PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21645239-4	2012	The purpose of this study was to determine the role of these domains in TACE-mediated TNFR1 shedding in response to histamine.	Histamine	116-125	ADAM metallopeptidase domain 17	Homo sapiens	72-76	
10818238-3	2000	Differentiation of U937 and HPM cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) enhanced the H1 receptor expression and rather suppressed the H2 receptor, resulting in up-regulation of the histamine-induced expression and secretion of TNF-alpha, modulated via TACE.	Histamine	195-204	ADAM metallopeptidase domain 17	Homo sapiens	266-270	
21645239-9	2012	In summary, we show that endothelial lipid rafts/caveolae co-localize TACE to surface expressed TNFR1, promoting efficient shedding of sTNFR1 in response to histamine.	Histamine	157-166	ADAM metallopeptidase domain 17	Homo sapiens	70-74