PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19547708-4 2009 Histamine exerts its biological effects through four different receptors designated H1R, H2R, H3R, and H4R. Histamine 0-9 histamine receptor H3 Mus musculus 84-97 20384344-1 2010 The terminal nitrogen atom of histamine was modified with lipophilic substituents to investigate the structure-activity relationship of histamine type 3 receptor (H3R) agonists. Histamine 30-39 histamine receptor H3 Mus musculus 136-166 21573995-0 2011 Histamine H3 receptor agonists decrease hypothalamic histamine levels and increase stereotypical biting in mice challenged with methamphetamine. Histamine 53-62 histamine receptor H3 Mus musculus 0-21 21573995-9 2011 These increases in histamine levels were significantly decreased by pretreatment with histamine H(3) receptor agonists, effects which would appear to underlie the shift from METH-induced stereotypical sniffing to biting. Histamine 19-28 histamine receptor H3 Mus musculus 86-109 19547708-5 2009 PRINCIPAL FINDINGS: In the present work, we explored the role of histamine signaling via the histamine H3 receptor (H3R) in the pathogenesis of murine CM. Histamine 65-74 histamine receptor H3 Mus musculus 93-114 19547708-5 2009 PRINCIPAL FINDINGS: In the present work, we explored the role of histamine signaling via the histamine H3 receptor (H3R) in the pathogenesis of murine CM. Histamine 65-74 histamine receptor H3 Mus musculus 116-119 19547708-7 2009 Additionally tele-methylhistamine, the major histamine metabolite in the brain, that was initially present at a higher level in the brain of H3R(-/-) mice was depleted more quickly post-infection in H3R(-/-) mice as compared to wild-type counterparts. Histamine 24-33 histamine receptor H3 Mus musculus 141-144 19547708-7 2009 Additionally tele-methylhistamine, the major histamine metabolite in the brain, that was initially present at a higher level in the brain of H3R(-/-) mice was depleted more quickly post-infection in H3R(-/-) mice as compared to wild-type counterparts. Histamine 24-33 histamine receptor H3 Mus musculus 199-202 19547708-8 2009 CONCLUSIONS: Our data suggest that histamine regulation through the H3R in the brain suppresses the development of CM. Histamine 35-44 histamine receptor H3 Mus musculus 68-71 16310812-7 2006 These findings suggest that histamine and acetylcholine are involved in the different processes of learning and memory in the brain and that histamine H(3) receptor antagonists might be useful in the treatment of cognitive impairment in epilepsy. Histamine 28-37 histamine receptor H3 Mus musculus 141-164 16648667-0 2006 Recent advances in molecular pharmacology of the histamine systems: physiology and pharmacology of histamine H3 receptor: roles in feeding regulation and therapeutic potential for metabolic disorders. Histamine 49-58 histamine receptor H3 Mus musculus 99-120 33773463-0 2021 The histamine H3R and dopamine D2R/D3R antagonist ST-713 ameliorates autism-like behavioral features in BTBR T+tf/J mice by multiple actions. Histamine 4-13 histamine receptor H3 Mus musculus 14-17 11728428-9 2001 Although further clarification is needed, these results suggest that some histamine H(3) receptor antagonists may promote the release of neuronal histamine, but also act to reduce histamine methylation in vivo by an unknown mechanism. Histamine 146-155 histamine receptor H3 Mus musculus 74-97 8088374-2 1994 Histamine H3 receptor agonists are reported to stimulate adrenocorticotropic hormone (ACTH) release from AtT-20 cells, an effect blocked by histamine H3 but not H1 or H2 receptor antagonists. Histamine 140-149 histamine receptor H3 Mus musculus 0-21 12706455-6 2003 Human embryonic kidney (HEK)-293 cells transiently transfected with mouse histamine H(3) receptor cDNA and Gq(i5) exhibited increases of intracellular Ca(2+) in response to histamine and several histamine H(3) receptor agonists. Histamine 74-83 histamine receptor H3 Mus musculus 195-218 11728428-1 2001 Thioperamide, the prototypical histamine H(3) receptor antagonist, acts at the brain histamine H(3) autoreceptor to promote the release and metabolism of neuronal histamine, resulting in higher brain levels of the metabolite tele-methylhistamine. Histamine 85-94 histamine receptor H3 Mus musculus 31-54 35204685-1 2022 Among the histamine receptors, growing evidence points to the histamine H3 receptor as a pharmacological candidate to counteract the autonomic neuropathy associated with diabetes. Histamine 10-19 histamine receptor H3 Mus musculus 62-83 34563511-3 2022 Histamine H3 receptor (H3R) is a presynaptic autoreceptor regulating histamine release via negative feedback way. Histamine 69-78 histamine receptor H3 Mus musculus 0-21 34563511-3 2022 Histamine H3 receptor (H3R) is a presynaptic autoreceptor regulating histamine release via negative feedback way. Histamine 69-78 histamine receptor H3 Mus musculus 23-26 35431009-7 2022 CONCLUSION: Treatment of mice with centrally acting histamine H3 receptor antagonists increases hypothalamic histamine contents and reduces high-dose METH effects, while potentiating low-dose effects, via histamine H1 receptors that bind released histamine. Histamine 109-118 histamine receptor H3 Mus musculus 52-73 35431009-7 2022 CONCLUSION: Treatment of mice with centrally acting histamine H3 receptor antagonists increases hypothalamic histamine contents and reduces high-dose METH effects, while potentiating low-dose effects, via histamine H1 receptors that bind released histamine. Histamine 205-214 histamine receptor H3 Mus musculus 52-73 35431009-7 2022 CONCLUSION: Treatment of mice with centrally acting histamine H3 receptor antagonists increases hypothalamic histamine contents and reduces high-dose METH effects, while potentiating low-dose effects, via histamine H1 receptors that bind released histamine. Histamine 247-256 histamine receptor H3 Mus musculus 52-73 32964244-5 2021 The histamine H3 receptor (H3R) antagonist ciproxifan was applied to increase histamine in the brain. Histamine 4-13 histamine receptor H3 Mus musculus 27-30 33682314-3 2021 Histamine H3 receptor (H3R) is a presynaptic autoreceptor regulating histamine release via negative feedback way. Histamine 69-78 histamine receptor H3 Mus musculus 0-21 33682314-3 2021 Histamine H3 receptor (H3R) is a presynaptic autoreceptor regulating histamine release via negative feedback way. Histamine 69-78 histamine receptor H3 Mus musculus 23-26 26854127-1 2016 Conclusion The present findings show that all four types of histamine receptors (H1R, H2R, H3R, and H4R) are present in the inner ear, thus supporting the hypothesis that histamine plays a physiological role in the inner ear. Histamine 60-69 histamine receptor H3 Mus musculus 81-103 32529860-1 2020 Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. Histamine 0-9 histamine receptor H3 Mus musculus 10-22 32529860-1 2020 Histamine H3 receptors (H3R) antagonists/inverse agonists are becoming a promising therapeutic approach for epilepsy. Histamine 0-9 histamine receptor H3 Mus musculus 24-27 32435195-7 2020 Control and Gabrd KO mice were treated with histamine receptor 3 (Hrh3) inverse agonists ciproxifan and pitolisant, which block Hrh3 autoreceptors on histamine/GABA neurons and histamine-dependently promote wakefulness. Histamine 44-53 histamine receptor H3 Mus musculus 66-70 33035498-4 2020 Because H3R is involved in feedback inhibition of histamine synthesis and secretion, the expression of the autoreceptor may also be reciprocally regulated by altered histamine levels in a pathological condition. Histamine 50-59 histamine receptor H3 Mus musculus 8-11 33035498-4 2020 Because H3R is involved in feedback inhibition of histamine synthesis and secretion, the expression of the autoreceptor may also be reciprocally regulated by altered histamine levels in a pathological condition. Histamine 166-175 histamine receptor H3 Mus musculus 8-11 33035498-5 2020 Thus, we investigated H3R expression in a mouse model of cow"s milk allergy, a condition associated with increased histamine levels. Histamine 115-124 histamine receptor H3 Mus musculus 22-25 32513388-0 2020 Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington"s disease. Histamine 40-49 histamine receptor H3 Mus musculus 50-62 32513388-2 2020 To reduce D1R over-activation, we present a strategy based on targeting complexes of D1R and histamine H3 receptors (H3R). Histamine 93-102 histamine receptor H3 Mus musculus 103-115 32513388-2 2020 To reduce D1R over-activation, we present a strategy based on targeting complexes of D1R and histamine H3 receptors (H3R). Histamine 93-102 histamine receptor H3 Mus musculus 117-120 32503208-1 2020 The histamine H3 receptor (H3R) functions as auto- and hetero-receptors, regulating the release of brain histamine (HA) and acetylcholine (ACh), respectively. Histamine 4-13 histamine receptor H3 Mus musculus 27-30 32503208-1 2020 The histamine H3 receptor (H3R) functions as auto- and hetero-receptors, regulating the release of brain histamine (HA) and acetylcholine (ACh), respectively. Histamine 116-118 histamine receptor H3 Mus musculus 4-25 32503208-1 2020 The histamine H3 receptor (H3R) functions as auto- and hetero-receptors, regulating the release of brain histamine (HA) and acetylcholine (ACh), respectively. Histamine 116-118 histamine receptor H3 Mus musculus 27-30 32435195-7 2020 Control and Gabrd KO mice were treated with histamine receptor 3 (Hrh3) inverse agonists ciproxifan and pitolisant, which block Hrh3 autoreceptors on histamine/GABA neurons and histamine-dependently promote wakefulness. Histamine 44-53 histamine receptor H3 Mus musculus 128-132 32435195-7 2020 Control and Gabrd KO mice were treated with histamine receptor 3 (Hrh3) inverse agonists ciproxifan and pitolisant, which block Hrh3 autoreceptors on histamine/GABA neurons and histamine-dependently promote wakefulness. Histamine 150-159 histamine receptor H3 Mus musculus 128-132 32435195-7 2020 Control and Gabrd KO mice were treated with histamine receptor 3 (Hrh3) inverse agonists ciproxifan and pitolisant, which block Hrh3 autoreceptors on histamine/GABA neurons and histamine-dependently promote wakefulness. Histamine 150-159 histamine receptor H3 Mus musculus 128-132 31790304-6 2020 qRT-PCR revealed significant expression of histamine receptor subtypes (Hrh1-Hrh3) in mouse lumbosacral dorsal root ganglia (DRG), bladder detrusor smooth muscle, mucosa, and isolated urothelial cells. Histamine 43-52 histamine receptor H3 Mus musculus 77-81 31675226-6 2019 The proposed H3R binding mode of 14d indicates key interactions similar to those attained by histamine. Histamine 93-102 histamine receptor H3 Mus musculus 13-16 30998358-1 2019 The histamine 3 receptor (H3R) is a presynaptic receptor, which modulates several neurotransmitters including histamine and various essential physiological processes, such as feeding, arousal, cognition, and pain. Histamine 4-13 histamine receptor H3 Mus musculus 26-29 26660098-2 2015 The aim of this study was to examine whether histamine mediates its effects on the circadian system through Hrh1 or Hrh3 receptors. Histamine 45-54 histamine receptor H3 Mus musculus 116-120 26826667-5 2016 Upon stimulation by H3R agonist histamine or imetit, H3R was shown to rapidly induce ERK1/2 phosphorylation via PLC/PKC-, PLDs-, and epidermal growth factor receptor (EGFR) transactivation-dependent pathways. Histamine 32-41 histamine receptor H3 Mus musculus 20-23 26826667-5 2016 Upon stimulation by H3R agonist histamine or imetit, H3R was shown to rapidly induce ERK1/2 phosphorylation via PLC/PKC-, PLDs-, and epidermal growth factor receptor (EGFR) transactivation-dependent pathways. Histamine 32-41 histamine receptor H3 Mus musculus 53-56 26945087-2 2016 Histamine also regulates alcohol reward and consumption via H3 receptor (H3R), possibly through an interaction with the brain dopaminergic system. Histamine 0-9 histamine receptor H3 Mus musculus 60-71 26945087-2 2016 Histamine also regulates alcohol reward and consumption via H3 receptor (H3R), possibly through an interaction with the brain dopaminergic system. Histamine 0-9 histamine receptor H3 Mus musculus 73-76 24566390-8 2014 Therefore, H3R promotes I/R injury while its antagonism protects against ischaemic injury via histamine-independent mechanisms that involve suppressing H3R/CLIC4 binding-activated autophagy, suggesting that H3R inhibition is a therapeutic target for cerebral ischaemia. Histamine 94-103 histamine receptor H3 Mus musculus 11-14 25500891-11 2015 By contrast, H3R may participate in the regulation of specialized myocyte functions, potentially by maintaining the relaxed state under the influence of constitutive H3R activity and low histamine concentrations, locally produced/released by non-professional histamine-producing cells. Histamine 187-196 histamine receptor H3 Mus musculus 13-16 25500891-11 2015 By contrast, H3R may participate in the regulation of specialized myocyte functions, potentially by maintaining the relaxed state under the influence of constitutive H3R activity and low histamine concentrations, locally produced/released by non-professional histamine-producing cells. Histamine 259-268 histamine receptor H3 Mus musculus 13-16 25102165-3 2014 Activation of presynaptic H3R inhibits the release of histamine and of non-histaminergic neurotransmitters. Histamine 54-63 histamine receptor H3 Mus musculus 26-29 25102165-6 2014 Constitutive H3R activity may add another layer of complexity by causing "histamine-independent histaminergic" processes, e.g. in Hdc(-/-) mice. Histamine 74-83 histamine receptor H3 Mus musculus 13-16