PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16920098-3 2006 Histamine and amthamine, a selective histamine H(2)-receptor agonist, concentration-dependently decreased myogenic tone, which was unchanged in the absence of endothelium. Histamine 0-9 histamine receptor H 2 Rattus norvegicus 37-60 26474912-7 2015 We found that the microinjection of histamine (0.05, 0.5, and 5mug) into FN significantly attenuated the SGMD, in a dose-dependent manner, whereas, the microinjection of histamine H2 receptor antagonist, ranitidine, and glutamic acid decarboxylase antagonist, 3-mercaptopropionic acid (3-MPA) exacerbated the SGMD. Histamine 36-45 histamine receptor H 2 Rattus norvegicus 170-191 25304183-10 2014 A plausible explanation for these findings is that histamine, due to excitatory action mediated by the histamine H2 receptor on noradrenergic cell bodies, promotes descending spinal alpha1/2-adrenoceptor-mediated inhibition of neuropathic hypersensitivity. Histamine 51-60 histamine receptor H 2 Rattus norvegicus 103-124 22926047-0 2013 Histamine at low concentrations aggravates rat liver BRL-3A cell injury induced by hypoxia/reoxygenation through histamine H2 receptor in vitro. Histamine 0-9 histamine receptor H 2 Rattus norvegicus 113-134 22926047-8 2013 CONCLUSION: Histamine at low concentrations (10(-7)-10(-9) M) aggravates hypoxia/reoxygenation mediated BRL-3A damage through histamine H2 receptor. Histamine 12-21 histamine receptor H 2 Rattus norvegicus 126-147 22314222-1 2012 A previous report showed that histamine in denuded mesenteric vascular beds produced a triphasic response; an initial small histamine H(2) receptor-mediated vasodilation, a transient histamine H(1) receptor-mediated vasoconstriction, and finally a long-lasting vasodilation. Histamine 30-39 histamine receptor H 2 Rattus norvegicus 124-147 27159606-1 2016 In this article we report a combined experimental and computational study concerning the effects of deuteration on the binding of histamine and two other histaminergic agonists to 3H-tiotidine-labeled histamine H2 receptor in neonatal rat astrocytes. Histamine 130-139 histamine receptor H 2 Rattus norvegicus 201-222 22418001-9 2013 Our results indicate that activation of post-synaptic H2R within the NBM by endogenous histamine is responsible for the potentiated expression of fear responses. Histamine 87-96 histamine receptor H 2 Rattus norvegicus 54-57 16920098-6 2006 The dilation to histamine was antagonized by tiotidine, a selective antagonist of histamine H(2)-receptor subtype, giving a pK(B) of 7.86 that was not altered in the absence of endothelium. Histamine 16-25 histamine receptor H 2 Rattus norvegicus 82-105 16920098-11 2006 These results suggest that histamine-mediated reversal of myogenic tone in rat cerebral arteries is endothelium-independent, mediated by histamine H(2)-receptor subtype with no involvement of guanylyl cyclase or adenylyl cyclase activation and most likely involves activation of K(V) potassium channels. Histamine 27-36 histamine receptor H 2 Rattus norvegicus 137-160 16337938-3 2006 Histamine-induced vasodilation was attenuated by L-NAME (nitric oxide (NO) synthase inhibitor, 100 microM) and olopatadine (histamine H(1) receptor antagonist, 1 microM) but not by lafutidine (histamine H(2) receptor antagonist, 1 microM). Histamine 0-9 histamine receptor H 2 Rattus norvegicus 193-216 16513821-1 2006 Short-term studies have shown that histamine is involved, via its H2 receptors (H2R), in the mediator network regulating trabecular bone loss in long bones of ovariectomized (OVX) rats. Histamine 35-44 histamine receptor H 2 Rattus norvegicus 66-78 16513821-1 2006 Short-term studies have shown that histamine is involved, via its H2 receptors (H2R), in the mediator network regulating trabecular bone loss in long bones of ovariectomized (OVX) rats. Histamine 35-44 histamine receptor H 2 Rattus norvegicus 80-83 14550905-3 2003 Histamine H2 receptor antagonist ranitidine effectively blocked the excitatory response of rubral neurons to histamine (n=26), but H1 receptor antagonist triprolidine did not (n=24). Histamine 109-118 histamine receptor H 2 Rattus norvegicus 0-21 16143415-5 2005 The excitatory effect of histamine on the GP neurons was not blocked by selective histamine H1 receptor antagonist triprolidine (n = 16) or chlorpheniramine (n = 6), but was effectively suppressed by ranitidine, a highly selective histamine H2 receptor antagonist (n = 21). Histamine 25-34 histamine receptor H 2 Rattus norvegicus 231-252 14575794-5 2003 Administration of histamine (40-80 microg/rat) and naloxone (0.5-1 microg/rat) increased, while morphine (2.5 microg/rat), pyrilamine (25-50 microg/rat), the histamine H1 receptor antagonist, and ranitidine (10-20 microg/rat), the histamine H2 receptor antagonist, decreased water intake in isolated rats. Histamine 18-27 histamine receptor H 2 Rattus norvegicus 231-252 11499019-4 1999 The excitatory response of PCs to histamine could be blocked by histamine H2 receptor antagonist ranitidine, but not by H1 receptor antagonist triprolidine readily. Histamine 34-43 histamine receptor H 2 Rattus norvegicus 64-85 12832854-9 2003 These results suggest that histamine is a potent inducer of osteoclast differentiation, at least in part, through the histamine H(2)-receptor, and cimetidine has a preventive effect on articular destruction and accompanying inflammation in arthritic rats. Histamine 27-36 histamine receptor H 2 Rattus norvegicus 118-141 12383956-6 2002 The histamine H(2) receptor antagonist ranitidine effectively blocked the excitatory response of IN cells to histamine (n=23), but the histamine H(1) receptor antagonist triprolidine could not significantly block the histamine-induced excitation, or only very slightly decreased the excitatory effect of histamine on the cells (n=21). Histamine 109-118 histamine receptor H 2 Rattus norvegicus 4-27 12383956-6 2002 The histamine H(2) receptor antagonist ranitidine effectively blocked the excitatory response of IN cells to histamine (n=23), but the histamine H(1) receptor antagonist triprolidine could not significantly block the histamine-induced excitation, or only very slightly decreased the excitatory effect of histamine on the cells (n=21). Histamine 109-118 histamine receptor H 2 Rattus norvegicus 4-27 12383956-10 2002 These results demonstrate that histamine excites cerebellar IN cells via the histamine H(2) receptor mechanism. Histamine 31-40 histamine receptor H 2 Rattus norvegicus 77-100 11226684-5 2001 Histamine H(2) receptor was also expressed during development in widespread areas of the central nervous system, coinciding with the transient production of histamine in the raphe neurons at embryonic day 15. Histamine 157-166 histamine receptor H 2 Rattus norvegicus 0-23 10678532-6 2000 The histamine H2 receptor antagonist ranitidine effectively blocked the excitatory response of PCs to histamine (n = 20), but triprolidine, an H1 receptor antagonist, could not significantly block the histamine-induced excitation, or only very slightly decreased the excitatory effect of histamine on the cells (n = 13). Histamine 102-111 histamine receptor H 2 Rattus norvegicus 4-25 10678532-6 2000 The histamine H2 receptor antagonist ranitidine effectively blocked the excitatory response of PCs to histamine (n = 20), but triprolidine, an H1 receptor antagonist, could not significantly block the histamine-induced excitation, or only very slightly decreased the excitatory effect of histamine on the cells (n = 13). Histamine 102-111 histamine receptor H 2 Rattus norvegicus 4-25 12972295-2 2003 To investigate histamine effects in H2-R-transfected rat atrial myocytes, endogenous GIRK currents and L-type Ca2+ currents were used as functional assays. Histamine 15-24 histamine receptor H 2 Rattus norvegicus 36-40 12972295-6 2003 In H2-R-overexpressing cells, histamine activated IK(ACh) via Gs-derived betagamma subunits since the histamine-induced current was insensitive to pertussis toxin. Histamine 30-39 histamine receptor H 2 Rattus norvegicus 3-7 12972295-8 2003 When IK(ACh) was maximally activated by GTP-gamma-S, histamine induced an irreversible inhibition of the inward current in a fraction of H2-R-transfected cells. Histamine 53-62 histamine receptor H 2 Rattus norvegicus 137-141 9653888-9 1998 We conclude that (i) histamine H1 receptor subtype predominantly mediates endothelium-dependent dilator effect of histamine, and (ii) vascular hyperpolarization through opening of K+ channels (SKCa) mediate the dilator responses to histamine H2 receptor (amthamine and dimaprit) and the putative histamine H3 receptor (R(-)-alpha-methylhistamine and imetit) agonists. Histamine 21-30 histamine receptor H 2 Rattus norvegicus 232-253 8098142-7 1993 The enhancement of the depolarizing afterpotential by histamine was mimicked by the histamine H1-receptor agonist 2-thiazolylethylamine and was reduced or blocked by the H1-receptor antagonist promethazine, but was not blocked or reduced in the presence of the histamine H2-receptor antagonist, cimetidine. Histamine 54-63 histamine receptor H 2 Rattus norvegicus 261-282 8927936-13 1996 Histamine-stimulated secretion was unaffected by alpha-FMH and abolished by the histamine H2-receptor antagonist ranitidine. Histamine 0-9 histamine receptor H 2 Rattus norvegicus 80-101 7515820-2 1994 Intracerebroventricular administration of histamine decreased 5-hydroxytryptamine (5-HT) and increased 5-hydroxyindoleacetic acid (5-HIAA) concentrations in several hypothalamic nuclei; these effects were blocked by the histamine H1 receptor antagonist mepyramine but not the histamine H2 receptor antagonist zolantidine. Histamine 42-51 histamine receptor H 2 Rattus norvegicus 276-297 33809380-15 2021 In contrast, the downregulation of the H+/K+ ATPase pathway as well as muscarinic receptor (M3R) and histamine receptor (H2R) inhibition was also involved in the gastroprotective effects of PUE; however, the expression of cholecystokinin-2 receptors (CCK2R) was unchanged. Histamine 101-110 histamine receptor H 2 Rattus norvegicus 121-124 2162708-7 1990 Because imidazoline binding sites also displayed weak affinities for imidazole compounds, such as histamine and cimetidine, the imidazoline site may be a subtype of histamine H2-receptor. Histamine 98-107 histamine receptor H 2 Rattus norvegicus 165-186 2569692-2 1989 The purpose of the present study was to determine whether histamine-induced changes in cerebrovascular permeability were mediated by the histamine H2-receptor. Histamine 58-67 histamine receptor H 2 Rattus norvegicus 137-158 7075670-11 1982 A component of both adjuvant and histamine-induced responses thus appears to be histamine H2-receptor mediated. Histamine 33-42 histamine receptor H 2 Rattus norvegicus 80-101 2470453-16 1989 6 We conclude that gastric histamine release in the rat is regulated via a histamine H2 receptor sensitive to the histamine agonists tested, but not to ranitidine. Histamine 27-36 histamine receptor H 2 Rattus norvegicus 75-96 2723676-6 1989 The increased brain water content as well as the elevated plasma and brain histamine levels were prevented by prior treatment with the histamine H2-receptor antagonist cimetidine. Histamine 75-84 histamine receptor H 2 Rattus norvegicus 135-156 40581-3 1979 The typical effects of organ relaxation, inhibition of contraction height and reduction of resting tension generated by histamine, could both be antagonized by the histamine H2-receptor blockers metiamide and cimetidine, while both compounds failed to reverse orciprenaline- or isoproterenol-induced inhibition of uterine contractility. Histamine 120-129 histamine receptor H 2 Rattus norvegicus 164-185 30310171-13 2018 Hypertrophy of cultured cardiac cells upon exposure to histamine and the H2R agonist amthamine substantiates the role of histamine in cardiac remodeling. Histamine 121-130 histamine receptor H 2 Rattus norvegicus 73-76 6121474-8 1981 Histamine H2-receptor blockers antagonized the increase in tail skin temperature after histamine administration, suggesting that h2-receptors are involved in a heat loss mechanism. Histamine 87-96 histamine receptor H 2 Rattus norvegicus 0-21 6108701-1 1980 The activation of histamine (HA) formation in rat stomach was measured after repeated administration of histamine H2-receptor antagonists and the potentiation of their antisecretory activity was examined in histidine decarboxylase inhibitor (HDI)-pretreated rats. Histamine 18-27 histamine receptor H 2 Rattus norvegicus 104-125 6108701-1 1980 The activation of histamine (HA) formation in rat stomach was measured after repeated administration of histamine H2-receptor antagonists and the potentiation of their antisecretory activity was examined in histidine decarboxylase inhibitor (HDI)-pretreated rats. Histamine 29-31 histamine receptor H 2 Rattus norvegicus 104-125 23336-2 1978 Starting from the structure of histamine, chemical modification led eventually to burimamide, the first described histamine H2-receptor antagonist. Histamine 31-40 histamine receptor H 2 Rattus norvegicus 114-135 20427-1 1977 Histamine stimulates acid secretion by the parietal cell and this secretion is inhibited by the histamine H2-receptor antagonists. Histamine 0-9 histamine receptor H 2 Rattus norvegicus 96-117