PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17928537-4	2007	Histamine enhanced TNF-alpha- or IFN-gamma-induced hBD-2 secretion and mRNA expression.	Histamine	0-9	defensin beta 4A	Homo sapiens	51-56	
17928537-12	2007	These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma-induced hBD-2 production dependent on NF-kappaB, AP-1, or STAT1 in human keratinocytes.	Histamine	27-36	defensin beta 4A	Homo sapiens	108-113	
30974892-12	2019	Together with tumor necrosis factor-alpha (TNF-alpha), histamine upregulated hBD-2 mRNA expression in HOKs.	Histamine	55-64	defensin beta 4A	Homo sapiens	77-82	
17928537-0	2007	Histamine enhances the production of human beta-defensin-2 in human keratinocytes.	Histamine	0-9	defensin beta 4A	Homo sapiens	43-58	
17928537-2	2007	hBD-2 induces histamine release from mast cells.	Histamine	14-23	defensin beta 4A	Homo sapiens	0-5	
17928537-3	2007	We examined the in vitro effects of histamine on hBD-2 production in normal human keratinocytes.	Histamine	36-45	defensin beta 4A	Homo sapiens	49-54	
17928537-13	2007	Histamine may potentiate anti-microbial defense, skin inflammation, and wound repair via the induction of hBD-2.	Histamine	0-9	defensin beta 4A	Homo sapiens	106-111	
17928537-6	2007	Antisense oligonucleotides against NF-kappaB components p50 and p65, AP-1 components c-Jun and c-Fos, or H1 antagonist pyrilamine suppressed hBD-2 production induced by histamine plus TNF-alpha or IFN-gamma.	Histamine	169-178	defensin beta 4A	Homo sapiens	141-146	
17928537-7	2007	Antisense oligonucleotide against STAT1 only suppressed hBD-2 production induced by histamine plus IFN-gamma.	Histamine	84-93	defensin beta 4A	Homo sapiens	56-61	
11298331-4	2001	Interestingly, histamine release and intracellular Ca(2+) mobilization elicited by hBD-2 and LL-37 were markedly suppressed by BAPTA-AM (an intracellular Ca(2+) chelating agent), pertussis toxin and U-73122 (a phospholipase C inhibitor).	Histamine	15-24	defensin beta 4A	Homo sapiens	83-88	
11298331-7	2001	These observations suggest that hBD-2 and LL-37 stimulate mast cells to mobilize intracellular Ca(2+) and release histamine or generate PGD(2) in a G protein-phospholipase C-dependent manner.	Histamine	114-123	defensin beta 4A	Homo sapiens	32-37