PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19734018-2	2009	hBD-3 induces histamine release from mast cells.	Histamine	14-23	defensin beta 103B	Homo sapiens	0-5	
19734018-0	2009	Histamine induces human beta-defensin-3 production in human keratinocytes.	Histamine	0-9	defensin beta 103B	Homo sapiens	24-39	
19734018-4	2009	OBJECTIVE: To examine in vitro effects of histamine on hBD-3 production in normal human keratinocytes.	Histamine	42-51	defensin beta 103B	Homo sapiens	55-60	
19734018-8	2009	RESULTS: Histamine enhanced hBD-3 secretion and mRNA expression in keratinocytes.	Histamine	9-18	defensin beta 103B	Homo sapiens	28-33	
19734018-9	2009	The histamine-induced hBD-3 production was suppressed by H1 antagonist pyrilamine and antisense oligonucleotides against signal transducer and activator of transcription 3 (STAT3) and AP-1 components c-Jun and c-Fos.	Histamine	4-13	defensin beta 103B	Homo sapiens	22-27	
19734018-12	2009	AG490 and PD98059 suppressed histamine-induced hBD-3 production and STAT3 activity.	Histamine	29-38	defensin beta 103B	Homo sapiens	47-52	
19734018-14	2009	CONCLUSION: It is suggested that histamine induces hBD-3 production in human keratinocytes through H1 receptors by activating STAT3 and AP-1 via JAK2 and MEK/ERK.	Histamine	33-42	defensin beta 103B	Homo sapiens	51-56	
19734018-15	2009	Histamine may promote cutaneous antimicrobial defense, inflammation, and wound repair through hBD-3.	Histamine	0-9	defensin beta 103B	Homo sapiens	94-99	
18345484-0	2008	The relationship between human beta-defensin 3 (hBD3) expression and mean histamine concentration in human placental tissue.	Histamine	74-83	defensin beta 103B	Homo sapiens	31-46	
18345484-0	2008	The relationship between human beta-defensin 3 (hBD3) expression and mean histamine concentration in human placental tissue.	Histamine	74-83	defensin beta 103B	Homo sapiens	48-52