PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32333821-0	2021	Multidrug resistance protein 4 (MRP4/ABCC4) expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux.	Histamine	71-80	ATP binding cassette subfamily C member 4	Homo sapiens	32-36	
32333821-0	2021	Multidrug resistance protein 4 (MRP4/ABCC4) expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux.	Histamine	71-80	ATP binding cassette subfamily C member 4	Homo sapiens	37-42	
32333821-4	2021	Acting through histamine H2 receptors histamine increases cAMP production/synthesis, while MRP4/ABCC4 is responsible for the exclusion of this cyclic nucleotide.	Histamine	15-24	ATP binding cassette subfamily C member 4	Homo sapiens	96-101	
32333821-5	2021	In this study, we show that histamine treatment induces MRP4/ABCC4 expression, augmenting cAMP efflux and that histamine, in combination with MRP inhibitors, is able to reduce AML cell proliferation.	Histamine	28-37	ATP binding cassette subfamily C member 4	Homo sapiens	56-60	
32333821-5	2021	In this study, we show that histamine treatment induces MRP4/ABCC4 expression, augmenting cAMP efflux and that histamine, in combination with MRP inhibitors, is able to reduce AML cell proliferation.	Histamine	28-37	ATP binding cassette subfamily C member 4	Homo sapiens	61-66	
32333821-6	2021	Histamine, through histamine H2 receptor, increases i-cAMP levels and induces MRP4 transcript and protein levels in U937, KG1a, and HL-60 cells.	Histamine	0-9	ATP binding cassette subfamily C member 4	Homo sapiens	78-82	
32333821-7	2021	Moreover, histamine induces MRP4 promoter activity in HEK293T cells transfected with histamine H2 receptor (HEK293T-H2 R).	Histamine	10-19	ATP binding cassette subfamily C member 4	Homo sapiens	28-32	
32333821-8	2021	Our results support that the cAMP/Epac-PKA pathway, and not MEK/ERK nor PI3K/AKT signaling cascades, is involved in histamine mediated upregulation of MRP4 levels.	Histamine	116-125	ATP binding cassette subfamily C member 4	Homo sapiens	151-155	
32333821-9	2021	Finally, the addition of histamine potentiates the inhibition of U937, KG1a, and HL-60 cell proliferation induced by MRP4 inhibitors.	Histamine	25-34	ATP binding cassette subfamily C member 4	Homo sapiens	117-121