamine release from 28 +/- 6 to 6 +/- 1% in the skin mast cells whereas similar treatment only reduced the response of lung mast cells from 36 +/- 5 to 26 +/- 6%. Histamine 60-69 immunoglobulin heavy constant epsilon Homo sapiens 47-50 1716823-1 1991 Mast cells isolated from human gastric mucosa released histamine on challenge with IgE-directed ligands and calcium ionophores but were essentially unresponsive to a variety of non-immunological stimuli. Histamine 55-64 immunoglobulin heavy constant epsilon Homo sapiens 83-86 1755579-3 1991 The cross-linking of the cell-bound IgE induces the production and/or release of various inflammatory mediators (histamine, leukotrienes, platelet-activating-factor, etc. Histamine 113-122 immunoglobulin heavy constant epsilon Homo sapiens 36-39 1700194-1 1990 Human skin mast cells release histamine in response to both immunologic stimulation mediated by anti-IgE and IgE-independent mechanisms of which substance P is a prototypical secretagogue. Histamine 30-39 immunoglobulin heavy constant epsilon Homo sapiens 101-104 1834585-2 1991 Opposite functions can be shown for triggering of IgE-mediated histamine release from human basophils in terms of anaphylactogenic or nonanaphylactogenic autoantibodies. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 50-53 1708690-6 1991 In five experiments, histamine release in the presence of 44% D2O was 9 +/- 2% and 46 +/- 4% using control IgE- and IgE+ sensitized cells, respectively. Histamine 21-30 immunoglobulin heavy constant epsilon Homo sapiens 107-110 1708690-6 1991 In five experiments, histamine release in the presence of 44% D2O was 9 +/- 2% and 46 +/- 4% using control IgE- and IgE+ sensitized cells, respectively. Histamine 21-30 immunoglobulin heavy constant epsilon Homo sapiens 116-119 1708690-9 1991 The percentage histamine release to D2O was directly related to both the amount of IgE+ used for passive sensitization and the concentration of D2O used for release. Histamine 15-24 immunoglobulin heavy constant epsilon Homo sapiens 83-86 2065460-3 1991 The results suggested that the antigen of Cysticercus cellulosae could induce IgE production and mast cell degranulation, resulting in the release of histamine. Histamine 150-159 immunoglobulin heavy constant epsilon Homo sapiens 78-81 1700194-1 1990 Human skin mast cells release histamine in response to both immunologic stimulation mediated by anti-IgE and IgE-independent mechanisms of which substance P is a prototypical secretagogue. Histamine 30-39 immunoglobulin heavy constant epsilon Homo sapiens 109-112 1700194-5 1990 Stimulation with either anti-IgE or substance P resulted in a net histamine release of 10.2 +/- 1.7% or 21.4 +/- 4.0%, respectively. Histamine 66-75 immunoglobulin heavy constant epsilon Homo sapiens 29-32 1695458-3 1990 A variability in the extent of histamine release upon stimulation by either anti-IgE or FMLP was found between donors. Histamine 31-40 immunoglobulin heavy constant epsilon Homo sapiens 81-84 1695458-4 1990 Non-responders for FMLP showed high histamine release for anti-IgE, and vice versa. Histamine 36-45 immunoglobulin heavy constant epsilon Homo sapiens 63-66 1695434-4 1990 IgE-mediated histamine release was not modulated. Histamine 13-22 immunoglobulin heavy constant epsilon Homo sapiens 0-3 1712002-1 1990 This study was undertaken to investigate the effect of estrogens on the histamine release mediated by IgE in rat peritoneal mast cells (PMC) and in sensitized human basophils. Histamine 72-81 immunoglobulin heavy constant epsilon Homo sapiens 102-105 1688523-2 1990 Both spontaneous histamine release and anti-IgE-induced histamine release were significantly increased in HIV-infected subjects, in comparison with seronegative drug addicts and normal controls. Histamine 56-65 immunoglobulin heavy constant epsilon Homo sapiens 44-47 1690179-3 1990 On the contrary, an increased histamine liberation was obtained by challenging basophils from hydatid patients with anti-human IgE. Histamine 30-39 immunoglobulin heavy constant epsilon Homo sapiens 127-130 1712002-2 1990 The estrogens were found to enhance the histamine release of either rat PMC and sensitized human basophils upon stimulation with anti-IgE. Histamine 40-49 immunoglobulin heavy constant epsilon Homo sapiens 134-137 1712002-8 1990 The enhancement of histamine release by estrogens is probably mediated by IgE molecules present on the cell membrane, since this effect was not observed on challenge with substance P or compound 48/80, two segretagogues known to induce histamine release not via IgE. Histamine 19-28 immunoglobulin heavy constant epsilon Homo sapiens 74-77 2475042-0 1989 Chironomidae as a cause of IgE-mediated histamine release in patients with asthma. Histamine 40-49 immunoglobulin heavy constant epsilon Homo sapiens 27-30 10864396-0 2000 Modulation of allergen and anti-igE induced human basophil activation by serial histamine dilutions. Histamine 80-89 immunoglobulin heavy constant epsilon Homo sapiens 32-35 2479302-5 1989 The maximal histamine release from leukocyte caused by anti-IgE also correlated highly with the severity of asthma. Histamine 12-21 immunoglobulin heavy constant epsilon Homo sapiens 60-63 2476485-0 1989 Recombinant human IL-1 alpha and -1 beta potentiate IgE-mediated histamine release from human basophils. Histamine 65-74 immunoglobulin heavy constant epsilon Homo sapiens 52-55 2476485-7 1989 rhIL-1, however, did augment IgE-dependent histamine release. Histamine 43-52 immunoglobulin heavy constant epsilon Homo sapiens 29-32 2476485-9 1989 At submaximal histamine release (less than 10%), there was enhancement of three IgE-dependent secretagogues: 125% with goat anti-human IgE (n = 7), 215% with Ag E (n = 10), and 260% with a histamine releasing factor (n = 7). Histamine 14-23 immunoglobulin heavy constant epsilon Homo sapiens 80-83 2479279-5 1989 The results show that IgE is responsible for the histamine release caused by CA and HSV-I in AIDS patients. Histamine 49-58 immunoglobulin heavy constant epsilon Homo sapiens 22-25 2475042-4 1989 There was a significant correlation between maximal histamine release and IgE antibody levels. Histamine 52-61 immunoglobulin heavy constant epsilon Homo sapiens 74-77 2475042-5 1989 Furthermore, a significant inverse relationship between the concentration of allergen causing 25% histamine release (HR25) and IgE antibody levels was observed. Histamine 98-107 immunoglobulin heavy constant epsilon Homo sapiens 127-130 2475042-7 1989 These results suggest that Chironomidae induce histamine release from leukocytes via IgE-mediated mechanism but histamine release cannot be replaced by RAST and also suggest that chironomid midge is one of the important allergens in Japan. Histamine 47-56 immunoglobulin heavy constant epsilon Homo sapiens 85-88 2473400-9 1989 We conclude that in patients with food hypersensitivity, exposure to the relevant antigens produces a cytokine (histamine-releasing factor) that interacts with IgE bound to the surface of basophils, causing them to release histamine. Histamine 112-121 immunoglobulin heavy constant epsilon Homo sapiens 160-163 2474353-0 1989 Differential release of histamine and eicosanoids from human skin mast cells activated by IgE-dependent and non-immunological stimuli. Histamine 24-33 immunoglobulin heavy constant epsilon Homo sapiens 90-93 2474353-4 1989 Challenge of gradient fractions with epsilon-chain-specific anti-human IgE stimulated the release of histamine, prostaglandin D2 (PGD2) and leukotriene C4 (LTC4). Histamine 101-110 immunoglobulin heavy constant epsilon Homo sapiens 71-74 2474353-10 1989 These studies suggest that IgE-dependent and non-immunological stimuli activate human skin mast cells by different secretory mechanisms, a hypothesis supported by our previous findings of differences in Ca2+ requirements and time-course of histamine release. Histamine 240-249 immunoglobulin heavy constant epsilon Homo sapiens 27-30 2459222-9 1988 Thus an interaction with cell-surface IgE to cause histamine release is not evident. Histamine 51-60 immunoglobulin heavy constant epsilon Homo sapiens 38-41 2473625-0 1989 Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils. Histamine 65-74 immunoglobulin heavy constant epsilon Homo sapiens 52-55 2473643-0 1989 Histamine release from human colonic mucosa in response to anti-IgE. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 64-67 2473643-5 1989 In general, whereas anti-IgE interestingly reduced the histamine release compared to the spontaneous in most of the patients within the polyps group, there was a stimulating effect of anti-IgE throughout all other groups. Histamine 55-64 immunoglobulin heavy constant epsilon Homo sapiens 25-28 2472226-4 1989 A positive relationship was seen between the specific IgE level and the histamine release in their differences before and after the treatment. Histamine 72-81 immunoglobulin heavy constant epsilon Homo sapiens 54-57 3207612-6 1988 However, AD patients who had high numbers of anti-IgE positive cells often had decreased numbers of histamine immunoreactive cells in the mucosa suggesting mast cell degranulation. Histamine 100-109 immunoglobulin heavy constant epsilon Homo sapiens 50-53 2469707-0 1989 Azelastine inhibits IgE-mediated human basophil histamine release. Histamine 48-57 immunoglobulin heavy constant epsilon Homo sapiens 20-23 2469707-2 1989 Azelastine was found to significantly inhibit anti-IgE-stimulated basophil histamine release. Histamine 75-84 immunoglobulin heavy constant epsilon Homo sapiens 51-54 2619510-1 1989 The aim of the study was to investigate the influence of verapamil on anti-IgE induced histamine release from basophils isolated from the blood of 10 atopic asthma patients. Histamine 87-96 immunoglobulin heavy constant epsilon Homo sapiens 75-78 2450919-3 1988 In the 18 basophil donors tested, maximum histamine release induced by monocyte supernatants was 33.8 +/- 5.9% (mean +/- SEM) of total basophil histamine content; optimum anti-IgE-induced release was 38.8 +/- 6.2%. Histamine 42-51 immunoglobulin heavy constant epsilon Homo sapiens 176-179 2455982-0 1988 Mast cells and IgE-mediated release of histamine and arachidonate metabolites from human kidney. Histamine 39-48 immunoglobulin heavy constant epsilon Homo sapiens 15-18 2455982-1 1988 We report a pilot study of mast cells and IgE-mediated release of histamine, leukotrienes and thromboxanes from human kidney. Histamine 66-75 immunoglobulin heavy constant epsilon Homo sapiens 42-45 2455231-1 1988 When human polymorphonuclear basophils, a type of white blood cell with antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties. Histamine 183-192 immunoglobulin heavy constant epsilon Homo sapiens 90-106 2455231-1 1988 When human polymorphonuclear basophils, a type of white blood cell with antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties. Histamine 183-192 immunoglobulin heavy constant epsilon Homo sapiens 108-111 2455231-1 1988 When human polymorphonuclear basophils, a type of white blood cell with antibodies of the immunoglobulin E (IgE) type on its surface, are exposed to anti-IgE antibodies, they release histamine from their intracellular granules and change their staining properties. Histamine 183-192 immunoglobulin heavy constant epsilon Homo sapiens 154-157 2454038-6 1988 In the placebo group histamine release from circulating basophils paralleled changes in basophil-bound IgE. Histamine 21-30 immunoglobulin heavy constant epsilon Homo sapiens 103-106 2454038-7 1988 In Cladosporium-treated patients, histamine release cell sensitivity after a lag phase (during immunotherapy dose-increase) declined two log steps, i.e. the cells became less responding in spite of a significant increase in cell-bound IgE. Histamine 34-43 immunoglobulin heavy constant epsilon Homo sapiens 235-238 2454038-13 1988 Changes in histamine release in the Cladosporium season were the only IgE-mediated parameter significantly related to the graded clinical efficacy of immunotherapy. Histamine 11-20 immunoglobulin heavy constant epsilon Homo sapiens 70-73 2450844-5 1988 PAF acted as an IgE-independent stimulus, but PAF-induced histamine release from leukocytes of allergic asthmatics, who had elevated serum IgE levels, was significantly higher than that from leukocytes of controls. Histamine 58-67 immunoglobulin heavy constant epsilon Homo sapiens 139-142 2449829-8 1988 The lack of histamine release response in some patients could be because their own membrane-bound IgE is unable to induce mediator release or, more likely, activation of one or more of the subcellular steps involved in the release is impaired. Histamine 12-21 immunoglobulin heavy constant epsilon Homo sapiens 98-101 3362108-3 1988 One possible mechanism may be the presence of IgG blocking antibodies which can block IgE mediated histamine release in vitro. Histamine 99-108 immunoglobulin heavy constant epsilon Homo sapiens 86-89 2443571-2 1987 The enzyme activity was detected in a preparation of dispersed human mast cells from lung of greater than 99% purity and was released with histamine after stimulation with goat anti-human IgE. Histamine 139-148 immunoglobulin heavy constant epsilon Homo sapiens 188-191 2453912-2 1988 CsA (3 X 10(-2) to 1 microgram/ml) dose-dependently inhibited IgE-mediated release of histamine and peptide leukotriene C4 (LTC4) from human lung mast cells. Histamine 86-95 immunoglobulin heavy constant epsilon Homo sapiens 62-65 3117171-0 1987 Extreme cutaneous histamine sensitivity with hay fever and increased IgE concentrations in an unselected population. Histamine 18-27 immunoglobulin heavy constant epsilon Homo sapiens 69-72 2442235-6 1987 Moreover, anti-IgE-induced histamine release was not influenced by P or estrogen. Histamine 27-36 immunoglobulin heavy constant epsilon Homo sapiens 15-18 2442235-8 1987 Culture with dexamethasone reduced anti-IgE-induced histamine release in all subjects, and the possibility that P might interfere with the effect of dexamethasone was also studied. Histamine 52-61 immunoglobulin heavy constant epsilon Homo sapiens 40-43 3117171-2 1987 Increased cutaneous sensitivity to histamine was strongly associated with an increased number of positive responses to prick tests, high serum concentrations of IgE, and hay fever. Histamine 35-44 immunoglobulin heavy constant epsilon Homo sapiens 161-164 2441900-0 1987 Non-IgE-dependent bacteria-induced histamine release from human lung and tonsillar mast cells. Histamine 35-44 immunoglobulin heavy constant epsilon Homo sapiens 4-7 3819231-1 1987 To test the hypothesis that IgE-mediated release of histamine may be, in part, responsible for the abnormal inflammatory response observed in the hyperimmunoglobulin E (HIE) and recurrent infection syndrome, urine and plasma histamine levels were measured. Histamine 52-61 immunoglobulin heavy constant epsilon Homo sapiens 28-31 2441621-2 1987 The histamine release induced by calcium ionophore A23187, f-met peptide and anti-IgE was inhibited, in a dose-dependent fashion, by nitrendipine in the concentration range of 1-100 microM. Histamine 4-13 immunoglobulin heavy constant epsilon Homo sapiens 82-85 2440260-2 1987 Enzymatical removal of sialic acid enhanced histamine release induced by allergen and anti-IgE, whereas an increase in membrane sialic acid content by insertion of sialic acid containing gangliosides into the membrane inhibited the mediator release. Histamine 44-53 immunoglobulin heavy constant epsilon Homo sapiens 91-94 2440272-0 1987 Monoclonal anti-human IgE: histamine release capacity and effect on in vitro sensitization of human basophils. Histamine 27-36 immunoglobulin heavy constant epsilon Homo sapiens 22-25 2440272-2 1987 Binding of IgE onto the anti-IgE inhibited the histamine release capacity of anti-IgE from basophils. Histamine 47-56 immunoglobulin heavy constant epsilon Homo sapiens 11-14 2440272-2 1987 Binding of IgE onto the anti-IgE inhibited the histamine release capacity of anti-IgE from basophils. Histamine 47-56 immunoglobulin heavy constant epsilon Homo sapiens 29-32 2440272-2 1987 Binding of IgE onto the anti-IgE inhibited the histamine release capacity of anti-IgE from basophils. Histamine 47-56 immunoglobulin heavy constant epsilon Homo sapiens 29-32 2440285-1 1987 Anti-IgE induced histamine release from isolated basophils after Cimetidine and Ranitidine administration was evaluated in 22 patients with atopic bronchial asthma. Histamine 17-26 immunoglobulin heavy constant epsilon Homo sapiens 5-8 2434549-8 1987 The enhancing activities of TCS on IgE synthesis and on histamine release could be removed by absorption with IgE-Sepharose and subsequently recovered by elution with glycine buffer. Histamine 56-65 immunoglobulin heavy constant epsilon Homo sapiens 110-113 2434549-9 1987 The results indicate that T cells of patients with asthma spontaneously release IgE-binding factors capable of increasing both the spontaneous IgE synthesis by B cells and the antigen-induced histamine release. Histamine 192-201 immunoglobulin heavy constant epsilon Homo sapiens 80-83 3819231-1 1987 To test the hypothesis that IgE-mediated release of histamine may be, in part, responsible for the abnormal inflammatory response observed in the hyperimmunoglobulin E (HIE) and recurrent infection syndrome, urine and plasma histamine levels were measured. Histamine 225-234 immunoglobulin heavy constant epsilon Homo sapiens 28-31 2432900-0 1987 Inhibition of IgE-mediated release of histamine and peptide leukotriene from human basophils and mast cells by forskolin. Histamine 38-47 immunoglobulin heavy constant epsilon Homo sapiens 14-17 3576057-5 1987 Histamine release was significantly increased upon anti-IgE in polyposis only. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 56-59 3576057-8 1987 The specific increase of histamine-release from polyps after challenge with anti-IgE and similar spontaneous release in all tested individuals indicate a different pattern of mucosal reactivity in patients suffering from nasal polyposis. Histamine 25-34 immunoglobulin heavy constant epsilon Homo sapiens 81-84 2432900-2 1987 We found that forskolin (10(-7) to 3 X 10(-5) M) caused a concentration-related inhibition of IgE-mediated release of histamine and peptide leukotriene C4 (LTC4) from human basophils and lung mast cells. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 94-97 2434111-3 1986 Sm 857 dose-dependently inhibited histamine release induced by mite antigen, anti-human IgE, calcium ionophore A23187 (A23187) and protein A from peripheral leukocytes of atopic patients, but had no effect on the levels of cyclic AMP and GMP in human leukocytes. Histamine 34-43 immunoglobulin heavy constant epsilon Homo sapiens 88-91 2448594-0 1987 Effect of antibiotics on immediate hypersensitivity reactions in vitro: suppression of IgE-mediated histamine release from peripheral blood basophils by fosfomycin. Histamine 100-109 immunoglobulin heavy constant epsilon Homo sapiens 87-90 2448594-1 1987 The effect of antibiotics on allergic reactions was studied in vitro using the release of histamine from human peripheral blood leukocytes (basophils) after incubation with anti-IgE. Histamine 90-99 immunoglobulin heavy constant epsilon Homo sapiens 178-181 2448594-3 1987 Since fosfomycin has proved to be capable of suppressing IgE-mediated histamine release non-cytotoxically, the effect of fosfomycin on histamine release induced by other secretagogues was further studied. Histamine 70-79 immunoglobulin heavy constant epsilon Homo sapiens 57-60 2952601-1 1987 The gene for a human epsilon chain Fc fragment has been cloned and expressed at a high level in Escherichia coli, and its biological activity in binding to the high-affinity receptors on mast cells and basophils and mediating histamine release has been examined in a variety of assays, including the inhibition of passive cutaneous anaphylaxis in human skin, which was induced by ragweed immunoglobulin IgE antibody and antigen. Histamine 226-235 immunoglobulin heavy constant epsilon Homo sapiens 403-406 2431036-5 1986 A significant intrapair correlation coefficient of the maximal percent of anti-IgE-induced histamine release was found in the MZ, whereas no significant correlation was found in the DZ. Histamine 91-100 immunoglobulin heavy constant epsilon Homo sapiens 79-82 2431036-6 1986 The mean intrapair variance of anti-IgE-induced histamine release in MZ (VMZ) and in DZ (VDZ) gave an F value equal to 3.84 (p less than 0.01) and a heritability (H) index of 0.74. Histamine 48-57 immunoglobulin heavy constant epsilon Homo sapiens 36-39 2433957-3 1986 Histamine was obtained after challenge with anti-IgE in 24 of the 32 samples. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 49-52 2433957-5 1986 The low histamine release in cord blood seemed to be associated with the immunological IgE receptor complex activation and not with an immature basic cell function, since the calcium ionophore A23187 which bypasses the receptor complex induced identical histamine release curves in cord and adult blood. Histamine 8-17 immunoglobulin heavy constant epsilon Homo sapiens 87-90 2434111-4 1986 In addition, antigen- or anti-human IgE-induced anaphylactic histamine release from human and monkey lung fragments passively sensitized with human reaginic serum sensitive to mite antigen as well as A23187-induced histamine release from non-sensitized monkey lung fragments, were inhibited dose-dependently by Sm 857. Histamine 61-70 immunoglobulin heavy constant epsilon Homo sapiens 36-39 2434111-4 1986 In addition, antigen- or anti-human IgE-induced anaphylactic histamine release from human and monkey lung fragments passively sensitized with human reaginic serum sensitive to mite antigen as well as A23187-induced histamine release from non-sensitized monkey lung fragments, were inhibited dose-dependently by Sm 857. Histamine 215-224 immunoglobulin heavy constant epsilon Homo sapiens 36-39 2439328-7 1986 Low plasma IgE may be associated with a deficiency in surface IgE on mast cells which therefore have an increased sensitivity to drugs that cause direct pharmacological histamine liberation. Histamine 169-178 immunoglobulin heavy constant epsilon Homo sapiens 11-14 2439328-7 1986 Low plasma IgE may be associated with a deficiency in surface IgE on mast cells which therefore have an increased sensitivity to drugs that cause direct pharmacological histamine liberation. Histamine 169-178 immunoglobulin heavy constant epsilon Homo sapiens 62-65 2423445-14 1986 Sensitization of human basophils for histamine release with mouse IgE anti-DNP was confirmed. Histamine 37-46 immunoglobulin heavy constant epsilon Homo sapiens 66-69 2427093-5 1986 SF mast cells from one of the mastocytosis patients were studied for histamine release; significant amounts of histamine were released upon exposure to anti-human IgE, but not compound 48/80. Histamine 111-120 immunoglobulin heavy constant epsilon Homo sapiens 163-166 2419444-5 1986 Preincubation of basophils with anti-IgE in calcium-free medium resulted in complete desensitization to macrophage factor-induced histamine release (i.e., when calcium and macrophage factor were added to the basophils, no histamine release occurred), and preincubation with macrophage factor in calcium-free medium resulted in partial desensitization to anti-IgE-induced histamine release. Histamine 130-139 immunoglobulin heavy constant epsilon Homo sapiens 37-40 2425583-5 1986 Rabbit anti-human IgE (1-10 micrograms/ml) dose-dependently induced the release of histamine (5 to 15% of the total histamine content) and of PGD2 (5 to 100 ng/g of wet tissue). Histamine 83-92 immunoglobulin heavy constant epsilon Homo sapiens 18-21 2425583-5 1986 Rabbit anti-human IgE (1-10 micrograms/ml) dose-dependently induced the release of histamine (5 to 15% of the total histamine content) and of PGD2 (5 to 100 ng/g of wet tissue). Histamine 116-125 immunoglobulin heavy constant epsilon Homo sapiens 18-21 2425583-7 1986 A significant linear correlation (rs = 0.90; p less than 0.001) was found between de novo synthesis of PGD2 and the secretion of histamine induced by anti-IgE challenge of human heart. Histamine 129-138 immunoglobulin heavy constant epsilon Homo sapiens 155-158 2425583-9 1986 Additionally, anti-IgE challenge of human heart in vitro induces the release of histamine and PGD2. Histamine 80-89 immunoglobulin heavy constant epsilon Homo sapiens 19-22 2422240-0 1986 IgE-mediated hypersensitivity in human heart tissue: histamine release and functional changes. Histamine 53-62 immunoglobulin heavy constant epsilon Homo sapiens 0-3 2422240-1 1986 In experiments described herein, it was observed that IgE-mediated hypersensitivity can result in significant histamine and thromboxane release from human myocardium, suggesting that the human heart may participate as a target organ in allergic reactions. Histamine 110-119 immunoglobulin heavy constant epsilon Homo sapiens 54-57 2419444-5 1986 Preincubation of basophils with anti-IgE in calcium-free medium resulted in complete desensitization to macrophage factor-induced histamine release (i.e., when calcium and macrophage factor were added to the basophils, no histamine release occurred), and preincubation with macrophage factor in calcium-free medium resulted in partial desensitization to anti-IgE-induced histamine release. Histamine 222-231 immunoglobulin heavy constant epsilon Homo sapiens 37-40 2419444-5 1986 Preincubation of basophils with anti-IgE in calcium-free medium resulted in complete desensitization to macrophage factor-induced histamine release (i.e., when calcium and macrophage factor were added to the basophils, no histamine release occurred), and preincubation with macrophage factor in calcium-free medium resulted in partial desensitization to anti-IgE-induced histamine release. Histamine 222-231 immunoglobulin heavy constant epsilon Homo sapiens 37-40 2419444-6 1986 Pretreatment of basophils with pH 3.9 lactic acid buffer, which dissociates basophil IgE from its receptors, markedly reduced the capacity of basophils to release histamine in response to macrophage factor. Histamine 163-172 immunoglobulin heavy constant epsilon Homo sapiens 85-88 2419444-13 1986 These results suggest that, although macrophage factor are heterogeneous, they are related, as they are a IgE-dependent factors that induce histamine release by interacting with cell surface IgE. Histamine 140-149 immunoglobulin heavy constant epsilon Homo sapiens 106-109 2419444-13 1986 These results suggest that, although macrophage factor are heterogeneous, they are related, as they are a IgE-dependent factors that induce histamine release by interacting with cell surface IgE. Histamine 140-149 immunoglobulin heavy constant epsilon Homo sapiens 191-194 2422776-4 1986 Anti-IgE induced histamine release from the bronchoalveolar cells of 15 subjects with sarcoidosis was significantly increased at all effective doses of anti-IgE. Histamine 17-26 immunoglobulin heavy constant epsilon Homo sapiens 5-8 2418093-4 1986 The maximum percent of histamine release induced by anti-IgE was significantly correlated (rs = 0.57; p less than 0.001) with the age of donors. Histamine 23-32 immunoglobulin heavy constant epsilon Homo sapiens 57-60 2418093-7 1986 However, we found a positive correlation (rs = 0.55; p less than 0.05) between serum IgE level and anti-IgE-induced histamine release in the group less than 20 years of age. Histamine 116-125 immunoglobulin heavy constant epsilon Homo sapiens 85-88 2418093-7 1986 However, we found a positive correlation (rs = 0.55; p less than 0.05) between serum IgE level and anti-IgE-induced histamine release in the group less than 20 years of age. Histamine 116-125 immunoglobulin heavy constant epsilon Homo sapiens 104-107 2418093-8 1986 In contrast, a negative correlation (rs = -0.32; p less than 0.05) between serum IgE level and anti-IgE-induced histamine secretion was found in the group greater than 21 years of age. Histamine 112-121 immunoglobulin heavy constant epsilon Homo sapiens 81-84 2418093-8 1986 In contrast, a negative correlation (rs = -0.32; p less than 0.05) between serum IgE level and anti-IgE-induced histamine secretion was found in the group greater than 21 years of age. Histamine 112-121 immunoglobulin heavy constant epsilon Homo sapiens 100-103 2422776-4 1986 Anti-IgE induced histamine release from the bronchoalveolar cells of 15 subjects with sarcoidosis was significantly increased at all effective doses of anti-IgE. Histamine 17-26 immunoglobulin heavy constant epsilon Homo sapiens 157-160 2422776-6 1986 The dose-response curve of anti-IgE induced histamine release from bronchoalveolar cells of subjects with more than 20% of lymphocytes in the lavage cell population was significantly greater than the dose-response curves of subjects with fewer than 20% of lymphocytes and of controls. Histamine 44-53 immunoglobulin heavy constant epsilon Homo sapiens 32-35 2418638-0 1985 Comparison of basophil histamine release induced by the cross-linking of IgE receptors. Histamine 23-32 immunoglobulin heavy constant epsilon Homo sapiens 73-76 3520720-4 1986 In vitro tests (which enable the different phases of the allergic reaction to be distinguished) to know the serum IgE antibody levels (total IgE, specific IgE and their fixation to cell receptors) cell tests on the degranulation of basophils and the dosage of chemical mediators: histamine, leukotrienes, prostaglandins, P.A.F. Histamine 280-289 immunoglobulin heavy constant epsilon Homo sapiens 114-117 2418638-2 1985 Basophils from patients under 40 years of age generally released a significantly large amount of histamine by stimulation with house dust and anti-IgE. Histamine 97-106 immunoglobulin heavy constant epsilon Homo sapiens 147-150 2580239-2 1985 Both mast cells and basophils possess receptors which bind the Fc portion of IgE with high affinity; crosslinking of membrane-bound IgE by allergen results in degranulation of the cell and release of a variety of pharmacologically active mediator including histamine. Histamine 257-266 immunoglobulin heavy constant epsilon Homo sapiens 77-80 2411446-0 1985 Histamine secretion from human skin slices induced by anti-IgE and artificial secretagogues and the effects of sodium cromoglycate and salbutamol. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 59-62 2411446-2 1985 Following passive sensitization with 1% atopic serum for 30 min at 37 degrees C human skin slices released histamine after challenge with anti-human IgE in a concentration dependent manner. Histamine 107-116 immunoglobulin heavy constant epsilon Homo sapiens 149-152 2411446-4 1985 Passive sensitization with 10% atopic serum increased the secretory response to anti-IgE but histamine release was only concentration related over the entire 1/1000 to 1/10 dilution range in half of the specimens studied, the remainder showing high dose tolerance to anti-IgE. Histamine 93-102 immunoglobulin heavy constant epsilon Homo sapiens 272-275 2411446-5 1985 Negligible histamine release occurred with anti-IgE challenge of slices which had not been passively sensitized. Histamine 11-20 immunoglobulin heavy constant epsilon Homo sapiens 48-51 2411446-10 1985 Histamine release caused by anti-IgE, A23187 and poly-L-lysine was shown to be dependent upon extracellular calcium while release stimulated by compound 48/80 was calcium independent. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 33-36 2582045-5 1985 These mast cells were functionally intact as assessed by survival in short-term culture, low spontaneous release, and appropriate IgE-mediated histamine release. Histamine 143-152 immunoglobulin heavy constant epsilon Homo sapiens 130-133 2411109-0 1985 Candida-induced histamine release from basophils: relationship to house dust- and anti-IgE-induced secretion. Histamine 16-25 immunoglobulin heavy constant epsilon Homo sapiens 87-90 2411109-2 1985 The release of histamine induced by C. albicans and that induced by house dust were closely related to the serum levels of specific IgE antibodies as expressed by RAST scores. Histamine 15-24 immunoglobulin heavy constant epsilon Homo sapiens 132-135 2411109-3 1985 A correlation of C. albicans-induced histamine release with the release caused by anti-IgE was not generally observed. Histamine 37-46 immunoglobulin heavy constant epsilon Homo sapiens 87-90 2411109-4 1985 On the other hand, a close correlation was found between house dust- and anti-IgE-induced histamine release. Histamine 90-99 immunoglobulin heavy constant epsilon Homo sapiens 78-81 2578914-4 1985 BAL cells released histamine in response to anti-human immunoglobulin E (IgE) in a dose-dependent manner that was optimal at a dilution of anti-IgE of 1:100. Histamine 19-28 immunoglobulin heavy constant epsilon Homo sapiens 55-71 2578914-4 1985 BAL cells released histamine in response to anti-human immunoglobulin E (IgE) in a dose-dependent manner that was optimal at a dilution of anti-IgE of 1:100. Histamine 19-28 immunoglobulin heavy constant epsilon Homo sapiens 73-76 2578914-4 1985 BAL cells released histamine in response to anti-human immunoglobulin E (IgE) in a dose-dependent manner that was optimal at a dilution of anti-IgE of 1:100. Histamine 19-28 immunoglobulin heavy constant epsilon Homo sapiens 144-147 2410511-5 1985 The cells exhibited a dose-dependent release of histamine on challenge with goat anti-human IgE or the ionophores A23187 and Br-x537A but were refractory to the action of compound 48/80. Histamine 48-57 immunoglobulin heavy constant epsilon Homo sapiens 92-95 2410511-6 1985 IgE-mediated histamine release from monkey intestinal mast cells differed from that observed from rat intestinal mast cells in that release was inhibited not only by quercetin but also by theophylline. Histamine 13-22 immunoglobulin heavy constant epsilon Homo sapiens 0-3 2580239-2 1985 Both mast cells and basophils possess receptors which bind the Fc portion of IgE with high affinity; crosslinking of membrane-bound IgE by allergen results in degranulation of the cell and release of a variety of pharmacologically active mediator including histamine. Histamine 257-266 immunoglobulin heavy constant epsilon Homo sapiens 132-135 2578909-5 1985 However, histamine release in basophils from nonallergic donors induced by antibody directed against IgE (anti-IgE) also was enhanced by LPS. Histamine 9-18 immunoglobulin heavy constant epsilon Homo sapiens 101-104 2578909-5 1985 However, histamine release in basophils from nonallergic donors induced by antibody directed against IgE (anti-IgE) also was enhanced by LPS. Histamine 9-18 immunoglobulin heavy constant epsilon Homo sapiens 111-114 2578909-6 1985 Potentiation of histamine release occurred if basophils were pretreated with LPS before addition of anti-IgE for as little as 5 min; there was no increase in release if anti-IgE and LPS were added simultaneously to cells. Histamine 16-25 immunoglobulin heavy constant epsilon Homo sapiens 100-108 2408509-2 1985 To implicate IgE in reactions, a history resembling anaphylaxis, the demonstration of drug-specific histamine release by intradermal testing and the demonstration of specific antibodies are necessary. Histamine 100-109 immunoglobulin heavy constant epsilon Homo sapiens 13-16 2409021-1 1985 We report differential effects of various compounds on inhibition of histamine release from washed leukocytes stimulated through IgE (using antigen or anti-IgE antibody) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) receptors. Histamine 69-78 immunoglobulin heavy constant epsilon Homo sapiens 129-132 2409021-1 1985 We report differential effects of various compounds on inhibition of histamine release from washed leukocytes stimulated through IgE (using antigen or anti-IgE antibody) or N-formyl-L-methionyl-L-leucyl-L-phenylalanine (FMLP) receptors. Histamine 69-78 immunoglobulin heavy constant epsilon Homo sapiens 156-159 2579911-0 1985 Relationship between specific circulating IgE, basophil cell-bound IgE and histamine release induced by purified allergens of Dermatophagoides farinae. Histamine 75-84 immunoglobulin heavy constant epsilon Homo sapiens 67-70 2409022-0 1985 Indomethacin enhances in vitro histamine release induced by anti-IgE and Ca-ionophore but inhibits C5a-induced release reactions from basophils of atopics and normals. Histamine 31-40 immunoglobulin heavy constant epsilon Homo sapiens 65-68 2579913-6 1985 The percent increase in histamine release produced by 5-HPETE in asthmatic subjects averaged 3.9 +/- 1.3% using 0.03 micrograms anti-IgE/ml and 4.8 +/- 3.2% using 0.1 microgram anti-IgE/ml (p less than 0.002, Wilcoxon"s signed rank test), and averaged 3.0 +/- 4.3 and 3.1 +/- 5.3%, respectively, in control subjects (p greater than 0.10). Histamine 24-33 immunoglobulin heavy constant epsilon Homo sapiens 133-136 2409008-3 1985 A positive correlation between serum IgE level and anti-IgE-induced histamine release was found in subjects below 20 years old. Histamine 68-77 immunoglobulin heavy constant epsilon Homo sapiens 37-40 2409022-1 1985 Preincubation of peripheral leukocytes from atopics and normals significantly enhanced histamine release induced by anti-IgE and calcium ionophore. Histamine 87-96 immunoglobulin heavy constant epsilon Homo sapiens 121-124 2409008-3 1985 A positive correlation between serum IgE level and anti-IgE-induced histamine release was found in subjects below 20 years old. Histamine 68-77 immunoglobulin heavy constant epsilon Homo sapiens 56-59 2409012-6 1985 Challenge of sensitized basophils with anti-IgE resulted in stimulation of phospholipid methylation, 45Ca uptake, release of both histamine and free arachidonic acid, and enhancement of phosphatidylinositol (PI) turnover. Histamine 130-139 immunoglobulin heavy constant epsilon Homo sapiens 44-47 2579913-6 1985 The percent increase in histamine release produced by 5-HPETE in asthmatic subjects averaged 3.9 +/- 1.3% using 0.03 micrograms anti-IgE/ml and 4.8 +/- 3.2% using 0.1 microgram anti-IgE/ml (p less than 0.002, Wilcoxon"s signed rank test), and averaged 3.0 +/- 4.3 and 3.1 +/- 5.3%, respectively, in control subjects (p greater than 0.10). Histamine 24-33 immunoglobulin heavy constant epsilon Homo sapiens 182-185 2409022-4 1985 In the group of patients with atopic eczema, anti-IgE-induced histamine release was significantly higher than in controls both without and with indomethacin. Histamine 62-71 immunoglobulin heavy constant epsilon Homo sapiens 50-53 2409013-1 1985 Naturally occurring plant flavonoids, normal dietary constituents, affect a variety of cell activation phenomena including the secretion of histamine from human basophils stimulated by a variety of agents (antigen, anti-IgE, concanavalin A, ionophore A23187, formyl-Met-Leu-Phe and tetradecanoyl phorbol acetate). Histamine 140-149 immunoglobulin heavy constant epsilon Homo sapiens 220-223 6206153-2 1984 Incubation of HDLC with anti-human IgE, which released a net 24.8 + 4.3% of mast cell-derived histamine, stimulated a 14-fold increase in the generation of PGD2, a seven-fold increase in TXB2, and less than a twofold increase in PGF2 alpha, immunoreactive PGE, (i-PGE) and 6-keto-PGF1 alpha. Histamine 94-103 immunoglobulin heavy constant epsilon Homo sapiens 35-38 2409021-0 1985 Differential inhibition of histamine release from human basophils induced by antigen, anti-IgE or N-formyl-L-methionyl-L-leucyl-L-phenylalanine. Histamine 27-36 immunoglobulin heavy constant epsilon Homo sapiens 91-94 6210089-0 1984 Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism. Histamine 49-58 immunoglobulin heavy constant epsilon Homo sapiens 35-38 6210089-2 1984 Addition of adenosine to the dispersed mast cells at times up to 5 min before immunological challenge with anti-human IgE inhibited histamine release. Histamine 132-141 immunoglobulin heavy constant epsilon Homo sapiens 118-121 6206153-7 1984 After separation of lung cells by isopyknic centrifugation, challenge with anti-IgE or A23187 released PGD2 only from those fractions containing mast cells, the amount released corresponding closely to both the mast cell concentration and net histamine release. Histamine 243-252 immunoglobulin heavy constant epsilon Homo sapiens 80-83 2578053-0 1985 Complement- and IgE-mediated release of histamine from basophils in vitro. Histamine 40-49 immunoglobulin heavy constant epsilon Homo sapiens 16-19 2578053-4 1985 We compared the effects of drugs, modulating arachidonic acid (AA) metabolism, on histamine release (HR) from human basophils stimulated by anti-IgE antibody or C5a anaphylatoxin. Histamine 82-91 immunoglobulin heavy constant epsilon Homo sapiens 145-148 6207053-3 1984 Sensitization of the cells with human IgE followed by challenge with anti-IgE resulted in the release of histamine and arachidonic acid (AA). Histamine 105-114 immunoglobulin heavy constant epsilon Homo sapiens 38-41 6207053-3 1984 Sensitization of the cells with human IgE followed by challenge with anti-IgE resulted in the release of histamine and arachidonic acid (AA). Histamine 105-114 immunoglobulin heavy constant epsilon Homo sapiens 74-77 6207053-4 1984 In both the cultured basophils and human lung mast cells, bridging of cell-bound IgE with anti-IgE induced a transient increase in phospholipid methylation and intracellular cyclic AMP (cAMP), and these processes were followed by Ca2+ uptake and release of both histamine and AA. Histamine 262-271 immunoglobulin heavy constant epsilon Homo sapiens 81-84 6207053-4 1984 In both the cultured basophils and human lung mast cells, bridging of cell-bound IgE with anti-IgE induced a transient increase in phospholipid methylation and intracellular cyclic AMP (cAMP), and these processes were followed by Ca2+ uptake and release of both histamine and AA. Histamine 262-271 immunoglobulin heavy constant epsilon Homo sapiens 95-98 6206153-8 1984 On pooling data from all experiments, the closest correlation was found between release of PGD2 and histamine when cells were stimulated with either anti-IgE (r = 0.813, p less than 0.001) or A23187 (r = 0.763, p less than 0.001), supporting a mast cell origin for PGD2. Histamine 100-109 immunoglobulin heavy constant epsilon Homo sapiens 154-157 6208754-7 1984 The results showed that IgE molecules contained in the serum participate in anti-IgE-induced histamine release from whole blood. Histamine 93-102 immunoglobulin heavy constant epsilon Homo sapiens 24-27 6470565-3 1984 Histamine release measured in the same supernatants of immunologically challenged cells correlated with neutrophil chemotactic activity release, consistent with the interpretation that basophils and IgE mediation are involved in this phenomenon. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 199-202 6208754-0 1984 Effect of a serum factor on IgE-mediated histamine release from whole blood. Histamine 41-50 immunoglobulin heavy constant epsilon Homo sapiens 28-31 6208754-1 1984 IgE-mediated histamine release from whole blood was analyzed in 44 patients with bronchial asthma by observing maximum present release and dose-response curves of histamine release induced by anti-IgE and house dust extract. Histamine 13-22 immunoglobulin heavy constant epsilon Homo sapiens 0-3 6208754-7 1984 The results showed that IgE molecules contained in the serum participate in anti-IgE-induced histamine release from whole blood. Histamine 93-102 immunoglobulin heavy constant epsilon Homo sapiens 81-84 6208754-1 1984 IgE-mediated histamine release from whole blood was analyzed in 44 patients with bronchial asthma by observing maximum present release and dose-response curves of histamine release induced by anti-IgE and house dust extract. Histamine 13-22 immunoglobulin heavy constant epsilon Homo sapiens 197-200 6208754-1 1984 IgE-mediated histamine release from whole blood was analyzed in 44 patients with bronchial asthma by observing maximum present release and dose-response curves of histamine release induced by anti-IgE and house dust extract. Histamine 163-172 immunoglobulin heavy constant epsilon Homo sapiens 0-3 6203844-0 1984 Inhibition of IgE-mediated histamine release from human basophils and mast cells by fenoterol. Histamine 27-36 immunoglobulin heavy constant epsilon Homo sapiens 14-17 6208754-1 1984 IgE-mediated histamine release from whole blood was analyzed in 44 patients with bronchial asthma by observing maximum present release and dose-response curves of histamine release induced by anti-IgE and house dust extract. Histamine 163-172 immunoglobulin heavy constant epsilon Homo sapiens 197-200 6208754-2 1984 The maximum histamine release from whole blood induced by anti-IgE correlated with total serum IgE levels. Histamine 12-21 immunoglobulin heavy constant epsilon Homo sapiens 63-66 6208754-2 1984 The maximum histamine release from whole blood induced by anti-IgE correlated with total serum IgE levels. Histamine 12-21 immunoglobulin heavy constant epsilon Homo sapiens 95-98 6208754-4 1984 In the maximum histamine release from whole blood induced by both anti-IgE and allergen, the interaction with a serum factor was not clearly recognized. Histamine 15-24 immunoglobulin heavy constant epsilon Homo sapiens 71-74 6208754-5 1984 Effect of a serum factor was shown in the dose-response curves of anti-IgE-induced histamine release, but not in those of allergen-induced histamine release. Histamine 83-92 immunoglobulin heavy constant epsilon Homo sapiens 71-74 6208754-6 1984 The dose-response curves caused by anti-IgE showed that basophils from cases with a high serum IgE level require much more anti-IgE to produce maximum histamine release than basophils from cases with a low serum IgE level. Histamine 151-160 immunoglobulin heavy constant epsilon Homo sapiens 40-43 6208754-6 1984 The dose-response curves caused by anti-IgE showed that basophils from cases with a high serum IgE level require much more anti-IgE to produce maximum histamine release than basophils from cases with a low serum IgE level. Histamine 151-160 immunoglobulin heavy constant epsilon Homo sapiens 95-98 6208754-6 1984 The dose-response curves caused by anti-IgE showed that basophils from cases with a high serum IgE level require much more anti-IgE to produce maximum histamine release than basophils from cases with a low serum IgE level. Histamine 151-160 immunoglobulin heavy constant epsilon Homo sapiens 95-98 6208754-6 1984 The dose-response curves caused by anti-IgE showed that basophils from cases with a high serum IgE level require much more anti-IgE to produce maximum histamine release than basophils from cases with a low serum IgE level. Histamine 151-160 immunoglobulin heavy constant epsilon Homo sapiens 95-98 6205544-0 1984 Histamine release from whole blood induced by anti-IgE: relationship to patient age, age at onset and serum IgE levels. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 51-54 6205544-0 1984 Histamine release from whole blood induced by anti-IgE: relationship to patient age, age at onset and serum IgE levels. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 108-111 6205544-1 1984 Anti-IgE-induced histamine release from basophils was examined in 46 asthmatic subjects using a whole blood method. Histamine 17-26 immunoglobulin heavy constant epsilon Homo sapiens 5-8 6205544-4 1984 There was a correlation between histamine release and serum IgE levels. Histamine 32-41 immunoglobulin heavy constant epsilon Homo sapiens 60-63 6205544-5 1984 However, individual dose-response curves of histamine release varied greatly in whom serum IgE levels were low. Histamine 44-53 immunoglobulin heavy constant epsilon Homo sapiens 91-94 6235759-5 1984 Indeed, histamine is known to activate suppressor cells capable, in turn, of suppressing IgG and IgE production from normal cells. Histamine 8-17 immunoglobulin heavy constant epsilon Homo sapiens 97-100 6430138-0 1984 Interaction between hyperosmolar and IgE-mediated histamine release from basophils and mast cells. Histamine 50-59 immunoglobulin heavy constant epsilon Homo sapiens 37-40 6430138-3 1984 Significant histamine release was seen above 360 mOsm/kg H2O, increasing to 11.9 +/- 1.0% at 770 mOsm/kg H2O, and release was synergistically enhanced by anti-IgE. Histamine 12-21 immunoglobulin heavy constant epsilon Homo sapiens 159-162 6430138-4 1984 Cells that had been rendered unresponsive to IgE-dependent stimuli by exposure to anti-IgE in the absence of Ca++ became markedly more responsive to hyperosmolar stimulation, and released as much as 32 +/- 2% histamine in hyperosmolar buffers alone. Histamine 209-218 immunoglobulin heavy constant epsilon Homo sapiens 87-90 6198291-0 1984 Allergen- and anti-IgE-induced histamine release from whole blood. Histamine 31-40 immunoglobulin heavy constant epsilon Homo sapiens 19-22 6198291-1 1984 The release of histamine by allergen and anti-IgE from whole blood was observed in 34 asthmatic subjects with a positive skin test to house dust. Histamine 15-24 immunoglobulin heavy constant epsilon Homo sapiens 46-49 6198291-2 1984 The time course of histamine release showed that the release by allergen and anti-IgE peaked after 15 min incubation. Histamine 19-28 immunoglobulin heavy constant epsilon Homo sapiens 82-85 6198291-4 1984 Anti-IgE-induced histamine release correlated to a certain extent with the serum IgE level. Histamine 17-26 immunoglobulin heavy constant epsilon Homo sapiens 5-8 6198291-4 1984 Anti-IgE-induced histamine release correlated to a certain extent with the serum IgE level. Histamine 17-26 immunoglobulin heavy constant epsilon Homo sapiens 81-84 6198291-8 1984 The amount of histamine release induced by anti-IgE paralleled the amount of the release by house dust in the cases sensitive to the allergen; less sensitive basophils to anti-IgE were less sensitive to house dust. Histamine 14-23 immunoglobulin heavy constant epsilon Homo sapiens 48-51 6198291-8 1984 The amount of histamine release induced by anti-IgE paralleled the amount of the release by house dust in the cases sensitive to the allergen; less sensitive basophils to anti-IgE were less sensitive to house dust. Histamine 14-23 immunoglobulin heavy constant epsilon Homo sapiens 176-179 6187824-0 1983 IgE-mediated release of histamine from human cutaneous mast cells. Histamine 24-33 immunoglobulin heavy constant epsilon Homo sapiens 0-3 6727776-2 1984 In this report we present the first in vitro evidence that such a reaction to cytarabine can be associated with the release of histamine and therefore might be immunoglobulin E (IgE) mediated. Histamine 127-136 immunoglobulin heavy constant epsilon Homo sapiens 160-176 6727776-2 1984 In this report we present the first in vitro evidence that such a reaction to cytarabine can be associated with the release of histamine and therefore might be immunoglobulin E (IgE) mediated. Histamine 127-136 immunoglobulin heavy constant epsilon Homo sapiens 178-181 6640890-3 1983 Elevated plasma histamine levels were found mostly in patients with severe eczema and high serum IgE levels. Histamine 16-25 immunoglobulin heavy constant epsilon Homo sapiens 97-100 6189877-7 1983 Muscle relaxant-induced histamine release was inhibited by in vitro anti-IgE leukocyte desensitization. Histamine 24-33 immunoglobulin heavy constant epsilon Homo sapiens 73-76 6189877-9 1983 Similarly, leukocyte desensitization also inhibited histamine release induced by anti-IgE but not by formyl-L-methionyl-L-leucyl-L-phenylalanine or poly-L-arginine. Histamine 52-61 immunoglobulin heavy constant epsilon Homo sapiens 86-89 6191549-3 1983 The study indicates that two different mechanisms of bacterial histamine release might exist, an IgE-mediated reaction and a non-immunological mechanism consisting of a direct interaction with the basophil cell surface. Histamine 63-72 immunoglobulin heavy constant epsilon Homo sapiens 97-100 6187853-0 1983 Biochemical analysis of initial triggering events of IgE-mediated histamine release from human lung mast cells. Histamine 66-75 immunoglobulin heavy constant epsilon Homo sapiens 53-56 6187853-2 1983 Purified human mast cells released histamine upon challenge with anti-IgE. Histamine 35-44 immunoglobulin heavy constant epsilon Homo sapiens 70-73 6187853-3 1983 An optimal concentration of anti-IgE for maximum histamine release from human lung mast cells was comparable to that required for histamine release from normal human basophil granulocytes. Histamine 49-58 immunoglobulin heavy constant epsilon Homo sapiens 33-36 6187853-3 1983 An optimal concentration of anti-IgE for maximum histamine release from human lung mast cells was comparable to that required for histamine release from normal human basophil granulocytes. Histamine 130-139 immunoglobulin heavy constant epsilon Homo sapiens 33-36 6187853-4 1983 Human lung mast cells could be passively sensitized with mouse monoclonal IgE antibody for antigen-induced histamine release. Histamine 107-116 immunoglobulin heavy constant epsilon Homo sapiens 74-77 6187853-12 1983 The results indicate that phospholipid methylation induced by bridging of IgE receptors on human mast cells is essential for Ca2+ influx and histamine release. Histamine 141-150 immunoglobulin heavy constant epsilon Homo sapiens 74-77 6187824-1 1983 We investigated the ability of antigen-IgE interactions to stimulate histamine release from human infant cutaneous mast cells. Histamine 69-78 immunoglobulin heavy constant epsilon Homo sapiens 39-42 6177206-4 1982 It seems that two different mechanisms of bacterial histamine release exist: interaction with the basophil-bound IgE and a direct interaction with the cell surface. Histamine 52-61 immunoglobulin heavy constant epsilon Homo sapiens 113-116 6189456-3 1983 We tested, furthermore, the releasability of histamine from skin sections of patients with atopic dermatitis and healthy controls upon challenge with acetylcholine, anti-IgE, and compound 48/80. Histamine 45-54 immunoglobulin heavy constant epsilon Homo sapiens 170-173 6189456-8 1983 Acetylcholine and 48/80 induced the same histamine release in both groups; with anti-IgE, almost the double amount of histamine was released from the skin of atopic dermatitis patients as compared to controls. Histamine 41-50 immunoglobulin heavy constant epsilon Homo sapiens 85-88 6189456-8 1983 Acetylcholine and 48/80 induced the same histamine release in both groups; with anti-IgE, almost the double amount of histamine was released from the skin of atopic dermatitis patients as compared to controls. Histamine 118-127 immunoglobulin heavy constant epsilon Homo sapiens 85-88 6185013-0 1982 Budesonide and nasal mucosal histamine content and anti-IgE induced histamine release. Histamine 68-77 immunoglobulin heavy constant epsilon Homo sapiens 56-59 6185013-2 1982 The influence of a topical steroid, budesonide, on the nasal mucosal histamine content and anti-IgE induced histamine release was studied in an open study. Histamine 108-117 immunoglobulin heavy constant epsilon Homo sapiens 96-99 6185013-4 1982 There was a decrease of histamine content after steroid treatment and also a blockade of the anti-IgE mediated histamine release, as shown in an in vitro release procedure. Histamine 111-120 immunoglobulin heavy constant epsilon Homo sapiens 98-101 6182178-2 1982 As expected, anti-IgE caused 8% to 76% histamine release from the leukocytes of each of 14 nonallergic donors. Histamine 39-48 immunoglobulin heavy constant epsilon Homo sapiens 18-21 6182178-3 1982 In one subject anti-IgE alone had no effect, but a 15% histamine release did occur after the subsequent addition of a goat anti-mouse IgG antiserum to crosslink cell-bound anti-IgE molecules. Histamine 55-64 immunoglobulin heavy constant epsilon Homo sapiens 177-180 6182178-7 1982 The results of this study indicate that monoclonal antibodies to IgG4 as well as to IgE can stimulate human peripheral blood leukocytes to release histamine. Histamine 147-156 immunoglobulin heavy constant epsilon Homo sapiens 84-87 6194101-2 1983 IgE-mediated hypersensitivity was demonstrated by elevated echinococcus-specific serum IgE-antibody concentrations, by allergen-induced histamine release from washed leukocytes, and by passive sensitization of nonsensitized leukocytes with the patient"s serum. Histamine 136-145 immunoglobulin heavy constant epsilon Homo sapiens 0-3 6183355-9 1983 Both the HBL cells and normal human basophils could be passively sensitized with murine IgE anti-DNP for antigen-induced histamine release. Histamine 121-130 immunoglobulin heavy constant epsilon Homo sapiens 88-91 6183355-11 1983 Pretreatment of basophils with human IgE, but not human IgG, abrogated the capacity of the murine IgE antibody to sensitize the cells for histamine release, which indicated that the human and rodent IgE were interacting with the same receptor. Histamine 138-147 immunoglobulin heavy constant epsilon Homo sapiens 37-40 6183355-11 1983 Pretreatment of basophils with human IgE, but not human IgG, abrogated the capacity of the murine IgE antibody to sensitize the cells for histamine release, which indicated that the human and rodent IgE were interacting with the same receptor. Histamine 138-147 immunoglobulin heavy constant epsilon Homo sapiens 98-101 6183355-11 1983 Pretreatment of basophils with human IgE, but not human IgG, abrogated the capacity of the murine IgE antibody to sensitize the cells for histamine release, which indicated that the human and rodent IgE were interacting with the same receptor. Histamine 138-147 immunoglobulin heavy constant epsilon Homo sapiens 98-101 6183359-3 1983 We found that the synthetically cross-linked trimer of IgE caused histamine release that was enhanced by indomethacin, whereas dimeric IgE induced-release was not. Histamine 66-75 immunoglobulin heavy constant epsilon Homo sapiens 55-58 6197487-2 1983 LC-6.2Cl blocks both IgE-mediated and non-IgE-mediated histamine release. Histamine 55-64 immunoglobulin heavy constant epsilon Homo sapiens 42-45 6197487-6 1983 The IC50 for IgE-mediated histamine release inhibition is in good agreement with the IC50 for inhibition of arachidonate lipoxygenase activity. Histamine 26-35 immunoglobulin heavy constant epsilon Homo sapiens 13-16 6182178-1 1982 Monoclonal murine antibodies to human IgE, IgG1, IgG2, IgG3, IgG4, IgM, and IgA1 were prepared and their abilities to stimulate histamine release from human peripheral blood leukocytes were investigated. Histamine 128-137 immunoglobulin heavy constant epsilon Homo sapiens 38-41 6177208-5 1982 These data are in accordance with an antigen-induced IgE-dependent liberation of the mast cell histamine stores. Histamine 95-104 immunoglobulin heavy constant epsilon Homo sapiens 53-56 7319556-1 1981 Recent evidence suggests that IgE molecules are heterogeneous with respect to ability to compete with IgE myeloma for sensitization of histamine release from chopped human lung and ability to passively sensitize human basophils for antigen-induced histamine release. Histamine 135-144 immunoglobulin heavy constant epsilon Homo sapiens 30-33 6177650-0 1982 Effect of inhibitors of arachidonic acid metabolism upon IgE and non-IgE-mediated histamine release. Histamine 82-91 immunoglobulin heavy constant epsilon Homo sapiens 69-72 6177650-3 1982 Agents inhibitory to the activity of lipoxygenases were effective blockers of IgE and non-IgE-mediated histamine release; agents antagonistic to cyclo-oxygenases, isomerases and thromboxane synthetases were not. Histamine 103-112 immunoglobulin heavy constant epsilon Homo sapiens 90-93 7129661-4 1982 Low doses of anti-IgE triggered only 0-12% histamine release during a 3-hour preincubation, yet initiated up to 100% desensitization upon rechallenge. Histamine 43-52 immunoglobulin heavy constant epsilon Homo sapiens 18-21 7319556-1 1981 Recent evidence suggests that IgE molecules are heterogeneous with respect to ability to compete with IgE myeloma for sensitization of histamine release from chopped human lung and ability to passively sensitize human basophils for antigen-induced histamine release. Histamine 248-257 immunoglobulin heavy constant epsilon Homo sapiens 30-33 6159030-1 1980 1 Eleven analogues of sodium cromoglycate have been tested for their ability to suppress histamine release induced by anti-IgE from passively sensitized human lung fragments in vitro. Histamine 89-98 immunoglobulin heavy constant epsilon Homo sapiens 123-126 6170475-0 1981 Increased release of histamine by anti-IgE from leucocytes of asthmatic patients and possible heterogeneity of IgE. Histamine 21-30 immunoglobulin heavy constant epsilon Homo sapiens 39-42 6170475-1 1981 A study was made of the significantly increased amounts of histamine released by anti-IgE from the leucocytes of asthmatic and allergic patients, particularly in patients with a low level of serum IgE. Histamine 59-68 immunoglobulin heavy constant epsilon Homo sapiens 86-89 6170475-1 1981 A study was made of the significantly increased amounts of histamine released by anti-IgE from the leucocytes of asthmatic and allergic patients, particularly in patients with a low level of serum IgE. Histamine 59-68 immunoglobulin heavy constant epsilon Homo sapiens 197-200 6170475-2 1981 By measuring cell-bound IgE and histamine release with anti-IgE, particularly after passive sensitization of human leucocytes, it was possible to show that serum IgE in some allergic patients differed from that in normal subjects in two respects. Histamine 32-41 immunoglobulin heavy constant epsilon Homo sapiens 60-63 6170475-2 1981 By measuring cell-bound IgE and histamine release with anti-IgE, particularly after passive sensitization of human leucocytes, it was possible to show that serum IgE in some allergic patients differed from that in normal subjects in two respects. Histamine 32-41 immunoglobulin heavy constant epsilon Homo sapiens 60-63 6170475-4 1981 Secondly, and more importantly, IgE of some patients could more readily mediate histamine release with anti-IgE, that is to say it had a greater efficacy. Histamine 80-89 immunoglobulin heavy constant epsilon Homo sapiens 32-35 6170475-4 1981 Secondly, and more importantly, IgE of some patients could more readily mediate histamine release with anti-IgE, that is to say it had a greater efficacy. Histamine 80-89 immunoglobulin heavy constant epsilon Homo sapiens 108-111 6166162-1 1981 Two groups of asthmatic children were found with regard to the influence of theophylline on the anti-IgE-induced histamine release from whole blood. Histamine 113-122 immunoglobulin heavy constant epsilon Homo sapiens 101-104 6160766-2 1980 An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient"s basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. Histamine 100-109 immunoglobulin heavy constant epsilon Homo sapiens 3-19 6160766-2 1980 An immunoglobulin E (IgE)-mediated hypersensitivity response was demonstrated by (1) the release of histamine from the patient"s basophils in vitro upon challenge with several different lots of factor VIII concentrate; (2) immediate cutaneous response to commercial factor VIII, factor IX and cryoprecipitate; and (3) measurement of IgE antibodies against a commercial factor VIII preparation. Histamine 100-109 immunoglobulin heavy constant epsilon Homo sapiens 21-24 6159103-1 1980 We present a model for the control of immunoglobulin E (IgE)-mediated histamine release from human basophils. Histamine 70-79 immunoglobulin heavy constant epsilon Homo sapiens 38-54 6159103-1 1980 We present a model for the control of immunoglobulin E (IgE)-mediated histamine release from human basophils. Histamine 70-79 immunoglobulin heavy constant epsilon Homo sapiens 56-59 6163338-0 1980 Inhibition of IgE-mediated histamine release from human leukocytes by a new xanthine derivative, D 4026. Histamine 27-36 immunoglobulin heavy constant epsilon Homo sapiens 14-17 6159889-0 1980 Augmentation of IgE-mediated release of histamine by 5-hydroxyeicosatetraenoic acid and 12-hydroxyeicosatetraenoic acid. Histamine 40-49 immunoglobulin heavy constant epsilon Homo sapiens 16-19 94295-11 1979 Rat IgE serum-induced degranulation and histamine release from mast cells were inhibited in a dose dependent fashion by BWD and the inhibition was specific to anti-BWND IgE antibody. Histamine 40-49 immunoglobulin heavy constant epsilon Homo sapiens 169-172 6154710-7 1980 After the mast cells were stimulated by rabbit anti-human IgE to release histamine, the contents of the granule were transformed from a crystalline to an amorphous state, and only granules with amorphous contents were seen discharging from the cell. Histamine 73-82 immunoglobulin heavy constant epsilon Homo sapiens 58-61 6165276-1 1980 We have presented evidence showing that interferon can enhance the IgE-mediated release of histamine. Histamine 91-100 immunoglobulin heavy constant epsilon Homo sapiens 67-70 90083-3 1979 It was observed previously that serum-treated zymosan particles (Zx) augmented antigen and anti-IgE stimulated histamine release. Histamine 111-120 immunoglobulin heavy constant epsilon Homo sapiens 96-99 90083-5 1979 This association between IgE-mediated histamine release and responsiveness to Zx was examined further in the present report. Histamine 38-47 immunoglobulin heavy constant epsilon Homo sapiens 25-28 90083-6 1979 Addition of Zx at various time intervals after release had been initiated indicated that the basophil responsiveness to Zx was limited in duration; maximum responsiveness to Zx correlated closely with the period in which the rate of IgE-mediated histamine release was maximum. Histamine 246-255 immunoglobulin heavy constant epsilon Homo sapiens 233-236 90083-10 1979 It is concluded that an obligatory link exists between ongoing IgE-mediated histamine release and enhancement by Zx. Histamine 76-85 immunoglobulin heavy constant epsilon Homo sapiens 63-66 6160007-0 1980 Enhancement of IgE-mediated histamine release from human basophils by immune-specific lymphokines. Histamine 28-37 immunoglobulin heavy constant epsilon Homo sapiens 15-18 6160007-1 1980 Human leucocytes (basophils) release histamine when exposed to ragweed antigen E or anti-IgE. Histamine 37-46 immunoglobulin heavy constant epsilon Homo sapiens 89-92 6160007-2 1980 The present study shows that when leucocytes from BCG-positive donors are first incubated with PPD and then challenged with anti-IgE, histamine release is enhanced. Histamine 134-143 immunoglobulin heavy constant epsilon Homo sapiens 129-132 6160007-9 1980 It is concluded that immune-specific stimulation of leucocytes results in the release of soluble mediators that are capable of enhancing IgE-mediated histamine release. Histamine 150-159 immunoglobulin heavy constant epsilon Homo sapiens 137-140 6156882-3 1980 Histamine release from mast cells or basophiles by drugs without regines (IgE, IgG4), 2. complement activation by a drug via the classic or alternative pathway without reaction with an antibody. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 74-77 88141-4 1978 Lectin also inhibits the allergen-specific histamine release from human leukocytes occurring through IgE; this can be demonstrated on leukocytes from patients with atopic extrinsic asthma. Histamine 43-52 immunoglobulin heavy constant epsilon Homo sapiens 101-104 87438-0 1979 Interferon-induced enhancement of IgE-mediated histamine release from human basophils requires RNA synthesis. Histamine 47-56 immunoglobulin heavy constant epsilon Homo sapiens 34-37 87438-1 1979 Incubation of human leukocytes with certain viruses results in the enhancement of IgE-mediated release of histamine. Histamine 106-115 immunoglobulin heavy constant epsilon Homo sapiens 82-85 84524-1 1978 Histamine has been shown to inhibit a variety of immune responses including the antigen-induced, IgE mediated, release of histamine from sensitized human leucocytes and from sensitized monkey and dog mast cells. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 97-100 84524-1 1978 Histamine has been shown to inhibit a variety of immune responses including the antigen-induced, IgE mediated, release of histamine from sensitized human leucocytes and from sensitized monkey and dog mast cells. Histamine 122-131 immunoglobulin heavy constant epsilon Homo sapiens 97-100 81805-3 1978 Sera that competed well with myeloma IgE were also able to sensitize for greater histamine release relative to IgE concentration when sensitized lung tissue was challenged with anti-IgE. Histamine 81-90 immunoglobulin heavy constant epsilon Homo sapiens 37-40 81805-4 1978 The converse was true of those sera that competed poorly with myeloma IgE in the antigen assay, in that they sensitized for histamine release only at relatively high IgE concentrations in the anti-IgE assay. Histamine 124-133 immunoglobulin heavy constant epsilon Homo sapiens 166-169 81805-4 1978 The converse was true of those sera that competed poorly with myeloma IgE in the antigen assay, in that they sensitized for histamine release only at relatively high IgE concentrations in the anti-IgE assay. Histamine 124-133 immunoglobulin heavy constant epsilon Homo sapiens 166-169 79298-1 1978 Antigen-induced IgE-mediated release of histamine from human leukocytes, an in vitro model of allergic reactions, was blocked by imidazole and imidazole-compounds such as oxymetazoline and clonidine. Histamine 40-49 immunoglobulin heavy constant epsilon Homo sapiens 16-19 91950-0 1979 A new concept of triggering mechanisms of IgE-mediated histamine release. Histamine 55-64 immunoglobulin heavy constant epsilon Homo sapiens 42-45 84541-1 1978 The IgE-mediated, antigen-induced release of histamine from human lung tissue causes profound changes in lung cyclic adenosine monophosphate and cyclic guanosine monophosphate. Histamine 45-54 immunoglobulin heavy constant epsilon Homo sapiens 4-7 75852-1 1978 We studied a unique patient with 77% basophils, not different from normal by a number of criteria, in order to measure the changes in cyclic AMP level associated with IgE-mediated histamine release. Histamine 180-189 immunoglobulin heavy constant epsilon Homo sapiens 167-170 75852-2 1978 In accordance with previous hypothesis and circumstantial evidence, anti-IgE challenge led to a significant fall in the cyclic AMP level which preceded histamine release. Histamine 152-161 immunoglobulin heavy constant epsilon Homo sapiens 73-76 563850-4 1978 Removal of IgG led to a significant increase in histamine release, suggesting that homocytotropic IgG competes with IgE, for binding sites on mast cells. Histamine 48-57 immunoglobulin heavy constant epsilon Homo sapiens 116-119 79558-5 1978 The results demonstrate that IgE antibodies can sensitize the heart and that the severity of cardiac dysfunction, which follows challenge with specific antigen, directly correlates with the magnitude of histamine released. Histamine 203-212 immunoglobulin heavy constant epsilon Homo sapiens 29-32 65434-11 1977 The data can be interpreted to indicate that IgE- and C5a-mediated reactions diverge at a late stage in the histamine release pathway. Histamine 108-117 immunoglobulin heavy constant epsilon Homo sapiens 45-48 66288-0 1977 Measurement of IgE on human basophils: relation to serum IgE and anti-IgE-induced histamine release. Histamine 82-91 immunoglobulin heavy constant epsilon Homo sapiens 15-18 66288-3 1977 Sensitivity of these cells to anti-IgE was tested to explore the relationship between cell-bound IgE and the concentration of anti-IgE required for histamine release. Histamine 148-157 immunoglobulin heavy constant epsilon Homo sapiens 97-100 66288-3 1977 Sensitivity of these cells to anti-IgE was tested to explore the relationship between cell-bound IgE and the concentration of anti-IgE required for histamine release. Histamine 148-157 immunoglobulin heavy constant epsilon Homo sapiens 97-100 67173-0 1977 Enhancement of IgE-mediated histamine release from human basophils by viruses: role of interferon. Histamine 28-37 immunoglobulin heavy constant epsilon Homo sapiens 15-18 67173-1 1977 Human leukocytes maintained in culture are induced to release histamine when exposed to ragweed antigen E or anti-IgE. Histamine 62-71 immunoglobulin heavy constant epsilon Homo sapiens 114-117 67173-3 1977 If, however, leukocyte cultures are first exposed to virus and then to ragweed antigen E or anti-IgE, significant enhancement of histamine release occurs. Histamine 129-138 immunoglobulin heavy constant epsilon Homo sapiens 97-100 51003-0 1975 Inhibition of IgE and compound 48/80-induced histamine release by lectins. Histamine 45-54 immunoglobulin heavy constant epsilon Homo sapiens 14-17 65338-3 1977 Leukocytes from 11 allergic individuals and from 9 normal subjects sensitized with the serum of allergic patients, were capable of releasing histamine with anti-human IgG4, anti-human IgE, and the specific allergen. Histamine 141-150 immunoglobulin heavy constant epsilon Homo sapiens 184-187 65338-5 1977 Leukocytes from the normal individuals released histamine from 3 to 20% with anti-human IgG4 and from 6 to 30% with anti-human IgE. Histamine 48-57 immunoglobulin heavy constant epsilon Homo sapiens 127-130 65338-6 1977 Moreover, normal leukocytes sensitized with IgG4 myeloma protein or a serum of an allergic patient heated at 56 degrees C for 2 h, released a significant amount of histamine on challenge with anti-human IgG4 whereas no response was obtained with anti-human IgE. Histamine 164-173 immunoglobulin heavy constant epsilon Homo sapiens 257-260 72406-6 1977 It was furthermore established that specific cell-bound IgE was linearly correlated to the pollen concentration releasing 20% of the histamine contents of the basophils. Histamine 133-142 immunoglobulin heavy constant epsilon Homo sapiens 56-59 61999-5 1976 The quantity of SRS-A generated with anti-IgE or specific antigen was relatively limited but confined to the mast cell-rich fractions and associated with release of histamine and eosinophilotactic activity. Histamine 165-174 immunoglobulin heavy constant epsilon Homo sapiens 42-45 58581-0 1976 Relation between skin tests, inhalation tests, and histamine release from leucocytes and IgE in house-dust mite allergy. Histamine 51-60 immunoglobulin heavy constant epsilon Homo sapiens 89-92 58581-1 1976 This study was concerned with the correlation between skin test, bronchial provocation test, and histamine release from leucocytes and the serum level of total and allergen-specific IgE in patients atopic to house-dust mite allergen (Dermatophagiodes pteronyssinus) as measured by an intracutaneous skin test. Histamine 97-106 immunoglobulin heavy constant epsilon Homo sapiens 182-185 1017894-7 1976 In the allergic patients, following histamine and allergen provocation, a relative increase in the concentration of IgE and albumin and a significant decrease of the IgA/albumin ratio in nasal secretion was found. Histamine 36-45 immunoglobulin heavy constant epsilon Homo sapiens 116-119 52671-1 1975 The antigen-induced IgE-mediated release of histamine from human basophils has previously been shown to require calcium, to be inhibited by agents which raise cyclic AMP levels and by high antigen levels, and to be unaffected by cyclic GMP. Histamine 44-53 immunoglobulin heavy constant epsilon Homo sapiens 20-23 58059-0 1976 Letter: The role of IgE in the release of histamine from human gingival mast cells. Histamine 42-51 immunoglobulin heavy constant epsilon Homo sapiens 20-23 58741-11 1976 Studies of cytophilic antibodies using histamine liberation after challenge with antibodies to immunoglobulin sub-classes in six patients showed a marked increase in IgG2 and lesser increases of IgE and IgG3. Histamine 39-48 immunoglobulin heavy constant epsilon Homo sapiens 195-198 51003-2 1975 In addition, histamine release in an IgE-mediated and a compound 48/80-mediated reaction was inhibited in cells which had been pretreated with these lectins. Histamine 13-22 immunoglobulin heavy constant epsilon Homo sapiens 37-40 51003-4 1975 However, the lectin-induced histamine release and the lectin-induced inhibition of subsequent IgE-mediated histamine release could be dissociated: thus L-rhamnose, a hexose not ordinarily found on mammalian cell membranes, a specifically inhibited histamine release which was caused by the lectin from R. communis without affecting the inhibition of IgE-mediated histamine release. Histamine 107-116 immunoglobulin heavy constant epsilon Homo sapiens 94-97 51003-4 1975 However, the lectin-induced histamine release and the lectin-induced inhibition of subsequent IgE-mediated histamine release could be dissociated: thus L-rhamnose, a hexose not ordinarily found on mammalian cell membranes, a specifically inhibited histamine release which was caused by the lectin from R. communis without affecting the inhibition of IgE-mediated histamine release. Histamine 107-116 immunoglobulin heavy constant epsilon Homo sapiens 94-97 51003-4 1975 However, the lectin-induced histamine release and the lectin-induced inhibition of subsequent IgE-mediated histamine release could be dissociated: thus L-rhamnose, a hexose not ordinarily found on mammalian cell membranes, a specifically inhibited histamine release which was caused by the lectin from R. communis without affecting the inhibition of IgE-mediated histamine release. Histamine 107-116 immunoglobulin heavy constant epsilon Homo sapiens 94-97 51003-5 1975 Conversely, D-fucose, which also is not a constituent of cell membrane glycolipids or glycoproteins prevented the inhibition of IgE-mediated histamine release by this lectin without affecting the lectin-induced histamine release. Histamine 141-150 immunoglobulin heavy constant epsilon Homo sapiens 128-131 51003-6 1975 Furthermore, the nominally galactose-specific lectins from Sophora japonica and Ulex europeus inhibited IgE-mediated histamine release while causing little if any histamine release themselves. Histamine 117-126 immunoglobulin heavy constant epsilon Homo sapiens 104-107 46921-1 1975 Antigen-induced, IgE-mediated release of histamine from human basophiles is an in vitro model of allergic reacttions; it is blocked by extracellular histamine, presumably as a result of its ability to increase adenosine 3",5"-monophosphate (cyclic AMP) levels. Histamine 41-50 immunoglobulin heavy constant epsilon Homo sapiens 17-20 1054760-0 1975 The role of IgE in the release of histamine from human gingival mast cells. Histamine 34-43 immunoglobulin heavy constant epsilon Homo sapiens 12-15 1054760-5 1975 The percentage of the total histamine released into the medium was 8.24 percent for cultured control, 56.7 percent for antihuman IgE, and 66.7 percent for compound 48/80. Histamine 28-37 immunoglobulin heavy constant epsilon Homo sapiens 129-132 1054760-6 1975 Significant histamine release into medium was noted for antihuman IgE (P less than 0.0005) and for compound 48/80 (P equals 0.005), but these two were not significantly different from each other (P greater than 0.25). Histamine 12-21 immunoglobulin heavy constant epsilon Homo sapiens 66-69 1054760-9 1975 The results demonstrate IgE in clinically healthy human gingiva, show its association with gingival mast cell histamine release, and establish an in vitro model system for further human mast cell study. Histamine 110-119 immunoglobulin heavy constant epsilon Homo sapiens 24-27 55323-1 1975 A previous study (Gillespie & Lichtenstein, 1972) demonstrated that there was potentiation of histamine release from human peripheral blood leucocytes following exposure to antigin or anti-IgE in deuterium oxide (D2O). Histamine 98-107 immunoglobulin heavy constant epsilon Homo sapiens 193-196 55323-2 1975 The current study confirms the results with human leucocytes and indicates that the degree of histamine release due to anti-IgE or its potentiation by D2O appeared independent of the serum IgE concentration of the cell donor. Histamine 94-103 immunoglobulin heavy constant epsilon Homo sapiens 124-127 55323-3 1975 Further studies demonstrated that the peripheral blood leucocytes from monkeys with a sufficient degree of IgE-mediated reactivity to Ascaris antigen-released histamine following exposure to that antigen. Histamine 159-168 immunoglobulin heavy constant epsilon Homo sapiens 107-110 55323-5 1975 Peripheral blood leucocytes from certain monkeys release histamine following exposure to anti-human IgE. Histamine 57-66 immunoglobulin heavy constant epsilon Homo sapiens 100-103 46921-1 1975 Antigen-induced, IgE-mediated release of histamine from human basophiles is an in vitro model of allergic reacttions; it is blocked by extracellular histamine, presumably as a result of its ability to increase adenosine 3",5"-monophosphate (cyclic AMP) levels. Histamine 149-158 immunoglobulin heavy constant epsilon Homo sapiens 17-20 4130686-2 1974 Diagnosis of IgE-mediated hymenoptera sensitivity by venom-induced histamine release. Histamine 67-76 immunoglobulin heavy constant epsilon Homo sapiens 13-16 56030-1 1975 Histamine release from normal human leukocytes can be induced by anti-IgE or protein A from Staphylococcus aureus. Histamine 0-9 immunoglobulin heavy constant epsilon Homo sapiens 70-73 4134528-0 1974 Involvement of IgE in con A-induced histamine release from human basophils in vitro. Histamine 36-45 immunoglobulin heavy constant epsilon Homo sapiens 15-18 51010-6 1975 Upon action of anti-IgE antiserum on IgE-coated rat mast cells, the mast cells released up to 47.5% of their total histamine content in a fluorometric histamine assay. Histamine 115-124 immunoglobulin heavy constant epsilon Homo sapiens 20-23 51010-6 1975 Upon action of anti-IgE antiserum on IgE-coated rat mast cells, the mast cells released up to 47.5% of their total histamine content in a fluorometric histamine assay. Histamine 115-124 immunoglobulin heavy constant epsilon Homo sapiens 37-40 51010-6 1975 Upon action of anti-IgE antiserum on IgE-coated rat mast cells, the mast cells released up to 47.5% of their total histamine content in a fluorometric histamine assay. Histamine 151-160 immunoglobulin heavy constant epsilon Homo sapiens 20-23 51010-6 1975 Upon action of anti-IgE antiserum on IgE-coated rat mast cells, the mast cells released up to 47.5% of their total histamine content in a fluorometric histamine assay. Histamine 151-160 immunoglobulin heavy constant epsilon Homo sapiens 37-40 51010-7 1975 A relationship was established between sensitizing doses of human IgE and histamine release. Histamine 74-83 immunoglobulin heavy constant epsilon Homo sapiens 66-69 4124210-0 1973 Surface IgE on human basophils during histamine release. Histamine 38-47 immunoglobulin heavy constant epsilon Homo sapiens 8-11 33884198-2 2021 IgE is responsible for the release of several asthma-associated inflammatory mediators from mast cells, such as histamine and prostaglandins. Histamine 112-121 immunoglobulin heavy constant epsilon Homo sapiens 0-3 4099007-0 1970 In vitro reversed anaphylaxis: characteristics of anti-IgE mediated histamine release. Histamine 68-77 immunoglobulin heavy constant epsilon Homo sapiens 55-58 30763592-6 2019 IgE-containing nasal polyp homogenates with or without IgG depletion were evaluated for their capacity to promote IgE-facilitated allergen presentation, basophil activation, and histamine release. Histamine 178-187 immunoglobulin heavy constant epsilon Homo sapiens 0-3 33002828-10 2020 RESULTS: Kaempferol dose-dependently attenuated ovalbumin/IgE-induced mice paw swelling, primary MC activation from paw skin, as well as rehabilitated the hypothermia, and reduced the serum concentrations of histamine, tumor necrosis factor-alpha, interleukin-8, and monocyte chemo-attractant protein-1. Histamine 208-217 immunoglobulin heavy constant epsilon Homo sapiens 58-61 30763592-9 2019 Depletion of IgG from nasal homogenates resulted in an increase in CD23-mediated IgE-facilitated allergen binding to B cells but also enhanced FcepsilonRI-mediated allergen-driven basophil activation and histamine release. Histamine 204-213 immunoglobulin heavy constant epsilon Homo sapiens 81-84