PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24610880-8 2014 In addition, histamine differentially influenced Arg1 and iNOS gene expression in MDSCs and greatly enhanced IL-4 and IL-13 message, especially in granulocytic MDSCs. Histamine 13-22 interleukin 4 Homo sapiens 109-113 18442791-5 2008 Incubation with IL-4 and IL-13 for 6 h increased adenosine A2A receptor expression and histamine secretion, but decreased IL-8 secretion. Histamine 87-96 interleukin 4 Homo sapiens 16-20 19116009-12 2008 Pre-treatment with IL-4 or IL-13 abrogated IL-13-induced augmentation of the calcium transient evoked by histamine. Histamine 105-114 interleukin 4 Homo sapiens 19-23 19116009-16 2008 CONCLUSION: Pre-treatment with IL-4 and IL-13, but not IFN-gamma, induced desensitization of the HASM cells to IL-13 as measured by eotaxin secretion and calcium transients to histamine. Histamine 176-185 interleukin 4 Homo sapiens 31-35 23962049-9 2014 IL-4 induces Duox1 gene and protein expression levels and enhances histamine-induced H2O2 production by epithelial cells. Histamine 67-76 interleukin 4 Homo sapiens 0-4 20112007-9 2010 Stimulation with histamine also up-regulated H1R mRNA, and co-stimulation with histamine and IL-4 elevated H1R mRNA level significantly higher than the stimulation with histamine or IL-4 alone did. Histamine 79-88 interleukin 4 Homo sapiens 182-186 20112007-9 2010 Stimulation with histamine also up-regulated H1R mRNA, and co-stimulation with histamine and IL-4 elevated H1R mRNA level significantly higher than the stimulation with histamine or IL-4 alone did. Histamine 79-88 interleukin 4 Homo sapiens 182-186 18538784-12 2008 Culture with IL-4 increased expression of tryptase, FcepsilonRI, CD117 and CD203c, secretion of histamine and PGD(2) of PBMC, and histamine secretion of CBMC. Histamine 96-105 interleukin 4 Homo sapiens 13-17 18538784-12 2008 Culture with IL-4 increased expression of tryptase, FcepsilonRI, CD117 and CD203c, secretion of histamine and PGD(2) of PBMC, and histamine secretion of CBMC. Histamine 130-139 interleukin 4 Homo sapiens 13-17 18442791-7 2008 Overnight stimulation with IL-4, IL-13 and subsequent stimulation with AMP/NECA for 1.5 h decreased A2AR expression which was accompanied by increased histamine secretion. Histamine 151-160 interleukin 4 Homo sapiens 27-31 12550104-7 2002 When SCF, IL-6 and IL-4 were used together, a further increase was observed in the anti-IgE-dependent liberation of histamine from the cultured mast cells, compared with the two-factor combinations. Histamine 116-125 interleukin 4 Homo sapiens 19-23 16940746-10 2006 IL-4 and IL-13 production correlated with histamine release and CD203c expression. Histamine 42-51 interleukin 4 Homo sapiens 0-4 16298365-0 2005 IL-4 modulates the histamine content of mast cells in a mast cell/fibroblast co-culture through a Stat6 signaling pathway in fibroblasts. Histamine 19-28 interleukin 4 Homo sapiens 0-4 16298365-5 2005 The over-expression of dominant-negative Stat6 in fibroblasts in the presence of IL-4 decreased the histamine content per mast cell, but not the number of mast cells. Histamine 100-109 interleukin 4 Homo sapiens 81-85 14500674-1 2003 Human recombinant histamine-releasing factor (HrHRF) preincubation enhances the secretion of histamine, IL-4, and IL-13 from FcepsilonRI-stimulated human basophils. Histamine 18-27 interleukin 4 Homo sapiens 104-108 16491014-11 2006 Histamine also augmented the IL-8 production caused by IL-4 or tumor necrosis factor-alpha. Histamine 0-9 interleukin 4 Homo sapiens 55-59 16185276-2 2005 In this study, we examined the effect of histamine, a prototypic mediator of allergic inflammation, on the granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin (IL)-4-driven differentiation of monocytes into monocyte-derived dendritic cells (MoDC), which typically showed CD1a+CD14- phenotype. Histamine 41-50 interleukin 4 Homo sapiens 169-187 12949246-0 2003 IL-4 primes human endothelial cells for secondary responses to histamine. Histamine 63-72 interleukin 4 Homo sapiens 0-4 12949246-4 2003 IL-4 alone did not enhance PAF synthesis or PGE(2) release; however, pretreatment with IL-4 primed for PAF synthesis and PGE(2) release in response to subsequent stimulation with histamine. Histamine 179-188 interleukin 4 Homo sapiens 0-4 12949246-4 2003 IL-4 alone did not enhance PAF synthesis or PGE(2) release; however, pretreatment with IL-4 primed for PAF synthesis and PGE(2) release in response to subsequent stimulation with histamine. Histamine 179-188 interleukin 4 Homo sapiens 87-91 12949246-8 2003 In addition, the dose-response curve for histamine-induced elevations in intracellular calcium was shifted following IL-4 stimulation. Histamine 41-50 interleukin 4 Homo sapiens 117-121 12949246-9 2003 Together, these data indicate that HR1 is up-regulated in IL-4-stimulated human umbilical vein endothelial cells (HUVEC) and suggest that this up-regulation may contribute to the enhanced responsiveness of IL-4-stimulated HUVEC to histamine. Histamine 231-240 interleukin 4 Homo sapiens 58-62 12949246-9 2003 Together, these data indicate that HR1 is up-regulated in IL-4-stimulated human umbilical vein endothelial cells (HUVEC) and suggest that this up-regulation may contribute to the enhanced responsiveness of IL-4-stimulated HUVEC to histamine. Histamine 231-240 interleukin 4 Homo sapiens 206-210 11692111-1 2001 BACKGROUND: The human recombinant histamine-releasing factor (HrHRF) acts as a complete stimulus for histamine release and IL-4 secretion from a subpopulation of highly allergic donor basophils, termed IgE(+) basophils. Histamine 34-43 interleukin 4 Homo sapiens 123-127 11916128-0 2002 Histamine-induced IL-6 and IL-8 production are differentially modulated by IFN-gamma and IL-4 in human keratinocytes. Histamine 0-9 interleukin 4 Homo sapiens 89-93 12444324-11 2002 However, sera that activated basophils so that they released histamine also produced leukotriene and IL-4, and leukotriene production by cutaneous mast cells and basophils was closely correlated. Histamine 61-70 interleukin 4 Homo sapiens 101-105 11916128-9 2002 Interestingly, IFN-gamma and IL-4 both significantly augmented the histamine-induced IL-6 production. Histamine 67-76 interleukin 4 Homo sapiens 29-33 11916128-10 2002 On the other hand, the production of IL-8 was inhibited by IFN-gamma, and IFN-gamma and IL-4 both completely abrogated the histamine-induced IL-8 production. Histamine 123-132 interleukin 4 Homo sapiens 88-92 11916128-11 2002 These results suggest that the histamine-induced IL-6 production and IL-8 production are differentially regulated by IFN-gamma and IL-4. Histamine 31-40 interleukin 4 Homo sapiens 131-135 10092096-4 1999 Lectins with high IL-4-inducing capacity also stimulated the release of IL-13 and histamine. Histamine 82-91 interleukin 4 Homo sapiens 18-22 11485386-3 2001 In humans, rapid allergen-dependent release of IL-4 and the related cytokine IL-13 from histamine-containing cells occurs primarily in basophils, along with other proinflammatory mediators such as histamine and LTC4. Histamine 88-97 interleukin 4 Homo sapiens 47-51 11485386-3 2001 In humans, rapid allergen-dependent release of IL-4 and the related cytokine IL-13 from histamine-containing cells occurs primarily in basophils, along with other proinflammatory mediators such as histamine and LTC4. Histamine 197-206 interleukin 4 Homo sapiens 47-51 11306145-3 2001 The aim of this study was to determine the presence and to characterize the role of the endogenously produced histamine during in vitro dendritic cell (DC) differentiation induced by interleukin-4 (IL-4) and granulocyte-monocyte colony stimulating factor (GM-CSF). Histamine 110-119 interleukin 4 Homo sapiens 183-196 11306145-3 2001 The aim of this study was to determine the presence and to characterize the role of the endogenously produced histamine during in vitro dendritic cell (DC) differentiation induced by interleukin-4 (IL-4) and granulocyte-monocyte colony stimulating factor (GM-CSF). Histamine 110-119 interleukin 4 Homo sapiens 198-202 11566179-5 2001 These findings suggest that histamine synthesized in the arterial wall participates in the initiation and progression of atherosclerosis and that IL-4 can act as an important inhibitory and/or stimulatory factor in the function of monocytes/macrophages modulated by histamine in relation to the process of atherosclerosis. Histamine 266-275 interleukin 4 Homo sapiens 146-150 10393951-5 1999 Moreover, IL-4, which by itself had no visible effect on human MC, enhanced the release of histamine, leukotriene C4, and IL-5 in MC triggered by IgE receptor crosslinking. Histamine 91-100 interleukin 4 Homo sapiens 10-14 9647730-3 1998 When KU812 cells were cultured with 1 ng/ml IL-4, cellular histamine content increased more than 10-fold. Histamine 59-68 interleukin 4 Homo sapiens 44-48 9647730-7 1998 In addition, IgE-mediated histamine release was observed, suggesting that the Fc epsilon RI induced by IL-4 was functional and was able to transduce a signal for degranulation. Histamine 26-35 interleukin 4 Homo sapiens 103-107 9469459-0 1998 Differential regulation of IL-4 and IL-13 secretion by human basophils: their relationship to histamine release in mixed leukocyte cultures. Histamine 94-103 interleukin 4 Homo sapiens 27-31 9569243-0 1998 Histamine affects interleukin-4, interleukin-5, and interferon-gamma production by human T cell clones from the airways and blood. Histamine 0-9 interleukin 4 Homo sapiens 18-31 9569243-2 1998 This study describes the effects of histamine on anti-CD3-induced production of IL-4, IL-5, and IFN-gamma by T cell clones from subjects with allergic asthma and healthy subjects. Histamine 36-45 interleukin 4 Homo sapiens 80-84 9569243-4 1998 The number of clones tested, and the percentage of clones in which histamine inhibited or enhanced cytokine production by more than 25%, were as follows: IL-4, 47, 8.5%, and 4.3%; IL-5, 43, 14%, and 30%; and IFN-gamma, 52, 40%, and 15%. Histamine 67-76 interleukin 4 Homo sapiens 154-158 9469459-4 1998 While the magnitude of IL-4 protein generated correlated with the percent histamine secreted (r = 0.8; p = 0.007), there was no relationship between the levels of IL-13 detected and the amount of either IL-4 or histamine in cultures activated with IL-3/anti-IgE. Histamine 74-83 interleukin 4 Homo sapiens 23-27 9200485-1 1997 Human recombinant histamine-releasing factor (HrHRF) is known to directly stimulate histamine release and IL-4 secretion from basophils of selected atopic donors in a reaction requiring the expression of a particular type of IgE, referred to as IgE+. Histamine 18-27 interleukin 4 Homo sapiens 106-110 9182905-0 1997 Different modulation by histamine of IL-4 and interferon-gamma (IFN-gamma) release according to the phenotype of human Th0, Th1 and Th2 clones. Histamine 24-33 interleukin 4 Homo sapiens 37-41 9182905-2 1997 We examined the effect of histamine on the release of the Th2-associated cytokines IL-4 and IL-5 and the Th1-associated cytokine IFN-gamma by 30 CD4+ T cell clones from peripheral blood or bronchial biopsy of one atopic subject. Histamine 26-35 interleukin 4 Homo sapiens 83-87 9182905-5 1997 Regarding Th0 clones, histamine inhibited IL-4 production (P < 0.02) in a dose-dependent manner and slightly inhibited IFN-gamma production, but had no effect on Th2-like cells. Histamine 22-31 interleukin 4 Homo sapiens 42-46 9182905-9 1997 These data demonstrate that histamine has different effects on IL-4 and IFN-gamma release by T helper cells according to their phenotype via H2-receptors. Histamine 28-37 interleukin 4 Homo sapiens 63-67 18472844-0 1997 Interleukin-4 (IL-4) enhances and soluble interleukin-4 receptor (sIL-4R) inhibits histamine release from peripheral blood basophils and mast cells in vitro and in vivo. Histamine 83-92 interleukin 4 Homo sapiens 42-55 9021924-8 1997 At a wall shear stress of 2 dyn/cm2, the mean T cell rolling velocities were significantly lower on 24-h IL-4-activated HUVECs (10.2 +/- 2.6 microgm/s) compared with either CHO-P cells (15.6 +/- 3.1 microm/s) or histamine-stimulated HUVECs (16.6 +/- 6.1 microm/s). Histamine 212-221 interleukin 4 Homo sapiens 105-109 18472844-1 1997 The aim of the study was to analyse the effect of interleukin-4 (IL-4) on allergen and anti-IgE mediated histamine release from basophils and human skin mast cells and to assess whether soluble recombinant interleukin-4 receptor (sIL4R) can inhibit these effects. Histamine 105-114 interleukin 4 Homo sapiens 50-63 18472844-1 1997 The aim of the study was to analyse the effect of interleukin-4 (IL-4) on allergen and anti-IgE mediated histamine release from basophils and human skin mast cells and to assess whether soluble recombinant interleukin-4 receptor (sIL4R) can inhibit these effects. Histamine 105-114 interleukin 4 Homo sapiens 65-69 8859220-12 1996 These findings strongly suggest that histamine upregulates VCAM-1 expression at the transcriptional level through newly generated of mRNA in endothelial cells stimulated with IL-4 and TNF-alpha. Histamine 37-46 interleukin 4 Homo sapiens 175-179 8988338-2 1996 Northern blot analysis revealed that addition of IL-4 with or without histamine stimulated the cells to increase the amount of proMMP-1 mRNA, and the IL-4 with histamine addition resulted in a 3.3-fold increase compared with histamine only. Histamine 160-169 interleukin 4 Homo sapiens 150-154 8988338-2 1996 Northern blot analysis revealed that addition of IL-4 with or without histamine stimulated the cells to increase the amount of proMMP-1 mRNA, and the IL-4 with histamine addition resulted in a 3.3-fold increase compared with histamine only. Histamine 160-169 interleukin 4 Homo sapiens 150-154 8859220-0 1996 Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells. Histamine 0-9 interleukin 4 Homo sapiens 40-44 8921414-7 1996 Fc epsilon RI induced by IL-4 was functional and caused histamine and beta-hexosaminidase release from mast cells upon cross-linking. Histamine 56-65 interleukin 4 Homo sapiens 25-29 8859220-3 1996 We used immunocytochemical staining analysis to examine the effect of chemical mediators, including histamine, leukotrienes and platelet-activating factor (PAF), on VCAM-1 expression in IL-4- and TNF-alpha-stimulated endothelial cells. Histamine 100-109 interleukin 4 Homo sapiens 186-190 8859220-4 1996 Histamine, significantly augmented (p < 0.05 to p < 0.01) VCAM-1 expression in both IL-4- and TNF-alpha-stimulated endothelial cells. Histamine 0-9 interleukin 4 Homo sapiens 90-94 8859220-5 1996 IL-4 and TNF-alpha were found to have a synergistic effect on endothelial cell VCAM-1 expression, when compared with the effect of stimulation with each of these cytokines separately, and the addition of histamine further increased VCAM-1 expression. Histamine 204-213 interleukin 4 Homo sapiens 0-4 8642270-2 1996 The secretion of IL-4 protein induced by rHRF significantly correlated with histamine release and the amount of protein generated, and the kinetics were identical to those caused by anti-IgE activation. Histamine 76-85 interleukin 4 Homo sapiens 17-21 8691152-7 1996 Under flow conditions, neutrophils rolled on P-selectin expressed by IL-4-treated HUVEC, and even more neutrophils rolled on P-selectin after IL-4-treated HUVEC were stimulated with histamine. Histamine 182-191 interleukin 4 Homo sapiens 142-146 8760789-2 1996 Histamine selectively enhanced IgE and IgG4 production in purified surface IgE and IgG4 negative (sIgE-sIgG4-) B cells from normal donors stimulated with interleukin (IL)-4 plus anti-CD58 or IL-13 plus anti-CD58 monoclonal antibody (mAb) without affecting production of IgG1, IgG2, IgG3, IgM, IgA1, or IgA2. Histamine 0-9 interleukin 4 Homo sapiens 154-172 8760789-3 1996 In cultures with IL-4 plus anti-CD58 mAb, histamine-induced enhancement of IgE and IgG4 production was specifically blocked by thioperamide (H3 receptor antagonist), and was inhibited by anti-IL-10 antibody (Ab). Histamine 42-51 interleukin 4 Homo sapiens 17-21 8760789-7 1996 Histamine increased IL-10 and IL-6 production without affecting IL-10 and IL-6 receptor expression, in cultures with IL-4 plus anti-CD58 mAb and with IL-13 plus anti-CD58 mAb, respectively, which was blocked by thioperamide and dimaprit, respectively. Histamine 0-9 interleukin 4 Homo sapiens 117-121 7480030-1 1995 Histamine inhibits IL-4 secretion from T helper type 2 cells but enhances IL-5 secretion from the same cells. Histamine 0-9 interleukin 4 Homo sapiens 19-23 8670730-12 1996 There was a correlation between the level of IL-4 and histamine (p = 0.0001). Histamine 54-63 interleukin 4 Homo sapiens 45-49 7579337-7 1995 Preincubation of mast cells with SCF, IL-4, IL-5, or IL-6 for 24 hours during sensitization with IgE enhanced IgE/anti-IgE antibody-induced histamine release from mast cells, whereas IL-3 showed a negligible effect. Histamine 140-149 interleukin 4 Homo sapiens 38-42 1372188-0 1992 Effects of in vivo administration of interleukin-2 (IL-2) and IL-4, alone and in combination, on ex vivo human basophil histamine release. Histamine 120-129 interleukin 4 Homo sapiens 62-66 7879707-3 1994 We have investigated the effect of histamine on anti-CD3 induced IL-4 and IL-5 production by TH2 cells. Histamine 35-44 interleukin 4 Homo sapiens 65-69 7879707-4 1994 Histamine in concentrations between 10(-7) and 10(-5) mol/l concentration-dependently increased anti-CD3 induced IL-5 production up to 120%, whereas IL-4 production was not affected. Histamine 0-9 interleukin 4 Homo sapiens 149-153 7519213-4 1994 We have used cells prepared using Percoll gradients (5 to 30% basophils) to study the relationship between histamine release and IL-4 synthesis. Histamine 107-116 interleukin 4 Homo sapiens 129-133 1430703-8 1992 Thus systemically administered IL-4 causes the subjective sensation of nasal congestion, increased histamine in nasal lavages, and the development of vascular unresponsiveness to histamine, without affecting parasympathetic responses to histamine. Histamine 99-108 interleukin 4 Homo sapiens 31-35 1430703-8 1992 Thus systemically administered IL-4 causes the subjective sensation of nasal congestion, increased histamine in nasal lavages, and the development of vascular unresponsiveness to histamine, without affecting parasympathetic responses to histamine. Histamine 179-188 interleukin 4 Homo sapiens 31-35 1430703-8 1992 Thus systemically administered IL-4 causes the subjective sensation of nasal congestion, increased histamine in nasal lavages, and the development of vascular unresponsiveness to histamine, without affecting parasympathetic responses to histamine. Histamine 179-188 interleukin 4 Homo sapiens 31-35 1520626-0 1992 Interleukin-4 and nerve growth factor can act as cofactors for interleukin-3-induced histamine production in human umbilical cord blood cells in serum-free culture. Histamine 85-94 interleukin 4 Homo sapiens 0-13 1520626-5 1992 In contrast, IL-3-promoted histamine production in serum-free cultures was significantly enhanced by IL-4 and NGF. Histamine 27-36 interleukin 4 Homo sapiens 101-113 1520626-6 1992 These results demonstrate that both IL-4 and NGF can function as cofactors with IL-3 in the support of histamine production in human umbilical cord blood cells. Histamine 103-112 interleukin 4 Homo sapiens 36-40 8144899-10 1994 IL-4 secretion was slower (t1/2 of 1.5 h) than histamine release and was inhibited by cycloheximide. Histamine 47-56 interleukin 4 Homo sapiens 0-4 1372188-6 1992 Both IL-2 and IL-4, alone and in combination, enhanced basophil histamine release induced by histamine releasing factors in human nasal washings. Histamine 64-73 interleukin 4 Homo sapiens 14-18 1372188-2 1992 The effect of 3 days of intravenous administration of IL-2 and/or IL-4 on basophil histamine release was examined in three groups of patients receiving IL-2, IL-4, or the combination of agents as part of a protocol to treat malignant melanoma or renal cell carcinoma. Histamine 83-92 interleukin 4 Homo sapiens 66-70 1372188-4 1992 IL-4 significantly inhibited IgE-mediated histamine release, while there was a trend for enhancement of IgE-mediated histamine release by IL-2. Histamine 42-51 interleukin 4 Homo sapiens 0-4 12810348-4 2003 Histamine enhances the secretion of Th2 cytokines such as IL-4 (interleukin-4), IL-5, IL-10 and IL-13 and inhibits the production of Th1 cytokines IL-2 and IFNgamma (interferon-gamma) and monokine IL-12. Histamine 0-9 interleukin 4 Homo sapiens 58-62 1695452-2 1990 Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). Histamine 103-112 interleukin 4 Homo sapiens 144-157 1695452-2 1990 Cells from approximately half of the AIDS patients, in contrast to none from the control group, showed histamine release after stimulation with interleukin-4 (IL-4), tumor necrosis factor alpha (TNF alpha), lymphotoxin (LT) and interferon gamma (IFN gamma). Histamine 103-112 interleukin 4 Homo sapiens 159-163 12810348-4 2003 Histamine enhances the secretion of Th2 cytokines such as IL-4 (interleukin-4), IL-5, IL-10 and IL-13 and inhibits the production of Th1 cytokines IL-2 and IFNgamma (interferon-gamma) and monokine IL-12. Histamine 0-9 interleukin 4 Homo sapiens 64-77 31805312-5 2020 IL-4, but not IL-5 or IL-17A, also increased the potency of histamine. Histamine 60-69 interleukin 4 Homo sapiens 0-4 34650557-13 2021 The expression level of mast cell/basophil specific CD203c were significantly increased in EVs derived from serum and basophils of HR patients, and the CD203c+-EVs production in mast cells is dramatically increased in the presence of IL4, which positively correlated with histamine, tryptase and inflammatory mediators. Histamine 272-281 interleukin 4 Homo sapiens 234-237 32587127-3 2020 Interleukin-4 (IL-4), which is crucial in the development of allergic inflammation, increases the expression and activity of ANO1 by stimulating histamine receptors. Histamine 145-154 interleukin 4 Homo sapiens 0-13 32587127-3 2020 Interleukin-4 (IL-4), which is crucial in the development of allergic inflammation, increases the expression and activity of ANO1 by stimulating histamine receptors. Histamine 145-154 interleukin 4 Homo sapiens 15-19 31783259-2 2020 A number of activators including interleukin 3 (IL-3) and IgE have been identified in the regulation of human basophils expressing mediators such as histamine and leukotriene C4 (LTC4) and cytokines, including IL-4 and IL-13. Histamine 149-158 interleukin 4 Homo sapiens 210-214 34958173-3 2022 Pathophysiologically, the histamine-independent pruritogens interleukin-31, interleukin-13, and interleukin-4, have been shown to play a major role in atopic dermatitis. Histamine 26-35 interleukin 4 Homo sapiens 96-109 32882088-0 2021 Histamine down-regulates the FCERI alpha-chain expression in human IL-4-activated M2 macrophages. Histamine 0-9 interleukin 4 Homo sapiens 67-71 31805312-6 2020 In HASMC, IL-13 and IL-4, but not IL-5 and IL-17A, enhanced the histamine-induced Ca2+-mobilisation that was accompanied with increased mRNA expression of histamine H1 and CysLT1 receptors. Histamine 64-73 interleukin 4 Homo sapiens 20-24 31805312-6 2020 In HASMC, IL-13 and IL-4, but not IL-5 and IL-17A, enhanced the histamine-induced Ca2+-mobilisation that was accompanied with increased mRNA expression of histamine H1 and CysLT1 receptors. Histamine 155-164 interleukin 4 Homo sapiens 20-24 25585347-4 2015 An evaluation of mast cell activator secretion revealed that IFN-gamma- or IL-4-pretreated HMC-1 cells released dramatically increased levels of beta-hexosaminidase and histamine when stimulated with iopromide. Histamine 169-178 interleukin 4 Homo sapiens 75-79 27756601-7 2016 Moreover, we observed significantly decreased IL-4 level in histamine/osthole theatment compared to histamine alone. Histamine 60-69 interleukin 4 Homo sapiens 46-50 27756601-7 2016 Moreover, we observed significantly decreased IL-4 level in histamine/osthole theatment compared to histamine alone. Histamine 100-109 interleukin 4 Homo sapiens 46-50 28546154-11 2017 Pretreatment with IL-4 augmented the histamine response that was suppressed by a TMEM16A inhibitor. Histamine 37-46 interleukin 4 Homo sapiens 18-22 28546154-14 2017 We elucidated histamine-induced fluid secretions in synergy with IL-4 through TMEM16A in the human airway epithelium. Histamine 14-23 interleukin 4 Homo sapiens 65-69 27650274-7 2016 FcepsilonRI cell surface expression, FcepsilonRIalpha-specific mRNA and FcepsilonRI-mediated histamine release are all augmented by IL-4, while histamine release elicited by the non-immunological stimulus, substance P, remains unaffected. Histamine 93-102 interleukin 4 Homo sapiens 132-136 27650274-9 2016 Intriguingly, IL-4 impacts granule-associated mediators, especially histamine whose synthesis is boosted in the presence of IL-4. Histamine 68-77 interleukin 4 Homo sapiens 14-18 27650274-9 2016 Intriguingly, IL-4 impacts granule-associated mediators, especially histamine whose synthesis is boosted in the presence of IL-4. Histamine 68-77 interleukin 4 Homo sapiens 124-128 27650274-10 2016 To our knowledge, an increase in histamine production by IL-4 has not been described yet for any type of MCs, but may well contribute to its pro-allergic effect given the significance of this biogenic amine to allergic symptoms. Histamine 33-42 interleukin 4 Homo sapiens 57-61 27226579-4 2016 By confocal microscopy and RT-PCR expression of Rac1/CdC42 Rho GTPases, responsible for actin remodeling, we show that histamine selectively modifies actin cytoskeleton organization induced by TLR4, but not TLR2 and this correlates with increased IL4 production and decreased IFNgamma by primed T cells. Histamine 119-128 interleukin 4 Homo sapiens 247-250