PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 8618029-4 1996 Based on histamine release from IgE-sensitized and nonsensitized basophil leukocytes of healthy donors, we detected anti-Fc epsilon RI alpha autoantibodies in sera from 38 (23%) urticaria patients and evidence for anti-IgE antibodies in a further nine patients. Histamine 9-18 Fc epsilon receptor Ia Homo sapiens 121-140 8618029-7 1996 Preincubation of sera or the IgG fraction with a recombinant alpha-chain of Fc epsilon RI inhibited histamine release from mast cells and basophils. Histamine 100-109 Fc epsilon receptor Ia Homo sapiens 76-89 8618029-9 1996 These studies demonstrate that circulating levels of anti-Fc epsilon RI alpha autoantibodies mediate histamine release from skin mast cells in vitro and, taken together with in vivo evidence of mast cell degranulation following intradermal injection of autologous serum, support the concept that anti-Fc epsilon RI alpha autoantibodies are relevant to the pathogenesis of severe chronic urticaria in about 25% of patients. Histamine 101-110 Fc epsilon receptor Ia Homo sapiens 58-77 8737919-3 1996 The nonselective inhibitor K252a suppressed Fc epsilon RI-mediated histamine release from basophils and skin mast cells dose-dependently with IC50 values of 0.01 and 0.28 mumol/l. Histamine 67-76 Fc epsilon receptor Ia Homo sapiens 44-57 7523523-6 1994 They release histamine in response to Fc epsilon RI-mediated stimulation, express Fc epsilon RI and BSP-1 ligand as analyzed by flow cytometry, and exhibit the known characteristic ultrastructural features of basophils by electron microscopy. Histamine 13-22 Fc epsilon receptor Ia Homo sapiens 38-51 7542518-5 1995 When we examined the relationship of histamine release and LTs production from AD donors induced through Fc epsilon RI, we found a significant exponential correlation between these two mediators (R2 = 0.58 in the absence of IL-3, R2 = 0.83 in the presence of IL-3). Histamine 37-46 Fc epsilon receptor Ia Homo sapiens 105-118 7543206-4 1995 Both the double mutant and wild-type hIgE-Fc bind to the high-affinity IgE receptor, Fc epsilon RI, with about the same affinity as myeloma IgE (Ka in the range 10(10)-10(11) M-1), and were able to sensitize isolated human basophils for anti-IgE triggering of histamine release. Histamine 260-269 Fc epsilon receptor Ia Homo sapiens 85-98 7525678-6 1994 Both FcERI-IgG and MaE11 completely abolished the AgE-induced contraction and histamine release in a dose-dependent manner. Histamine 78-87 Fc epsilon receptor Ia Homo sapiens 5-10 7622863-0 1995 Allergen-induced histamine release in rat mast cells transfected with the alpha subunits of Fc epsilon RI. Histamine 17-26 Fc epsilon receptor Ia Homo sapiens 92-105 7533185-10 1995 Heart mast cells released histamine in response to immunologic (anti-IgE, anti-Fc epsilon RI, and C5a) and nonimmunologic stimuli (recombinant human stem cell factor, A23187, and compound 48/80) but did not respond to substance P, FMLP, 12-O-tetradecanoylphorbol-13-acetate, or acetylcholine. Histamine 26-35 Fc epsilon receptor Ia Homo sapiens 79-92 7533185-13 1995 There was a linear correlation between the percentage of histamine secretion and tryptase release (r = 0.67; p < 0.001) induced by cross-linking of Fc epsilon RI. Histamine 57-66 Fc epsilon receptor Ia Homo sapiens 151-164 7506863-2 1993 The potent inhibitors Ro 31-7549, Ro 31-8220, calphostin C and ilmofosine (BM 41.440), which show selectivity for PKC in vitro, significantly potentiated Fc epsilon RI-mediated histamine release up to 50% vs. controls at concentrations > 10(-7) mumol/l but were without any intrinsic histamine releasing activity. Histamine 177-186 Fc epsilon receptor Ia Homo sapiens 154-167 7692457-3 1993 CGP 41251 exerted strong concentration-dependent inhibitory effects on Fc epsilon RI-mediated histamine release from both cell populations. Histamine 94-103 Fc epsilon receptor Ia Homo sapiens 71-84 7685756-13 1993 Both proteins blocked the release of histamine from RBL cells expressing human Fc epsilon RI alpha in a dose-dependent manner. Histamine 37-46 Fc epsilon receptor Ia Homo sapiens 79-98 7506863-2 1993 The potent inhibitors Ro 31-7549, Ro 31-8220, calphostin C and ilmofosine (BM 41.440), which show selectivity for PKC in vitro, significantly potentiated Fc epsilon RI-mediated histamine release up to 50% vs. controls at concentrations > 10(-7) mumol/l but were without any intrinsic histamine releasing activity. Histamine 287-296 Fc epsilon receptor Ia Homo sapiens 154-167 1710221-7 1991 Both classes of antibodies bind to natural Fc epsilon RI present on human basophils and induce histamine release from these cells. Histamine 95-104 Fc epsilon receptor Ia Homo sapiens 43-56 7686798-12 1993 The negative correlation between anti-IgE and FMP-induced histamine release in unresponsive basophils may suggest individual differences in the ratio of Fc epsilon RI and FMP receptors on the surface of basophils. Histamine 58-67 Fc epsilon receptor Ia Homo sapiens 153-166 14616869-9 2003 FcepsilonRI cross-linking resulted in intracellular calcium mobilization, histamine release and synthesis of cysteinyl leukotrienes. Histamine 74-83 Fc epsilon receptor Ia Homo sapiens 0-11 2693365-7 1989 In man, only IgE binds to the high-affinity Fc receptors (Fc epsilon RI) on mast cells and basophils and induces histamine and leukotriene release. Histamine 113-122 Fc epsilon receptor Ia Homo sapiens 58-71 35159247-2 2022 The high-affinity receptor for IgE (FceRI) is expressed on the basophil cell surface and powerful inflammatory mediators such as histamine, granzyme B, and cytokines are stored in dense cytoplasmic granules, ready to be secreted in response to a range of immune stimuli. Histamine 129-138 Fc epsilon receptor Ia Homo sapiens 36-41 28292887-9 2017 Mediator release assays confirm that FcepsilonRI-mediated calcium influx through Orai is necessary for histamine and TNFalpha release but is differentially involved in the generation of cytokines and eicosanoids. Histamine 103-112 Fc epsilon receptor Ia Homo sapiens 37-48 31629474-1 2020 Mast cells express high-affinity IgE receptor (FcepsilonRI) on their surface, cross-linking of which leads to the immediate release of proinflammatory mediators such as histamine but also late-phase cytokine secretion, which are central to the pathogenesis of allergic diseases. Histamine 169-178 Fc epsilon receptor Ia Homo sapiens 47-58 30472514-2 2019 Aggregation of the high affinity IgE receptor (FcepsilonRI) eventually leads to the release of granule components such as histamine, as well as the de novo synthesis of inflammatory cytokines and lipid mediators. Histamine 122-131 Fc epsilon receptor Ia Homo sapiens 47-58 29454616-4 2018 Treatment with zoledronate significantly diminished exocytosis of mast cells, which was reflected by a decrease of FcepsilonRI-dependent histamine release compared to that in vehicle-treated mast cells. Histamine 137-146 Fc epsilon receptor Ia Homo sapiens 115-126 26706922-6 2016 Surface expression of FcepsilonRI was positively associated with FcepsilonRIalpha mRNA content, histamine content with HDC mRNA, and chymase activity with chymase mRNA. Histamine 96-105 Fc epsilon receptor Ia Homo sapiens 22-33 27650274-7 2016 FcepsilonRI cell surface expression, FcepsilonRIalpha-specific mRNA and FcepsilonRI-mediated histamine release are all augmented by IL-4, while histamine release elicited by the non-immunological stimulus, substance P, remains unaffected. Histamine 93-102 Fc epsilon receptor Ia Homo sapiens 37-83 26706922-9 2016 FcepsilonRI triggered histamine release was highly variable and was unrelated to FcepsilonRI expression but unexpectedly tightly correlated with histamine release elicited by Ca(2+) ionophore. Histamine 22-31 Fc epsilon receptor Ia Homo sapiens 0-11 26706922-9 2016 FcepsilonRI triggered histamine release was highly variable and was unrelated to FcepsilonRI expression but unexpectedly tightly correlated with histamine release elicited by Ca(2+) ionophore. Histamine 145-154 Fc epsilon receptor Ia Homo sapiens 0-11 26541454-6 2015 Moreover, ABS-IgE prevented histamine release from mast cells and basophils by neutralizing MGL_1304 not only in a free form in solution, but also on FcepsilonRI expressed on the cell surface without cell activation. Histamine 28-37 Fc epsilon receptor Ia Homo sapiens 150-161 22561855-1 2012 latilobum suppresses histamine release and calcium influx via down-regulation of FcepsilonRI alpha chain expression. Histamine 21-30 Fc epsilon receptor Ia Homo sapiens 81-98 23414213-8 2013 RESULTS: We demonstrated that FcepsilonRI stimulation promotes the generation of H1R-expressing macrophage-like cells with enhanced histamine biosynthesis and H1R-mediated proinflammatory properties. Histamine 132-141 Fc epsilon receptor Ia Homo sapiens 30-41 23163656-3 2012 While fundamental MC properties (FcepsilonRI, c-Kit, tryptase; histamine release upon FcepsilonRI cross-linking) were unaffected or slightly reduced (chymase) by testosterone, the hormone had a more profound impact on the production of cytokines, with IL-6 being a target (reduction by 53%). Histamine 63-72 Fc epsilon receptor Ia Homo sapiens 86-97 25257818-8 2015 In contrast, preincubation of mast cells with DARPin Fc fusion protein, a positive control for negative signalling via FcepsilonRI-FcgammaRIIb cross activation, significantly diminished histamine release. Histamine 186-195 Fc epsilon receptor Ia Homo sapiens 119-130 25271543-4 2014 While tryptase and chymase, the most specific markers, strongly decline, FcepsilonRI surface expression, and FcepsilonRI-mediated histamine release steeply increase (from 15.5% to 60%), replicated by similar increments in TNF-alpha secretion. Histamine 130-139 Fc epsilon receptor Ia Homo sapiens 109-120 25280024-2 2014 Mast cells mature under local tissue microenvironmental factors and are necessary for the development of allergic reactions, through crosslinking of their surface receptors for IgE (FcepsilonRI), leading to degranulation and the release of vasoactive, pro-inflammatory and nociceptive mediators that include histamine, pro-inflammatory and anti-inflammatory cytokines and proteolytic enzymes. Histamine 308-317 Fc epsilon receptor Ia Homo sapiens 182-193 24404388-6 2014 Genetic polymorphisms in histamine-related genes, including FcepsilonRI and HNMT, were suggested to be involved in mast cell activation and histamine metabolism. Histamine 25-34 Fc epsilon receptor Ia Homo sapiens 60-71 24404388-6 2014 Genetic polymorphisms in histamine-related genes, including FcepsilonRI and HNMT, were suggested to be involved in mast cell activation and histamine metabolism. Histamine 140-149 Fc epsilon receptor Ia Homo sapiens 60-71 22698521-3 2012 Histamine is one of the main mediators released on FcepsilonRI triggering of basophils and mast cells, and it exerts its functions through histamine receptors (HRs). Histamine 0-9 Fc epsilon receptor Ia Homo sapiens 51-62 22561855-4 2012 We determined that 6-methoxyluteolin inhibited anti-FcepsilonRI alpha chain antibody (CRA-1)-induced histamine release, as well as elevation of intracellular calcium concentration [Ca2+]i in a dose-dependent manner. Histamine 101-110 Fc epsilon receptor Ia Homo sapiens 52-69 22561855-6 2012 Therefore, these results show that 6- methoxyluteolin is a potent inhibitor of histamine release and calcium influx via down-regulation of the FcepsilonRI alpha chain. Histamine 79-88 Fc epsilon receptor Ia Homo sapiens 143-160 20863570-2 2010 This is particularly true for mast cells which play a key regulatory role in allergy and inflammation through activation via high-affinity IgE receptors (FceRI) leading to activation of signaling cascades and subsequent release of histamine and other pro-inflammatory mediators. Histamine 231-240 Fc epsilon receptor Ia Homo sapiens 154-159 22374203-6 2012 RESULTS: The time-course analysis of the mRNA expression of MC-related genes, including FcepsilonRI, in Kit(+) sorted cells during the differentiation and histamine experiments revealed that the expression level of FcepsilonRI in 5 week (w)-cultured MCs was not sufficient to induce degranulation following FcepsilonRI aggregation but that 5 w-cultured MCs were fully responsive to calcium ionophore. Histamine 155-164 Fc epsilon receptor Ia Homo sapiens 215-226 22374203-7 2012 By addition of IgE in culture medium FcepsilonRI expression level and FcepsilonRI-mediated histamine release of 5 w-cultured MCs were significantly increased compared with those without addition of IgE, whereas the expression level of tryptase and number of MCs was not affected. Histamine 91-100 Fc epsilon receptor Ia Homo sapiens 70-81 22374203-8 2012 Omalizumab significantly inhibited IgE-dependent enhancement of FcepsilonRI expression level and FcepsilonRI-mediated histamine release. Histamine 118-127 Fc epsilon receptor Ia Homo sapiens 97-108 21307580-1 2011 Human skin mast cells proliferated in the presence of interleukin (IL)-4+SCF (expanding 18-fold in 8 weeks) and acquired profound responsiveness towards high affinity IgE receptor (FcepsilonRI) cross-linking, liberating about 75% of their histamine. Histamine 239-248 Fc epsilon receptor Ia Homo sapiens 181-192 19026096-14 2009 These data show that in vitro basophil histamine release can be used to measure antibodies to FceRI, FceRII/CD23, or IgE and identify patients with autoimmune urticaria. Histamine 39-48 Fc epsilon receptor Ia Homo sapiens 94-99 19307764-7 2009 Kaempferol showed its suppressive effects on intracellular Ca2+ concentration and histamine release from anti-FcepsilonRI alpha- chain antibody-stimulated cells in a concentration-dependent manner. Histamine 82-91 Fc epsilon receptor Ia Homo sapiens 110-121 19650847-5 2009 It has only moderate specificity as a marker for functional autoantibodies against IgE or the high affinity IgE receptor (FcepsilonRI), detected by the basophil histamine release assay, but high negative predictive value for CU patients without them. Histamine 161-170 Fc epsilon receptor Ia Homo sapiens 122-133 19362683-1 2009 BACKGROUND: FcepsilonRI-mediated signal pathway in basophils and mast cells leads to release of histamine and other mediators. Histamine 96-105 Fc epsilon receptor Ia Homo sapiens 12-23 17125820-0 2007 Basophil FcepsilonRI histamine release parallels expression of Src-homology 2-containing inositol phosphatases in chronic idiopathic urticaria. Histamine 21-30 Fc epsilon receptor Ia Homo sapiens 9-20 18036650-9 2008 However, preincubation with Siglec-8 mAbs significantly (P < .05) inhibited FcepsilonRI-dependent histamine and prostaglandin D(2) release, Ca++ flux, and anti-IgE-evoked contractions of human bronchial rings. Histamine 101-110 Fc epsilon receptor Ia Homo sapiens 79-90 18541101-4 2008 At serum dilution of 12.5%, the mean percent of histamine liberation was 40.8% (range 18%-77%; normal <16.5%), which indicated the presence of autoantibodies to Fc epsilon RI and/or to the IgE-Fc epsilon RI complex. Histamine 48-57 Fc epsilon receptor Ia Homo sapiens 164-177 17967729-2 2007 Studies carried out during the last 2 decades have demonstrated an autoimmune pathogenesis mediated by functionally active autoantibodies to the high affinity IgE receptor (FcepsilonRI) or to IgE which are able to induce histamine release from basophils and mast cells. Histamine 221-230 Fc epsilon receptor Ia Homo sapiens 173-184 17372017-1 2007 Most human blood basophils respond to FcepsilonRI cross-linking by releasing histamine and other inflammatory mediators. Histamine 77-86 Fc epsilon receptor Ia Homo sapiens 38-49 18214796-6 2008 Surface expression and mRNA level of FcepsilonRIalpha and histamine release by crosslinking of FcepsilonRIalpha did not differ from one preparation to the next. Histamine 58-67 Fc epsilon receptor Ia Homo sapiens 95-111 17125820-3 2007 Basophils of patients with CIU have altered FcepsilonRI-mediated histamine release (HR); however, the mechanism is unknown. Histamine 65-74 Fc epsilon receptor Ia Homo sapiens 44-55 16918506-12 2006 Histamine release was not affected by short-term priming with IL-13, but was upregulated by priming for 5 days suggesting that this effect was mediated by the increased FcepsilonRI expression. Histamine 0-9 Fc epsilon receptor Ia Homo sapiens 169-180 16110160-3 2006 Crosslinkage of IgE receptor I (Fc epsilonRI) on cord blood-derived mast cells by myeloma IgE and anti-human IgE is used to induce histamine release. Histamine 131-140 Fc epsilon receptor Ia Homo sapiens 32-44 16499637-3 2006 OBJECTIVE: The aim of the present study was to investigate whether cross-linking of FcepsilonRI and FcgammaRIIB contributes to IgG-mediated inhibition of histamine release in human basophils in a system using the sera from specific immunotherapy (SIT) patients and the major allergen from birch pollen, Bet v 1. Histamine 154-163 Fc epsilon receptor Ia Homo sapiens 84-95 16227089-1 2005 Mast cells and basophils are the only cells expressing the tetrameric (alphabetagamma2) structure of the high affinity receptor for IgE (FcepsilonRI) and synthesizing histamine in humans. Histamine 167-176 Fc epsilon receptor Ia Homo sapiens 137-148 16008669-11 2005 However, only in a minority of patients in vitro functional evidence of histamine-releasing autoantibodies (anti-FcepsilonRI or anti-IgE) was obtained. Histamine 72-81 Fc epsilon receptor Ia Homo sapiens 113-124 16131914-5 2005 Recent work has confirmed that autoantibodies to FcepsilonRI can be functional, meaning that they can cause histamine release from basophils in vitro. Histamine 108-117 Fc epsilon receptor Ia Homo sapiens 49-60 12847486-15 2003 CONCLUSIONS: Basogranulin is secreted along with histamine in response to both FcepsilonR I-related and unrelated stimuli. Histamine 49-58 Fc epsilon receptor Ia Homo sapiens 79-91 15242876-5 2004 Coligation of LIR3 to LIR7 or to FcepsilonRI by means of a second monoclonal antibody significantly inhibited net histamine release, cysLT production, and IL-4 generation. Histamine 114-123 Fc epsilon receptor Ia Homo sapiens 33-44 12209081-1 2002 BACKGROUND: In human basophils, FcepsilonRI signal initiation, leading to histamine release, relies on activation of Syk protein tyrosine kinase. Histamine 74-83 Fc epsilon receptor Ia Homo sapiens 32-43 12738245-6 2003 However, several PAHs enhanced histamine release and IL-4 production in response to crosslinking the high-affinity IgE receptor, Fc epsilon RI. Histamine 31-40 Fc epsilon receptor Ia Homo sapiens 129-142 12558077-2 2003 Aggregation of the high affinity IgE receptor (FcepsilonRI) on mast cells triggers degranulation with the release of chemical mediators such as histamine, production of cytokines and leukotrienes. Histamine 144-153 Fc epsilon receptor Ia Homo sapiens 47-58 12385747-6 2002 Cross-linking of Fc epsilon RI by autoantibodies against the alpha-chain of the Fc epsilon RI, causing subsequent histamine release is thought to be involved in the pathogenesis of other diseases such as chronic idiopathic urticaria (CIU). Histamine 114-123 Fc epsilon receptor Ia Homo sapiens 17-30 12385747-6 2002 Cross-linking of Fc epsilon RI by autoantibodies against the alpha-chain of the Fc epsilon RI, causing subsequent histamine release is thought to be involved in the pathogenesis of other diseases such as chronic idiopathic urticaria (CIU). Histamine 114-123 Fc epsilon receptor Ia Homo sapiens 80-93 12236706-9 2002 The cross-linkage of FcepsilonRI causes the activation of basophils, which leads to the secretion of inflammatory mediators including histamine. Histamine 134-143 Fc epsilon receptor Ia Homo sapiens 21-32 12550104-1 2002 We examined whether interleukin (IL)-6 exerts the stimulatory effects on the secretion of histamine from human mast cells triggered by crosslinking of the high affinity IgE receptor (FcepsilonRI) with IgE and anti-IgE. Histamine 90-99 Fc epsilon receptor Ia Homo sapiens 183-194 12237101-6 2002 Treatment with PGA(1) or 15d-PGJ(2) separately also reduced histamine release from KU812 cells in response to cross-linkage of Fc epsilon RI. Histamine 60-69 Fc epsilon receptor Ia Homo sapiens 127-140 11398085-1 2001 BACKGROUND: Approximately 35% to 40% of patients with chronic urticaria possess a circulating antibody directed to the alpha subunit of the high-affinity type I IgE receptor (FcepsilonRI), which is detectable by using histamine release assays or immunoblotting. Histamine 218-227 Fc epsilon receptor Ia Homo sapiens 175-186 11994101-2 2002 OBJECTIVE: To evaluate the association between FcepsilonRI-mediated histamine release from basophils and four bi-allelic single nucleotide polymorphisms of the FcepsilonRI-beta gene. Histamine 68-77 Fc epsilon receptor Ia Homo sapiens 47-58 12214775-9 2002 IgE bound to FcepsilonRI sets off the release of inflammatory mediators, including histamine, leukotrienes and cytokines, and leads to eosinophilic infiltration and inflammation in the affected mucosa or skin. Histamine 83-92 Fc epsilon receptor Ia Homo sapiens 13-24 11641254-6 2001 These high-affinity antibodies recognize Fc(epsilon)RIalpha on cells and trigger histamine release from freshly isolated blood basophils. Histamine 81-90 Fc epsilon receptor Ia Homo sapiens 41-59 11641254-8 2001 The same conditional histamine release is seen when using sera from individual normal donors and affinity-purified anti-Fc(epsilon)RIalpha antibodies isolated from multidonor therapeutic IgG preparations. Histamine 21-30 Fc epsilon receptor Ia Homo sapiens 120-138 11799375-1 2002 BACKGROUND: Histamine release in chronic urticaria is initiated by cross-linking of the alpha subunit of FcepsilonRI by means of IgG antibody, followed by complement activation. Histamine 12-21 Fc epsilon receptor Ia Homo sapiens 105-116 11146388-0 2000 Inhibition of IgE-dependent histamine release from human peripheral blood basophils by humanized Fab fragments that recognize the membrane proximal domain of the human Fc epsilon RI alpha-chain. Histamine 28-37 Fc epsilon receptor Ia Homo sapiens 168-193 11222380-8 2001 These findings suggest that SH2 domain-mediated membrane translocation of Syk is essential for the FcepsilonRI-mediated activation of Syk for downstream signaling events leading to histamine release. Histamine 181-190 Fc epsilon receptor Ia Homo sapiens 99-110 11134951-2 2001 A Fab fragment (Fab) of a humanized antibody against the membrane proximal IgE-binding domain of human Fc(epsilon)RIalpha inhibits the release of histamine from human basophils. Histamine 146-155 Fc epsilon receptor Ia Homo sapiens 103-121 11067953-1 2000 Human basophils respond to Ag-induced cross-linking of their high affinity IgE receptor, FcepsilonRI, by releasing histamine and other mediators from granules, producing IL-4 and other cytokines and, as shown in this study, by forming membrane ruffles and showing increased very late Ag-4 (VLA-4)-mediated adhesion to VCAM-1-expressing target cells. Histamine 115-124 Fc epsilon receptor Ia Homo sapiens 89-100 11067953-5 2000 Furthermore, culturing nonreleaser basophils for 4 days with IL-3 restores Syk protein expression and FcepsilonRI-mediated histamine release. Histamine 123-132 Fc epsilon receptor Ia Homo sapiens 102-113 11129586-1 2000 Binding of allergen-IgE complexes to the high affinity IgE receptor (Fc epsilonRI) on mast cells and basophils leads to the release of various mediaters such as histamine. Histamine 161-170 Fc epsilon receptor Ia Homo sapiens 69-81 10931839-8 2000 In FcepsilonRI-stimulated mast cells, the total Syk tyrosine phosphorylation paralleled the phosphorylation of its activation loop tyrosines and downstream propagation of signals for histamine release. Histamine 183-192 Fc epsilon receptor Ia Homo sapiens 3-14 11129586-2 2000 Fab fragments prepared by the papain digestion of humanized antibody against human Fc epsilonRI inhibited the release of histamine from human basophils. Histamine 121-130 Fc epsilon receptor Ia Homo sapiens 83-95 9766628-8 1998 Fc epsilonRI cross-linking results in a time and dose-dependent release of histamine. Histamine 75-84 Fc epsilon receptor Ia Homo sapiens 0-12 10887319-1 2000 BACKGROUND: We previously found that persimmon leaf extract contains antiallergic substances that inhibit histamine release by human basophilic cell line KU812 in response to cross-linkage of FcepsilonRI. Histamine 106-115 Fc epsilon receptor Ia Homo sapiens 192-203 10208881-1 1999 Human cultured mast cells (HCMC) release histamine and sulfidoleukotrienes (LTs) upon IgE-FcepsilonRI-mediated mast cell activation. Histamine 41-50 Fc epsilon receptor Ia Homo sapiens 90-101 9647730-7 1998 In addition, IgE-mediated histamine release was observed, suggesting that the Fc epsilon RI induced by IL-4 was functional and was able to transduce a signal for degranulation. Histamine 26-35 Fc epsilon receptor Ia Homo sapiens 78-91 9802375-3 1998 METHODS: Basophil histamine release to the anti-Fc(epsilon)RI mAb 22E7, anti-IgE, and formyl-methionyl-leucyl-phenylalanine (fMLP); basophil numbers; and total cellular histamine were measured in 26 patients with CIU and 18 healthy control subjects. Histamine 18-27 Fc epsilon receptor Ia Homo sapiens 48-61 9802375-9 1998 CONCLUSION: Patients with autoantibodies have both markedly reduced basophil numbers and basophil histamine release to factors acting through Fc(epsilon)RI, which indicates either a residual pool of functionally distinct basophils or may be a consequence of desensitization of the Fc(epsilon)RI pathway. Histamine 98-107 Fc epsilon receptor Ia Homo sapiens 142-155 9179431-2 1997 Histamine and other chemical mediators are synthesized and immunologically released by human peripheral blood basophils and tissue mast cells (Fc epsilon RI+ cells). Histamine 0-9 Fc epsilon receptor Ia Homo sapiens 143-156 9421487-9 1998 Complement-activating properties of anti-FcepsilonRIalpha autoAbs can indeed be of pathogenetic relevance, because C5a receptor blockade on basophils as well as decomplementation reduced drastically the histamine-releasing capacity of most anti-FcepsilonRIalpha-reactive CU sera. Histamine 203-212 Fc epsilon receptor Ia Homo sapiens 41-57 8670335-8 1996 Isolated synovial mast cells released histamine in response to immunologic (anti-IgE and anti-Fc epsilon receptor I [anti-Fc epsilon RI]) and nonimmunologic (substance P, recombinant human stem cell factor, and 48/80) stimuli, but did not respond to recombinant human C5a in vitro. Histamine 38-47 Fc epsilon receptor Ia Homo sapiens 122-135 9014819-0 1996 Interferon-gamma promotes the survival and Fc epsilon RI-mediated histamine release in cultured human mast cells. Histamine 66-75 Fc epsilon receptor Ia Homo sapiens 43-56 8951508-1 1996 The antigen induced stimulation of mast cells by aggregation of Fc epsilon RI receptors activates a signal transduction cascade leading to release of mediators of inflammation like histamine, arachidonic acid metabolites and cytokines. Histamine 181-190 Fc epsilon receptor Ia Homo sapiens 64-77 8921414-7 1996 Fc epsilon RI induced by IL-4 was functional and caused histamine and beta-hexosaminidase release from mast cells upon cross-linking. Histamine 56-65 Fc epsilon receptor Ia Homo sapiens 0-13 8670335-10 1996 There was a linear correlation between the percentage of histamine secretion and tryptase release (r = 0.79, P < 0.001) induced by cross-linking of Fc epsilon RI. Histamine 57-66 Fc epsilon receptor Ia Homo sapiens 151-164