PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 3095942-3 1986 Exogenous carnosine was degraded in the body by carnosinase and histidine decarboxylase to yield histamine. Histamine 97-106 histidine decarboxylase Rattus norvegicus 64-87 4083043-4 1985 Histamine, but not pentagastrin, is known to evoke gastric acid secretion in the nephrectomized rat, and histamine, but not pentagastrin, was found to lower the serum gastrin level and the gastric histidine decarboxylase activity, indicating that after nephrectomy gastrin was still secreted and that the secretion could be suppressed by increased acid output. Histamine 105-114 histidine decarboxylase Rattus norvegicus 197-220 3728207-1 1986 The hypothesis of a causal relationship between a progressive and unrestrained increase of tissue histamine formation by activation of an inducible histidine decarboxylase (HDC) and lethality in endotoxic shock (Schayer"s "induced histamine concept") was tested in a standardized rat endotoxic shock model. Histamine 98-107 histidine decarboxylase Rattus norvegicus 148-171 3728207-1 1986 The hypothesis of a causal relationship between a progressive and unrestrained increase of tissue histamine formation by activation of an inducible histidine decarboxylase (HDC) and lethality in endotoxic shock (Schayer"s "induced histamine concept") was tested in a standardized rat endotoxic shock model. Histamine 98-107 histidine decarboxylase Rattus norvegicus 173-176 3728207-1 1986 The hypothesis of a causal relationship between a progressive and unrestrained increase of tissue histamine formation by activation of an inducible histidine decarboxylase (HDC) and lethality in endotoxic shock (Schayer"s "induced histamine concept") was tested in a standardized rat endotoxic shock model. Histamine 231-240 histidine decarboxylase Rattus norvegicus 148-171 3728207-1 1986 The hypothesis of a causal relationship between a progressive and unrestrained increase of tissue histamine formation by activation of an inducible histidine decarboxylase (HDC) and lethality in endotoxic shock (Schayer"s "induced histamine concept") was tested in a standardized rat endotoxic shock model. Histamine 231-240 histidine decarboxylase Rattus norvegicus 173-176 2420333-12 1986 Both release of endogenous histamine and formation of radiolabeled histamine from labeled histidine were inhibited by the histidine decarboxylase inhibitor alpha-fluoromethylhistidine (10 microM). Histamine 27-36 histidine decarboxylase Rattus norvegicus 122-145 2420333-12 1986 Both release of endogenous histamine and formation of radiolabeled histamine from labeled histidine were inhibited by the histidine decarboxylase inhibitor alpha-fluoromethylhistidine (10 microM). Histamine 67-76 histidine decarboxylase Rattus norvegicus 122-145 6313401-1 1983 The data suggest that estradiol enhances the formation of histamine in rat uterus by induction of histidine decarboxylase; histamine activates adenylate cyclase providing accumulation of cyclic 3",5"-AMP, which, probably, induces glycolytic enzymes via phosphorylation of chromatin proteins, and mediates other estradiol effects. Histamine 58-67 histidine decarboxylase Rattus norvegicus 98-121 4058657-2 1985 For our assay conditions, we determined a Km for L-histidine of 320 microM and a Vmax for histidine decarboxylase of 110 pmol histamine/hr/mg protein in rat hypothalamus. Histamine 126-135 histidine decarboxylase Rattus norvegicus 90-113 4050476-5 1985 Interestingly, however, endocrine cells in the oxyntic mucosa (the histamine-containing ECL cells) proliferated greatly and the pentagastrin- and cholecystokinin octapeptide-induced activation of the histamine-forming enzyme, histidine decarboxylase, in these cells was much greater than in control rats. Histamine 67-76 histidine decarboxylase Rattus norvegicus 226-249 6651615-2 1983 We studied rat aortic endothelial and smooth muscle cell de novo histamine synthesis mediated by histidine decarboxylase (HD) and the effects of its inhibition by alpha-hydrazinohistidine on the intracellular histamine content and intraaortic albumin accumulation in streptozotocin-induced diabetes. Histamine 65-74 histidine decarboxylase Rattus norvegicus 97-120 6355911-1 1983 Histamine-containing cells in rats were identified by indirect immunofluorescent histochemistry using an antibody raised against histidine decarboxylase (HDC), the enzyme forming histamine, which was purified from fetal rat liver. Histamine 0-9 histidine decarboxylase Rattus norvegicus 129-152 6355911-1 1983 Histamine-containing cells in rats were identified by indirect immunofluorescent histochemistry using an antibody raised against histidine decarboxylase (HDC), the enzyme forming histamine, which was purified from fetal rat liver. Histamine 0-9 histidine decarboxylase Rattus norvegicus 154-157 6355911-1 1983 Histamine-containing cells in rats were identified by indirect immunofluorescent histochemistry using an antibody raised against histidine decarboxylase (HDC), the enzyme forming histamine, which was purified from fetal rat liver. Histamine 179-188 histidine decarboxylase Rattus norvegicus 129-152 6355911-1 1983 Histamine-containing cells in rats were identified by indirect immunofluorescent histochemistry using an antibody raised against histidine decarboxylase (HDC), the enzyme forming histamine, which was purified from fetal rat liver. Histamine 179-188 histidine decarboxylase Rattus norvegicus 154-157 7056851-11 1982 The increase in glomerular histamine was blocked by the histidine decarboxylase inhibitor bromocresine. Histamine 27-36 histidine decarboxylase Rattus norvegicus 56-79 6669925-6 1983 Histamine mobilization from gastric endocrine cells is reflected in the activity of gastric histidine decarboxylase. Histamine 0-9 histidine decarboxylase Rattus norvegicus 92-115 6191521-1 1983 Histidine decarboxylase activity in rat peritoneal mast cells is depressed temporarily after histamine secretion induced by antigen in sensitized cells or by compound 48/80. Histamine 93-102 histidine decarboxylase Rattus norvegicus 0-23 7282485-10 1981 The increases in tissue histamine concentrations observed in the tissues analyzed generally reflected the changes and magnitudes of enzyme activities for HMT and HDC. Histamine 24-33 histidine decarboxylase Rattus norvegicus 162-165 6108701-0 1980 Induction of gastric histamine synthesis by H2-receptor antagonists: potentiation of their antisecretory activity by histidine decarboxylase inhibitors. Histamine 21-30 histidine decarboxylase Rattus norvegicus 117-140 7202943-2 1981 The distribution of histamine in the various density-gradient fractions was highly correlated with that for both histidine decarboxylase and DOPA-decarboxylase. Histamine 20-29 histidine decarboxylase Rattus norvegicus 113-136 102131-2 1978 We have studied the dynamics of cyclic compound formation between histamine or histidine and pyridoxal 5"-phosphate (Hi-PLP or His-PLP) in incubates of rat gastric mucosa histidine decarboxylase (HD), rat intestinal diamine oxidase (DAO) or homogenates of either rat liver, intestine or gastric mucosa. Histamine 66-75 histidine decarboxylase Rattus norvegicus 171-194 6246414-3 1980 The data suggest that estradiol enhances by induction of histidine decarboxylase the formation of histamine, the latter activates adenylate cyclase providing accumulation of cyclic 3",5"-AMP, which, probably, induces glycolytic enzymes through phosphorylation of chromatin proteins, and mediates other estradiol effects. Histamine 98-107 histidine decarboxylase Rattus norvegicus 57-80 119426-3 1979 It is suggested that a higher gastric acid secretion is secondary to histamine production in gastric mucosa, induced by acetylcholine yields gastrin yields histidine decarboxylase mechanism. Histamine 69-78 histidine decarboxylase Rattus norvegicus 156-179 210651-6 1978 In the pathogenesis of the histamine alteration the increased histidine content in the brain of uremic rats must be considered, since the specific histidine decarboxylase is not saturated by the normal endogenous level of the amino acid precursor. Histamine 27-36 histidine decarboxylase Rattus norvegicus 147-170 856608-6 1977 Results suggest that the increased level of serum histamine is the consequence of the increased activity of histidine decarboxylase in the tissues and a rapid elimination of the newly formed histamine into the blood. Histamine 50-59 histidine decarboxylase Rattus norvegicus 108-131 686917-0 1978 Urinary methylhistamine as an index of histamine formation during histidine decarboxylase inhibition in the rat. Histamine 14-23 histidine decarboxylase Rattus norvegicus 66-89 685766-0 1978 Regulation of histamine synthesis: metiamide-induced synthesis of histamine in the rat stomach and the effect of histidine decarboxylase inhibitors on the elevated 14C-histamine level and histidine decarboxylase activity [proceedings]. Histamine 14-23 histidine decarboxylase Rattus norvegicus 113-136 685766-0 1978 Regulation of histamine synthesis: metiamide-induced synthesis of histamine in the rat stomach and the effect of histidine decarboxylase inhibitors on the elevated 14C-histamine level and histidine decarboxylase activity [proceedings]. Histamine 14-23 histidine decarboxylase Rattus norvegicus 188-211 903603-1 1977 The quantitative histologic distribution of pyridoxal phosphate (PLP), the coenzyme of histidine decarboxylase in the biosynthesis of histamine as well as the coenzyme of other enzyme systems, was established in the rat glandular stomach in different secretory states. Histamine 134-143 histidine decarboxylase Rattus norvegicus 87-110 894608-4 1977 Kinetic analysis of enzyme-catalysed histidine decarboxylation in extracts from untreated vagotomized and from histamine-treated vagotomized rats showed that the histamine-induced suppression of histidine decarboxylase activity probably reflects a reduced enzyme concentration. Histamine 111-120 histidine decarboxylase Rattus norvegicus 195-218 894608-4 1977 Kinetic analysis of enzyme-catalysed histidine decarboxylation in extracts from untreated vagotomized and from histamine-treated vagotomized rats showed that the histamine-induced suppression of histidine decarboxylase activity probably reflects a reduced enzyme concentration. Histamine 162-171 histidine decarboxylase Rattus norvegicus 195-218 894608-6 1977 These observations suggest that administration of histamine not only inhibits enzyme synthesis but also causes an accelerated rate of elimination of histidine decarboxylase.3. Histamine 50-59 histidine decarboxylase Rattus norvegicus 149-172 67049-3 1977 The results suggest a) that histamine release and histidine decarboxylase activation are independent events, and b) that microtubules are involved in the release of histamine. Histamine 165-174 histidine decarboxylase Rattus norvegicus 50-73 5573952-1 1971 Histamine content of rat brain was lowered quickly by inhibitors of histidine decarboxylase, suggesting that a portion of brain histamine turns over rapidly. Histamine 0-9 histidine decarboxylase Rattus norvegicus 68-91 5898-0 1976 Histidine decarboxylase-mediated histamine synthesis in glomeruli from rat kidneys. Histamine 33-42 histidine decarboxylase Rattus norvegicus 0-23 185510-3 1976 It has been found that pentagastrin induces histidine decarboxylase in gastric mucosa, ensuring local accumulation of histamine. Histamine 118-127 histidine decarboxylase Rattus norvegicus 44-67 185510-8 1976 The findings raise the possibility that histamine and 3",5"-AMP, mediating gastrin action, form together with enzymes (histidine decarboxylase, adenylate cyclase, protein kinase, carbonic anhydrase) a caascade of amplifiers. Histamine 40-49 histidine decarboxylase Rattus norvegicus 119-142 6600-5 1976 The histidine decarboxylase assay permits measurement of nanogram quantities of newly formed histamine from as few as 2 X 10(4) rat peritoneal mast cells or rat basophilic leukemia cells with an error of less than 5 per cent. Histamine 93-102 histidine decarboxylase Rattus norvegicus 4-27 5138032-0 1971 Histamine in rat brain: sensitive assay of endogenous levels, formation in vivo and lowering by inhibitors of histidine decarboxylase. Histamine 0-9 histidine decarboxylase Rattus norvegicus 110-133 5573952-1 1971 Histamine content of rat brain was lowered quickly by inhibitors of histidine decarboxylase, suggesting that a portion of brain histamine turns over rapidly. Histamine 128-137 histidine decarboxylase Rattus norvegicus 68-91 27444242-5 2016 (ii) Expression of the histamine-synthesizing enzyme, histidine decarboxylase (HDC) by western blot and (iii) thioperamide an H3 histamine receptor antagonist, on an object recognition memory task. Histamine 23-32 histidine decarboxylase Rattus norvegicus 54-77 5772595-1 1969 Effect of histidine decarboxylase inhibitors on rates of decline of tissue 3H-histamine in the female rat. Histamine 75-87 histidine decarboxylase Rattus norvegicus 10-33 27997552-4 2016 We tested the hypothesis that the rate-limiting enzyme for histamine biosynthesis, L-histidine decarboxylase (HDC), would be up-regulated during chronic rapid eye movement sleep deprivation (REM-SD) because histamine plays a major role in maintaining wakefulness. Histamine 59-68 histidine decarboxylase Rattus norvegicus 83-108 5765855-4 1969 Following inhibition of histamine formation by alpha-methyl histidine, a specific inhibitor of histidine decarboxylase, the rate of incorporation of [(14)C]leucine was substantially diminished in foetal but not in liver of the young.4. Histamine 24-33 histidine decarboxylase Rattus norvegicus 95-118 4161301-0 1966 [Action of an inhibitor of histidine decarboxylase on the liberation and reconstitution of cutaneous histamine in rats]. Histamine 101-110 histidine decarboxylase Rattus norvegicus 27-50 28453392-3 2017 We also quantitatively compared results of immunohistochemical labeling of the histamine-producing enzyme, histidine decarboxylase (HDC) in adult and aged MLVs. Histamine 79-88 histidine decarboxylase Rattus norvegicus 107-130 28453392-3 2017 We also quantitatively compared results of immunohistochemical labeling of the histamine-producing enzyme, histidine decarboxylase (HDC) in adult and aged MLVs. Histamine 79-88 histidine decarboxylase Rattus norvegicus 132-135 27997552-4 2016 We tested the hypothesis that the rate-limiting enzyme for histamine biosynthesis, L-histidine decarboxylase (HDC), would be up-regulated during chronic rapid eye movement sleep deprivation (REM-SD) because histamine plays a major role in maintaining wakefulness. Histamine 59-68 histidine decarboxylase Rattus norvegicus 110-113 27997552-4 2016 We tested the hypothesis that the rate-limiting enzyme for histamine biosynthesis, L-histidine decarboxylase (HDC), would be up-regulated during chronic rapid eye movement sleep deprivation (REM-SD) because histamine plays a major role in maintaining wakefulness. Histamine 207-216 histidine decarboxylase Rattus norvegicus 83-108 27997552-4 2016 We tested the hypothesis that the rate-limiting enzyme for histamine biosynthesis, L-histidine decarboxylase (HDC), would be up-regulated during chronic rapid eye movement sleep deprivation (REM-SD) because histamine plays a major role in maintaining wakefulness. Histamine 207-216 histidine decarboxylase Rattus norvegicus 110-113 27444242-5 2016 (ii) Expression of the histamine-synthesizing enzyme, histidine decarboxylase (HDC) by western blot and (iii) thioperamide an H3 histamine receptor antagonist, on an object recognition memory task. Histamine 23-32 histidine decarboxylase Rattus norvegicus 79-82 25575430-2 2015 Histidine decarboxylase regulates histamine synthesis. Histamine 34-43 histidine decarboxylase Rattus norvegicus 0-23 26275700-5 2015 Injection of chemokines in the rat skin provoke the recruitment of inflammatory cells, release of cytokines, and activation of transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, which may cause fatal anaphylactic shock. Histamine 220-229 histidine decarboxylase Rattus norvegicus 144-167 26275700-5 2015 Injection of chemokines in the rat skin provoke the recruitment of inflammatory cells, release of cytokines, and activation of transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, which may cause fatal anaphylactic shock. Histamine 220-229 histidine decarboxylase Rattus norvegicus 169-172 26980430-9 2016 Data suggest that in addition to the antihistaminic and inverse agonistic activities, certain antihistamines possess additional properties unrelated to receptor binding and alleviate nasal symptoms in the late phase by inhibiting synthesis and release of histamine by suppressing HDC gene transcription. Histamine 98-107 histidine decarboxylase Rattus norvegicus 280-283 25575430-12 2015 Carbon tetrachloride treatment enhanced biliary apoptosis, and decreased histidine decarboxylase and serum histamine levels and biliary proliferation, changes that were restored by histamine. Histamine 181-190 histidine decarboxylase Rattus norvegicus 73-96 21782040-2 2011 We have demonstrated that histamine signaling-related H1R and histidine decarboxylase (HDC) genes are allergic diseases sensitive genes and their expression level affects severity of the allergic symptoms. Histamine 26-35 histidine decarboxylase Rattus norvegicus 87-90 19596986-0 2009 Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions. Histamine 28-37 histidine decarboxylase Rattus norvegicus 151-174 20864504-1 2011 Data from rat models for alcohol preference and histidine decarboxylase knockout (HDC KO) mice suggest that brain histamine regulates alcohol-related behaviors. Histamine 114-123 histidine decarboxylase Rattus norvegicus 48-71 18360087-6 2008 Provocation with TDI also induced mRNA elevation of histidine decarboxylase, a sole histamine-forming enzyme, followed by the increase of both HDC activity and histamine content in nasal mucosa of allergy model rats. Histamine 84-93 histidine decarboxylase Rattus norvegicus 52-75 19352071-7 2009 These data suggest that oral administration of Kujin showed anti-allergic activity through suppression of histamine signaling by the inhibition of TDI-induced H1R and HDC mRNA elevations followed by decrease in H1R, HDC protein level, and histamine content in the nasal mucosa of TDI-sensitized rats. Histamine 106-115 histidine decarboxylase Rattus norvegicus 167-170 15447682-5 2004 The tyrosine hydroxylase positive dopaminergic sensor cells of juvenile rats express the histamine biosynthesis enzyme, histidine decarboxylase. Histamine 89-98 histidine decarboxylase Rattus norvegicus 120-143 17075268-0 2006 Dexamethasone suppresses histamine synthesis by repressing both transcription and activity of HDC in allergic rats. Histamine 25-34 histidine decarboxylase Rattus norvegicus 94-97 17075268-1 2006 BACKGROUND: Histamine synthesized by histidine decarboxylase (HDC) from L-histidine is a major chemical mediator in the development of nasal allergy which is characterized by nasal hypersensitivity. Histamine 12-21 histidine decarboxylase Rattus norvegicus 37-60 17075268-1 2006 BACKGROUND: Histamine synthesized by histidine decarboxylase (HDC) from L-histidine is a major chemical mediator in the development of nasal allergy which is characterized by nasal hypersensitivity. Histamine 12-21 histidine decarboxylase Rattus norvegicus 62-65 17075268-2 2006 However the regulatory mechanism of histamine synthesis by HDC remains to be elucidated. Histamine 36-45 histidine decarboxylase Rattus norvegicus 59-62 17075268-10 2006 CONCLUSIONS: These findings indicate that increased synthesis of histamine through up-regulation of HDC gene expression and HDC activity in nasal mucosa plays an important role in the development of nasal hypersensitivity. Histamine 65-74 histidine decarboxylase Rattus norvegicus 100-103 17075268-10 2006 CONCLUSIONS: These findings indicate that increased synthesis of histamine through up-regulation of HDC gene expression and HDC activity in nasal mucosa plays an important role in the development of nasal hypersensitivity. Histamine 65-74 histidine decarboxylase Rattus norvegicus 124-127 16923161-7 2006 Double immunostaining for HDC and NMDA receptor subunits showed that histamine neurons of the rat tuberomammillary nucleus express NMDA receptor subunit 1 (NR1) with NMDA receptor subunit 2A (NR2A) and NMDA receptor 2B subunit (NR2B). Histamine 69-78 histidine decarboxylase Rattus norvegicus 26-29 17924984-3 2008 Immunohistochemical analysis revealed that ischemia induces histamine (HA) accumulation in the core of the infarct 6-12 h post-ischemia, and in the penumbra at 24-48 h, although in situ hybridization failed to detect any histidine decarboxylase gene transcripts in these regions. Histamine 60-69 histidine decarboxylase Rattus norvegicus 221-244 17760865-3 2007 This TRH-induced suppression of food intake was attenuated partially in histamine-depleted rats pre-treated with alpha-fluoromethylhistidine (a specific suicide inhibitor of histidine decarboxylase) and in mice with targeted disruption of histamine H1 receptors. Histamine 72-81 histidine decarboxylase Rattus norvegicus 174-197 17531387-2 2007 Histamine is synthesized by histidine decarboxylase (HDC) from histidine. Histamine 0-9 histidine decarboxylase Rattus norvegicus 28-51 17531387-2 2007 Histamine is synthesized by histidine decarboxylase (HDC) from histidine. Histamine 0-9 histidine decarboxylase Rattus norvegicus 53-56 29435881-5 2006 The expression level of the active form (53 kDa) of L-histidine decarboxylase, the enzyme which synthesizes histamine, was partially suppressed by Mao. Histamine 108-117 histidine decarboxylase Rattus norvegicus 54-77 29435881-10 2006 From these results it is understood that Mao decreased histamine content by inhibiting cell proliferation and expression of histidine decarboxylase. Histamine 55-64 histidine decarboxylase Rattus norvegicus 124-147 15662050-9 2005 Pretreatment with the irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine, which is known to eliminate histamine from ECL cells, prevented the rise in microdialysate histamine. Histamine 130-139 histidine decarboxylase Rattus norvegicus 48-71 15662050-9 2005 Pretreatment with the irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine, which is known to eliminate histamine from ECL cells, prevented the rise in microdialysate histamine. Histamine 193-202 histidine decarboxylase Rattus norvegicus 48-71 15214862-12 2004 In neurones of the tuberomammillary nucleus, GABA(A)R alpha(2) and alpha(5) subunits were colocalized with histidine decarboxylase, a marker for histamine-containing neurones. Histamine 145-154 histidine decarboxylase Rattus norvegicus 107-130 15089748-1 2004 Full-length rat HDC (L-histidine decarboxylase) translated in reticulocyte cell lysate reactions is inactive, whereas C-terminally truncated isoforms are capable of histamine biosynthesis. Histamine 165-174 histidine decarboxylase Rattus norvegicus 16-19 15316670-1 2004 OBJECTIVE: Having previously demonstrated release of histamine from mast-cell-deficient rat aorta, the objective of this study was to determine and localize histamine synthesis capability in the aorta by detecting histidine decarboxylase (HDC), the enzyme that catalyzes histamine formation. Histamine 157-166 histidine decarboxylase Rattus norvegicus 214-237 15316670-1 2004 OBJECTIVE: Having previously demonstrated release of histamine from mast-cell-deficient rat aorta, the objective of this study was to determine and localize histamine synthesis capability in the aorta by detecting histidine decarboxylase (HDC), the enzyme that catalyzes histamine formation. Histamine 157-166 histidine decarboxylase Rattus norvegicus 239-242 15316670-1 2004 OBJECTIVE: Having previously demonstrated release of histamine from mast-cell-deficient rat aorta, the objective of this study was to determine and localize histamine synthesis capability in the aorta by detecting histidine decarboxylase (HDC), the enzyme that catalyzes histamine formation. Histamine 157-166 histidine decarboxylase Rattus norvegicus 214-237 15316670-1 2004 OBJECTIVE: Having previously demonstrated release of histamine from mast-cell-deficient rat aorta, the objective of this study was to determine and localize histamine synthesis capability in the aorta by detecting histidine decarboxylase (HDC), the enzyme that catalyzes histamine formation. Histamine 157-166 histidine decarboxylase Rattus norvegicus 239-242 15316670-7 2004 CONCLUSIONS: The results of this study are the first to demonstrate the presence of HDC mRNA and protein in rat aorta and more specifically in RASMC, indicative of their capability to synthesize histamine. Histamine 195-204 histidine decarboxylase Rattus norvegicus 84-87 14563668-1 2004 For the production and vesicle storage of histamine, Enterochromaffin-like (ECL) cells express histidine decarboxylase (HDC) and vesicular monoamine transporter 2 (VMAT2). Histamine 42-51 histidine decarboxylase Rattus norvegicus 95-118 14759558-10 2004 We suggest that the HDC-like immunoreactivity in the antrum represents a cross-reaction with non-HDC proteins and conclude that histamine and HDC are hallmark features of ECL cells but not of G cells. Histamine 128-137 histidine decarboxylase Rattus norvegicus 20-23 14563668-1 2004 For the production and vesicle storage of histamine, Enterochromaffin-like (ECL) cells express histidine decarboxylase (HDC) and vesicular monoamine transporter 2 (VMAT2). Histamine 42-51 histidine decarboxylase Rattus norvegicus 120-123 11956952-5 2002 Treatment with the H3R agonist known to decrease histamine neuron activity initially reduced HDC and galanin gene expression but an inverse change, presumably reflecting a compensatory mechanism, was observed after 3 h on both markers. Histamine 49-58 histidine decarboxylase Rattus norvegicus 93-96 12816760-1 2004 The enterochromaffin-like (ECL) cell controls gastric acid secretion via histamine, generated by l-histidine decarboxylase (HDC). Histamine 73-82 histidine decarboxylase Rattus norvegicus 124-127 12763636-8 2003 Inhibition of histamine uptake into ECL-cell granules by reserpine, a blocker of the vesicular monoamine transporter type-2, lowered the HDC activity and prevented the gastrin-induced HDC activation. Histamine 14-23 histidine decarboxylase Rattus norvegicus 137-140 12763636-8 2003 Inhibition of histamine uptake into ECL-cell granules by reserpine, a blocker of the vesicular monoamine transporter type-2, lowered the HDC activity and prevented the gastrin-induced HDC activation. Histamine 14-23 histidine decarboxylase Rattus norvegicus 184-187 12763636-9 2003 We suggest that HDC activation reflects enhanced transcription, translation and/or posttranslational enzyme activation as well as stabilization, and that a high cytosolic histamine concentration suppresses HDC activation. Histamine 171-180 histidine decarboxylase Rattus norvegicus 206-209 12414789-1 2003 Post-translational processing of the histamine-producing enzyme, L-histidine decarboxylase (HDC), leads to the formation of multiple carboxyl-truncated isoforms. Histamine 37-46 histidine decarboxylase Rattus norvegicus 65-90 12414789-1 2003 Post-translational processing of the histamine-producing enzyme, L-histidine decarboxylase (HDC), leads to the formation of multiple carboxyl-truncated isoforms. Histamine 37-46 histidine decarboxylase Rattus norvegicus 92-95 12816760-1 2004 The enterochromaffin-like (ECL) cell controls gastric acid secretion via histamine, generated by l-histidine decarboxylase (HDC). Histamine 73-82 histidine decarboxylase Rattus norvegicus 97-122 11459816-11 2001 Diverging effects of gastrin on histidine decarboxylase, chromogranin A, and vesicular monoamine transporter subtype 2 promoter may account for the coordinated synthesis and storage of histamine in this neuroendocrine cell type. Histamine 185-194 histidine decarboxylase Rattus norvegicus 32-55 11788786-5 2002 Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05). Histamine 212-221 histidine decarboxylase Rattus norvegicus 109-132 11788786-5 2002 Pretreatment of the rats with an ip bolus injection of alpha-fluoromethylhistidine, a suicide inhibitor of a histidine decarboxylase (HDC), at a dosage of 224 micromol/kg blocked the conversion of histidine into histamine and attenuated the suppressive effect of histidine on food intake from 64.2% to 88.1% of the controls (P < 0.05). Histamine 212-221 histidine decarboxylase Rattus norvegicus 134-137 10848618-2 2000 Gastrin is a peptide hormone that binds to the cholecystokinin B-gastrin receptor and regulates the activity of L-histidine decarboxylase (HDC), the enzyme that produces histamine. Histamine 170-179 histidine decarboxylase Rattus norvegicus 112-137 10913579-3 2000 alpha-Fluoromethylhistidine, an irreversible inhibitor of the histamine-forming enzyme, histidine decarboxylase depletes ECL-cell but not mast-cell histamine. Histamine 62-71 histidine decarboxylase Rattus norvegicus 88-111 10913579-4 2000 This report shows that the effectiveness by which histidine decarboxylase inhibition depletes ECL-cell histamine depends on the rate of histamine secretion. Histamine 103-112 histidine decarboxylase Rattus norvegicus 50-73 10913579-4 2000 This report shows that the effectiveness by which histidine decarboxylase inhibition depletes ECL-cell histamine depends on the rate of histamine secretion. Histamine 136-145 histidine decarboxylase Rattus norvegicus 50-73 10913579-8 2000 The half-life of oxyntic mucosal histamine (determined upon histidine decarboxylase inhibition) was 2.6 h in fed rats and 19.4 h in fasted rats. Histamine 33-42 histidine decarboxylase Rattus norvegicus 60-83 10913579-14 2000 In conclusion, the combination of histidine decarboxylase inhibition and a high rate of histamine secretion will promptly exhaust the ECL-cell histamine pool, while histidine decarboxylase inhibition and a low secretion rate will affect the histamine pool much less. Histamine 143-152 histidine decarboxylase Rattus norvegicus 34-57 10913579-14 2000 In conclusion, the combination of histidine decarboxylase inhibition and a high rate of histamine secretion will promptly exhaust the ECL-cell histamine pool, while histidine decarboxylase inhibition and a low secretion rate will affect the histamine pool much less. Histamine 143-152 histidine decarboxylase Rattus norvegicus 34-57 10848618-2 2000 Gastrin is a peptide hormone that binds to the cholecystokinin B-gastrin receptor and regulates the activity of L-histidine decarboxylase (HDC), the enzyme that produces histamine. Histamine 170-179 histidine decarboxylase Rattus norvegicus 139-142 10792508-1 2000 To identify histamine-producing cells at the late phase of allergic inflammation, the expression of L-histidine decarboxylase (HDC) was examined in the infiltrating leucocytes in the inflammatory locus. Histamine 12-21 histidine decarboxylase Rattus norvegicus 100-125 10955282-5 2000 These results suggest that the gastric histidine decarboxylase activity and plasma gastrin level are increased in connection with the depletion of insulin in streptozotocin-induced diabetic rats, and gastric acid secretion is stimulated at a basal level, presumably due to increases in the concentrations of histamine and gastrin in oxyntic mucosa. Histamine 308-317 histidine decarboxylase Rattus norvegicus 39-62 10893046-1 2000 OBJECTIVE AND DESIGN: L-Histidine decarboxylase (HDC) is the primary enzyme regulating histamine biosynthesis. Histamine 87-96 histidine decarboxylase Rattus norvegicus 22-47 10893046-1 2000 OBJECTIVE AND DESIGN: L-Histidine decarboxylase (HDC) is the primary enzyme regulating histamine biosynthesis. Histamine 87-96 histidine decarboxylase Rattus norvegicus 49-52 10893046-10 2000 CONCLUSIONS: L-Histidine uptaken by rat BMEC was shown to be converted to histamine, suggesting that HDC plays an important role in BBB. Histamine 74-83 histidine decarboxylase Rattus norvegicus 101-104 11025357-2 2000 AIMS: This study was designed to investigate how water extracts (WE) of Hp applied on rat gastric mucosa affect gastric secretion and mucosal histamine concentration as well as the gene expression for histamine decarboxylase (HDC), the key enzyme converting histidine to histamine and for interleukin-1beta (IL-1beta), the important proinflammatory cytokine. Histamine 201-210 histidine decarboxylase Rattus norvegicus 226-229 10343136-9 1999 This local and transient downregulation of HDC was accompanied by a similar decrease in ECL cell histamine. Histamine 97-106 histidine decarboxylase Rattus norvegicus 43-46 10580415-5 1999 These results indicate that leptin increases histamine turnover by affecting the posttranscriptional process of HDC formation or histamine release per se. Histamine 45-54 histidine decarboxylase Rattus norvegicus 112-115 10507457-2 1999 The formation of histamine is catalysed by the enzyme histidine decarboxylase. Histamine 17-26 histidine decarboxylase Rattus norvegicus 54-77 9722982-1 1998 Histidine decarboxylase catalyses the formation of histamine, an important biological messenger. Histamine 51-60 histidine decarboxylase Rattus norvegicus 0-23 9809794-1 1998 Histidine decarboxylase (HDC) catalyzes the formation of histamine, which takes part in a variety of physiological processes including gastric acid secretion, neurotransmission and inflammation. Histamine 57-66 histidine decarboxylase Rattus norvegicus 0-23 9809794-1 1998 Histidine decarboxylase (HDC) catalyzes the formation of histamine, which takes part in a variety of physiological processes including gastric acid secretion, neurotransmission and inflammation. Histamine 57-66 histidine decarboxylase Rattus norvegicus 25-28 9751525-4 1998 We used immunocytochemical methods to visualize histamine, histidine decarboxylase (HDC, the enzyme that converts histidine to histamine), and the type 1 vesicular monoamine transporter (VMAT1, the protein responsible for moving histamine into vesicles for storage and release). Histamine 127-136 histidine decarboxylase Rattus norvegicus 84-87 9751525-4 1998 We used immunocytochemical methods to visualize histamine, histidine decarboxylase (HDC, the enzyme that converts histidine to histamine), and the type 1 vesicular monoamine transporter (VMAT1, the protein responsible for moving histamine into vesicles for storage and release). Histamine 127-136 histidine decarboxylase Rattus norvegicus 84-87 9700103-1 1998 Histidine decarboxylase (HDC) is the primary enzyme regulating histamine biosynthesis. Histamine 63-72 histidine decarboxylase Rattus norvegicus 0-23 9700103-1 1998 Histidine decarboxylase (HDC) is the primary enzyme regulating histamine biosynthesis. Histamine 63-72 histidine decarboxylase Rattus norvegicus 25-28 9722982-2 1998 In spite of the essential biological functions exerted by histamine the knowledge about the mechanisms involved in the regulation of histidine decarboxylase is rather limited. Histamine 58-67 histidine decarboxylase Rattus norvegicus 133-156 9395296-3 1997 However, modification of the translated 74 kDa form of HDC in histamine-forming cells is unknown. Histamine 62-71 histidine decarboxylase Rattus norvegicus 55-58 9352362-11 1997 Steady-state levels of HDC mRNA levels were induced after 4 h. These results were confirmed by the higher amount of histamine release, compared to the control PBS, in the enucleated tissue from the MCP-1 injection sites. Histamine 116-125 histidine decarboxylase Rattus norvegicus 23-26 9202335-4 1997 ), a specific and irreversible inhibitor of histidine decarboxylase, reduced the histamine release to <35% of the basal value at 1% halothane anesthesia in the AHy, and also decreased the anesthetic requirement for halothane, evaluated as the minimum alveolar concentration (MAC), by 26%. Histamine 81-90 histidine decarboxylase Rattus norvegicus 44-67 9361993-1 1997 Glucose suppressed the activity of oxyntic mucosal histidine decarboxylase within 2 h when given either intragastrically or intraperitoneally to rats fasted for 24 h. Serum levels of gastrin, secretin, glucagon, and somatostatin and oxyntic mucosal levels of gastrin, histamine, and somatostatin showed no significant changes after glucose. Histamine 268-277 histidine decarboxylase Rattus norvegicus 51-74 8696935-0 1996 Histamine regulates the expression of histidine decarboxylase in N-nitroso-N-methylurea (NMU)-induced mammary tumors in rats. Histamine 0-9 histidine decarboxylase Rattus norvegicus 38-61 9166854-7 1997 In a Northern blot analysis from homogeneous tissue biopsy from the intradermal injection sites, RANTES was more potent than MCP-1 in increasing histidine decarboxylase (HDC) mRNA, the sole enzyme responsible for the production of histamine from histidine. Histamine 231-240 histidine decarboxylase Rattus norvegicus 145-168 9166854-7 1997 In a Northern blot analysis from homogeneous tissue biopsy from the intradermal injection sites, RANTES was more potent than MCP-1 in increasing histidine decarboxylase (HDC) mRNA, the sole enzyme responsible for the production of histamine from histidine. Histamine 231-240 histidine decarboxylase Rattus norvegicus 170-173 8898415-0 1996 Depletion of enterochromaffin-like cell histamine increases histidine decarboxylase and chromogranin A mRNA levels in rat stomach by a gastrin-independent mechanism. Histamine 40-49 histidine decarboxylase Rattus norvegicus 60-83 8898415-1 1996 BACKGROUND: Gastrin activates histidine decarboxylase (HDC) and increases HDC and chromogranin A (CGA) mRNA levels in histamine-producing enterochromaffin-like (ECL) cells in the rat stomach. Histamine 118-127 histidine decarboxylase Rattus norvegicus 74-77 8898415-2 1996 We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels. Histamine 20-29 histidine decarboxylase Rattus norvegicus 72-75 8898415-2 1996 We have studied how histamine depletion by subcutaneous infusion of the HDC inhibitor alpha-fluoromethyl-histidine (alpha-FMH) affects how ECL cells respond to hypergastrinemia in terms of HDC and CGA mRNA levels. Histamine 20-29 histidine decarboxylase Rattus norvegicus 189-192 8898415-11 1996 CONCLUSION: ECL-cell histamine depletion will increase mRNA levels for HDC and CGA by a gastrin-independent mechanism, possibly involving abolished histamine autofeedback inhibition. Histamine 21-30 histidine decarboxylase Rattus norvegicus 71-74 8928792-1 1996 The enzyme L-histidine decarboxylase (HDC; EC 4.1.1.22), which converts L-histidine to histamine, plays a key role in the regulation of acid secretion. Histamine 87-96 histidine decarboxylase Rattus norvegicus 11-36 8928792-1 1996 The enzyme L-histidine decarboxylase (HDC; EC 4.1.1.22), which converts L-histidine to histamine, plays a key role in the regulation of acid secretion. Histamine 87-96 histidine decarboxylase Rattus norvegicus 38-41 8594930-6 1995 These results suggest that IL-1 beta may stimulate synthesis and release of hypothalamic histamine in presynaptic terminals by activation of HDC and facilitate degradation of extracellular histamine by activation of MHT. Histamine 89-98 histidine decarboxylase Rattus norvegicus 141-144 9041686-2 1996 The key enzyme for the generation of histamine is histidine decarboxylase (HDC), which converts the amino acid L-histidine to histamine. Histamine 37-46 histidine decarboxylase Rattus norvegicus 50-73 9041686-2 1996 The key enzyme for the generation of histamine is histidine decarboxylase (HDC), which converts the amino acid L-histidine to histamine. Histamine 37-46 histidine decarboxylase Rattus norvegicus 75-78 9041686-2 1996 The key enzyme for the generation of histamine is histidine decarboxylase (HDC), which converts the amino acid L-histidine to histamine. Histamine 126-135 histidine decarboxylase Rattus norvegicus 50-73 9041686-2 1996 The key enzyme for the generation of histamine is histidine decarboxylase (HDC), which converts the amino acid L-histidine to histamine. Histamine 126-135 histidine decarboxylase Rattus norvegicus 75-78 8594930-3 1995 However, depletion of neuronal histamine induced by intraperitoneal injection of 160 mumol/rat alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the suppressive effect on drinking, and enhanced the elevating effect on rectal temperature. Histamine 31-40 histidine decarboxylase Rattus norvegicus 147-170 8569054-1 1995 Effects of carbachol and antigen (dinitrophenylated bovine serum albumin) on histamine release and histidine decarboxylase (HDC, the enzyme synthesizing histamine) activity were studied in 2H3-m1 cells, a subclone of rat basophilic leukemia cells that expresses human muscarinic m1 receptors through transfection with the gene. Histamine 153-162 histidine decarboxylase Rattus norvegicus 99-122 8653565-3 1995 Rats were pretreated with alpha-fluoromethylhistidine (a suicide inhibitor of histidine decarboxylase, a synthesizing enzyme of histamine), H1-receptor antagonist (chlorpheniramine maleate), H2-antagonist (cimetidine), or H3-antagonist (thioperamide) before ischemia-reperfusion (I/R). Histamine 128-137 histidine decarboxylase Rattus norvegicus 78-101 8653552-3 1995 Depletion of neuronal histamine in the hypothalamus induced by alpha-fluoromethylhistidine, a suicide inhibitor of the histamine synthesizing enzyme histidine decarboxylase (HDC), attenuated the suppressive effect of IL-1 beta on food intake, facilitated the inhibitory effect on water intake, and enhanced its thermogenic effect. Histamine 22-31 histidine decarboxylase Rattus norvegicus 149-172 8569054-1 1995 Effects of carbachol and antigen (dinitrophenylated bovine serum albumin) on histamine release and histidine decarboxylase (HDC, the enzyme synthesizing histamine) activity were studied in 2H3-m1 cells, a subclone of rat basophilic leukemia cells that expresses human muscarinic m1 receptors through transfection with the gene. Histamine 153-162 histidine decarboxylase Rattus norvegicus 124-127 7720459-6 1995 The increase of ornithine decarboxylase activity was attenuated when the increase of histamine synthesis was suppressed by the inhibition of histidine decarboxylase activity caused by pretreatment with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase. Histamine 85-94 histidine decarboxylase Rattus norvegicus 141-164 7586491-9 1995 Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development. Histamine 164-173 histidine decarboxylase Rattus norvegicus 81-106 7586491-9 1995 Administration of (S) alpha-fluoromethylhistidine (FMH), a specific inhibitor of L-histidine decarboxylase (HDC), significantly decreased both the HDC activity and histamine concentration during postnatal development. Histamine 164-173 histidine decarboxylase Rattus norvegicus 108-111 7720459-1 1995 We previously demonstrated that both histamine synthesis (histidine decarboxylase activity) and polyamine synthesis (ornithine decarboxylase activity) increased in the rat intestinal mucosa after ischemia-reperfusion, whereas the relationship between these two factors remains unclear. Histamine 37-46 histidine decarboxylase Rattus norvegicus 58-81 7720459-6 1995 The increase of ornithine decarboxylase activity was attenuated when the increase of histamine synthesis was suppressed by the inhibition of histidine decarboxylase activity caused by pretreatment with alpha-fluoromethylhistidine, a suicide inhibitor of histidine decarboxylase. Histamine 85-94 histidine decarboxylase Rattus norvegicus 254-277 7720459-8 1995 These results indicate that the newly synthesized histamine, as indicated by an increase of histidine decarboxylase activity, increases ornithine decarboxylase activity after ischemia-reperfusion of the rat intestinal mucosa. Histamine 50-59 histidine decarboxylase Rattus norvegicus 92-115 7537617-8 1994 At 4 and 8 h, only the liver showed a strong increase in HDC activity which can explain the increase in histamine content. Histamine 104-113 histidine decarboxylase Rattus norvegicus 57-60 1384983-5 1992 Histamine synthesis was inhibited with alpha-fluoromethylhistidine (3 mg.kg-1.h-1) given via osmotic minipumps over a period of 24 h. The treatment reduced the histidine decarboxylase activity (approximately 20% remaining) and histamine concentration (less than 20% remaining) in the oxyntic mucosa, as well as the intensity of histamine- and chromogranin A-immunostaining in the ECL cells, compared to control rats. Histamine 0-9 histidine decarboxylase Rattus norvegicus 160-183 8229845-2 1993 Histidine decarboxylase in the enterochromaffin-like cells of the gastric corpus mucosa converts histidine to histamine which in turn stimulates gastric acid secretion. Histamine 110-119 histidine decarboxylase Rattus norvegicus 0-23 8229845-14 1993 The results suggest that histamine-mediated changes in postprandial acid secretion depend on control of histidine decarboxylase mRNA levels, and that gastrin regulates production of this enzyme in the rat over periods of a few hours. Histamine 25-34 histidine decarboxylase Rattus norvegicus 104-127 1487235-1 1992 The formation of histamine from its precursor histidine is catalyzed by histidine decarboxylase (HDC), a pyridoxal phosphate (PLP)-dependent decarboxylase. Histamine 17-26 histidine decarboxylase Rattus norvegicus 72-95 1487235-1 1992 The formation of histamine from its precursor histidine is catalyzed by histidine decarboxylase (HDC), a pyridoxal phosphate (PLP)-dependent decarboxylase. Histamine 17-26 histidine decarboxylase Rattus norvegicus 97-100 8156416-1 1994 Intraperitoneal injection of alpha-fluoromethylhistidine (alpha-FMH; 200 mg/kg), a specific inhibitor of histidine decarboxylase produced a severe depletion of neocortical and hippocampal histamine 3 h later as determined by a radioenzymatic assay. Histamine 188-197 histidine decarboxylase Rattus norvegicus 105-128 1341077-8 1992 Recently, we could show that alpha-fluoromethylhistidine, which is a suicide inhibitor of histidine decarboxylase, effectively depletes the ECL cells of histamine and that the histamine-depleted ECL cells respond to gastrin with hyperplasia in a manner identical to normal ECL cells. Histamine 153-162 histidine decarboxylase Rattus norvegicus 90-113 1341077-8 1992 Recently, we could show that alpha-fluoromethylhistidine, which is a suicide inhibitor of histidine decarboxylase, effectively depletes the ECL cells of histamine and that the histamine-depleted ECL cells respond to gastrin with hyperplasia in a manner identical to normal ECL cells. Histamine 176-185 histidine decarboxylase Rattus norvegicus 90-113 1600560-1 1992 An antiserum against conjugated histamine and two oligonucleotide probes that detect the mRNA encoding L-histidine decarboxylase (HDC) involved in histamine synthesis were used to study the appearance of histamine and its location in the kidneys of fetal, newborn and young postnatal rats and in the kidneys of pregnant rats. Histamine 147-156 histidine decarboxylase Rattus norvegicus 103-128 1381000-1 1992 In rat basophilic leukemia cells (2H3), a tumor analog of mast cells, the aggregation of IgE receptors results in histamine secretion and the increase in histidine decarboxylase activity which synthesizes histamine. Histamine 205-214 histidine decarboxylase Rattus norvegicus 154-177 1600560-1 1992 An antiserum against conjugated histamine and two oligonucleotide probes that detect the mRNA encoding L-histidine decarboxylase (HDC) involved in histamine synthesis were used to study the appearance of histamine and its location in the kidneys of fetal, newborn and young postnatal rats and in the kidneys of pregnant rats. Histamine 147-156 histidine decarboxylase Rattus norvegicus 130-133 1600560-1 1992 An antiserum against conjugated histamine and two oligonucleotide probes that detect the mRNA encoding L-histidine decarboxylase (HDC) involved in histamine synthesis were used to study the appearance of histamine and its location in the kidneys of fetal, newborn and young postnatal rats and in the kidneys of pregnant rats. Histamine 147-156 histidine decarboxylase Rattus norvegicus 103-128 1600560-1 1992 An antiserum against conjugated histamine and two oligonucleotide probes that detect the mRNA encoding L-histidine decarboxylase (HDC) involved in histamine synthesis were used to study the appearance of histamine and its location in the kidneys of fetal, newborn and young postnatal rats and in the kidneys of pregnant rats. Histamine 147-156 histidine decarboxylase Rattus norvegicus 130-133 1729265-5 1992 These increases in HDC activity, and mucosal and lymph histamine levels were suppressed by pretreatment of alpha-fluoromethylhistidine (alpha-FMH), a suicide inhibitor of HDC. Histamine 55-64 histidine decarboxylase Rattus norvegicus 171-174 1559640-3 1992 To demonstrate the distribution of neuronal antibodies against histidine decarboxylase (HDC), the sole enzyme responsible for histamine formation, was used, although the purification of the HDC from fetal rat liver was a difficult task. Histamine 126-135 histidine decarboxylase Rattus norvegicus 63-86 1559640-3 1992 To demonstrate the distribution of neuronal antibodies against histidine decarboxylase (HDC), the sole enzyme responsible for histamine formation, was used, although the purification of the HDC from fetal rat liver was a difficult task. Histamine 126-135 histidine decarboxylase Rattus norvegicus 88-91 1559640-8 1992 alpha-Fluoromethylhistidine, a specific inhibitor of HDC, is a powerful tool for reducing the neuronal histamine in the brain. Histamine 103-112 histidine decarboxylase Rattus norvegicus 53-56 1414511-5 1992 As demonstrated in experiments with an inhibitor of histidine decarboxylase--semicarbazide, this effect comprised 15% inhibition evoked by the histamine precursor--histidine, whereas the remaining 60% inhibition could be ascribed to the effect of newly synthesized histamine. Histamine 143-152 histidine decarboxylase Rattus norvegicus 52-75 1414511-5 1992 As demonstrated in experiments with an inhibitor of histidine decarboxylase--semicarbazide, this effect comprised 15% inhibition evoked by the histamine precursor--histidine, whereas the remaining 60% inhibition could be ascribed to the effect of newly synthesized histamine. Histamine 265-274 histidine decarboxylase Rattus norvegicus 52-75 2053511-1 1991 The histaminergic neuron systems in rat brain have been identified by immunocytochemical techniques using antibodies against histidine decarboxylase or histamine itself. Histamine 4-13 histidine decarboxylase Rattus norvegicus 125-148 2015894-1 1991 The conversion of histidine to histamine by histidine decarboxylase (HDC) is of central importance in the control of vertebrate acid secretion. Histamine 31-40 histidine decarboxylase Rattus norvegicus 44-67 2015894-1 1991 The conversion of histidine to histamine by histidine decarboxylase (HDC) is of central importance in the control of vertebrate acid secretion. Histamine 31-40 histidine decarboxylase Rattus norvegicus 69-72 2377078-5 1990 The elevation in HDC activity in these tissues probably accounts for the increase in tissue and plasma concentrations of histamine in diabetic animals, since there is no change in histamine catabolism. Histamine 121-130 histidine decarboxylase Rattus norvegicus 17-20 2050296-4 1991 Activity of the two histamine-metabolizing enzymes, histidine decarboxylase (HD) and histamine N-methyl-transferase (HMT), were drastically lowered, by 40% (p less than 0.02) and 60% of control (p less than 0.05), respectively. Histamine 20-29 histidine decarboxylase Rattus norvegicus 52-75 2293080-1 1990 L-Histidine decarboxylase catalyzes the formation of histamine from the amino acid L-histidine. Histamine 53-62 histidine decarboxylase Rattus norvegicus 2-25 2293080-3 1990 The expression of mRNA for histidine decarboxylase was detected in the hypothalamic tuberomammillary nucleus that has been shown to contain histidine decarboxylase-like and histamine-like immunoreactivity, but not in any other brain area. Histamine 173-182 histidine decarboxylase Rattus norvegicus 27-50 19912749-1 1990 The recent cloning of a cDNA encoding fetal rat liver histidine decarboxylase (HDC), the synthesizing enzyme for histamine, allows the study of the central histaminergic system at the molecular level. Histamine 113-122 histidine decarboxylase Rattus norvegicus 54-77 19912749-1 1990 The recent cloning of a cDNA encoding fetal rat liver histidine decarboxylase (HDC), the synthesizing enzyme for histamine, allows the study of the central histaminergic system at the molecular level. Histamine 113-122 histidine decarboxylase Rattus norvegicus 79-82 2210091-2 1990 This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. Histamine 60-69 histidine decarboxylase Rattus norvegicus 87-110 2210091-2 1990 This was done by examining the effects of inhibition of the histamine-producing enzyme histidine decarboxylase (HDC) with alpha-fluoromethylhistidine (alpha-FMH) and the effects of degranulation of the mucosal mast cells with dexamethasone. Histamine 60-69 histidine decarboxylase Rattus norvegicus 112-115 2505088-2 1989 ), a specific inhibitor of histidine decarboxylase, significantly decreased the histamine content of the rat right atrium in a time-dependent manner; the maximal decrease of 22.2% was observed 4 h after injection. Histamine 80-89 histidine decarboxylase Rattus norvegicus 27-50 2325822-1 1990 Histidine decarboxylase, the synthetic enzyme for histamine, was partially purified from regions of rat or rabbit brain rich in the enzyme. Histamine 50-59 histidine decarboxylase Rattus norvegicus 0-23 2300558-2 1990 In biological systems the formation of histamine from its precursor histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC; L-histidine carboxy-lyase, EC 4.1.1.22). Histamine 39-48 histidine decarboxylase Rattus norvegicus 105-130 2300558-2 1990 In biological systems the formation of histamine from its precursor histidine is catalyzed by the enzyme L-histidine decarboxylase (HDC; L-histidine carboxy-lyase, EC 4.1.1.22). Histamine 39-48 histidine decarboxylase Rattus norvegicus 132-135 2512773-4 1989 A correlation was observed between histamine and histidine decarboxylase (p less than 0.01), both of them being even in the small intestine (11.8 +/- 2.3 ng/mg ww and 112.5 +/- 21.2 fmoles/hr/mg ww respectively), significantly higher in the caecum (16.3 +/- 1.9 and 178 +/- 20.1) and significantly smaller in the colon (7.3 +/- 1.1 and 65.3 +/- 11.5) than in other intestinal segments. Histamine 35-44 histidine decarboxylase Rattus norvegicus 49-72 2487969-5 1989 It was concluded that tetragastrin activated HDC which increased histamine release into the gastric contents. Histamine 65-74 histidine decarboxylase Rattus norvegicus 45-48 2521450-3 1989 Concomitantly, the activity of histidine decarboxylase, the enzyme responsible for histamine synthesis, was augmented. Histamine 83-92 histidine decarboxylase Rattus norvegicus 31-54 2521450-5 1989 These results suggest the pivotal role of activation of histidine decarboxylase, presumably through ADP-ribosylation of the enzyme, in interferon-induced histamine synthesis. Histamine 154-163 histidine decarboxylase Rattus norvegicus 56-79 2470688-7 1989 The histamine-production-increasing activity rose until 24 h after the antigen challenge, but fell at 48 h in parallel with changes both of histamine levels in the pouch fluid and histidine decarboxylase activity in inflammatory tissues. Histamine 4-13 histidine decarboxylase Rattus norvegicus 180-203 2476345-4 1989 To supplement the released histamine, the activity of histidine decarboxylase, a histamine-forming enzyme, increased 5-fold several hours after the stimulation by an IgE oligomer, and this increase may be mediated by protein kinase C system. Histamine 27-36 histidine decarboxylase Rattus norvegicus 54-77 3256940-9 1988 These results suggest that HDC-containing endocrine cells, in only the basal parts of the mucosal layer of the fundus, were similar to ECL cells and have important parts for biosynthesis of internal gastric histamine. Histamine 207-216 histidine decarboxylase Rattus norvegicus 27-30 2971025-1 1988 We examined retinal de novo histamine synthesis mediated by retinal histidine decarboxylase in normal and streptozotocin-diabetic male, Sprague Dawley rats that were diabetic for 21 days. Histamine 28-37 histidine decarboxylase Rattus norvegicus 68-91 2854108-1 1988 Histamine (HA) is synthesized from L-histidine by histidine decarboxylase (HDC), and HA released from neurons is predominantly methylated to tele-methylhistamine (t-MH), which is further metabolized by MAO. Histamine 0-9 histidine decarboxylase Rattus norvegicus 50-73 2854108-1 1988 Histamine (HA) is synthesized from L-histidine by histidine decarboxylase (HDC), and HA released from neurons is predominantly methylated to tele-methylhistamine (t-MH), which is further metabolized by MAO. Histamine 0-9 histidine decarboxylase Rattus norvegicus 75-78 3256940-2 1988 Histidine decarboxylase (HDC) is the only synthetic enzyme of histamine in the mast cell or enterochromaffin like (ECL) cell. Histamine 62-71 histidine decarboxylase Rattus norvegicus 0-23 3256940-2 1988 Histidine decarboxylase (HDC) is the only synthetic enzyme of histamine in the mast cell or enterochromaffin like (ECL) cell. Histamine 62-71 histidine decarboxylase Rattus norvegicus 25-28 2971025-4 1988 Results indicate that the retina contains an active histidine decarboxylase enzyme system, and that in streptozotocin diabetes retinal histamine synthesis is increased 197%. Histamine 135-144 histidine decarboxylase Rattus norvegicus 52-75 3367243-1 1988 Addition of concanavalin A (Con A) to a culture of spleen cells of ODS-od/od rats, which cannot synthesize ascorbic acid, increased the activity of histidine decarboxylase (HDC) in the culture, leading to accumulation of histamine (Hm) in the medium. Histamine 221-230 histidine decarboxylase Rattus norvegicus 148-171 3367243-1 1988 Addition of concanavalin A (Con A) to a culture of spleen cells of ODS-od/od rats, which cannot synthesize ascorbic acid, increased the activity of histidine decarboxylase (HDC) in the culture, leading to accumulation of histamine (Hm) in the medium. Histamine 221-230 histidine decarboxylase Rattus norvegicus 173-176 3367243-1 1988 Addition of concanavalin A (Con A) to a culture of spleen cells of ODS-od/od rats, which cannot synthesize ascorbic acid, increased the activity of histidine decarboxylase (HDC) in the culture, leading to accumulation of histamine (Hm) in the medium. Histamine 232-234 histidine decarboxylase Rattus norvegicus 148-171 3367243-1 1988 Addition of concanavalin A (Con A) to a culture of spleen cells of ODS-od/od rats, which cannot synthesize ascorbic acid, increased the activity of histidine decarboxylase (HDC) in the culture, leading to accumulation of histamine (Hm) in the medium. Histamine 232-234 histidine decarboxylase Rattus norvegicus 173-176 3367243-5 1988 At concentrations of more than 10(-10) M, exogenously added Hm suppressed the Con A-dependent uptake of [3H]thymidine by the lymphocytes, but it significantly augmented the response at 10(-14) M. The addition of ascorbic acid (10(-8)-10(-5) M) to the culture suppressed the Con A-mediated HDC induction and inhibited Hm biosynthesis. Histamine 60-62 histidine decarboxylase Rattus norvegicus 289-292 3268170-2 1988 Histamine- as well as histidine decarboxylase-immunoreactive cells were found within or in the vicinity of the plexus epithelium, with processes extending to the neighbouring epithelial cells or surrounding tissue, suggesting a specific function for histamine on the choroid plexus. Histamine 250-259 histidine decarboxylase Rattus norvegicus 22-45 3359251-2 1988 The cultures were examined after immunohistochemical localization of the histamine synthetic enzyme, L-histidine decarboxylase (HDC). Histamine 73-82 histidine decarboxylase Rattus norvegicus 128-131 2885414-5 1987 The histamine increase in the postanaphylactic phase was accompanied by the increase of histidine decarboxylase activity in inflammatory tissues. Histamine 4-13 histidine decarboxylase Rattus norvegicus 88-111