PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20012759-2 2010 MATERIAL AND METHODS: The concentration of histamine as a modulator of inflammation was quantified in pericardial fluid and expression of histamine H(4) receptor (H(4)R) and histamine-releasing factor (HRF) was determined at mRNA and protein levels. Histamine 43-52 tumor protein, translationally-controlled 1 Homo sapiens 174-200 24404387-3 2014 HRF can stimulate histamine release and IL-4 and IL-13 production from IgE-sensitized basophils and mast cells. Histamine 18-27 tumor protein, translationally-controlled 1 Homo sapiens 0-3 20012759-2 2010 MATERIAL AND METHODS: The concentration of histamine as a modulator of inflammation was quantified in pericardial fluid and expression of histamine H(4) receptor (H(4)R) and histamine-releasing factor (HRF) was determined at mRNA and protein levels. Histamine 43-52 tumor protein, translationally-controlled 1 Homo sapiens 202-205 18625911-0 2008 Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models. Histamine 87-96 tumor protein, translationally-controlled 1 Homo sapiens 69-72 18625911-0 2008 Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models. Histamine 87-96 tumor protein, translationally-controlled 1 Homo sapiens 73-77 18625911-1 2008 Previously, we demonstrated a negative correlation between histamine release to histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of SHIP-1 in human basophils. Histamine 59-68 tumor protein, translationally-controlled 1 Homo sapiens 149-152 18625911-1 2008 Previously, we demonstrated a negative correlation between histamine release to histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of SHIP-1 in human basophils. Histamine 59-68 tumor protein, translationally-controlled 1 Homo sapiens 153-157 8942025-1 1996 Histamine-releasing factor (HRF) consists of a group of cytokines that can cause basophil/mast cell to release histamine, however, the composition of HRF still remains undefined. Histamine 111-120 tumor protein, translationally-controlled 1 Homo sapiens 0-26 18625911-7 2008 The functional knockdown was measured by HRF/TCTP-induced histamine release. Histamine 58-67 tumor protein, translationally-controlled 1 Homo sapiens 41-44 18625911-7 2008 The functional knockdown was measured by HRF/TCTP-induced histamine release. Histamine 58-67 tumor protein, translationally-controlled 1 Homo sapiens 45-49 18625911-9 2008 Histamine release to HRF/TCTP was increased only slightly in two experiments. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 21-24 18625911-9 2008 Histamine release to HRF/TCTP was increased only slightly in two experiments. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 25-29 18625911-11 2008 Histamine release to HRF/TCTP in these basophils was dependent on the amount of SHIP knockdown. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 21-24 18625911-11 2008 Histamine release to HRF/TCTP in these basophils was dependent on the amount of SHIP knockdown. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 25-29 17645945-7 2008 The latter was able to cause histamine release from human basophils with about half the efficiency compared to its human homolog HRF. Histamine 29-38 tumor protein, translationally-controlled 1 Homo sapiens 129-132 15319436-2 2004 TCTP (also called histamine-releasing factor) has been described previously as a secreted protein that participates in inflammatory responses by promoting the release of histamine. Histamine 18-27 tumor protein, translationally-controlled 1 Homo sapiens 0-4 12948934-1 2004 An IgE-dependent histamine-releasing factor (HRF p23; also known as translationally controlled tumor protein or p23) stimulates the release of histamine, IL-4, and IL-13 from a subpopulation of highly allergic donor basophils. Histamine 17-26 tumor protein, translationally-controlled 1 Homo sapiens 49-52 12948934-1 2004 An IgE-dependent histamine-releasing factor (HRF p23; also known as translationally controlled tumor protein or p23) stimulates the release of histamine, IL-4, and IL-13 from a subpopulation of highly allergic donor basophils. Histamine 17-26 tumor protein, translationally-controlled 1 Homo sapiens 112-115 12956736-2 2003 The current review is focussed on IgE-dependent HRF that require the presence of certain types of IgE (designated IgE+) to induce histamine release. Histamine 130-139 tumor protein, translationally-controlled 1 Homo sapiens 48-51 11535839-1 2001 The Plasmodium falciparum translationally controlled tumor protein (TCTP) is a homolog of the mammalian histamine-releasing factor (HRF), which causes histamine release from human basophils and IL-8 secretion from eosinophils. Histamine 104-113 tumor protein, translationally-controlled 1 Homo sapiens 68-72 11535839-1 2001 The Plasmodium falciparum translationally controlled tumor protein (TCTP) is a homolog of the mammalian histamine-releasing factor (HRF), which causes histamine release from human basophils and IL-8 secretion from eosinophils. Histamine 104-113 tumor protein, translationally-controlled 1 Homo sapiens 132-135 11535839-5 2001 Recombinant malarial TCTP, like HRF, stimulated histamine release from basophils and IL-8 secretion from eosinophils in vitro. Histamine 48-57 tumor protein, translationally-controlled 1 Homo sapiens 21-25 11535839-5 2001 Recombinant malarial TCTP, like HRF, stimulated histamine release from basophils and IL-8 secretion from eosinophils in vitro. Histamine 48-57 tumor protein, translationally-controlled 1 Homo sapiens 32-35 11172935-1 2001 Histamine-releasing factor (HRF) stimulates secretion of histamine that is widely distributed in brain and released as neurotransmitter. Histamine 57-66 tumor protein, translationally-controlled 1 Homo sapiens 0-26 11172935-1 2001 Histamine-releasing factor (HRF) stimulates secretion of histamine that is widely distributed in brain and released as neurotransmitter. Histamine 57-66 tumor protein, translationally-controlled 1 Homo sapiens 28-31 11172935-3 2001 Based upon deranged histamine metabolism in brain of patients with AD and Down Syndrome (DS), we aimed to study HRF in brain of AD and DS. Histamine 20-29 tumor protein, translationally-controlled 1 Homo sapiens 112-115 9700033-9 1998 This histamine release was decreased by precipitation of TCTP/IgE-dependent histamine-releasing factor from these supernatants. Histamine 5-14 tumor protein, translationally-controlled 1 Homo sapiens 57-61 18042794-1 2008 We previously identified a negative correlation between histamine release to histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of the Src homology 2 domain-containing inositol 5" phosphatase (SHIP) in basophils. Histamine 56-65 tumor protein, translationally-controlled 1 Homo sapiens 146-149 18042794-1 2008 We previously identified a negative correlation between histamine release to histamine releasing factor/translationally controlled tumor protein (HRF/TCTP) and protein levels of the Src homology 2 domain-containing inositol 5" phosphatase (SHIP) in basophils. Histamine 56-65 tumor protein, translationally-controlled 1 Homo sapiens 150-154 18042794-3 2008 The purpose of this study was to begin characterization of signal transduction events directly induced by HRF/TCTP and to investigate these events when HRF/TCTP is used as a priming agent for human basophil histamine release. Histamine 207-216 tumor protein, translationally-controlled 1 Homo sapiens 152-155 18042794-3 2008 The purpose of this study was to begin characterization of signal transduction events directly induced by HRF/TCTP and to investigate these events when HRF/TCTP is used as a priming agent for human basophil histamine release. Histamine 207-216 tumor protein, translationally-controlled 1 Homo sapiens 156-160 18042794-6 2008 There was a biphasic calcium response to HRF/TCTP, which corresponded to the magnitude of histamine release. Histamine 90-99 tumor protein, translationally-controlled 1 Homo sapiens 41-44 18042794-6 2008 There was a biphasic calcium response to HRF/TCTP, which corresponded to the magnitude of histamine release. Histamine 90-99 tumor protein, translationally-controlled 1 Homo sapiens 45-49 18042794-7 2008 Furthermore, those donors who have direct histamine release when exposed to HRF/TCTP (HRF/TCTP responder [HRF/TCTP-R] donors) have phosphorylation of Syk, Akt, MEK, and ERK. Histamine 42-51 tumor protein, translationally-controlled 1 Homo sapiens 76-79 18042794-7 2008 Furthermore, those donors who have direct histamine release when exposed to HRF/TCTP (HRF/TCTP responder [HRF/TCTP-R] donors) have phosphorylation of Syk, Akt, MEK, and ERK. Histamine 42-51 tumor protein, translationally-controlled 1 Homo sapiens 80-84 18042794-7 2008 Furthermore, those donors who have direct histamine release when exposed to HRF/TCTP (HRF/TCTP responder [HRF/TCTP-R] donors) have phosphorylation of Syk, Akt, MEK, and ERK. Histamine 42-51 tumor protein, translationally-controlled 1 Homo sapiens 86-89 18042794-7 2008 Furthermore, those donors who have direct histamine release when exposed to HRF/TCTP (HRF/TCTP responder [HRF/TCTP-R] donors) have phosphorylation of Syk, Akt, MEK, and ERK. Histamine 42-51 tumor protein, translationally-controlled 1 Homo sapiens 90-94 18042794-7 2008 Furthermore, those donors who have direct histamine release when exposed to HRF/TCTP (HRF/TCTP responder [HRF/TCTP-R] donors) have phosphorylation of Syk, Akt, MEK, and ERK. Histamine 42-51 tumor protein, translationally-controlled 1 Homo sapiens 86-89 18042794-7 2008 Furthermore, those donors who have direct histamine release when exposed to HRF/TCTP (HRF/TCTP responder [HRF/TCTP-R] donors) have phosphorylation of Syk, Akt, MEK, and ERK. Histamine 42-51 tumor protein, translationally-controlled 1 Homo sapiens 90-94 12487227-2 2002 Sera capable of passively sensitizing basophils to release histamine to HRF were designated IgE+ sera. Histamine 59-68 tumor protein, translationally-controlled 1 Homo sapiens 72-75 8942025-1 1996 Histamine-releasing factor (HRF) consists of a group of cytokines that can cause basophil/mast cell to release histamine, however, the composition of HRF still remains undefined. Histamine 111-120 tumor protein, translationally-controlled 1 Homo sapiens 28-31 8756800-4 1996 IgE-dependent HRF was determined by measuring the increase in histamine release between 1 min and 60 min, which was designated delta HRF. Histamine 62-71 tumor protein, translationally-controlled 1 Homo sapiens 14-17 8756800-4 1996 IgE-dependent HRF was determined by measuring the increase in histamine release between 1 min and 60 min, which was designated delta HRF. Histamine 62-71 tumor protein, translationally-controlled 1 Homo sapiens 133-136 1382479-0 1992 Interleukin-8 and RANTES inhibit basophil histamine release induced with monocyte chemotactic and activating factor/monocyte chemoattractant peptide-1 and histamine releasing factor. Histamine 42-51 tumor protein, translationally-controlled 1 Homo sapiens 116-181 7687607-8 1993 HRF activity was also higher in blister fluids from nonlesional skin of patients with CU than that of control subjects, in spite of equivalent histamine content. Histamine 143-152 tumor protein, translationally-controlled 1 Homo sapiens 0-3 1382479-1 1992 The objective of this study was to investigate the effect of interleukin-8 (IL-8) and RANTES on basophil histamine release induced with monocyte chemoattractant peptide-1 (MCP-1) and crude histamine releasing factor (HRF). Histamine 105-114 tumor protein, translationally-controlled 1 Homo sapiens 189-215 1371775-5 1992 In the same experiments the mean histamine release by anti-IgE and histamine releasing factor (HRF) was 27.05 +/- 4% and 32.70 +/- 2.7%, respectively. Histamine 33-42 tumor protein, translationally-controlled 1 Homo sapiens 67-93 1371775-5 1992 In the same experiments the mean histamine release by anti-IgE and histamine releasing factor (HRF) was 27.05 +/- 4% and 32.70 +/- 2.7%, respectively. Histamine 33-42 tumor protein, translationally-controlled 1 Homo sapiens 95-98 1371775-8 1992 The histamine release was significantly correlated between MCAF and HRF (P less than 0.01), but not between MCAF and anti-IgE (P greater than 0.05). Histamine 4-13 tumor protein, translationally-controlled 1 Homo sapiens 68-71 1697311-2 1990 As elevated bronchoalveolar lavage (BAL) fluid histamine levels are noted in patients with pulmonary fibrosis (PF), we assayed BAL fluid from 16 patients with PF for the presence of a histamine releasing factor (HRF). Histamine 47-56 tumor protein, translationally-controlled 1 Homo sapiens 184-210 1714484-2 1991 HRF is capable of inducing degranulation of basophils and release of histamine. Histamine 69-78 tumor protein, translationally-controlled 1 Homo sapiens 0-3 1714484-4 1991 HRF activity was tested by culturing the supernatants with fresh peripheral blood leukocytes and measuring the percentage of histamine released. Histamine 125-134 tumor protein, translationally-controlled 1 Homo sapiens 0-3 1697311-11 1990 The presence of the HRF could explain elevated BAL histamine levels in patients with PF. Histamine 51-60 tumor protein, translationally-controlled 1 Homo sapiens 20-23 2439589-6 1987 This partially purified HRF induced histamine release from basophils of certain individuals. Histamine 36-45 tumor protein, translationally-controlled 1 Homo sapiens 24-27 2460539-9 1988 These data, taken together, suggest that the capacity of HRA-N to induce RBL and human basophil histamine release and of HRF-NW to stimulate RBL histamine release is independent of IgE. Histamine 145-154 tumor protein, translationally-controlled 1 Homo sapiens 121-124 3148281-4 1988 MNC from intrinsic asthmatics and healthy controls were preincubated with killed bacteria for 4 h, then washed and cultured for 18 h. HRF activity of the cell-free supernatants was assayed in the histamine release test using basophils from normal subjects. Histamine 196-205 tumor protein, translationally-controlled 1 Homo sapiens 134-137 35138574-1 2022 PURPOSE: Translational controlled tumor protein (TCTP) is a functionally important protein in most eukaryotes because it participates in a wide variety of processes, the most representative being proliferation, differentiation, histamine release, cell death, protein synthesis and response to stress conditions. Histamine 228-237 tumor protein, translationally-controlled 1 Homo sapiens 9-47 35138574-1 2022 PURPOSE: Translational controlled tumor protein (TCTP) is a functionally important protein in most eukaryotes because it participates in a wide variety of processes, the most representative being proliferation, differentiation, histamine release, cell death, protein synthesis and response to stress conditions. Histamine 228-237 tumor protein, translationally-controlled 1 Homo sapiens 49-53 2469713-4 1989 In contrast, both HRF and anti-IgE released significant amounts of histamine from all donors. Histamine 67-76 tumor protein, translationally-controlled 1 Homo sapiens 18-21 2469713-9 1989 The results of this study demonstrated that although IL-3 and GM-CSF release small amounts of histamine only from a select group of allergic patients, mononuclear cell-derived HRF is more potent in their action and release histamine from normals as well as allergic patients. Histamine 223-232 tumor protein, translationally-controlled 1 Homo sapiens 176-179 2468702-10 1989 The change in the provocative concentration of histamine that causes 20% fall in FEV1 during the pollen season highly correlated with the change in HRF production. Histamine 47-56 tumor protein, translationally-controlled 1 Homo sapiens 148-151 2439589-7 1987 Histamine release occurred via a mechanism which is IgE-dependent in that: basophils desensitized by exposure to anti-IgE in the absence of calcium no longer respond to HRF, and desensitization with HRF reduces responsiveness to anti-IgE; and removal of IgE from the basophil surface by using lactic acid renders cells unresponsive to HRF. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 169-172 2439589-7 1987 Histamine release occurred via a mechanism which is IgE-dependent in that: basophils desensitized by exposure to anti-IgE in the absence of calcium no longer respond to HRF, and desensitization with HRF reduces responsiveness to anti-IgE; and removal of IgE from the basophil surface by using lactic acid renders cells unresponsive to HRF. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 199-202 2439589-7 1987 Histamine release occurred via a mechanism which is IgE-dependent in that: basophils desensitized by exposure to anti-IgE in the absence of calcium no longer respond to HRF, and desensitization with HRF reduces responsiveness to anti-IgE; and removal of IgE from the basophil surface by using lactic acid renders cells unresponsive to HRF. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 199-202 2439589-12 1987 We conclude that nasal lavage fluids contain an HRF which induces basophil histamine release in a specific, IgE-dependent fashion but only from individuals with the appropriate type of IgE. Histamine 75-84 tumor protein, translationally-controlled 1 Homo sapiens 48-51 2439589-13 1987 Because we have shown that basophils are recruited into the nose during the late-phase reaction, we suggest that nasal HRF may induce these cells to release histamine and other mediators which could contribute to the symptomatology of the late-phase reaction. Histamine 157-166 tumor protein, translationally-controlled 1 Homo sapiens 119-122 2420159-1 1985 Histamine release induced by the lymphokine-histamine releasing factor (HRF), like IgE-mediated release is a two step event--the Ca2+-independent activation step in which HRF primes the cells for histamine release and the Ca2+-dependent histamine release. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 33-70 2425574-1 1986 The speculation that human histamine releasing factor (HRF) - a lymphokine that releases histamine from human tissues, might be the same as gamma-interferon was investigated. Histamine 27-36 tumor protein, translationally-controlled 1 Homo sapiens 55-58 2425574-2 1986 The speculation arose from the fact that HRF and gamma-interferons are both lymphokines and have both been reported to affect histamine release from human basophils. Histamine 126-135 tumor protein, translationally-controlled 1 Homo sapiens 41-44 2425575-2 1986 We have found that HRF produced in vitro by lymphocytes of asthmatic patients can act independently from the animal species and induces histamine secretion from mouse peritoneal mast cells. Histamine 136-145 tumor protein, translationally-controlled 1 Homo sapiens 19-22 2442980-0 1987 Histamine release from mast cells of various species induced by histamine releasing factor from human lymphocytes. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 64-90 2442980-2 1987 We found that human HRF is able to release histamine from the examined mast cell populations in a dose-dependent fashion. Histamine 43-52 tumor protein, translationally-controlled 1 Homo sapiens 20-23 2442980-4 1987 The presence of 50% D2O in the medium significantly increased HRF-induced histamine release from rat mast cells, while the addition of phosphatidylserine did not change it. Histamine 74-83 tumor protein, translationally-controlled 1 Homo sapiens 62-65 2442980-5 1987 HRF-induced histamine release from guinea-pig mesenteric mast cells was not related to sensitization of these cells. Histamine 12-21 tumor protein, translationally-controlled 1 Homo sapiens 0-3 2442980-6 1987 We also compared histamine release from guinea-pig pulmonary and mesenteric mast cells induced by human HRF produced in vitro by lymphocytes obtained from atopic and non-atopic asthmatics. Histamine 17-26 tumor protein, translationally-controlled 1 Homo sapiens 104-107 2442980-8 1987 Our studies give evidence that human HRF acts across the species barrier and induces histamine release from mast cells of various species. Histamine 85-94 tumor protein, translationally-controlled 1 Homo sapiens 37-40 2433231-1 1987 In a penicillin-allergic patient who showed a strong dual skin reaction (immediate and late components) to an intradermal injection of the antigen, we investigated the possibility that the lymphokine, histamine-releasing factor (HRF), which has been shown to release histamine from human basophils and mast cells, might play a part in the elicitation of the late phase of the "dual reaction". Histamine 201-210 tumor protein, translationally-controlled 1 Homo sapiens 229-232 2433231-3 1987 The purified HRF released histamine from the patient"s own leucocytes and also caused immediate wheal and flare reaction on intradermal injection. Histamine 26-35 tumor protein, translationally-controlled 1 Homo sapiens 13-16 2437145-4 1986 The mean value of histamine release evoked by the embryo-derived histamine-releasing factor (EHRF) was 56.7%. Histamine 18-27 tumor protein, translationally-controlled 1 Homo sapiens 65-91 2420159-1 1985 Histamine release induced by the lymphokine-histamine releasing factor (HRF), like IgE-mediated release is a two step event--the Ca2+-independent activation step in which HRF primes the cells for histamine release and the Ca2+-dependent histamine release. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 72-75 2420159-1 1985 Histamine release induced by the lymphokine-histamine releasing factor (HRF), like IgE-mediated release is a two step event--the Ca2+-independent activation step in which HRF primes the cells for histamine release and the Ca2+-dependent histamine release. Histamine 0-9 tumor protein, translationally-controlled 1 Homo sapiens 171-174 2420159-1 1985 Histamine release induced by the lymphokine-histamine releasing factor (HRF), like IgE-mediated release is a two step event--the Ca2+-independent activation step in which HRF primes the cells for histamine release and the Ca2+-dependent histamine release. Histamine 44-53 tumor protein, translationally-controlled 1 Homo sapiens 72-75 2420159-1 1985 Histamine release induced by the lymphokine-histamine releasing factor (HRF), like IgE-mediated release is a two step event--the Ca2+-independent activation step in which HRF primes the cells for histamine release and the Ca2+-dependent histamine release. Histamine 44-53 tumor protein, translationally-controlled 1 Homo sapiens 171-174 2420159-1 1985 Histamine release induced by the lymphokine-histamine releasing factor (HRF), like IgE-mediated release is a two step event--the Ca2+-independent activation step in which HRF primes the cells for histamine release and the Ca2+-dependent histamine release. Histamine 196-205 tumor protein, translationally-controlled 1 Homo sapiens 33-70 2420159-1 1985 Histamine release induced by the lymphokine-histamine releasing factor (HRF), like IgE-mediated release is a two step event--the Ca2+-independent activation step in which HRF primes the cells for histamine release and the Ca2+-dependent histamine release. Histamine 196-205 tumor protein, translationally-controlled 1 Homo sapiens 72-75 2420159-1 1985 Histamine release induced by the lymphokine-histamine releasing factor (HRF), like IgE-mediated release is a two step event--the Ca2+-independent activation step in which HRF primes the cells for histamine release and the Ca2+-dependent histamine release. Histamine 196-205 tumor protein, translationally-controlled 1 Homo sapiens 171-174 2420159-3 1985 By the "receptor desensitization" approach, HRF appears to possess specific receptors on basophils as demonstrated by its ability to desensitize the cells to itself for subsequent histamine release. Histamine 180-189 tumor protein, translationally-controlled 1 Homo sapiens 44-47 2412974-1 1985 A human histamine releasing lymphokine (histamine releasing factor, HRF) was studied for its ability to release slow reacting substance (SRS) alongside histamine from human leucocytes. Histamine 8-17 tumor protein, translationally-controlled 1 Homo sapiens 68-71 2417943-1 1985 Histamine releasing factor (HRF)--a human lymphokine--has been shown previously to release histamine from basophils in vitro. Histamine 91-100 tumor protein, translationally-controlled 1 Homo sapiens 0-26 2417943-1 1985 Histamine releasing factor (HRF)--a human lymphokine--has been shown previously to release histamine from basophils in vitro. Histamine 91-100 tumor protein, translationally-controlled 1 Homo sapiens 28-31 2417943-7 1985 We conclude that histamine release from mouse peritoneal mast cells can serve as an in vitro test for the assay of human HRF. Histamine 17-26 tumor protein, translationally-controlled 1 Homo sapiens 121-124 6203373-6 1984 This supports the belief that histamine release by this histamine-releasing factor ( HRF ) is a secretory process. Histamine 30-39 tumor protein, translationally-controlled 1 Homo sapiens 56-82 6203373-6 1984 This supports the belief that histamine release by this histamine-releasing factor ( HRF ) is a secretory process. Histamine 30-39 tumor protein, translationally-controlled 1 Homo sapiens 85-88