PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 4059585-9 1985 We conclude that by an H-2 mechanism, exogenous histamine reduces bombesin-stimulated gastrin release in dog. Histamine 48-57 gastrin Canis lupus familiaris 86-93 3023163-3 1986 Whether endogenous histamine mediates gastrin and/or acetylcholine stimulation, at least partially, remains to be elucidated. Histamine 19-28 gastrin Canis lupus familiaris 38-45 3023163-4 1986 If cAMP in the gastric juice reflects H2 receptor activity, we can investigate whether endogenous histamine mediates gastrin and/or acetylcholine stimulation in vivo. Histamine 98-107 gastrin Canis lupus familiaris 117-124 2423027-2 1986 Gastrin has direct actions on the parietal cell and on the somatostatin cell; action on the parietal cell, but not somatostatin cell, is potentiated by histamine. Histamine 152-161 gastrin Canis lupus familiaris 0-7 2423027-5 1986 The profound effects of H2 antagonists on gastrin action may also reflect an effect mediated by histamine release, but this possibility awaits direct confirmation. Histamine 96-105 gastrin Canis lupus familiaris 42-49 4059585-0 1985 Intravenous histamine reduces bombesin-stimulated gastrin release in dogs. Histamine 12-21 gastrin Canis lupus familiaris 50-57 4059585-1 1985 The effect of histamine on gastrin release was studied in 7 conscious mongrel dogs with chronic gastric and duodenal fistulas. Histamine 14-23 gastrin Canis lupus familiaris 27-34 91322-8 1979 The mechanisms underlying the potentiating interactions between histamine, carbachol, and gastrin involve step(s) beyond stimulation of cyclic AMP generation. Histamine 64-73 gastrin Canis lupus familiaris 90-97 4059585-6 1985 Gastrin release, as expressed by the integrated response during the last 50 min of the bombesin infusion was significantly (P less than 0.05) decreased by all doses of histamine, compared to control. Histamine 168-177 gastrin Canis lupus familiaris 0-7 4059585-7 1985 The infusion doses of histamine studied, 20, 40, 80, and 160 micrograms/kg per h reduced bombesin-stimulated gastrin release 16%, 19%, 19%, and 30%, respectively. Histamine 22-31 gastrin Canis lupus familiaris 109-116 2580744-6 1985 administration of histamine increased the level of the serum gastrin. Histamine 18-27 gastrin Canis lupus familiaris 61-68 6151805-0 1984 Gastric acid secretion results from antagonistic effects of antral histamine (Antramine) and somatostatin on gastrin. Histamine 67-76 gastrin Canis lupus familiaris 109-116 6151805-7 1984 Somatostatin and histamine might act antagonistically on gastrin which would be their common substrate, and thus they could intervene in a regulation process of acid secretion. Histamine 17-26 gastrin Canis lupus familiaris 57-64 6154063-5 1980 PGE2 did, however, inhibit aminopyrine uptake stimulated by carbachol and gastrin when the response to these agents was potentiated by histamine. Histamine 135-144 gastrin Canis lupus familiaris 74-81 6873562-1 1983 Histamine isolated from the gastric antral mucosa probably potentiates the secretory activity of gastrin by suppression of the inhibitory effect of somatostatin on gastrin. Histamine 0-9 gastrin Canis lupus familiaris 97-104 6873562-1 1983 Histamine isolated from the gastric antral mucosa probably potentiates the secretory activity of gastrin by suppression of the inhibitory effect of somatostatin on gastrin. Histamine 0-9 gastrin Canis lupus familiaris 164-171 6873562-7 1983 Thus, histamine, especially of antral origin, might be an important component of the secretion mechanism, by modulation of gastrin activity; both substances could be the main mediators of somatostatin-induced inhibition. Histamine 6-15 gastrin Canis lupus familiaris 123-130 6134446-0 1983 Histamine is able to suppress the inhibitory effect of somatostatin on exogenous gastrin: comparison between extractive antral histamine and synthetic histamine. Histamine 0-9 gastrin Canis lupus familiaris 81-88 6134446-5 1983 We suggest that antral histamine might intervene in the complex regulation of gastric secretion where somatostatin and gastrin act antagonistically and where the stimulatory as well as inhibitory fibers of the vagus intervene. Histamine 23-32 gastrin Canis lupus familiaris 119-126 6127428-6 1982 Increased serum gastrin induced by perfusion of the antrum with liver extract solution disturbed receptive relaxation and this response was inhibited by pretreatment with transamine, an inhibitor of histamine release from histamine secreting cells. Histamine 199-208 gastrin Canis lupus familiaris 16-23 6127428-6 1982 Increased serum gastrin induced by perfusion of the antrum with liver extract solution disturbed receptive relaxation and this response was inhibited by pretreatment with transamine, an inhibitor of histamine release from histamine secreting cells. Histamine 222-231 gastrin Canis lupus familiaris 16-23 2124627-6 1990 Additionally, plasma gastrin concentrations were inversely related to plasma histamine concentrations, which provided indirect evidence for the presence of hyperacidity secondary to hyperhistaminemia (r2 = 57.7). Histamine 77-86 gastrin Canis lupus familiaris 21-28 9277419-3 1997 Thirty minutes later, acid secretion was stimulated first by sham feeding for 5 min, then, 60 min later, by an intravenous infusion of a maximum stimulatory dose of histamine (40 micrograms/kg) for 60 min, and after returning to basal, by intravenous infusion of a submaximal stimulatory dose of gastrin (200 pmol.kg-1.h-1) for 60 min. Histamine 165-174 gastrin Canis lupus familiaris 296-303 8930176-5 1996 Gastrin I (150 pg/ml) stimulated histamine release to a peak of 10.6 +/- 4.6 ng/min, which was inhibited to 2.1 +/- 0.5 ng/min by secretin (40 pg/ml). Histamine 33-42 gastrin Canis lupus familiaris 0-7 1285199-6 1992 After short-term culture, histamine was released in response to gastrin, cholecystokinin, carbachol, and forskolin. Histamine 26-35 gastrin Canis lupus familiaris 64-71 1384357-0 1992 Gastrin induction of histamine release from primary cultures of canine oxyntic mucosal cells. Histamine 21-30 gastrin Canis lupus familiaris 0-7 1384357-7 1992 Gastrin, carbachol, and forskolin increased histamine release from the LDF. Histamine 44-53 gastrin Canis lupus familiaris 0-7 1384357-8 1992 The induction of histamine release by gastrin was evident within 5 min and was sustained for at least 60 min. Histamine 17-26 gastrin Canis lupus familiaris 38-45 1384357-9 1992 The response to gastrin was dose dependent between concentrations of 10(-11) and 10(-8) M. In contrast, in the mast cell-enriched SCEF, basal release was higher and gastrin was without effect; however, concanavalin A stimulated and epinephrine inhibited histamine release indicating that histamine-release mechanisms were intact in this fraction. Histamine 254-263 gastrin Canis lupus familiaris 16-23 1384357-9 1992 The response to gastrin was dose dependent between concentrations of 10(-11) and 10(-8) M. In contrast, in the mast cell-enriched SCEF, basal release was higher and gastrin was without effect; however, concanavalin A stimulated and epinephrine inhibited histamine release indicating that histamine-release mechanisms were intact in this fraction. Histamine 288-297 gastrin Canis lupus familiaris 16-23 1384357-10 1992 Our methods provide a preparation of low density oxyntic mucosal histamine cells that demonstrate gastrin-responsive histamine release; we speculate that enterochromaffin-like cells account for this gastrin response. Histamine 65-74 gastrin Canis lupus familiaris 98-105 1384357-10 1992 Our methods provide a preparation of low density oxyntic mucosal histamine cells that demonstrate gastrin-responsive histamine release; we speculate that enterochromaffin-like cells account for this gastrin response. Histamine 65-74 gastrin Canis lupus familiaris 199-206 1675027-0 1991 Gastrin-histamine interactions: direct and paracrine elements. Histamine 8-17 gastrin Canis lupus familiaris 0-7 1675027-3 1991 There is also increasing evidence for a gastrin-inducible pool of histamine in the fundic mucosa which is presumably stored in histamine-enterochromaffin-like cells. Histamine 66-75 gastrin Canis lupus familiaris 40-47 1675027-3 1991 There is also increasing evidence for a gastrin-inducible pool of histamine in the fundic mucosa which is presumably stored in histamine-enterochromaffin-like cells. Histamine 127-136 gastrin Canis lupus familiaris 40-47 1675027-4 1991 From the vantage point of studies in the canine fundic mucosa, the issue is no longer which cell type has the gastrin receptor but to sort out the mechanisms by which the effects of the gastrin receptors on endocrine/paracrine (histamine and somatostatin) cells and exocrine (parietal) cells are integrated to regulate secretory function and mucosal growth and differentiation. Histamine 228-237 gastrin Canis lupus familiaris 186-193 10807412-7 2000 CONCLUSIONS: The mechanisms by which peptone-beer and peptone-ethanol stimulate gastric acid secretion may be mediated not only by increased plasma gastrin, but also by the action of histamine and acetylcholine coupled with the increased plasma gastrin. Histamine 183-192 gastrin Canis lupus familiaris 245-252 9227485-1 1997 Somatostatin is a potent inhibitor of gastrin-stimulated acid secretion by activation of somatostatin receptor type 2 (sst2) in vivo, probably in part by blocking gastrin-stimulated histamine release from enterochromaffin-like cells expressing sst2. Histamine 182-191 gastrin Canis lupus familiaris 38-45 9227485-1 1997 Somatostatin is a potent inhibitor of gastrin-stimulated acid secretion by activation of somatostatin receptor type 2 (sst2) in vivo, probably in part by blocking gastrin-stimulated histamine release from enterochromaffin-like cells expressing sst2. Histamine 182-191 gastrin Canis lupus familiaris 163-170 8949948-6 1996 Integrated histamine responses for 20 min to beer and wine paralleled gastrin concentrations and were of the same magnitude of those induced by intravenous infusion of pentagastrin at 1 and 6 micrograms/ kg/h, respectively. Histamine 11-20 gastrin Canis lupus familiaris 70-77 8949948-7 1996 We conclude that: 1) beer and red wine, but not pure ethanol, are potent releasers of histamine; 2) histamine release seems to be related to the gastrin response and probably occurs at the level of enterochromaffin-like (ECL) cells; 3) the ethanol content of these drinks is not important for their stimulant effect, indicating that some other components of beer and wine are responsible for gastrin and histamine release from the dog stomach. Histamine 100-109 gastrin Canis lupus familiaris 145-152 8949948-7 1996 We conclude that: 1) beer and red wine, but not pure ethanol, are potent releasers of histamine; 2) histamine release seems to be related to the gastrin response and probably occurs at the level of enterochromaffin-like (ECL) cells; 3) the ethanol content of these drinks is not important for their stimulant effect, indicating that some other components of beer and wine are responsible for gastrin and histamine release from the dog stomach. Histamine 100-109 gastrin Canis lupus familiaris 392-399 8949948-7 1996 We conclude that: 1) beer and red wine, but not pure ethanol, are potent releasers of histamine; 2) histamine release seems to be related to the gastrin response and probably occurs at the level of enterochromaffin-like (ECL) cells; 3) the ethanol content of these drinks is not important for their stimulant effect, indicating that some other components of beer and wine are responsible for gastrin and histamine release from the dog stomach. Histamine 100-109 gastrin Canis lupus familiaris 145-152 8949948-7 1996 We conclude that: 1) beer and red wine, but not pure ethanol, are potent releasers of histamine; 2) histamine release seems to be related to the gastrin response and probably occurs at the level of enterochromaffin-like (ECL) cells; 3) the ethanol content of these drinks is not important for their stimulant effect, indicating that some other components of beer and wine are responsible for gastrin and histamine release from the dog stomach. Histamine 100-109 gastrin Canis lupus familiaris 392-399 7990981-7 1994 In conclusion these data demonstrate that histamine H3 receptors may represent an effective mechanism for the negative control of stimulated gastric acid secretion in the dog; however, since the inhibition was mainly evident against stimuli which involve the release of histamine, a location of H3 receptors in paracrine cells of the gastric mucosa rather than in gastrin producing cells or parietal cells seems more likely. Histamine 42-51 gastrin Canis lupus familiaris 364-371 7502519-3 1994 Studies with cells isolated from the acid secreting canine oxyntic mucosa indicate that gastrin and cholinergic receptors are present on parietal cells, somatostatin cells, and the histamine-enterochromaffin-like cell (ECL). Histamine 181-190 gastrin Canis lupus familiaris 88-95 7692744-2 1993 The S6 monoclonal antibody to somatostatin, but not control antibodies, enhanced gastrin-stimulated histamine release. Histamine 100-109 gastrin Canis lupus familiaris 81-88 7692744-3 1993 In the presence of S6, the somatostatin analogue SMS-201-995 (10(-7) M) inhibited gastrin-stimulated histamine release by 95%. Histamine 101-110 gastrin Canis lupus familiaris 82-89 7692744-7 1993 Thus somatostatin selectively inhibited the gastrin-responsive histamine pool, which presumably is stored in oxyntic mucosal endocrine cells. Histamine 63-72 gastrin Canis lupus familiaris 44-51 7692744-9 1993 Furthermore, enhancement of gastrin-stimulated histamine release by immunoneutralization of somatostatin indicates an important role for endogenous somatostatin as a paracrine inhibitor of non-mast cell histamine release. Histamine 47-56 gastrin Canis lupus familiaris 28-35 7692744-9 1993 Furthermore, enhancement of gastrin-stimulated histamine release by immunoneutralization of somatostatin indicates an important role for endogenous somatostatin as a paracrine inhibitor of non-mast cell histamine release. Histamine 203-212 gastrin Canis lupus familiaris 28-35