PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6290232-4 1982 Gastrin binding was not inhibited by secretin, glucagon, Met-enkephalin, physalaemin, eledoisin, BPP, VIP, carbachol, histamine, atropine or cimetidine. Histamine 118-127 gastrin Oryctolagus cuniculus 0-7 6320314-4 1983 In the case of secretagogue stimulation (1) benzotript slightly affected histamine-induced AP (15% inhibition at 5 X 10(-3) M), proglumide did not; (2) both proglumide and benzotript inhibited in a non-competitive manner acetylcholine-induced AP; (3) these isolated cells were sensitive to gastrin and the dose-response curve for the stimulant was biphasic (maximum for 1 X 10(-9) M), suggesting a desensitization mechanism. Histamine 73-82 gastrin Oryctolagus cuniculus 290-297 2763388-0 1989 Cholecystokinin and gastrin inhibit histamine stimulated aminopyrine uptake in isolated rabbit gastric glands. Histamine 36-45 gastrin Oryctolagus cuniculus 20-27 6192726-10 1983 Somatostatin also acts indirectly to inhibit gastrin, perhaps by blocking the release of histamine from paracrine- or endocrinelike cells present in the glands. Histamine 89-98 gastrin Oryctolagus cuniculus 45-52 6282143-8 1982 Combinations of gastrin and histamine showed an additive response over a wide range of histamine concentrations. Histamine 87-96 gastrin Oryctolagus cuniculus 16-23 6282143-9 1982 However, time-course studies revealed a transient potentiation of gastrin response by histamine, which reached a peak at 15 min and was reduced to an additive response by 30 min. Histamine 86-95 gastrin Oryctolagus cuniculus 66-73 6282143-11 1982 The transient potentiation of the gastrin response by histamine was also found in the isolated cell preparation. Histamine 54-63 gastrin Oryctolagus cuniculus 34-41 6282143-13 1982 The results are interpreted to indicate that gastrin stimulates acid secretion through three separate actions: 1) a direct stimulation of parietal cell activity, 2) a potentiating interaction with histamine, and 3) for more intact preparations, a release of histamine, which in turn acts as a paracrine stimulus. Histamine 197-206 gastrin Oryctolagus cuniculus 45-52 6282143-13 1982 The results are interpreted to indicate that gastrin stimulates acid secretion through three separate actions: 1) a direct stimulation of parietal cell activity, 2) a potentiating interaction with histamine, and 3) for more intact preparations, a release of histamine, which in turn acts as a paracrine stimulus. Histamine 258-267 gastrin Oryctolagus cuniculus 45-52 15474551-12 2004 Divergent effects on histamine-stimulated acid secretion were observed; 18 hours pre-treatment with gastrin enhanced acid secretion by 50% but IL-1beta inhibited acid secretion in both control and gastrin pre-treated parietal cells. Histamine 21-30 gastrin Oryctolagus cuniculus 100-107 10594403-0 1999 Nalpha-methyl histamine and histamine stimulate gastrin release from rabbit G-cells via histamine H2-receptors. Histamine 14-23 gastrin Oryctolagus cuniculus 48-55 10594403-12 1999 Gastrin release was also stimulated by histamine (10-7-10-4 M) from a basal value of 3.0 +/- 0.3% to 5.4 +/- 0.5% TCC (P < 0.001). Histamine 39-48 gastrin Oryctolagus cuniculus 0-7 8750713-11 1995 Similarly, the CCK(B)/gastrin receptor antagonists were tested against histamine-induced [14C]aminopyrine accumulation and surprisingly, only compound L-365,260 appeared active and even more potent than cimetidine. Histamine 71-80 gastrin Oryctolagus cuniculus 22-29 90419-2 1979 An indirect stimulus like gastrin inducing one type of cell to liberate histamine which then acts on the oxyntic cells will not be detectable because of the very high dilution of the liberated substance. Histamine 72-81 gastrin Oryctolagus cuniculus 26-33 90419-4 1979 There is no evidence that gastrin acts directly on the oxyntic cells but it does liberate histamine in a dose-effect relationship, which would in an intact stomach give histamine concentrations sufficient to effectively stimulate the acid secretion. Histamine 90-99 gastrin Oryctolagus cuniculus 26-33 90419-5 1979 Thus in the rabbit histamine seems to be a normal physiological mediator for gastrin stimulation. Histamine 19-28 gastrin Oryctolagus cuniculus 77-84 8638712-0 1996 Gastrin stimulation of histamine synthesis in enterochromaffin-like cells from rabbit fundic mucosa. Histamine 23-32 gastrin Oryctolagus cuniculus 0-7 8638712-1 1996 This work aimed to investigate the molecular role of gastrin in histamine synthesis in isolated rabbit fundic mucosal cells enriched in enterochromaffin-like (ECL) cells (37%). Histamine 64-73 gastrin Oryctolagus cuniculus 53-60 8638712-8 1996 We concluded that gastrin, acting through "gastrin/CCK-B type" receptors coupled to PTX-sensitive G protein, exerts a short-term regulation of histamine synthesis in gastric ECL cells by increasing both the affinity of HDC for L-histidine and the number of active enzyme molecules. Histamine 143-152 gastrin Oryctolagus cuniculus 18-25 8638712-8 1996 We concluded that gastrin, acting through "gastrin/CCK-B type" receptors coupled to PTX-sensitive G protein, exerts a short-term regulation of histamine synthesis in gastric ECL cells by increasing both the affinity of HDC for L-histidine and the number of active enzyme molecules. Histamine 143-152 gastrin Oryctolagus cuniculus 43-50 7692707-2 1993 Gastrin (HG-17), pentagastrin and CCK-8 (C-terminal octapeptide of cholecystokinin) dose-dependently stimulated histamine release (EC50, respectively, 0.126 +/- 0.03, 0.92 +/- 0.15 and 0.211 +/- 0.025 nM) and somatostatin inhibited this release. Histamine 112-121 gastrin Oryctolagus cuniculus 0-7 7692707-3 1993 PGE1, PGE2 and PGD2 alone were unable to enhance histamine release even at high concentrations but, when used in combination with gastrin of CCK-8, the release of histamine caused by these peptides was potentiated (about 1.5- to 2-fold). Histamine 163-172 gastrin Oryctolagus cuniculus 130-137 1341064-4 1992 Both gastrin and acetylcholine release histamine from histamine-containing cells. Histamine 39-48 gastrin Oryctolagus cuniculus 5-12 1341064-4 1992 Both gastrin and acetylcholine release histamine from histamine-containing cells. Histamine 54-63 gastrin Oryctolagus cuniculus 5-12 1714275-11 1991 CCK-8 interacts with both receptor-types with the same affinity; (ii) the release of histamine from histamine-containing cells could be induced following "gastrin-type" receptors activation; (iii) somatostatin release from D-cells present in this non-parietal cells population could be induced following "CCK-type" receptors activation. Histamine 85-94 gastrin Oryctolagus cuniculus 155-162 1714275-11 1991 CCK-8 interacts with both receptor-types with the same affinity; (ii) the release of histamine from histamine-containing cells could be induced following "gastrin-type" receptors activation; (iii) somatostatin release from D-cells present in this non-parietal cells population could be induced following "CCK-type" receptors activation. Histamine 100-109 gastrin Oryctolagus cuniculus 155-162 1714276-2 1991 In the preceding paper, by means of selective agonists to gastrin (HG-17) and cholecystokinin (CCK-39), we evidenced the existence of "gastrin-type" receptors that could regulate histamine release and "CCK-type" receptors that could stimulate somatostatin release in isolated rabbit fundic non-parietal cells (F1 cells). Histamine 179-188 gastrin Oryctolagus cuniculus 58-65 1714276-2 1991 In the preceding paper, by means of selective agonists to gastrin (HG-17) and cholecystokinin (CCK-39), we evidenced the existence of "gastrin-type" receptors that could regulate histamine release and "CCK-type" receptors that could stimulate somatostatin release in isolated rabbit fundic non-parietal cells (F1 cells). Histamine 179-188 gastrin Oryctolagus cuniculus 135-142 1714276-9 1991 These results led to conclude: (i) the existence of a "gastrin-type" receptor related to histamine release: (ii) the existence of a "CCK-A-type" receptor related to somatostatin release; (iii) the existence of "gastrin type" and "CCK-A-type" receptors linked to the phosphoinositide breakdown pathway. Histamine 89-98 gastrin Oryctolagus cuniculus 55-62