PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16185276-2 2005 In this study, we examined the effect of histamine, a prototypic mediator of allergic inflammation, on the granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4-driven differentiation of monocytes into monocyte-derived dendritic cells (MoDC), which typically showed CD1a+CD14- phenotype. Histamine 41-50 colony stimulating factor 2 Homo sapiens 107-155 19663260-14 2009 It was also discovered that the CSF histamine was low in narcolepsy and other hypersomnia of central origin. Histamine 36-45 colony stimulating factor 2 Homo sapiens 32-35 17470620-6 2007 However, histamine increased IL-1beta-induced GM-CSF release and markedly reduced TNF-alpha-induced RANTES release by both asthmatic and nonasthmatic cells to a similar extent, but did not modulate PGE(2) release. Histamine 9-18 colony stimulating factor 2 Homo sapiens 46-52 16491014-8 2006 Ro-31-8220, a PKC inhibitor, and PD98059, a mitogen-activated protein/ERK kinase inhibitor, suppressed the histamine-induced ERK activation and the production of granulocyte macrophage colony-stimulating factor and IL-8. Histamine 107-116 colony stimulating factor 2 Homo sapiens 162-210 16491014-0 2006 Histamine H1 receptor-stimulated interleukin 8 and granulocyte macrophage colony-stimulating factor production by bronchial epithelial cells requires extracellular signal-regulated kinase signaling via protein kinase C. BACKGROUND: Histamine stimulates the release of several cytokines, such as interleukin (IL)-8 and granulocyte macrophage colony-stimulating factor, from bronchial epithelial cells. Histamine 0-9 colony stimulating factor 2 Homo sapiens 51-99 16185276-2 2005 In this study, we examined the effect of histamine, a prototypic mediator of allergic inflammation, on the granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4-driven differentiation of monocytes into monocyte-derived dendritic cells (MoDC), which typically showed CD1a+CD14- phenotype. Histamine 41-50 colony stimulating factor 2 Homo sapiens 157-163 10963852-11 2000 These results suggest a possible role of TK and PI3-K in basophil histamine release induced by anti-IgE, IL-3 and GM-CSF. Histamine 66-75 colony stimulating factor 2 Homo sapiens 114-120 15514212-1 2005 OBJECTIVE: To study the effect of granulocyte macrophage-colony-stimulating factor (GM-CSF) on histamine metabolism in arteriosclerosis, the expression of histidine decarboxylase (HDC; histamine-producing enzyme), histamine receptors 1 and 2 (HH1R and HH2R), and GM-CSF was investigated in human and mouse arteriosclerotic carotid arteries. Histamine 95-104 colony stimulating factor 2 Homo sapiens 34-82 15514212-1 2005 OBJECTIVE: To study the effect of granulocyte macrophage-colony-stimulating factor (GM-CSF) on histamine metabolism in arteriosclerosis, the expression of histidine decarboxylase (HDC; histamine-producing enzyme), histamine receptors 1 and 2 (HH1R and HH2R), and GM-CSF was investigated in human and mouse arteriosclerotic carotid arteries. Histamine 95-104 colony stimulating factor 2 Homo sapiens 84-90 15514212-5 2005 In U937 cells, GM-CSF enhanced histamine secretion and gene expression of HDC and HH1R. Histamine 31-40 colony stimulating factor 2 Homo sapiens 15-21 15514212-10 2005 In monocytic U937 cells, GM-CSF upregulated the expression of histamine and HH1R. Histamine 62-71 colony stimulating factor 2 Homo sapiens 25-31 15102074-0 2004 Histamine enhances the production of granulocyte-macrophage colony-stimulating factor via protein kinase Calpha and extracellular signal-regulated kinase in human keratinocytes. Histamine 0-9 colony stimulating factor 2 Homo sapiens 37-85 15102074-3 2004 We examined the effects of histamine on GM-CSF production in human keratinocytes. Histamine 27-36 colony stimulating factor 2 Homo sapiens 40-46 15102074-4 2004 Histamine increased GM-CSF secretion, mRNA stability and promoter activity. Histamine 0-9 colony stimulating factor 2 Homo sapiens 20-26 15102074-10 2004 Histamine-induced GM-CSF production was completely abolished by H1 antagonist pyrilamine and conventional protein kinase C inhibitor Go6976, and partially suppressed by PD98059 which inhibits the activation of extracellular signal-regulated kinase. Histamine 0-9 colony stimulating factor 2 Homo sapiens 18-24 15102074-14 2004 These results suggest that histamine may enhance GM-CSF production at transcriptional and posttranscriptional levels via H1 receptor, protein kinase Calpha and extracellular signal-regulated kinase. Histamine 27-36 colony stimulating factor 2 Homo sapiens 49-55 11306145-3 2001 The aim of this study was to determine the presence and to characterize the role of the endogenously produced histamine during in vitro dendritic cell (DC) differentiation induced by interleukin-4 (IL-4) and granulocyte-monocyte colony stimulating factor (GM-CSF). Histamine 110-119 colony stimulating factor 2 Homo sapiens 208-254 11306145-3 2001 The aim of this study was to determine the presence and to characterize the role of the endogenously produced histamine during in vitro dendritic cell (DC) differentiation induced by interleukin-4 (IL-4) and granulocyte-monocyte colony stimulating factor (GM-CSF). Histamine 110-119 colony stimulating factor 2 Homo sapiens 256-262 15652235-5 2005 Histamine induced concentration- and time-dependent production of granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-8 and IL-6, which was completely blocked by olopatadine, an H1 antagonist. Histamine 0-9 colony stimulating factor 2 Homo sapiens 66-114 15652235-5 2005 Histamine induced concentration- and time-dependent production of granulocyte-macrophage-colony stimulating factor (GM-CSF), interleukin (IL)-8 and IL-6, which was completely blocked by olopatadine, an H1 antagonist. Histamine 0-9 colony stimulating factor 2 Homo sapiens 116-122 12946446-4 2003 Moreover, the percentage of apoptotic neutrophils was also markedly increased by treating with 10 mM histamine in the presence of inflammatory mediators, such as lipopolysaccharide (LPS), granulocyte macrophage-colony stimulating factor (GM-CSF), dibutyryl-cAMP (db-cAMP), or dexamethasone. Histamine 101-110 colony stimulating factor 2 Homo sapiens 188-236 12946446-4 2003 Moreover, the percentage of apoptotic neutrophils was also markedly increased by treating with 10 mM histamine in the presence of inflammatory mediators, such as lipopolysaccharide (LPS), granulocyte macrophage-colony stimulating factor (GM-CSF), dibutyryl-cAMP (db-cAMP), or dexamethasone. Histamine 101-110 colony stimulating factor 2 Homo sapiens 238-244 11409570-3 2001 Under all culture conditions, GM-CSF induced a dose- and time-dependent reduction in intracellular histamine levels, tryptase activity, and numbers of cells immunoreactive for c-Kit and FcepsilonRIalpha. Histamine 99-108 colony stimulating factor 2 Homo sapiens 30-36 10963852-2 2000 The aim of this study was to evaluate the effects of TK and PI3-K inhibitors on basophil histamine release induced by anti-IgE, IL-3 and GM-CSF. Histamine 89-98 colony stimulating factor 2 Homo sapiens 137-143 10963852-3 2000 Since IL-3 and GM-CSF cause histamine release from normal human basophils only when the inhibitory effect of extracellular Na(+) has been removed, peripheral blood leukocytes were suspended in isotonic solutions containing either 140 mM NaCl or 140 mM N-methyl-D-glucamine(+). Histamine 28-37 colony stimulating factor 2 Homo sapiens 15-21 10963852-8 2000 Tyrphostin 51 caused a weak inhibition of histamine release induced by IL-3, GM-CSF and anti-IgE in a low Na(+) medium, but not in a physiological Na(+)-containing medium. Histamine 42-51 colony stimulating factor 2 Homo sapiens 77-83 10233691-0 1999 Granulocyte-macrophage colony-stimulating factor and interleukin-3 cause basophil histamine release by a common pathway: downregulation by sodium. Histamine 82-91 colony stimulating factor 2 Homo sapiens 0-48 11071123-2 2000 METHODS: Leukocytes were suspended in solutions containing physiological or low Na+ concentrations, since IL-3 and GM-CSF were shown to induce histamine release only when the inhibitory effect of extracellular Na+ has been removed. Histamine 143-152 colony stimulating factor 2 Homo sapiens 115-121 11071123-4 2000 RESULTS: Staurosporine and chelerythrine exerted a significant inhibitory effect on histamine release induced by anti-IgE, IL-3 and GM-CSF at concentrations much higher than those required to inhibit PKC. Histamine 84-93 colony stimulating factor 2 Homo sapiens 132-138 11071123-7 2000 U73122 exerted a significant and dose-dependent inhibitory effect on basophil histamine release induced by anti-IgE, FMLP, IL-3 and GM-CSF. Histamine 78-87 colony stimulating factor 2 Homo sapiens 132-138 10233691-1 1999 Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) are recognized as enhancers, but not as inducers, of histamine release from normal human basophils. Histamine 136-145 colony stimulating factor 2 Homo sapiens 0-48 10233691-1 1999 Granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) are recognized as enhancers, but not as inducers, of histamine release from normal human basophils. Histamine 136-145 colony stimulating factor 2 Homo sapiens 50-56 10233691-3 1999 The aim of this study was to evaluate whether GM-CSF can induce basophil histamine release using the same pathway of IL-3. Histamine 73-82 colony stimulating factor 2 Homo sapiens 46-52 10233691-6 1999 However, when extracellular Na+ was substituted iso-osmotically with N-methyl-d-glucamine+ or with choline+, GM-CSF and IL-3 were able to trigger histamine release from either mixed leucocyte suspensions or purified human basophils. Histamine 146-155 colony stimulating factor 2 Homo sapiens 109-115 10233691-7 1999 The effect of GM-CSF on basophil histamine release was dose dependent, with optimal release at a dose of 1 ng/ml after incubation at 37 degrees for 60-120 min. Histamine 33-42 colony stimulating factor 2 Homo sapiens 14-20 10233691-10 1999 When extracellular Na+ concentration was increased from 0 to 140 mm, histamine release induced by GM-CSF, IL-3 and anti-IgE was reduced progressively. Histamine 69-78 colony stimulating factor 2 Homo sapiens 98-104 10233691-12 1999 These results provide indirect evidence that GM-CSF and IL-3 can induce basophil histamine release by a common pathway that is downregulated by Na+. Histamine 81-90 colony stimulating factor 2 Homo sapiens 45-51 9566351-1 1998 The present studies demonstrate that histamine induces the secretion of IL-6, IL-8 and GM-CSF from human conjunctival epithelial cells in a dose- and time-dependent manner. Histamine 37-46 colony stimulating factor 2 Homo sapiens 87-93 9600507-6 1998 Most strikingly, addition of thapsigargin made basophils extremely sensitive for histamine release induced by IL-3 (maximum histamine release, 71% +/- 7%), IL-5 (maximum histamine release, 43% +/- 8%), or granulocyte-macrophage colony-stimulating factor (GM-CSF) (maximum histamine release, 57% +/- 10%). Histamine 81-90 colony stimulating factor 2 Homo sapiens 205-253 9600507-6 1998 Most strikingly, addition of thapsigargin made basophils extremely sensitive for histamine release induced by IL-3 (maximum histamine release, 71% +/- 7%), IL-5 (maximum histamine release, 43% +/- 8%), or granulocyte-macrophage colony-stimulating factor (GM-CSF) (maximum histamine release, 57% +/- 10%). Histamine 81-90 colony stimulating factor 2 Homo sapiens 255-261 10051702-11 1999 The amount of IL-8 and GM-CSF, induced by histamine, was significantly higher in DEP extract pretreated HNECs and HMMECs than nontreated HNECs and HMMECs. Histamine 42-51 colony stimulating factor 2 Homo sapiens 23-29 10051702-12 1999 CONCLUSION: These results strongly suggest that DEP accelerates the inflammatory change by not only directly upregulating H1R expression but also increasing histamine-induced IL-8 and GM-CSF production. Histamine 157-166 colony stimulating factor 2 Homo sapiens 184-190 9566351-3 1998 Emedastine potently inhibited histamine-induced IL-6, IL-8 and GM-CSF secretion with mean IC50 values of 2.23, 3.42 and 1.50 nM, respectively. Histamine 30-39 colony stimulating factor 2 Homo sapiens 63-69 9606035-4 1998 Histamine (100 microM) and acetylcholine ( 100 nM) stimulated GM-CSF release more than two-fold above the baseline. Histamine 0-9 colony stimulating factor 2 Homo sapiens 62-68 8765829-7 1996 Preincubation of basophils with granulocyte-macrophage colony-stimulating factor (30 and 100 pmol/L), but not IL-1 beta (30 and 100 ng/ml), concentration-dependently reversed the inhibitory effect of CsH on FMLP-induced histamine release. Histamine 220-229 colony stimulating factor 2 Homo sapiens 32-80 9130550-0 1997 GM-CSF downregulates expression of tryptase, Fc epsilon RI and histamine in HMC-1 mast cells. Histamine 63-72 colony stimulating factor 2 Homo sapiens 0-6 8859222-1 1996 Interleukins 3 and 5 and GM-CSF enhance histamine release from basophils triggered by various stimuli. Histamine 40-49 colony stimulating factor 2 Homo sapiens 25-31 7580291-3 1995 Histamine, but not PAF or endothelin-1, showed a dose-dependent stimulatory effect on the release of interleukin-6, interleukin-8 and granulocyte-macrophage colony-stimulating factor by normal and transformed human bronchial epithelial cells when studied 6 h after the treatment. Histamine 0-9 colony stimulating factor 2 Homo sapiens 134-182 8789915-3 1996 CSF levels of histamine"s primary metabolite, tele-methylhistamine, an index of brain histaminergic activity, were positively correlated (p < 0.005) with daily urine volume. Histamine 14-23 colony stimulating factor 2 Homo sapiens 0-3 8754960-2 1996 An activity of GM-CSF was determined in serum and BAL-fluid of 12 asthma patients with bronchial hyperreactivity to histamine before and 24 hours after challenge test. Histamine 116-125 colony stimulating factor 2 Homo sapiens 15-21 8754960-3 1996 It was found statistically significant increase (p < 0.05) of GM-CSF activity in patients with bronchial hyperreactivity to histamine. Histamine 127-136 colony stimulating factor 2 Homo sapiens 65-71 7561521-0 1995 Histamine enhances granulocyte-macrophage colony-stimulating factor and interleukin-6 production by human peripheral blood mononuclear cells. Histamine 0-9 colony stimulating factor 2 Homo sapiens 19-67 7561521-3 1995 Using ELISA and radioimmunoassay kits, histamine was found to enhance the production of GM-CSF (9.6-fold) and IL-6 (8.2-fold) by mononuclear cells but not by nonadherent cells or large granular lymphocytes. Histamine 39-48 colony stimulating factor 2 Homo sapiens 88-94 7561521-4 1995 Anti-GM-CSF and anti-IL-6 antibodies markedly blocked cytokine activity in CM-PBS, whereas the blocking effect in CM-histamine was moderate, indicating enhanced GM-CSF and IL-6 activity in CM-histamine. Histamine 192-201 colony stimulating factor 2 Homo sapiens 161-167 7561521-7 1995 We conclude that histamine is able to activate human mononuclear cells to generate cytokines such as GM-CSF and IL-6 via H1 and H2 receptors. Histamine 17-26 colony stimulating factor 2 Homo sapiens 101-107 7531728-0 1995 Histamine release from human basophils induced by platelet activating factor: the role of extracellular calcium, interleukin-3, and granulocyte-macrophage colony-stimulating factor. Histamine 0-9 colony stimulating factor 2 Homo sapiens 132-180 7543541-4 1995 Preincubation with GM-CSF similarly enhanced MBP-induced histamine release. Histamine 57-66 colony stimulating factor 2 Homo sapiens 19-25 7798535-6 1994 Provocative concentration of histamine causing a 20% fall in forced expiratory volume in 1 second was correlated with GM-CSF expression (r = -0.462, p < 0.05). Histamine 29-38 colony stimulating factor 2 Homo sapiens 118-124 7531728-5 1995 We found that there is synergy between interleukin-3 (1 to 3 ng/ml) and PAF (1 mumol/L) for secretion of histamine from human basophils (p < 0.05) and that GM-CSF (10 ng/ml) significantly (p < 0.02) potentiates the secretion of histamine activated by PAF (1 mumol/L). Histamine 105-114 colony stimulating factor 2 Homo sapiens 159-165 7531728-6 1995 Our results demonstrate that: (1) the kinetics of the interaction between Ca2+ and the activation pathway that leads to histamine secretion are central events in the release reaction elicited by PAF in human basophils, and (2) interleukin-3 and GM-CSF can potentiate the secretory response of human basophils stimulated by PAF. Histamine 120-129 colony stimulating factor 2 Homo sapiens 245-251 7513312-8 1994 NaF-induced histamine release was enhanced up to 60 and 30% by GM-CSF and G-CSF priming, respectively. Histamine 12-21 colony stimulating factor 2 Homo sapiens 63-69 7522070-7 1994 Unlike what was observed with lung fragments, IL-3, GM-CSF and to a lesser extent IL-5, were potent enhancing agents of anti-IgE (1/2,000)-induced histamine release from leukocytes. Histamine 147-156 colony stimulating factor 2 Homo sapiens 52-58 7513312-4 1994 GM-CSF pretreatment led to an increased chemiluminescence response from human PMN by up to 100%, leukotriene B4 generation was enhanced up to fivefold, and histamine release from human LMB increased from 45% +/- 15% to 75% +/- 5% (mean +/- standard distribution) of the total histamine content. Histamine 156-165 colony stimulating factor 2 Homo sapiens 0-6 7513312-4 1994 GM-CSF pretreatment led to an increased chemiluminescence response from human PMN by up to 100%, leukotriene B4 generation was enhanced up to fivefold, and histamine release from human LMB increased from 45% +/- 15% to 75% +/- 5% (mean +/- standard distribution) of the total histamine content. Histamine 276-285 colony stimulating factor 2 Homo sapiens 0-6 7544549-4 1994 Preincubation of leukocytes with IL-3, GM-CSF, or IL-5 (0.02-2 ng/ml), but not with IL-8 and SCF, caused a dose-dependent enhancement of antigen-induced basophilic histamine release in all subjects tested. Histamine 164-173 colony stimulating factor 2 Homo sapiens 39-45 7976804-1 1994 Measurements of the concentrations of histamine"s metabolites, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), in brain have been used to evaluate histamine turnover in brains of animals, and the same measurements in CSF have been used to infer histaminergic activity in brains of man. Histamine 38-47 colony stimulating factor 2 Homo sapiens 243-246 1537596-6 1992 GM-CSF release was significantly enhanced by 10(-6) M histamine (1.6 +/- 0.7 versus 2.13 +/- 0.8 ng GM-CSF/10(6) cells; n = 9) and 5 ng/ml interleukin-1 (IL-1) (0.6 +/- 0.2 versus 3.2 +/- 0.5 ng GM-CSF/10(6) cells; n = 3). Histamine 54-63 colony stimulating factor 2 Homo sapiens 0-6 8007458-5 1993 IL-3, GM-CSF, IL-5 and IGF-I enhanced basophil histamine release. Histamine 47-56 colony stimulating factor 2 Homo sapiens 6-12 7684660-0 1993 Inducing and enhancing effects of IL-3, -5, and -6 and GM-CSF on histamine release from human basophils. Histamine 65-74 colony stimulating factor 2 Homo sapiens 55-61 7684660-1 1993 The effects of interleukin (IL)-2, -3, -4, -5, -6, and -7 and granulocyte-macrophage colony-stimulating factor (GM-CSF) on histamine release from human basophils were evaluated. Histamine 123-132 colony stimulating factor 2 Homo sapiens 62-110 7684660-1 1993 The effects of interleukin (IL)-2, -3, -4, -5, -6, and -7 and granulocyte-macrophage colony-stimulating factor (GM-CSF) on histamine release from human basophils were evaluated. Histamine 123-132 colony stimulating factor 2 Homo sapiens 112-118 7684660-5 1993 IL-3, IL-5, IL-6, and GM-CSF enhanced significantly anti-IgE- and FMLP-induced histamine release. Histamine 79-88 colony stimulating factor 2 Homo sapiens 22-28 7684660-7 1993 These results indicate that IL-3 can induce and IL-3, -5, and -6 and GM-CSF can enhance histamine release from human basophils, suggesting a possible role of these cytokines in the expression of allergic reactions. Histamine 88-97 colony stimulating factor 2 Homo sapiens 69-75 1380308-2 1992 IL-3, GM-CSF, and IL-5 enhanced basophil histamine release and in-vitro survival, while G-CSF, M-CSF, and IL-4 had no enhancing activities at all. Histamine 41-50 colony stimulating factor 2 Homo sapiens 6-12 1959978-0 1991 Human upper airway epithelial cell-derived granulocyte-macrophage colony-stimulating factor induces histamine-containing cell differentiation of human progenitor cells. Histamine 100-109 colony stimulating factor 2 Homo sapiens 43-91 1716491-0 1991 Interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF): two cytokines increasing histamine synthesis by hematopoietic cells. Histamine 109-118 colony stimulating factor 2 Homo sapiens 25-73 1716491-0 1991 Interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF): two cytokines increasing histamine synthesis by hematopoietic cells. Histamine 109-118 colony stimulating factor 2 Homo sapiens 75-81 1834679-0 1991 GM-CSF in association with IL-1 triggers day-8 CFU-S into cell cycle: role of histamine. Histamine 78-87 colony stimulating factor 2 Homo sapiens 0-6 1834679-4 1991 We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine. Histamine 106-115 colony stimulating factor 2 Homo sapiens 91-97 1834679-6 1991 In addition, we provide an argument in support of a histamine receptor modulation by GM-CSF that could explain the lack of effect of factor-induced histamine on day-8 CFU-S cell cycling. Histamine 52-61 colony stimulating factor 2 Homo sapiens 85-91 1834679-8 1991 Taken together, our data support the conclusion that IL-1 makes CFU-S sensitive to GM-CSF-induced endogeneous histamine that will trigger them into cell cycle, while GM-CSF alone has no such effect on this biological activity. Histamine 110-119 colony stimulating factor 2 Homo sapiens 83-89 1959978-7 1991 Finally, we show that the histamine-containing cell differentiation of HL-60 cells as well as the colony growth induced by EpCM can be fully inhibited by preincubating this CM with a monoclonal neutralizing antibody to human GM-CSF. Histamine 26-35 colony stimulating factor 2 Homo sapiens 225-231 2139273-5 1990 Pretreatment of neutrophils with granulocyte macrophage- colony stimulating factor (GM-CSF), or basophils with interleukin-3 (IL-3) renders these cells capable of producing or releasing inflammatory mediators, such as histamine, leukotrienes or platelet activating-factor (PAF). Histamine 218-227 colony stimulating factor 2 Homo sapiens 33-82 1695452-4 1990 IL-1 alpha, IL-1 beta, IL-3, colony stimulating factor (CSF) and granulocyte-macrophage-CSF (GM-CSF) caused significant histamine release from cells from a similar number of AIDS patients and controls. Histamine 120-129 colony stimulating factor 2 Homo sapiens 29-54 1695452-4 1990 IL-1 alpha, IL-1 beta, IL-3, colony stimulating factor (CSF) and granulocyte-macrophage-CSF (GM-CSF) caused significant histamine release from cells from a similar number of AIDS patients and controls. Histamine 120-129 colony stimulating factor 2 Homo sapiens 56-59 1695452-4 1990 IL-1 alpha, IL-1 beta, IL-3, colony stimulating factor (CSF) and granulocyte-macrophage-CSF (GM-CSF) caused significant histamine release from cells from a similar number of AIDS patients and controls. Histamine 120-129 colony stimulating factor 2 Homo sapiens 65-91 1695452-4 1990 IL-1 alpha, IL-1 beta, IL-3, colony stimulating factor (CSF) and granulocyte-macrophage-CSF (GM-CSF) caused significant histamine release from cells from a similar number of AIDS patients and controls. Histamine 120-129 colony stimulating factor 2 Homo sapiens 93-99 2139273-5 1990 Pretreatment of neutrophils with granulocyte macrophage- colony stimulating factor (GM-CSF), or basophils with interleukin-3 (IL-3) renders these cells capable of producing or releasing inflammatory mediators, such as histamine, leukotrienes or platelet activating-factor (PAF). Histamine 218-227 colony stimulating factor 2 Homo sapiens 84-90 2455733-0 1988 Human recombinant granulocyte-macrophage colony-stimulating factor and interleukin 3 cause basophil histamine release. Histamine 100-109 colony stimulating factor 2 Homo sapiens 18-66 2460553-2 1988 Both granulocyte (G)-macrophage (M) CSF and IL-3 markedly enhanced histamine release upon stimulation with anti-IgE in a dose-dependent manner (maximal enhancement 25.5% by GM-CSF and 30.8% by IL-3 as expressed as percent increase against total cellular histamine content), whereas G-CSF, M-CSF, and IL-4 had no effect. Histamine 67-76 colony stimulating factor 2 Homo sapiens 36-39 2460553-2 1988 Both granulocyte (G)-macrophage (M) CSF and IL-3 markedly enhanced histamine release upon stimulation with anti-IgE in a dose-dependent manner (maximal enhancement 25.5% by GM-CSF and 30.8% by IL-3 as expressed as percent increase against total cellular histamine content), whereas G-CSF, M-CSF, and IL-4 had no effect. Histamine 67-76 colony stimulating factor 2 Homo sapiens 173-179 2460553-2 1988 Both granulocyte (G)-macrophage (M) CSF and IL-3 markedly enhanced histamine release upon stimulation with anti-IgE in a dose-dependent manner (maximal enhancement 25.5% by GM-CSF and 30.8% by IL-3 as expressed as percent increase against total cellular histamine content), whereas G-CSF, M-CSF, and IL-4 had no effect. Histamine 254-263 colony stimulating factor 2 Homo sapiens 36-39 2469713-7 1989 IL-3, GM-CSF, and IL-1 can also release histamine at lower concentrations (less than 5 ng/ml) when incubated with basophils in the presence of D2O. Histamine 40-49 colony stimulating factor 2 Homo sapiens 6-12 2469713-9 1989 The results of this study demonstrated that although IL-3 and GM-CSF release small amounts of histamine only from a select group of allergic patients, mononuclear cell-derived HRF is more potent in their action and release histamine from normals as well as allergic patients. Histamine 94-103 colony stimulating factor 2 Homo sapiens 62-68 2735222-1 1989 The metabolites of histamine, tele-methylhistamine (t-MH) and tele-methylimidazoleacetic acid (t-MIAA), have a large concentration gradient between cisternal and lumbar CSF in the rhesus monkey. Histamine 19-28 colony stimulating factor 2 Homo sapiens 169-172 2735222-9 1989 The concentration gradient of histamine metabolites in CSF confirms the rostral-caudal gradient observed in monkey and argues against plasma or spinal cord as major sources of these metabolites. Histamine 30-39 colony stimulating factor 2 Homo sapiens 55-58 25723478-10 2015 H1R and H2R, but not H3R or H4R, were constitutively expressed by primary and immortalized cells, and epithelial histamine stimulation induced GM-CSF, TNFalpha, and IL-8, but not TSLP or eotaxin-3 secretion. Histamine 113-122 colony stimulating factor 2 Homo sapiens 143-149 25723478-11 2015 Epithelial priming with the TLR3 ligand poly (I:C) induced H1R and H2R expression, and enhanced histamine-induced GM-CSF, TNFalpha, and IL-8 secretion. Histamine 96-105 colony stimulating factor 2 Homo sapiens 114-120 23024434-1 2012 STUDY OBJECTIVES: To determine the activity of cerebral histaminergic system evaluated by CSF levels of histamine (HA) and tele-methylhistamine (t-MHA), its major metabolite, and their relationships with hypocretin-1 levels in a large population of patients with hypersomnia and neurological conditions. Histamine 56-65 colony stimulating factor 2 Homo sapiens 90-93 23024434-1 2012 STUDY OBJECTIVES: To determine the activity of cerebral histaminergic system evaluated by CSF levels of histamine (HA) and tele-methylhistamine (t-MHA), its major metabolite, and their relationships with hypocretin-1 levels in a large population of patients with hypersomnia and neurological conditions. Histamine 115-117 colony stimulating factor 2 Homo sapiens 90-93