PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27666706-13 2016 Bone marrow MC were shown to have the highest expression of FcepsilonRIalpha and NK-1R in culture of 20 mug/L IL-4 by the detection of Western blot, meanwhile these MC could be activated to degranulate by a lower concentration of SP (0.01 mg/L), with the release rate of histamine from MC showing a positive correlation with SP concentrations. Histamine 271-280 interleukin 4 Mus musculus 110-114 29157947-6 2018 RESULTS: IL-4 exacerbation of histamine-induced hypovolemic shock in mice was dependent on VE expression of IL-4Ralpha. Histamine 30-39 interleukin 4 Mus musculus 9-13 29157947-10 2018 CONCLUSION: IL-4 amplifies IgE- and histamine-induced VE dysfunction, fluid extravasation, and the severity of anaphylaxis through a VE IL-4Ralpha/ABL1-dependent mechanism. Histamine 36-45 interleukin 4 Mus musculus 12-16 26084192-8 2015 Conversely, Th2 adjuvant, histamine-pulsed LDCs induced a Th2-prone immune response, as represented by up-regulation of IL-4 production and down-regulation of IFN-gamma production. Histamine 26-35 interleukin 4 Mus musculus 120-124 24504982-6 2014 IL-4 as an anti-inflammatory substance increased the histamine-, substance P-, and somatostatin-sensitive populations only in microglia from adult, but not in neonatal cells. Histamine 53-62 interleukin 4 Mus musculus 0-4 26346531-8 2015 Histamine increased interferon-gamma production in GM-CSF + IL-4-cultured cells; it also enhanced IL-10 production, but suppressed IL-12 production in LPS-stimulated DCs with no DCL. Histamine 0-9 interleukin 4 Mus musculus 60-64 23938254-5 2013 Furthermore, they inhibited the expression of the allergic cytokines, IL-4 and TNF-alpha as well as the activation of their transcription factors NF-kappaB, AP-1 and p38 in histamine-stimulated skin tissues. Histamine 173-182 interleukin 4 Mus musculus 70-74 22156496-0 2012 Cutting edge: histamine is required for IL-4-driven eosinophilic allergic responses. Histamine 14-23 interleukin 4 Mus musculus 40-44 22156496-2 2012 In this study, we show that histamine is necessary to generate IL-4-driven eosinophilic inflammation, as histamine-deficient mice cannot generate eosinophilic lung inflammation in response to intratracheal IL-4 and exogenous histamine restores responsiveness. Histamine 28-37 interleukin 4 Mus musculus 63-67 22156496-2 2012 In this study, we show that histamine is necessary to generate IL-4-driven eosinophilic inflammation, as histamine-deficient mice cannot generate eosinophilic lung inflammation in response to intratracheal IL-4 and exogenous histamine restores responsiveness. Histamine 105-114 interleukin 4 Mus musculus 63-67 22156496-2 2012 In this study, we show that histamine is necessary to generate IL-4-driven eosinophilic inflammation, as histamine-deficient mice cannot generate eosinophilic lung inflammation in response to intratracheal IL-4 and exogenous histamine restores responsiveness. Histamine 105-114 interleukin 4 Mus musculus 63-67 20552026-4 2010 Our laboratory purified and cloned a histamine releasing factor (HRF) that was a complete stimulus for histamine and IL-4 secretion from a subpopulation of allergic donors" basophils. Histamine 37-46 interleukin 4 Mus musculus 117-121 20585891-3 2010 These agents inhibited the expression of the allergic cytokines, IL-4 and TNF-alpha, and the activation of the transcription factors, NF-kappaB and c-jun, in histamine-stimulated skin tissues. Histamine 158-167 interleukin 4 Mus musculus 65-69 22210038-7 2011 LP potently inhibited histamine-induced cytokine production: it (1 x 10(10) CFU per mouse) inhibited IL-4, IL-1beta, and TNF-alpha expression by 88.9%, 88.6%, and 98.9%, respectively. Histamine 22-31 interleukin 4 Mus musculus 101-105 19801847-0 2009 Interleukin-4-mediated suppression of histamine synthesis in a murine mast cell line, BNu-2cl3. Histamine 38-47 interleukin 4 Mus musculus 0-13 19801847-5 2009 IL-4 drastically suppressed histamine synthesis at the transcriptional levels. Histamine 28-37 interleukin 4 Mus musculus 0-4 19801847-6 2009 Storage of histamine was significantly decreased upon prolonged treatment with IL-4. Histamine 11-20 interleukin 4 Mus musculus 79-83 19801847-9 2009 These results suggest that IL-4 should play a critical role in suppression of histamine synthesis in mucosal-type mast cells. Histamine 78-87 interleukin 4 Mus musculus 27-31 17276885-0 2007 Histamine affects STAT6 phosphorylation via its effects on IL-4 secretion: role of H1 receptors in the regulation of IL-4 production. Histamine 0-9 interleukin 4 Mus musculus 59-63 19155466-2 2009 In this study we demonstrate that histamine-free histidine decarboxylase-deficient (HDC(-/-)) mice present a numerical and functional deficit in invariant NK T (iNKT) cells as evidenced by a drastic decrease of IL-4 and IFN-gamma production. Histamine 34-43 interleukin 4 Mus musculus 211-215 19277450-12 2009 Further, these suppressive effects of histamine for Th1-cytokine and IL-4 did not accompany the enhancement of IL-10 production or IL-10 mRNA level in IELs. Histamine 38-47 interleukin 4 Mus musculus 52-73 19416272-10 2009 Treatment with mouse IL-4 DNA augmented the ear swelling and thickness with an increased dermal eosinophil count, plasma histamine level, and production of splenocyte IL-4. Histamine 121-130 interleukin 4 Mus musculus 21-25 19277450-9 2009 Histamine significantly decreased Th1-cytokine (IFN-gamma, TNF-alpha, and IL-2) and also IL-4 production in IELs as well as splenocytes. Histamine 0-9 interleukin 4 Mus musculus 89-93 17276885-12 2007 The effects of histamine on the STAT6 phosphorylation were indirect since they were blocked either by the antibodies to IL-4 and IL-13 or in IL-4 knock out mice in the presence of IL-13 antibody. Histamine 15-24 interleukin 4 Mus musculus 120-124 17276885-12 2007 The effects of histamine on the STAT6 phosphorylation were indirect since they were blocked either by the antibodies to IL-4 and IL-13 or in IL-4 knock out mice in the presence of IL-13 antibody. Histamine 15-24 interleukin 4 Mus musculus 141-145 17276885-13 2007 These observations suggest that histamine indirectly affected the STAT6 phosphorylation via its effects on the secretion of cytokines (IL-4) and H1 receptor played a role in this process. Histamine 32-41 interleukin 4 Mus musculus 135-139 10692110-5 2000 In both interleukin-4-/- mice and Wf/Wf mice, the mast cell product, histamine, was immunosuppressive implicating mast cells as the dysfunctional cell in interleukin-4-/- mice. Histamine 69-78 interleukin 4 Mus musculus 8-21 17118966-6 2007 However, real-time PCR analysis of in vivo CFA-induced IL-12p35, IFNgamma, IL-10 and IL-4 expression showed that DCs matured in a histamine-free environment exhibit significantly elevated levels of IL-12p35 and IFNgamma mRNA. Histamine 130-139 interleukin 4 Mus musculus 85-89 12370375-9 2002 Responses to PGE(2) and histamine, which were dependent on mast cells and STAT6, were enhanced by IL-4C, but not by IL-13. Histamine 24-33 interleukin 4 Mus musculus 98-103 15655289-8 2005 Nonetheless, the increased IFN-gamma / IL-4 ratios were markedly suppressed by histamine administration compared with vehicle. Histamine 79-88 interleukin 4 Mus musculus 39-43 10692110-5 2000 In both interleukin-4-/- mice and Wf/Wf mice, the mast cell product, histamine, was immunosuppressive implicating mast cells as the dysfunctional cell in interleukin-4-/- mice. Histamine 69-78 interleukin 4 Mus musculus 154-167 18472844-2 1997 Anti-IgE stimulated histamine release from peripheral blood basophils and mast cells of atopic donors was enhanced after preincubation with IL-4, whereas after preincubation with sIL-4R it was inhibited. Histamine 20-29 interleukin 4 Mus musculus 140-144 9003216-7 1997 Changes in IgE and histamine levels after intragastric challenge could be blocked by treating the animals with neutralizing antibodies against IL-4 or IL-10. Histamine 19-28 interleukin 4 Mus musculus 143-147 10210323-5 1999 Furthermore, cytoplasmic granulation and histamine synthesis of BM-derived mast cells were increased in presence of IL-4 and SCF. Histamine 41-50 interleukin 4 Mus musculus 116-120 18472844-4 1997 In IL-4 preincubated skin mast cells, there was a similar enhancement of anti-IgE stimulated histamine release, which could again be inhibited by sIL-4R. Histamine 93-102 interleukin 4 Mus musculus 3-7 18472844-8 1997 This indicates that IL4 exerts priming effects on histamine release by effector cells of the allergic response and that these effects are potently antagonized by soluble IL-4R both in vitro and in vivo. Histamine 50-59 interleukin 4 Mus musculus 20-23 7530742-8 1995 In BMMC, the histamine and serotonin release induced by ET-1 (10(-6) M) was inhibited by an ETA-R-specific antagonist (cyclic [D-Asp-Pro-D-Val-Leu-D-Trp]) in a dose-dependent manner, with complete inhibition at an antagonist concentration of 10(-8) M. ET-1 stimulated leukotriene C4 biosynthesis up to 4.5-fold in BMMC cultured in the presence of IL-4. Histamine 13-22 interleukin 4 Mus musculus 347-351 7530742-4 1995 ET-1 induced a very rapid (< or = 1 min) and dose-dependent release of histamine and serotonin from BMMC cultured in the presence of both IL-3 and IL-4. Histamine 74-83 interleukin 4 Mus musculus 150-154 7528573-9 1995 We have also found that the mast cells generated in colonies stimulated by IL-4, IL-10, and SCF produced high levels of histamine (6-8 pg per cell). Histamine 120-129 interleukin 4 Mus musculus 75-79