PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29600327-7 2018 In fully differentiated M1 macrophages, histamine or ST-1006 decreased the IFN-Y- and LPS-induced CCL4 mRNA expression and protein production, whereas CCL3 or IL-23 production was not regulated via H4R. Histamine 40-49 interferon gamma Homo sapiens 75-80 31583075-4 2019 The results confirmed that H4R has the functional effects of mediating cytokine production (i.e., down-regulating IFN-gamma and up-regulating IL-6) in cells from a monocyte cell line following challenge with histamine. Histamine 208-217 interferon gamma Homo sapiens 114-123 27542662-11 2017 Stimulation with lipopolysaccharide (LPS) or interferon-gamma upregulated HDC-gene transcript in HOKs, whereas this was downregulated with high histamine concentration and tumour necrosis factor-alpha. Histamine 144-153 interferon gamma Homo sapiens 45-61 21324712-5 2011 Histamine suppressed tumor necrosis factor alpha (TNF-alpha)- and interferon-gamma (IFN-gamma)-induced production of CC chemokine ligand 17(CCL17), a type 2 T-helper (Th2) chemokine, by HaCaT KCs. Histamine 0-9 interferon gamma Homo sapiens 66-93 25656974-7 2015 The expression of IL-8 and TNF-alpha was negatively correlated with l-lactate and positively correlated with NH3 and putrescine, whereas the expression of IFN-gamma was positively correlated with histamine and 4-ethylphenol (P< 0 05). Histamine 196-205 interferon gamma Homo sapiens 155-164 25585347-4 2015 An evaluation of mast cell activator secretion revealed that IFN-gamma- or IL-4-pretreated HMC-1 cells released dramatically increased levels of beta-hexosaminidase and histamine when stimulated with iopromide. Histamine 169-178 interferon gamma Homo sapiens 61-70 22037448-0 2012 Histamine increases the level of IFNgamma produced by HIV-1 specific CTLs and this production depends on total IgE level. Histamine 0-9 interferon gamma Homo sapiens 33-41 22037448-6 2012 Changes in the production of IFNgamma after incubation with histamine were compared with the levels of total IgE (immunoglobulin E, measured using a Dade Behring analyzer), because histamine is endogenously released through IgE. Histamine 60-69 interferon gamma Homo sapiens 29-37 22037448-9 2012 CONCLUSIONS: We found an increase in IFNgamma production after the activation of HIV-1 specific CD8+ T lymphocytes by histamine (this elevation was blocked by cimetidine), furthermore, we demonstrated a negative correlation between the production of IFNgamma and levels of total IgE. Histamine 118-127 interferon gamma Homo sapiens 37-45 22037448-9 2012 CONCLUSIONS: We found an increase in IFNgamma production after the activation of HIV-1 specific CD8+ T lymphocytes by histamine (this elevation was blocked by cimetidine), furthermore, we demonstrated a negative correlation between the production of IFNgamma and levels of total IgE. Histamine 118-127 interferon gamma Homo sapiens 250-258 22304689-4 2012 Interferon-gamma augmented the surface expression of the NKG2D ligands, and this augmentation was significantly attenuated by histamine. Histamine 126-135 interferon gamma Homo sapiens 0-16 21324712-7 2011 In contrast, histamine enhanced the production of CXC chemokine ligand 10 (CXCL10), a Th1 chemokine, by TNF-alpha- and IFN-gamma-stimulated HaCaT KCs and NHKs. Histamine 13-22 interferon gamma Homo sapiens 119-128 21324712-8 2011 TNF-alpha- and IFN-gamma-induced CXCL10 production was upregulated by suppression of p38 MAP kinase or NF-kappaB activity, which could explain histamine involvement. Histamine 143-152 interferon gamma Homo sapiens 15-24 16556265-8 2006 In addition, histamine and PGE2 down-regulated IFN-gamma-induced CXCL10 production by monocyte-derived DC. Histamine 13-22 interferon gamma Homo sapiens 47-56 17928537-4 2007 Histamine enhanced TNF-alpha- or IFN-gamma-induced hBD-2 secretion and mRNA expression. Histamine 0-9 interferon gamma Homo sapiens 33-42 17928537-5 2007 Histamine alone enhanced transcriptional activities of NF-kappaB and activator protein-1 (AP-1) and potentiated TNF-alpha-induced NF-kappaB and AP-1 activities or IFN-gamma-induced NF-kappaB and STAT1 activities. Histamine 0-9 interferon gamma Homo sapiens 163-172 17928537-6 2007 Antisense oligonucleotides against NF-kappaB components p50 and p65, AP-1 components c-Jun and c-Fos, or H1 antagonist pyrilamine suppressed hBD-2 production induced by histamine plus TNF-alpha or IFN-gamma. Histamine 169-178 interferon gamma Homo sapiens 197-206 17928537-8 2007 Histamine induced serine phosphorylation of inhibitory NF-kappaBalpha (IkappaBalpha) alone or together with TNF-alpha or IFN-gamma. Histamine 0-9 interferon gamma Homo sapiens 121-130 17928537-10 2007 Histamine induced serine phosphorylation of STAT1 alone or together with IFN-gamma, whereas it did not further enhance IFN-gamma-induced tyrosine phosphorylation of STAT1. Histamine 0-9 interferon gamma Homo sapiens 73-82 17928537-12 2007 These results suggest that histamine stimulates H1 receptor and potentiates TNF-alpha- or IFN-gamma-induced hBD-2 production dependent on NF-kappaB, AP-1, or STAT1 in human keratinocytes. Histamine 27-36 interferon gamma Homo sapiens 90-99 17903241-7 2007 RESULTS: Treatment of Human ASM cells with IL-13, IFN gamma or salmeterol for 24 hours lead to a modest augmentation of histamine induced IPx responses (144.3 +/- 9.3, 126.4 +/- 7.5 and 117.7 +/- 5.2%, p < 0.05). Histamine 120-129 interferon gamma Homo sapiens 50-59 16556265-0 2006 Histamine and prostaglandin E up-regulate the production of Th2-attracting chemokines (CCL17 and CCL22) and down-regulate IFN-gamma-induced CXCL10 production by immature human dendritic cells. Histamine 0-9 interferon gamma Homo sapiens 122-131 16556265-10 2006 Finally, histamine and PGE2 also up-regulated CCL17 and CCL22 and decreased IFN-gamma-induced CXCL10 production by purified human myeloid DC. Histamine 9-18 interferon gamma Homo sapiens 76-85 12364868-0 2002 Effect of histamine on intercellular adhesion molecule-1 expression and production of interferon-gamma and interleukin-12 in mixed lymphocyte reaction stimulated with interleukin-18. Histamine 10-19 interferon gamma Homo sapiens 86-102 15536428-8 2004 Treatment of keratinocytes with histamine (10 -7 to 10 -4 mol/L) or beta-histine increased the IFN-gamma-induced expression of membrane intercellular adhesion molecule 1 and MHC class I but not MHC class II molecules. Histamine 32-41 interferon gamma Homo sapiens 95-104 15867854-5 2005 A screening of various factors (histamine, IFN-gamma, IL-1beta, IL-2, IL-3, IL-4, IL-5, IL-8, IL-12, and TNF-alpha) identified IFN-gamma as a potent factor capable of reducing epithelial barrier properties and enhancing transepithelial allergen penetration. Histamine 32-41 interferon gamma Homo sapiens 127-136 15867854-6 2005 Increased submucosal allergen concentrations caused by IFN-gamma-mediated reduction of epithelial barrier function provoked a more than 7-fold augmentation of histamine release from sensitized basophils. Histamine 159-168 interferon gamma Homo sapiens 55-64 11367520-7 2001 The up-regulation of IL-10 production by histamine in splenocytes was accompanied by inhibitory effects of histamine on IFN gamma production. Histamine 41-50 interferon gamma Homo sapiens 120-129 12013392-0 2002 Histamine influences the expression of IFN-gamma in atopic and nonatopic human Th1 cell cultures. Histamine 0-9 interferon gamma Homo sapiens 39-48 11916128-0 2002 Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes. Histamine 0-9 interferon gamma Homo sapiens 75-84 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 42-51 interferon gamma Homo sapiens 168-177 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interferon gamma Homo sapiens 168-177 11752121-2 2002 In the present study, we demonstrate that histamine inhibited the ICAM-1 expression in monocytes induced by IL-18 using flow cytometry and that the responses of IL-12, IFN-gamma, and TNF-alpha induced by IL-18 were concentration dependently inhibited by coexisting histamine, whereas IL-18-inhibited IL-10 production was reversed by the same concentrations of histamine. Histamine 265-274 interferon gamma Homo sapiens 168-177 11496824-4 2001 Using human PBMC culture, it was demonstrated that histamine was a potent inducer of IL-18, IFN-gamma in human PBMC. Histamine 51-60 interferon gamma Homo sapiens 92-101 11916128-9 2002 Interestingly, IFN-gamma and IL-4 both significantly augmented the histamine-induced IL-6 production. Histamine 67-76 interferon gamma Homo sapiens 15-24 11916128-10 2002 On the other hand, the production of IL-8 was inhibited by IFN-gamma, and IFN-gamma and IL-4 both completely abrogated the histamine-induced IL-8 production. Histamine 123-132 interferon gamma Homo sapiens 74-83 11916128-11 2002 These results suggest that the histamine-induced IL-6 production and IL-8 production are differentially regulated by IFN-gamma and IL-4. Histamine 31-40 interferon gamma Homo sapiens 117-126 11752121-4 2002 The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine 45-54 interferon gamma Homo sapiens 32-41 11752121-4 2002 The inhibition of IL-18-induced IFN-gamma by histamine was ascribed to the strong inhibition of IL-12 production by histamine. Histamine 116-125 interferon gamma Homo sapiens 32-41 11357887-4 2001 The splenocytes were treated with histamine in the presence or absence of JAK-STAT inhibitor, tyrphostin, activated with IFNgamma for 30 min, and phosphorylated STAT1 was detected by immunoblotting. Histamine 34-43 interferon gamma Homo sapiens 121-129 11357887-6 2001 We then studied the effects of tyrphostin on histamine-mediated inhibition of IFNgamma production and histamine-mediated stimulation of IL-5 and IL-10 production. Histamine 45-54 interferon gamma Homo sapiens 78-86 11357887-7 2001 Tyrphostin dose-dependently reversed the effects of histamine on IFNgamma, IL-5 and IL-10 production, as evident by ELISA. Histamine 52-61 interferon gamma Homo sapiens 65-73 11367520-7 2001 The up-regulation of IL-10 production by histamine in splenocytes was accompanied by inhibitory effects of histamine on IFN gamma production. Histamine 107-116 interferon gamma Homo sapiens 120-129 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 37-46 interferon gamma Homo sapiens 120-129 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 37-46 interferon gamma Homo sapiens 185-194 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 87-96 interferon gamma Homo sapiens 120-129 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 87-96 interferon gamma Homo sapiens 185-194 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 87-96 interferon gamma Homo sapiens 120-129 11367520-8 2001 The pretreatment of splenocytes with histamine in the presence of anti-IL-10 abrogated histamine-mediated inhibition of IFN gamma production suggesting that the effects of histamine on IFN gamma secretion were regulated by IL-10 in multi-cell system. Histamine 87-96 interferon gamma Homo sapiens 185-194 10572065-5 1999 BEAS-2B constitutively expressed IL-16 messenger RNA (mRNA) and protein; IL-16 expression was significantly upregulated in a concentration-dependent manner within 24 h by stimulation with histamine, IL-1beta, or tumor necrosis factor (TNF)-alpha whereas interferon-gamma did not significantly increase IL-16. Histamine 188-197 interferon gamma Homo sapiens 254-270 10843724-1 2000 Histamine (10-7 to 10-4 M) concentration-dependently stimulated the production of IL-18 and IFN-gamma and inhibited the production of IL-2 and IL-10 in human PBMCs. Histamine 0-9 interferon gamma Homo sapiens 92-101 10843724-9 2000 IFN-gamma production induced by IL-18 was inhibited by anti-IL-12 Ab, showing the marked contrast of the effect of histamine. Histamine 115-124 interferon gamma Homo sapiens 0-9 11028755-8 2000 CONCLUSIONS: Since previously the inhibitory effect of histamine on gene expression of interferon gamma was detected, a reciprocal inhibition between histamine and IFNgamma is proposed. Histamine 55-64 interferon gamma Homo sapiens 87-103 11028755-8 2000 CONCLUSIONS: Since previously the inhibitory effect of histamine on gene expression of interferon gamma was detected, a reciprocal inhibition between histamine and IFNgamma is proposed. Histamine 55-64 interferon gamma Homo sapiens 164-172 10843724-0 2000 Histamine is a potent inducer of IL-18 and IFN-gamma in human peripheral blood mononuclear cells. Histamine 0-9 interferon gamma Homo sapiens 43-52 10841949-1 2000 Histamine, an important inflammatory mediator in allergic diseases and asthma, was reported to have modulatory effects on T cells by down-regulating Th1-type cell cytokines like interleukin 2 (IL-2) and interferon-gamma (IFN-gamma). Histamine 0-9 interferon gamma Homo sapiens 203-219 10841949-1 2000 Histamine, an important inflammatory mediator in allergic diseases and asthma, was reported to have modulatory effects on T cells by down-regulating Th1-type cell cytokines like interleukin 2 (IL-2) and interferon-gamma (IFN-gamma). Histamine 0-9 interferon gamma Homo sapiens 221-230 10841949-2 2000 In this study we examined the effect of histamine and the histamine-receptor antagonists cimetidine and diphenhydramine on the production of neopterin after stimulation with IFN-gamma in the myelomonocytoma cell line THP-1. Histamine 40-49 interferon gamma Homo sapiens 174-183 10841949-3 2000 Increasing concentrations of histamine markedly suppressed IFN-gamma induced neopterin formation. Histamine 29-38 interferon gamma Homo sapiens 59-68 10841949-6 2000 Our results suggest, that histamine may be a potent inhibitor of effects or mechanisms induced by IFN-gamma in monocytes/macrophages. Histamine 26-35 interferon gamma Homo sapiens 98-107 10864407-0 2000 Reciprocal inhibitory interactions between interferon gamma and histamine in melanoma. Histamine 64-73 interferon gamma Homo sapiens 43-59 10569698-6 1999 These results suggest, that inhibition of IFNgamma gene expression by histamine is a direct effect of histamine on H2 receptor of T lymphocytes; however, the superinduction of IFNgamma by cimetidine requires the presence of other (probably primarily B) cell subsets. Histamine 70-79 interferon gamma Homo sapiens 42-50 10569698-0 1999 Histamine and histamine-receptor antagonists modify gene expression and biosynthesis of interferon gamma in peripheral human blood mononuclear cells and in CD19-depleted cell subsets. Histamine 0-9 interferon gamma Homo sapiens 88-104 10569698-1 1999 The effect of histamine and histamine antagonists was examined on gene expression and biosynthesis of bacterial endotoxin (LPS) induced interferon gamma (IFNgamma) both in human peripheral mononuclear cells (PMBC) and in T-cell enriched fractions. Histamine 14-23 interferon gamma Homo sapiens 136-163 10569698-1 1999 The effect of histamine and histamine antagonists was examined on gene expression and biosynthesis of bacterial endotoxin (LPS) induced interferon gamma (IFNgamma) both in human peripheral mononuclear cells (PMBC) and in T-cell enriched fractions. Histamine 28-37 interferon gamma Homo sapiens 136-163 10569698-2 1999 We found, that histamine inhibited the LPS induced transcription of IFNgamma gene and biosynthesis of IFNgamma protein in PMBC and also in CD19-depleted cell populations. Histamine 15-24 interferon gamma Homo sapiens 68-76 10569698-2 1999 We found, that histamine inhibited the LPS induced transcription of IFNgamma gene and biosynthesis of IFNgamma protein in PMBC and also in CD19-depleted cell populations. Histamine 15-24 interferon gamma Homo sapiens 102-110 10569698-3 1999 The inhibitory effect of histamine could be reversed by the H2 histamine receptor (HR2) antagonists cimetidine and ranitidine both in PMBC and in CD19-depleted cells, but not with triprolidine, an H1 receptor antagonist, suggesting that the inhibition of IFNgamma production is mediated through H2 receptors in these cell populations. Histamine 25-34 interferon gamma Homo sapiens 255-263 10569698-6 1999 These results suggest, that inhibition of IFNgamma gene expression by histamine is a direct effect of histamine on H2 receptor of T lymphocytes; however, the superinduction of IFNgamma by cimetidine requires the presence of other (probably primarily B) cell subsets. Histamine 102-111 interferon gamma Homo sapiens 42-50 9182905-0 1997 Different modulation by histamine of IL-4 and interferon-gamma (IFN-gamma) release according to the phenotype of human Th0, Th1 and Th2 clones. Histamine 24-33 interferon gamma Homo sapiens 64-73 10228104-12 1999 Lower IFN-gamma production at the time of bronchiolitis is an indicator of lower pulmonary function and increased responsiveness to histamine 4.9 mo after bronchiolitis and is related to the development of asthma after bronchiolitis in infants. Histamine 132-141 interferon gamma Homo sapiens 6-15 9949326-0 1999 Decreased release of histamine and sulfidoleukotrienes by human peripheral blood leukocytes after wasp venom immunotherapy is partially due to induction of IL-10 and IFN-gamma production of T cells. Histamine 21-30 interferon gamma Homo sapiens 166-175 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. Histamine 322-331 interferon gamma Homo sapiens 52-61 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. Histamine 322-331 interferon gamma Homo sapiens 124-133 9949326-7 1999 This was at least partially due to the induction of IFN-gamma and IL-10 production, because (1) neutralization of IL-10 and IFN-gamma by mAbs partially restored the release after the initiation of VIT and (2) the addition of exogenous IFN-gamma and IL-10 caused a statistically significant diminution of the venom-induced histamine and sulfidoleukotriene release before VIT. Histamine 322-331 interferon gamma Homo sapiens 124-133 9949326-9 1999 CONCLUSION: These data indicate that T cells (producing IL-10 and IFN-gamma after VIT) play a key role for the inhibition of histamine and sulfidoleukotriene release of effector cells. Histamine 125-134 interferon gamma Homo sapiens 66-75 9569243-0 1998 Histamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood. Histamine 0-9 interferon gamma Homo sapiens 52-68 9569243-2 1998 This study describes the effects of histamine on anti-CD3-induced production of IL-4, IL-5, and IFN-gamma by T cell clones from subjects with allergic asthma and healthy subjects. Histamine 36-45 interferon gamma Homo sapiens 96-105 9569243-11 1998 The enhancement of IFN-gamma production by histamine, however, was found only in clones from healthy subjects. Histamine 43-52 interferon gamma Homo sapiens 19-28 9182905-4 1997 Histamine inhibited IFN-gamma production by Th1-like cells (P < 0.02, Kruskall-Wallis), especially from bronchial biopsy, but had no effect on IL-4 release. Histamine 0-9 interferon gamma Homo sapiens 20-29 9182905-5 1997 Regarding Th0 clones, histamine inhibited IL-4 production (P < 0.02) in a dose-dependent manner and slightly inhibited IFN-gamma production, but had no effect on Th2-like cells. Histamine 22-31 interferon gamma Homo sapiens 122-131 9182905-9 1997 These data demonstrate that histamine has different effects on IL-4 and IFN-gamma release by T helper cells according to their phenotype via H2-receptors. Histamine 28-37 interferon gamma Homo sapiens 72-81 8660811-0 1996 Dual control of human interleukin-2 and interferon-gamma gene expression by histamine: activation and suppression. Histamine 76-85 interferon gamma Homo sapiens 40-56 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Histamine 0-9 interferon gamma Homo sapiens 131-140 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Histamine 0-9 interferon gamma Homo sapiens 234-243 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Histamine 184-193 interferon gamma Homo sapiens 131-140 8706348-7 1996 Histamine, a biogenic amine which inhibits the generation of reactive oxygen metabolites in monocytes, abrogated the inhibition of IFN-gamma production in NK cells; by this mechanism, histamine strongly synergized with IL-2 to induce IFN-gamma in mixtures of NK cells and monocytes. Histamine 184-193 interferon gamma Homo sapiens 234-243 8706348-9 1996 We conclude that: (i) the induction of IFN-gamma mRNA in NK cells is effectively down-regulated by products of the oxidative metabolism of monocytes; and (ii) histamine effectively enhances IFN-gamma production by preventing monocyte-induced oxidative damage to NK cells. Histamine 159-168 interferon gamma Homo sapiens 39-48 8706348-9 1996 We conclude that: (i) the induction of IFN-gamma mRNA in NK cells is effectively down-regulated by products of the oxidative metabolism of monocytes; and (ii) histamine effectively enhances IFN-gamma production by preventing monocyte-induced oxidative damage to NK cells. Histamine 159-168 interferon gamma Homo sapiens 190-199 9014819-0 1996 Interferon-gamma promotes the survival and Fc epsilon RI-mediated histamine release in cultured human mast cells. Histamine 66-75 interferon gamma Homo sapiens 0-16 9014819-5 1996 When mast cells were incubated with IFN-gamma in serum-free medium for more than 4 hr during sensitization, immunoglobulin E (IgE)/anti-IgE antibody-induced histamine release was effectively enhanced. Histamine 157-166 interferon gamma Homo sapiens 36-45 8948120-0 1996 The role of reactive oxygen metabolites in the transcriptional regulation of IFN-gamma gene expression by histamine in NK cells following IL-2 stimulation. Histamine 106-115 interferon gamma Homo sapiens 77-86 8948120-4 1996 Both catalase, a scavenger of hydrogen peroxide and histamine, a biogenic amine which inhibits the generation of ROMs by monocytes, strongly abrogated the inhibition of IFN-gamma production. Histamine 52-61 interferon gamma Homo sapiens 169-178 8948120-5 1996 We thereby conclude that histamine behaves synergistically with IL-2 at a transcriptional level to induce IFN-gamma even in an admixture of NK cells and monocytes. Histamine 25-34 interferon gamma Homo sapiens 106-115 8660811-2 1996 In agreement with this concept, we show that histamine elicits a strong inhibition of the induced expression of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) genes. Histamine 45-54 interferon gamma Homo sapiens 137-153 8660811-2 1996 In agreement with this concept, we show that histamine elicits a strong inhibition of the induced expression of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) genes. Histamine 45-54 interferon gamma Homo sapiens 155-164 8660811-8 1996 These results support the concept that histamine, released during an immune response, exerts opposite regulatory effects by first activating cells able to express the IL-2 and IFN-gamma genes and only then suppressive cells that become responsive to histamine more slowly, but once activated shut off the expression of these genes. Histamine 39-48 interferon gamma Homo sapiens 176-185 8428396-7 1993 For other agonists and cytokines the increases in permeability were: (i) histamine (50-400 pmol/ml) increased uptake 5-22%; (ii) TNF (12.5-100 ng/ml) increased uptake 2-12%; (iii) IFN-gamma (125-250 U/ml) increased uptake 1.5-3%. Histamine 73-82 interferon gamma Homo sapiens 180-189 12810348-4 2003 Histamine enhances the secretion of Th2 cytokines such as IL-4 (interleukin-4), IL-5, IL-10 and IL-13 and inhibits the production of Th1 cytokines IL-2 and IFNgamma (interferon-gamma) and monokine IL-12. Histamine 0-9 interferon gamma Homo sapiens 156-164 1695452-2 1990 Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). Histamine 103-112 interferon gamma Homo sapiens 228-244 1695452-2 1990 Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). Histamine 103-112 interferon gamma Homo sapiens 246-255 12810348-4 2003 Histamine enhances the secretion of Th2 cytokines such as IL-4 (interleukin-4), IL-5, IL-10 and IL-13 and inhibits the production of Th1 cytokines IL-2 and IFNgamma (interferon-gamma) and monokine IL-12. Histamine 0-9 interferon gamma Homo sapiens 166-182 12810348-7 2003 We have also demonstrated that the Jak-STAT (Janus kinase-signal transducers and activators of transcription) pathway is involved in histamine-mediated regulation of Th2 cytokines IL-5, IL-10, IL-13 and Th1 cytokine IFNgamma. Histamine 133-142 interferon gamma Homo sapiens 216-224 2976521-3 1988 Histamine was shown to suppress to a similar extent the production of interleukin 2 (IL-2) and gamma interferon (IFN-gamma) by Leu 3+, Leu 3+8+, and Leu 3+8- cell subsets. Histamine 0-9 interferon gamma Homo sapiens 95-122 2976521-6 1988 The IFN-gamma production by the Leu 3+ and Leu 3+18- cells and the marginal production by Leu 3+18+ cells were significantly suppressed by histamine. Histamine 139-148 interferon gamma Homo sapiens 4-13 2976521-8 1988 It was shown that the inhibitory effect of histamine on the early production of IL-2 and the major production of IFN-gamma by T helper cells is mediated via action on both the Leu 3+18-8- and the Leu 3+18-8+ cells. Histamine 43-52 interferon gamma Homo sapiens 113-122 3118749-4 1987 Interferon gamma production was reduced to less than 2% of control value in the presence of histamine. Histamine 92-101 interferon gamma Homo sapiens 0-16 3115598-0 1987 Histamine acts directly on human T cells to inhibit interleukin-2 and interferon-gamma production. Histamine 0-9 interferon gamma Homo sapiens 70-86 3115598-2 1987 Histamine inhibits the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) by purified human peripheral T cells activated in the presence of either intact monocytes or metabolically inactive fixed Raji and U698 cells as accessory cells. Histamine 0-9 interferon gamma Homo sapiens 62-78 3115598-2 1987 Histamine inhibits the production of interleukin-2 (IL-2) and interferon-gamma (IFN-gamma) by purified human peripheral T cells activated in the presence of either intact monocytes or metabolically inactive fixed Raji and U698 cells as accessory cells. Histamine 0-9 interferon gamma Homo sapiens 80-89 2944612-0 1986 Histamine inhibits interferon-gamma production via suppression of interleukin 2 synthesis. Histamine 0-9 interferon gamma Homo sapiens 19-35 2944612-1 1986 Histamine, a modulator of various immune functions, inhibits the production of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) by polyclonally activated human blood mononuclear cells. Histamine 0-9 interferon gamma Homo sapiens 104-120 2944612-1 1986 Histamine, a modulator of various immune functions, inhibits the production of interleukin 2 (IL-2) and interferon-gamma (IFN-gamma) by polyclonally activated human blood mononuclear cells. Histamine 0-9 interferon gamma Homo sapiens 122-131 2944612-2 1986 The histamine-induced inhibition of IFN-gamma synthesis can be completely eliminated by the addition of recombinant IL-2. Histamine 4-13 interferon gamma Homo sapiens 36-45 2944612-4 1986 It is concluded that histamine acts primarily on the interleukin 2 synthesis by the T4+ lymphocytes and as a consequence of this inhibition, interferon-gamma production is reduced. Histamine 21-30 interferon gamma Homo sapiens 141-157 3939107-0 1985 Histamine modulates the production of interferon-gamma and interleukin-2 by mitogen-activated human mononuclear blood cells. Histamine 0-9 interferon gamma Homo sapiens 38-54 3939107-1 1985 Histamine inhibited the production of interferon-gamma and interleukin 2 (IL-2) induced in human peripheral blood mononuclear cells by Staphylococcal Enterotoxin A (SEA) but had no effect on the expression of IL-2 receptors. Histamine 0-9 interferon gamma Homo sapiens 38-54