PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18181977-3 2008 Substance P is a neuropeptide and has the capacity to provoke histamine release from skin mast cells. Histamine 62-71 tachykinin precursor 1 Homo sapiens 0-11 17716784-4 2008 Under certain conditions, however, stress hormones, substance P, ATP and the activation of the corticotropin-releasing hormone/substance P-histamine axis may actually facilitate inflammation, through induction of interleukin (IL)-1, IL-6, IL-8, IL-18, tumor necrosis factor (TNF)-alpha and CRP production. Histamine 139-148 tachykinin precursor 1 Homo sapiens 127-138 17845422-8 2007 Histamine release from the cells could be brought about by IgE-anti-IgE cross-linkage, compound 48/80, substance P, and anaphylatoxin C3a. Histamine 0-9 tachykinin precursor 1 Homo sapiens 103-114 16842920-8 2006 This suggests that substance P is a histamine-dependent pruritogen also in lesional skin under sensitized conditions but that bradykinin and serotonin are histamine-independent pruritogens in lesional skin. Histamine 36-45 tachykinin precursor 1 Homo sapiens 19-30 11089903-0 2000 Substance P induced histamine release from nasal mucosa of subjects with and without allergic rhinitis. Histamine 20-29 tachykinin precursor 1 Homo sapiens 0-11 12398158-5 2002 The muscularis mucosae isolated from the guinea pig distal colon demonstrated a concentration-dependent contraction in response to neurokinin A, carbachol, histamine and acetylcholine, but not to prostaglandin F2alpha or 5-hydroxytryptamine, and the maximum contraction was obtained with histamine. Histamine 288-297 tachykinin precursor 1 Homo sapiens 131-143 11414293-7 2001 Acid, substance P, and capsaicin all increased histamine release. Histamine 47-56 tachykinin precursor 1 Homo sapiens 6-17 11121135-5 2000 Substance P and calcitonin gene-related peptide applied intradermally via large cut-off plasmapheresis capillaries induced dose-dependent local vasodilation, but only SP provoked protein extravasation in concentrations greater than 10(-9) M. Substance P-induced (10(-8)-10(-6) M) protein extravasation was not accompanied by histamine release and was unaffected by cetirizine (histamine H1 blocker, 200 microg per ml). Histamine 325-334 tachykinin precursor 1 Homo sapiens 0-11 11121135-6 2000 Only the highest concentration of substance P (10(-5) M) induced significant histamine release. Histamine 77-86 tachykinin precursor 1 Homo sapiens 34-45 11121135-8 2000 In human skin calcitonin gene-related peptide and substance P induce vasodilation by a mechanism not involving histamine. Histamine 111-120 tachykinin precursor 1 Homo sapiens 50-61 16964646-0 2006 [Influence of substance P on the release of histamine in the human hypertrophic scar tissue]. Histamine 44-53 tachykinin precursor 1 Homo sapiens 14-25 16964646-1 2006 OBJECTIVE: To investigate the influence of substance P (SP) on the release of histamine in the human hypertrophic scar tissue, and to explore the prerequisite of their interaction. Histamine 78-87 tachykinin precursor 1 Homo sapiens 43-54 16964646-1 2006 OBJECTIVE: To investigate the influence of substance P (SP) on the release of histamine in the human hypertrophic scar tissue, and to explore the prerequisite of their interaction. Histamine 78-87 tachykinin precursor 1 Homo sapiens 56-58 16964646-4 2006 RESULTS: There was obvious release of histamine when SP concentration was 1 x 10(-6) mol/L , and the release rate was (50.0 +/- 3.6) %, which was significantly higher than that by SP in the concentration of 0 mol/L [(44.0 +/- 3.2) %, P < 0.01]. Histamine 38-47 tachykinin precursor 1 Homo sapiens 53-55 16964646-4 2006 RESULTS: There was obvious release of histamine when SP concentration was 1 x 10(-6) mol/L , and the release rate was (50.0 +/- 3.6) %, which was significantly higher than that by SP in the concentration of 0 mol/L [(44.0 +/- 3.2) %, P < 0.01]. Histamine 38-47 tachykinin precursor 1 Homo sapiens 180-182 16964646-6 2006 About 90% of histamine was released within 15 minutes of 5 x 10(-1) mol/L Substance P stimulation, and it was also time-dependent. Histamine 13-22 tachykinin precursor 1 Homo sapiens 74-85 16964646-8 2006 In all occasions, the influence of SP on the histamine release by MC in hypertrophic scar (HS) was markedly higher than that in normal skin (NS) (P < 0.01). Histamine 45-54 tachykinin precursor 1 Homo sapiens 35-37 16964646-9 2006 Conclusion The influence of SP on the histamine release by MC in HS was markedly higher than that in NS, and it might be closely related to itching sensation and the formation of hypertrophic scar. Histamine 38-47 tachykinin precursor 1 Homo sapiens 28-30 16543066-7 2006 They showed typical mast cell morphology and released histamine upon stimulation by substance P or compound 48/80 in vitro. Histamine 54-63 tachykinin precursor 1 Homo sapiens 84-95 16543066-10 2006 The expanded mast cells showed histamine release after substance P or compound 48/80 stimulation. Histamine 31-40 tachykinin precursor 1 Homo sapiens 55-66 15885311-1 2005 To resolve the controversy regarding substance P (SP) mediated stimulation of mast cells (MC), we demonstrate that SP triggers histamine release from purified human skin MC (sMC), but contrast to stimulation via FcepsilonRI, does not effect the production of TNF-alpha or IL-8. Histamine 127-136 tachykinin precursor 1 Homo sapiens 115-117 15885311-4 2005 Contrast to sMC, LAD2 MC respond to SP with stronger histamine release and robust TNF-alpha production in an only partially neurokinin-1R mediated manner, while histamine release of sMC is chiefly mediated by this receptor. Histamine 53-62 tachykinin precursor 1 Homo sapiens 36-38 11359454-2 2001 Studies with animal skin and rat peritoneal mast cells have suggested that substance P induces the release of histamine and leukotriene B4 (LTB4), a potent chemoattractant for granulocytes, from skin mast cells. Histamine 110-119 tachykinin precursor 1 Homo sapiens 75-86 11089903-9 2000 CONCLUSION: These findings suggest a role of SP in inducing release of histamine from human nasal mucosa, thereby influencing physiologic and pathophysiologic nasal conditions, especially in allergic inflammatory processes. Histamine 71-80 tachykinin precursor 1 Homo sapiens 45-47 10362651-5 1999 SP caused TTX- and lodoxamide-sensitive histamine release from colonic mucosa. Histamine 40-49 tachykinin precursor 1 Homo sapiens 0-2 10854844-2 2000 To investigate cytokines involved in the substance P-induced inflammation and the mechanism of cell activation, we studied the release of TNF (tumor necrosis factor)-alpha and histamine from human skin slices in response to substance P and antigen. Histamine 176-185 tachykinin precursor 1 Homo sapiens 224-235 10854844-3 2000 Substance P induced the release of histamine and TNF-alpha in a dose-dependent manner at concentrations from 0.8 to 100 microM. Histamine 35-44 tachykinin precursor 1 Homo sapiens 0-11 10854844-7 2000 These results suggest that substance P, in addition to antigen, induced TNF-alpha release from human skin by a mitogen-activated protein (MAP) kinase, predominantly extracellular signaling-regulated protein kinase (ERK)-dependent, and dexamethasone-sensitive pathway, which is separate from that for histamine release from mast cells. Histamine 300-309 tachykinin precursor 1 Homo sapiens 27-38 10491292-3 1999 In contrast, adrenaline, acetylcholine, histamine and CGRP induced only low amount of SP from cultured normal human KCs. Histamine 40-49 tachykinin precursor 1 Homo sapiens 86-88 10362651-8 1999 We conclude that SP stimulates Cl--dependent secretion in human colon by a pathway(s) involving mucosal nerves, mast cells, and the mast cell product histamine. Histamine 150-159 tachykinin precursor 1 Homo sapiens 17-19 10423066-0 1999 Effect of substance P on histamine secretion from gut mucosa in inflammatory bowel disease. Histamine 25-34 tachykinin precursor 1 Homo sapiens 10-21 10423066-6 1999 In contrast, mucosal specimens taken from inflamed IBD tissue or from uninvolved Crohn disease tissue showed a considerably enhanced rate of histamine secretion towards substance P, alone or in combination with anti-IgE. Histamine 141-150 tachykinin precursor 1 Homo sapiens 169-180 10423066-2 1999 Since mast cell-nerve interactions might have some impact on intestinal inflammation, the present study investigated whether the neuropeptide substance P causes histamine secretion from human gut mucosal mast cells. Histamine 161-170 tachykinin precursor 1 Homo sapiens 142-153 9259478-5 1997 Inside the histamine-induced flare reaction a significant increase of calcitonin gene related peptide (CGRP) was found, whereas the increase of substance P (SP) was not significant. Histamine 11-20 tachykinin precursor 1 Homo sapiens 144-155 9508337-2 1998 In the skin, SP-containing neurons stimulate the release of histamine from connective tissue mast cells (MC). Histamine 60-69 tachykinin precursor 1 Homo sapiens 13-15 9291295-1 1997 BACKGROUND: Studies in rodents" skin have indicated substance P to be the main inflammatory mediator involved in neurogenic inflammation, acting partly by release of histamine from skin mast cells. Histamine 166-175 tachykinin precursor 1 Homo sapiens 52-63 9291295-8 1997 Intradermally injected substance P (1 and 3 microM, 25 and 75 pmol) released significant amounts of histamine (peak levels being 90 and 475 nM), evoked weal-and-flare reactions, but did not cause pain. Histamine 100-109 tachykinin precursor 1 Homo sapiens 23-34 9297575-0 1997 Histamine release from human bronchoalveolar lavage mast cells by neurokinin A and bradykinin. Histamine 0-9 tachykinin precursor 1 Homo sapiens 66-78 9793689-5 1998 Substance P (10 nM) stimulated a biphasic increase in levels of inositol (1,4,5) trisphosphate (Ins(1,4,5)P3) with a peak of 97 +/- 5 pmoles/mg protein at 10 s. In contrast, the Ins(1,4,5)P3 response to 100 microM histamine was only marginally above basal levels of around 12 pmoles/mg protein. Histamine 214-223 tachykinin precursor 1 Homo sapiens 0-11 9793689-6 1998 However, concentrations of histamine and substance P giving similar Ins(1,4,5)P3 responses produce similar peak increases in [Ca2+]i. HPLC analysis indicated that histamine stimulated the production of [3H]-Ins(1,4,5)P3 and its metabolites, although the magnitude of response was smaller than that observed with substance P. Histamine 27-36 tachykinin precursor 1 Homo sapiens 312-323 9793689-6 1998 However, concentrations of histamine and substance P giving similar Ins(1,4,5)P3 responses produce similar peak increases in [Ca2+]i. HPLC analysis indicated that histamine stimulated the production of [3H]-Ins(1,4,5)P3 and its metabolites, although the magnitude of response was smaller than that observed with substance P. Histamine 163-172 tachykinin precursor 1 Homo sapiens 41-52 9793689-6 1998 However, concentrations of histamine and substance P giving similar Ins(1,4,5)P3 responses produce similar peak increases in [Ca2+]i. HPLC analysis indicated that histamine stimulated the production of [3H]-Ins(1,4,5)P3 and its metabolites, although the magnitude of response was smaller than that observed with substance P. Histamine 163-172 tachykinin precursor 1 Homo sapiens 312-323 9812802-4 1997 The results suggest that SP plays a role in SOM, might accelerate vasodilation and increase the permeability of cupillary in middle ear mucosa mediated by histamine. Histamine 155-164 tachykinin precursor 1 Homo sapiens 25-27 8670335-8 1996 Isolated synovial mast cells released histamine in response to immunologic (anti-IgE and anti-Fc epsilon receptor I [anti-Fc epsilon RI]) and nonimmunologic (substance P, recombinant human stem cell factor, and 48/80) stimuli, but did not respond to recombinant human C5a in vitro. Histamine 38-47 tachykinin precursor 1 Homo sapiens 158-169 8808644-0 1996 Substance P activates the release of histamine from human skin mast cells through a pertussis toxin-sensitive and protein kinase C-dependent mechanism. Histamine 37-46 tachykinin precursor 1 Homo sapiens 0-11 8808644-1 1996 Using pharmacologic agents, we explored the mechanism by which a potent neuropeptide, substance P, induces the secretion of histamine from human skin mast cells and compared their effects on substance P-induced histamine release to the secretion activated by anti-IgE. Histamine 124-133 tachykinin precursor 1 Homo sapiens 86-97 8808644-1 1996 Using pharmacologic agents, we explored the mechanism by which a potent neuropeptide, substance P, induces the secretion of histamine from human skin mast cells and compared their effects on substance P-induced histamine release to the secretion activated by anti-IgE. Histamine 211-220 tachykinin precursor 1 Homo sapiens 86-97 8808644-1 1996 Using pharmacologic agents, we explored the mechanism by which a potent neuropeptide, substance P, induces the secretion of histamine from human skin mast cells and compared their effects on substance P-induced histamine release to the secretion activated by anti-IgE. Histamine 211-220 tachykinin precursor 1 Homo sapiens 191-202 8808644-2 1996 Histamine release from human cutaneous mast cells induced by substance P was inhibited by the Ge-protein inhibitor pertussis toxin that, in turn, did not affect the IgE-mediated secretion. Histamine 0-9 tachykinin precursor 1 Homo sapiens 61-72 8712637-5 1996 The magnitude of the increase in NAR was LTD4 > SP > histamine when compared on a molar basis. Histamine 59-68 tachykinin precursor 1 Homo sapiens 51-53 8800300-5 1996 Substance P (250 pmol) induced histamine release peak (66.1 +/- 52.5 nM, n = 8) in the 0-15 or 15-30 min fraction. Histamine 31-40 tachykinin precursor 1 Homo sapiens 0-11 8800300-7 1996 A single substance P injection was sufficient to induce major histamine release in three out of four experiments; and the release kinetics of the second injection (1 h later) mimicked that of the first injection. Histamine 62-71 tachykinin precursor 1 Homo sapiens 9-20 8800300-10 1996 The present study shows that neuropeptides substance P and vasoactive intestinal peptide, but not calcitonin gene-related peptide, can induce activation of mast cells and release of histamine into the extracellular space. Histamine 182-191 tachykinin precursor 1 Homo sapiens 43-54 8745892-11 1996 The second allergen challenge was unable to induce marked additional histamine release, but SP induced extensive histamine liberation in those patients who did not exhibit histamine release during the preceding prick tests. Histamine 113-122 tachykinin precursor 1 Homo sapiens 92-94 8696907-0 1996 Further characterisation of substance P induced histamine release from human bronchoalveolar lavage mast cells. Histamine 48-57 tachykinin precursor 1 Homo sapiens 28-39 8745892-11 1996 The second allergen challenge was unable to induce marked additional histamine release, but SP induced extensive histamine liberation in those patients who did not exhibit histamine release during the preceding prick tests. Histamine 113-122 tachykinin precursor 1 Homo sapiens 92-94 7542055-4 1995 Thus, we examined the influence of SP on histamine release and its morphological effects on human nasal mucosa using a previously described histoculture technique. Histamine 41-50 tachykinin precursor 1 Homo sapiens 35-37 8846429-1 1995 Tachykinin peptides, substance P (SP) and neurokinin A (NKA), are released from airway sensory nerves upon exposure to irritant chemicals and endogenous agents including bradykinin, prostaglandins, histamine, and protons, The released neuropeptides are potent inducers of a cascade of responses, including vasodilatation, mucus secretion, plasma protein extravasation, leukocyte adhesion--activation, and bronchoconstriction. Histamine 198-207 tachykinin precursor 1 Homo sapiens 21-32 8846429-1 1995 Tachykinin peptides, substance P (SP) and neurokinin A (NKA), are released from airway sensory nerves upon exposure to irritant chemicals and endogenous agents including bradykinin, prostaglandins, histamine, and protons, The released neuropeptides are potent inducers of a cascade of responses, including vasodilatation, mucus secretion, plasma protein extravasation, leukocyte adhesion--activation, and bronchoconstriction. Histamine 198-207 tachykinin precursor 1 Homo sapiens 34-36 8846429-1 1995 Tachykinin peptides, substance P (SP) and neurokinin A (NKA), are released from airway sensory nerves upon exposure to irritant chemicals and endogenous agents including bradykinin, prostaglandins, histamine, and protons, The released neuropeptides are potent inducers of a cascade of responses, including vasodilatation, mucus secretion, plasma protein extravasation, leukocyte adhesion--activation, and bronchoconstriction. Histamine 198-207 tachykinin precursor 1 Homo sapiens 42-54 8846429-1 1995 Tachykinin peptides, substance P (SP) and neurokinin A (NKA), are released from airway sensory nerves upon exposure to irritant chemicals and endogenous agents including bradykinin, prostaglandins, histamine, and protons, The released neuropeptides are potent inducers of a cascade of responses, including vasodilatation, mucus secretion, plasma protein extravasation, leukocyte adhesion--activation, and bronchoconstriction. Histamine 198-207 tachykinin precursor 1 Homo sapiens 56-59 7542070-1 1995 Monocytes and lymphocytes from human blood contain 0.043 +/- 0.007 and 0.053 +/- 0.014 pg histamine/cell, respectively, which can be released by a number of stimulants (A 23187, C5a, substance P, specific allergen). Histamine 90-99 tachykinin precursor 1 Homo sapiens 183-194 8822506-2 1996 However, comparing the antigen-evoked release of mediators into nasal secretions with that of a substance P-pretreated antigen challenge, we found a significant enhancement of kinins, TAME esterase activity (p < 0.05-0.01), and histamine (p < 0.001, NS) 10-20 min after antigen challenge. Histamine 231-240 tachykinin precursor 1 Homo sapiens 96-107 8837963-4 1995 In each experiment human recombinant stem cell factor and/or exogenously applied substance P effectively evoked histamine release from the explants, attesting to the viability of the mast cells in the preparation. Histamine 112-121 tachykinin precursor 1 Homo sapiens 81-92 8837963-5 1995 The concentrations of exogenously applied substance P required to elicit histamine release, however, were large (> 10 microM). Histamine 73-82 tachykinin precursor 1 Homo sapiens 42-53 7542055-5 1995 Compared to controls, the histamine content in the culture bath was significantly elevated after SP stimulation (p < 0.05). Histamine 26-35 tachykinin precursor 1 Homo sapiens 97-99 7533185-10 1995 Heart mast cells released histamine in response to immunologic (anti-IgE, anti-Fc epsilon RI, and C5a) and nonimmunologic stimuli (recombinant human stem cell factor, A23187, and compound 48/80) but did not respond to substance P, FMLP, 12-O-tetradecanoylphorbol-13-acetate, or acetylcholine. Histamine 26-35 tachykinin precursor 1 Homo sapiens 218-229 7538443-5 1995 Both substance P (50 microM) and A23187 caused histamine release (median 26.7% range 6.2-62.8% and 32.1%, 7.7-56.8% respectively) which was significantly greater (P < 0.0001) than the spontaneous release (median 15.6%, range 4.1-33.4%), i.e. that in the absence of any stimulus. Histamine 47-56 tachykinin precursor 1 Homo sapiens 5-16 7538443-6 1995 Substance P induced histamine release was via an energy dependent process and was blocked by preincubation with antimycin A. Histamine 20-29 tachykinin precursor 1 Homo sapiens 0-11 7538443-9 1995 The substance P induced histamine secretion was elicited at similar concentrations to those used with rodent and human skin mast cells. Histamine 24-33 tachykinin precursor 1 Homo sapiens 4-15 1283698-2 1992 Inhibition of HS- and SP-induced weal and flare reactions was less marked after loratadine and blood flow in the expanding flare after HS and SP showed significant fluctuations over time. Histamine 14-16 tachykinin precursor 1 Homo sapiens 142-144 7531109-0 1994 Do nasal mast cells release histamine on stimulation with substance P in allergic rhinitis? Histamine 28-37 tachykinin precursor 1 Homo sapiens 58-69 7531109-2 1994 Responses to substance P were assessed by posterior rhinomanometry (measuring nasal airway resistance) and by measure of histamine, protein and albumin production and cell recovery in nasal lavage fluids before and after challenge. Histamine 121-130 tachykinin precursor 1 Homo sapiens 13-24 8214946-1 1993 The tachykinins substance P (SP) and neurokinin A (NKA) have been demonstrated in sensory airway nerves of animals and man and are thought to be neurotransmitters of local axon reflexes, generated by stimuli such as cigarette smoke, dust, histamine, and bradykinin. Histamine 239-248 tachykinin precursor 1 Homo sapiens 16-27 8214946-1 1993 The tachykinins substance P (SP) and neurokinin A (NKA) have been demonstrated in sensory airway nerves of animals and man and are thought to be neurotransmitters of local axon reflexes, generated by stimuli such as cigarette smoke, dust, histamine, and bradykinin. Histamine 239-248 tachykinin precursor 1 Homo sapiens 29-31 8214946-1 1993 The tachykinins substance P (SP) and neurokinin A (NKA) have been demonstrated in sensory airway nerves of animals and man and are thought to be neurotransmitters of local axon reflexes, generated by stimuli such as cigarette smoke, dust, histamine, and bradykinin. Histamine 239-248 tachykinin precursor 1 Homo sapiens 37-49 8214946-1 1993 The tachykinins substance P (SP) and neurokinin A (NKA) have been demonstrated in sensory airway nerves of animals and man and are thought to be neurotransmitters of local axon reflexes, generated by stimuli such as cigarette smoke, dust, histamine, and bradykinin. Histamine 239-248 tachykinin precursor 1 Homo sapiens 51-54 8214946-4 1993 In this study, we demonstrate that the bronchoconstriction caused by SP and NKA in Fisher 344 rats is accompanied by a dose-dependent release of histamine and serotonin in bronchoalveolar lavage (BAL) fluid. Histamine 145-154 tachykinin precursor 1 Homo sapiens 76-79 8214946-6 1993 Local instillation of NKA in the airways caused a significant dose-dependent increase in BAL histamine. Histamine 93-102 tachykinin precursor 1 Homo sapiens 22-25 8214946-7 1993 After pretreatment with thiorphan, an inhibitor of neutral endopeptidase (NEP), the bronchoconstriction and the histamine and serotonin release in BAL fluid caused by SP and NKA were enhanced. Histamine 112-121 tachykinin precursor 1 Homo sapiens 174-177 7692870-10 1993 Itch and flare are partly due to histamine release from mast cells in response to substance P. Histamine 33-42 tachykinin precursor 1 Homo sapiens 82-93 7693287-11 1993 The angiogenic action of substance P and IL-1 alpha was resistant to modification by mepyramine (1 nmol day-1) and/or cimetidine (10 nmol day-1), indomethacin (7 nmol day-1) or the platelet-activating factor (PAF) antagonist, WEB-2086 (22 nmol day-1), indicating that histamine, prostaglandins and PAF are not likely to be involved in this neovascular response. Histamine 268-277 tachykinin precursor 1 Homo sapiens 25-36 7538443-0 1995 Substance P induces histamine release from human pulmonary mast cells. Histamine 20-29 tachykinin precursor 1 Homo sapiens 0-11 7538443-1 1995 Substance P elicits histamine release from human skin and rodent mast cells. Histamine 20-29 tachykinin precursor 1 Homo sapiens 0-11 7538443-4 1995 Histamine release experiments were performed in a standard manner using substance P and the calcium ionophore A23187. Histamine 0-9 tachykinin precursor 1 Homo sapiens 72-83 7523474-0 1994 The use of cutaneous microdialysis to measure substance P-induced histamine release in intact human skin in vivo. Histamine 66-75 tachykinin precursor 1 Homo sapiens 46-57 7523474-2 1994 Using this technique, we have studied the histamine releasing properties of substance P, a putative skin mast cell releasing agent. Histamine 42-51 tachykinin precursor 1 Homo sapiens 76-87 7523474-9 1994 Peak histamine release after injection of vehicle, 0.5, 1, 2, and 4 mumol/L substance P was 0.0, 1.0, 6.0, 44.5, and 88.5 ng/ml, respectively (p = 0.00002). Histamine 5-14 tachykinin precursor 1 Homo sapiens 76-87 7523474-10 1994 Statistically significant histamine release was demonstrated with 1.0 mumol/L substance P and greater. Histamine 26-35 tachykinin precursor 1 Homo sapiens 78-89 7523474-13 1994 CONCLUSIONS: This study showed that substance P releases histamine in a dose-dependent manner from intact human skin in normal subjects. Histamine 57-66 tachykinin precursor 1 Homo sapiens 36-47 7526645-5 1994 Further, Group A had significantly elevated corrected SP-induced histamine release compared to Group B but the corrected calcium ionophore A23187-induced responses were similar. Histamine 65-74 tachykinin precursor 1 Homo sapiens 54-56 7514197-0 1994 Eosinophil granule proteins inhibit substance P-induced histamine release from human skin mast cells. Histamine 56-65 tachykinin precursor 1 Homo sapiens 36-47 7514197-3 1994 However, a brief incubation (15 minutes) of two of the four principal eosinophil granule proteins, MBP and EPO, at concentrations of 50 to 200 micrograms/ml, caused a significant concentration-related inhibition of histamine release induced by 30 mumol/L substance P. Histamine 215-224 tachykinin precursor 1 Homo sapiens 255-266 7514197-4 1994 The concentrations producing 50% inhibition for MBP and EPO on substance P-induced histamine release were 30 micrograms/ml and 100 micrograms/ml, respectively. Histamine 83-92 tachykinin precursor 1 Homo sapiens 63-74 7513741-12 1994 However, the activation site for C3a and C5a appears to be different to that for substance P as the substance P antagonist (D-Pro4, D-Trp7,9,10) SP4-11 inhibited histamine release stimulated by substance P but not that induced by C3a and C5a. Histamine 162-171 tachykinin precursor 1 Homo sapiens 81-92 7513741-12 1994 However, the activation site for C3a and C5a appears to be different to that for substance P as the substance P antagonist (D-Pro4, D-Trp7,9,10) SP4-11 inhibited histamine release stimulated by substance P but not that induced by C3a and C5a. Histamine 162-171 tachykinin precursor 1 Homo sapiens 100-111 7513741-12 1994 However, the activation site for C3a and C5a appears to be different to that for substance P as the substance P antagonist (D-Pro4, D-Trp7,9,10) SP4-11 inhibited histamine release stimulated by substance P but not that induced by C3a and C5a. Histamine 162-171 tachykinin precursor 1 Homo sapiens 100-111 7506467-4 1993 SP is known to produce a flare reaction that is dependent on axon reflexes and release of mast cell histamine. Histamine 100-109 tachykinin precursor 1 Homo sapiens 0-2 1283698-4 1992 We demonstrate that SP weals induced by pricking are largely inhibited by a potent H1 blockade which supports the view that this phenomenon, as well as the SP-flare, is due to SP-induced histamine liberation. Histamine 187-196 tachykinin precursor 1 Homo sapiens 20-22 1283698-4 1992 We demonstrate that SP weals induced by pricking are largely inhibited by a potent H1 blockade which supports the view that this phenomenon, as well as the SP-flare, is due to SP-induced histamine liberation. Histamine 187-196 tachykinin precursor 1 Homo sapiens 156-158 1283698-4 1992 We demonstrate that SP weals induced by pricking are largely inhibited by a potent H1 blockade which supports the view that this phenomenon, as well as the SP-flare, is due to SP-induced histamine liberation. Histamine 187-196 tachykinin precursor 1 Homo sapiens 156-158 1282290-1 1992 Having found an inability of patients with atopic eczema to distinguish different levels of iontophoretically applied histamine concentrations, as shown by their diminished vascular reactions and itch responses, and reviewing this result in the light of our new findings of smaller flare reactions and weaker itch sensations following different concentrations of intradermally injected substance P, we have concluded that unmyelinated afferent skin nerve fibres in these patients seem to be affected by the pathophysiological mechanism of atopic eczema. Histamine 118-127 tachykinin precursor 1 Homo sapiens 386-397 1373708-0 1992 Substance P provokes cutaneous erythema and edema through a histamine-independent pathway. Histamine 60-69 tachykinin precursor 1 Homo sapiens 0-11 1373708-7 1992 These data support the hypothesis that substance P provokes erythema and edema both with histamine-dependent and histamine-independent pathways. Histamine 89-98 tachykinin precursor 1 Homo sapiens 39-50 1373708-7 1992 These data support the hypothesis that substance P provokes erythema and edema both with histamine-dependent and histamine-independent pathways. Histamine 113-122 tachykinin precursor 1 Homo sapiens 39-50 1717608-0 1991 Responses of human dermal microvascular endothelial cells to histamine and their modulation by interleukin 1 and substance P. Histamine 61-70 tachykinin precursor 1 Homo sapiens 113-124 1700194-1 1990 Human skin mast cells release histamine in response to both immunologic stimulation mediated by anti-IgE and IgE-independent mechanisms of which substance P is a prototypical secretagogue. Histamine 30-39 tachykinin precursor 1 Homo sapiens 145-156 1870876-4 1991 It is possible that interactions between histamine-containing mast cells and SP-containing and CGRP-containing nerves--neurogenic inflammation--is one of the mechanisms involved in vessel permeability changes in otitis media with effusion. Histamine 41-50 tachykinin precursor 1 Homo sapiens 77-79 1708211-2 1991 We also studied in these two groups the basophilic histamine release induced by substance P and gastrin with that obtained with anti-human IgE and Con A. Intradermal injection of substance P (3-300 pM) and gastrin (3-30 pM) caused a wheal and flare reaction which was comparable in both groups of subjects. Histamine 51-60 tachykinin precursor 1 Homo sapiens 80-91 1708211-3 1991 Substance P 10(-4)M caused a mean basophilic histamine release of about 15% in atopic and non-atopic subjects. Histamine 45-54 tachykinin precursor 1 Homo sapiens 0-11 1718893-1 1991 Unlike human mast cells associated with mucosal surfaces such as lung, adenoids, tonsils and intestine, skin mast cells may be stimulated to release histamine by the neuropeptides substance P, vaso-active intestinal polypeptide and somatostatin or by other basic secretagogues such as morphine and compound 48/80. Histamine 149-158 tachykinin precursor 1 Homo sapiens 180-191 1722414-1 1991 Mast cells of the human skin not only release mediators following immunological activation, but may also be stimulated to release histamine by the neuropeptides substance P, vasoactive intestinal polypeptide and somatostatin or by other basic secretagogues such as morphine, poly-L-lysine and compound 48/80. Histamine 130-139 tachykinin precursor 1 Homo sapiens 161-172 1716843-2 1991 Pertussis toxin (100 ng/ml) inhibited histamine release induced by compound 48/80, substance P, mastoparan, peptide 401, bradykinin and spermine showing that a G-protein sensitive to pertussis toxin was involved in the non-immunological histamine release. Histamine 38-47 tachykinin precursor 1 Homo sapiens 83-94 1700194-5 1990 Stimulation with either anti-IgE or substance P resulted in a net histamine release of 10.2 +/- 1.7% or 21.4 +/- 4.0%, respectively. Histamine 66-75 tachykinin precursor 1 Homo sapiens 36-47 1700194-8 1990 Degranulation channels occupied 30 to 60% of the cytoplasmic volume after substance P stimulation and 10 to 40% after anti-IgE, which compared well with the greater histamine release measured after substance P. Histamine 165-174 tachykinin precursor 1 Homo sapiens 198-209 1690249-4 1990 In this study, we exposed organ cultures of neonatal human foreskins for 45 min to substance P or to a substance P analogue (D-pro4, D-trp7,9)SP(4-11) that binds to the identical mast cell surface receptor but which does not provoke histamine release. Histamine 233-242 tachykinin precursor 1 Homo sapiens 103-114 35362938-6 2022 These allergens may cross the skin barrier and directly trigger neurons to release substance P, resulting in mast cell degranulation and dumping of histamine and prostaglandin D2. Histamine 148-157 tachykinin precursor 1 Homo sapiens 83-94 1691013-4 1990 As substance P causes mast cell histamine release, the increased weal volumes produced by substance P in the atopics may be entirely due to the exaggerated atopic weal reaction to histamine. Histamine 180-189 tachykinin precursor 1 Homo sapiens 90-101 1695502-6 1990 In bronchoalveolar lavage studies in rats, performed immediately following the peak bronchoconstriction caused by the neurokinins, we were able to show that both substance P and neurokinin A cause histamine release into the airways. Histamine 197-206 tachykinin precursor 1 Homo sapiens 162-173 1695502-6 1990 In bronchoalveolar lavage studies in rats, performed immediately following the peak bronchoconstriction caused by the neurokinins, we were able to show that both substance P and neurokinin A cause histamine release into the airways. Histamine 197-206 tachykinin precursor 1 Homo sapiens 178-190 1707400-0 1990 Substance P-induced histamine release from human basophils, skin and lung fragments: effect of nedocromil sodium and theophylline. Histamine 20-29 tachykinin precursor 1 Homo sapiens 0-11 1707400-1 1990 We compared histamine release induced by substance P with those obtained with classical secretagogues on human basophils, lung and skin fragments. Histamine 12-21 tachykinin precursor 1 Homo sapiens 41-52 1707400-3 1990 Substance P (10(-4) M) caused a noncytotoxic histamine release (about 10% of total) from basophils, lung and skin fragments. Histamine 45-54 tachykinin precursor 1 Homo sapiens 0-11 1707400-4 1990 Substance P-induced histamine release was always smaller than that obtained with optimal doses of anti-IgE, formyl-methionine phenylalanine or compound 48/80. Histamine 20-29 tachykinin precursor 1 Homo sapiens 0-11 1707400-6 1990 In contrast, it significantly inhibited anti-IgE- or substance P-induced histamine release from human lung. Histamine 73-82 tachykinin precursor 1 Homo sapiens 53-64 1691013-4 1990 As substance P causes mast cell histamine release, the increased weal volumes produced by substance P in the atopics may be entirely due to the exaggerated atopic weal reaction to histamine. Histamine 32-41 tachykinin precursor 1 Homo sapiens 3-14 2436021-6 1987 In vitro studies showed that NKA was the most potent of the tachykinins as a bronchoconstrictor agent, being several hundred-fold more active than SP, acetylcholine and histamine. Histamine 169-178 tachykinin precursor 1 Homo sapiens 29-32 2463223-8 1988 Neither mucosal or muscle mast cells released significant amounts of histamine in response to compound 48/80, substance P, morphine, poly-L-lysine or f-met-leu-phe. Histamine 69-78 tachykinin precursor 1 Homo sapiens 110-121 2569004-7 1989 MC-derived histamine and possibly other mediators induce axon reflexes in unmyelinated sensory nerves leading to the release of neurotransmitters such as substance P, calcitonin gene-related peptide, and adenine nucleotides. Histamine 11-20 tachykinin precursor 1 Homo sapiens 154-165 2541975-5 1989 Plasma substance P was reduced after histamine provocation performed during placebo treatment, whereas this reduction was abolished by enalapril. Histamine 37-46 tachykinin precursor 1 Homo sapiens 7-18 2653005-3 1989 The first is the ability of human skin mast cells, but not those derived from lung, adenoids, tonsils or intestine, to release histamine in response to stimulation by neuropeptides including substance P, vasoactive intestinal polypeptide (VIP) and somatostatin. Histamine 127-136 tachykinin precursor 1 Homo sapiens 191-202 2468622-1 1989 Mast cells of human skin, but not lung, adenoids, tonsils, or intestine, release histamine in response to substance P, vasoactive intestinal polypeptide, and somatostatin. Histamine 81-90 tachykinin precursor 1 Homo sapiens 106-117 2699764-5 1989 In addition, many neuropeptides, for example substance P (SP) and calcitonin gene-related peptide (CGRP), seem to be involved and may interact with histamine or bradykinin. Histamine 148-157 tachykinin precursor 1 Homo sapiens 45-56 2699764-5 1989 In addition, many neuropeptides, for example substance P (SP) and calcitonin gene-related peptide (CGRP), seem to be involved and may interact with histamine or bradykinin. Histamine 148-157 tachykinin precursor 1 Homo sapiens 58-60 2464382-2 1988 Human skin mast cells, unlike other human mast cells so far studied, released histamine in a concentration-related manner in response to substance P, vasoactive intestinal peptide (VIP) and somatostatin (1 microM to 30 microM). Histamine 78-87 tachykinin precursor 1 Homo sapiens 137-148 2464382-7 1988 The relative potencies of substance P and its fragments SP2-11, SP3-11, SP4-11 and SP1-4 in releasing histamine from human skin mast cells suggests that both the basic N-terminal amino acids and the lipophilic C-terminal portion of substance P are essential for activity. Histamine 102-111 tachykinin precursor 1 Homo sapiens 26-37 2464382-11 1988 The substance P analogue, [D-Pro4,D-Trp7,9,10] SP4-11 (SPA), not only reduced substance P-induced histamine release in a concentration-related manner but also inhibited that induced by VIP, somatostatin, compound 48/80, poly-L-lysine and morphine but not anti-IgE. Histamine 98-107 tachykinin precursor 1 Homo sapiens 4-15 2464382-11 1988 The substance P analogue, [D-Pro4,D-Trp7,9,10] SP4-11 (SPA), not only reduced substance P-induced histamine release in a concentration-related manner but also inhibited that induced by VIP, somatostatin, compound 48/80, poly-L-lysine and morphine but not anti-IgE. Histamine 98-107 tachykinin precursor 1 Homo sapiens 78-89 2464382-13 1988 The similar characteristics of histamine release induced by substance P, VIP, somatostatin, compound 48/80, poly-L-lysine and morphine suggest that they share a common pathway of activation-secretion coupling distinct from that of IgE-dependent activation. Histamine 31-40 tachykinin precursor 1 Homo sapiens 60-71 2462373-4 1988 A significantly increased outflow of both SP-LI and NKA-LI was observed during perfusion of the lung with high potassium concentration (60 mM), the C-fiber activator capsaicin (1 microM), bradykinin (1 microM), histamine (100 microM), or the nicotinic agonist dimethylphenyl piperazinium (DMPP) (32 microM). Histamine 211-220 tachykinin precursor 1 Homo sapiens 52-55 2450114-1 1988 We have compared the ability of anti-IgE, calcium ionophore A23187, substance P, compound 48/80, poly-L-lysine, and morphine to release histamine from mast cells of human skin, lung, adenoids, tonsils, and colon. Histamine 136-145 tachykinin precursor 1 Homo sapiens 68-79 2892555-9 1987 5 The H1-histamine antagonist terfenadine (60 mg orally) significantly inhibited the wheal and distant flare response to histamine (5 nmol) and NKA, but not that caused by NKB. Histamine 9-18 tachykinin precursor 1 Homo sapiens 144-147 2446892-7 1987 The results suggest that mast-cell histamine and an intact sensory nerve supply are essential for the flare response to both SP and NKA. Histamine 35-44 tachykinin precursor 1 Homo sapiens 125-127 2446892-7 1987 The results suggest that mast-cell histamine and an intact sensory nerve supply are essential for the flare response to both SP and NKA. Histamine 35-44 tachykinin precursor 1 Homo sapiens 132-135 2438355-0 1987 Substance P-induced histamine release in human cutaneous mast cells. Histamine 20-29 tachykinin precursor 1 Homo sapiens 0-11 6188619-4 1983 Substance P pretreatment induced tachyphylaxis, as assessed by standard methods with adequate controls, to both histamine and to substance P and vice versa. Histamine 112-121 tachykinin precursor 1 Homo sapiens 0-11 2437050-5 1987 Substance P and other neuropeptides release histamine from isolated rat and human skin mast cells. Histamine 44-53 tachykinin precursor 1 Homo sapiens 0-11 2427144-0 1986 Histamine is released from skin by substance P but does not act as the final vasodilator in the axon reflex. Histamine 0-9 tachykinin precursor 1 Homo sapiens 35-46 2427144-3 1986 Intradermal injections of substance P (50 pmol) produced a weal and flare response which was associated with increased histamine concentration in blood draining the site (mean plasma histamine concentration before injection 0.17 +/- 0.02 ng ml-1 (+/- s.e.mean), concentration one minute after injection 1.26 +/- 0.28 ng ml-1, n = 6). Histamine 119-128 tachykinin precursor 1 Homo sapiens 26-37 2427144-3 1986 Intradermal injections of substance P (50 pmol) produced a weal and flare response which was associated with increased histamine concentration in blood draining the site (mean plasma histamine concentration before injection 0.17 +/- 0.02 ng ml-1 (+/- s.e.mean), concentration one minute after injection 1.26 +/- 0.28 ng ml-1, n = 6). Histamine 183-192 tachykinin precursor 1 Homo sapiens 26-37 2427144-5 1986 Substance P releases histamine from human skin in vivo. Histamine 21-30 tachykinin precursor 1 Homo sapiens 0-11 2433912-5 1986 Plasma substance P-like immunoreactivity was decreased during spontaneous attack of cluster headache and migraine and during histamine precipitated attack of cluster headache. Histamine 125-134 tachykinin precursor 1 Homo sapiens 7-18 2417614-6 1986 CGRP was about fourfold less potent than substance P in releasing histamine. Histamine 66-75 tachykinin precursor 1 Homo sapiens 41-52 2417614-7 1986 The substance P analogue, [D-Pro4, D-Trp7,9,10]SP4-11 10 microM, and benzalkonium chloride 10 microM inhibited histamine release from rat mast cells stimulated by either CGRP or substance P. Histamine 111-120 tachykinin precursor 1 Homo sapiens 4-15 2417614-7 1986 The substance P analogue, [D-Pro4, D-Trp7,9,10]SP4-11 10 microM, and benzalkonium chloride 10 microM inhibited histamine release from rat mast cells stimulated by either CGRP or substance P. Histamine 111-120 tachykinin precursor 1 Homo sapiens 178-189 2419264-2 1986 Peritoneal mast cells from rat, mouse and hamster but not human cells gave a concentration-dependent release of histamine in response to substance P. Histamine 112-121 tachykinin precursor 1 Homo sapiens 137-148 2419264-4 1986 Mast cells from rat mesentery, lung and heart released histamine in response to substance P, but heart mast cells responded only weakly. Histamine 55-64 tachykinin precursor 1 Homo sapiens 80-91 2425383-2 1986 Among the four tachykinins, a significantly dose-dependent histamine release from rat mast cells and a flare response in human skin was observed only with substance P, indicating the possible implication of histamine in this response. Histamine 59-68 tachykinin precursor 1 Homo sapiens 155-166 2425383-2 1986 Among the four tachykinins, a significantly dose-dependent histamine release from rat mast cells and a flare response in human skin was observed only with substance P, indicating the possible implication of histamine in this response. Histamine 207-216 tachykinin precursor 1 Homo sapiens 155-166 6203362-1 1984 (D-Pro4 D- Trp7 ,9,10)SP4-11 (SPA) has been shown to be a competitive antagonist of the histamine releasing action of substance P in rat peritoneal mast cells. Histamine 88-97 tachykinin precursor 1 Homo sapiens 118-129 6200170-1 1984 The peptides, neurotensin, substance P, somatostatin, and bombesin, several analogues and fragments of neurotensin and compound 48/80, all caused the secretion of both endogenous 5-hydroxytryptamine (5-HT) and histamine. Histamine 210-219 tachykinin precursor 1 Homo sapiens 27-38 6200170-3 1984 Amitriptyline prevented the secretion of histamine in response to stimulation by neurotensin, substance P, somatostatin or compound 48/80 but was without effect on the secretion of endogenous 5-HT. Histamine 41-50 tachykinin precursor 1 Homo sapiens 94-105 6191526-0 1983 Substance P antagonists release histamine from peritoneal mast cells. Histamine 32-41 tachykinin precursor 1 Homo sapiens 0-11 2449138-6 1987 It is concluded that SP and VIP may potentiate histamine in wheal formation and thus contribute to the increased reactivity of the skin to trauma and temperature changes in patients with physical urticaria. Histamine 47-56 tachykinin precursor 1 Homo sapiens 21-23 6188619-9 1983 These results support a possible role for substance P in cutaneous inflammation acting either directly or via histamine release from mast cells. Histamine 110-119 tachykinin precursor 1 Homo sapiens 42-53 6182939-6 1982 4 [D-Arg8]neurotensin, [D-Arg9]neurotensin, xenopsin and the C-terminal octapeptide of substance P (SP4-11) all inhibited histamine release by substance P, but physalaemin did not. Histamine 122-131 tachykinin precursor 1 Homo sapiens 87-98 6187030-0 1982 Histamine release from mast cells by substance P and substance P sequences. Histamine 0-9 tachykinin precursor 1 Homo sapiens 37-48 6187030-0 1982 Histamine release from mast cells by substance P and substance P sequences. Histamine 0-9 tachykinin precursor 1 Homo sapiens 53-64 6182939-6 1982 4 [D-Arg8]neurotensin, [D-Arg9]neurotensin, xenopsin and the C-terminal octapeptide of substance P (SP4-11) all inhibited histamine release by substance P, but physalaemin did not. Histamine 122-131 tachykinin precursor 1 Homo sapiens 143-154 6182939-8 1982 6 [D-Trp7,9]substance P released histamine from rat mast cells and was about 12 times more potent than substance P itself. Histamine 33-42 tachykinin precursor 1 Homo sapiens 12-23 81243-6 1978 It was concluded that substance P is a potent histamine liberator in human skin. Histamine 46-55 tachykinin precursor 1 Homo sapiens 22-33 23734637-3 2013 In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between histamine and neuropeptides in neurogenic inflammation is established. Histamine 9-18 tachykinin precursor 1 Homo sapiens 41-52 31333418-6 2019 Substance P (5 x 10-7 M - 5 x 10-6 M) induced histamine and tryptase release from HSMCs and to a lesser extent from HSyMCs, but not from HLMCs and human cardiac MCs (HHMCs). Histamine 46-55 tachykinin precursor 1 Homo sapiens 0-11 26804667-9 2016 Substance P concentration in tears significantly correlated with eye itchiness after histamine and hypertonic saline and with tearing after allergen. Histamine 85-94 tachykinin precursor 1 Homo sapiens 0-11 25545415-2 2015 Recent studies suggest that substance P (SP), which has been associated with both psychosocial factors and malocclusion, and histamine, whose release can be induced by SP, may be implicated in the pathogenetic process. Histamine 125-134 tachykinin precursor 1 Homo sapiens 168-170 25545415-9 2015 Correlation analysis reveals a significant correlation between histamine and SP concentrations. Histamine 63-72 tachykinin precursor 1 Homo sapiens 77-79 81243-3 1978 The findings indicate that the responses induced by substance P were mainly mediated by histamine released from the dermal mast cells. Histamine 88-97 tachykinin precursor 1 Homo sapiens 52-63 33429916-8 2021 TSLP-assisted histamine liberation triggered by compound 48/80 or Substance P, two canonical MRGPRX2 agonists, was accompanied by an increase in CD107a+ cells (a MC activation marker). Histamine 14-23 tachykinin precursor 1 Homo sapiens 66-77 31617730-6 2020 In Fura-2 loaded non-asthmatic and asthmatic human ASM cells, we found that prolonged (24h) exposure to ERalpha agonist (PPT) increased [Ca2+]i response to histamine, whereas ERbeta activation (WAY) led to decreased [Ca2+]compared to vehicle. Histamine 156-165 tachykinin precursor 1 Homo sapiens 121-124 32787755-0 2020 Role of histamine as a peripheral sympathetic neuromediator and its interrelation with substance P. Histamine 8-17 tachykinin precursor 1 Homo sapiens 87-98 30660328-6 2019 We found that while neurokinin A did not induce cardiac mast cell degranulation, both substance P and hemokinin-1 induced a concentration-dependent release of histamine; the maximal response to hemokinin-1 was greater than to substance P. Histamine 159-168 tachykinin precursor 1 Homo sapiens 86-97 30660328-6 2019 We found that while neurokinin A did not induce cardiac mast cell degranulation, both substance P and hemokinin-1 induced a concentration-dependent release of histamine; the maximal response to hemokinin-1 was greater than to substance P. Histamine 159-168 tachykinin precursor 1 Homo sapiens 226-237 30660328-7 2019 Neurokinin-1 receptor blockade prevented substance P-induced histamine release, while only partially attenuating hemokinin-1-induced histamine release. Histamine 61-70 tachykinin precursor 1 Homo sapiens 41-52 30660328-9 2019 Selective PPAR-gamma agonists attenuated histamine release in response to substance P. Histamine 41-50 tachykinin precursor 1 Homo sapiens 74-85 30104151-4 2018 In contrast to pathomechanisms of dry skin observed in SS, we recently reported that reduced sweating function and dry skin seen in atopic dermatitis (AD) are mediated by histamine or substance P, those are usually restored to normal levels after improvement of the dermatitis by topical corticosteroid ointment with or without oral anti-histamine. Histamine 338-347 tachykinin precursor 1 Homo sapiens 184-195 28366675-11 2017 Synovial MCs were activated with SP through MrgX2 to release histamine without producing proinflammatory cytokines. Histamine 61-70 tachykinin precursor 1 Homo sapiens 33-35 27147256-0 2016 Upregulated expression of substance P in basophils of the patients with chronic spontaneous urticaria: induction of histamine release and basophil accumulation by substance P. Histamine 116-125 tachykinin precursor 1 Homo sapiens 26-37 27147256-6 2016 Once added, SP induced up to 41.2 % net histamine release from basophils of CSU patients, which was comparable with that provoked by anti-IgE, and fMLP. Histamine 40-49 tachykinin precursor 1 Homo sapiens 12-14 26600671-5 2015 Here, we investigated the impact of amarogentin on substance P-induced release of histamine and TNF-alpha from the human mast cell line LAD-2. Histamine 82-91 tachykinin precursor 1 Homo sapiens 51-62 23734637-3 2013 In turn, histamine evokes the release of substance P and calcitonin gene-related peptide; thus, a bidirectional link between histamine and neuropeptides in neurogenic inflammation is established. Histamine 125-134 tachykinin precursor 1 Homo sapiens 41-52 19483309-10 2009 In addition, the effect of Columbianetin was investigated on the histamine release from HMC-1 stimulated by substance P, which promotes histamine release. Histamine 65-74 tachykinin precursor 1 Homo sapiens 108-119 20435351-5 2010 The histidine residue in first position of the peptide chain of neurokinin A coordinates strongly to Cu(II) ion with histamine-like {NH(2), N(Im)} coordination mode. Histamine 117-126 tachykinin precursor 1 Homo sapiens 64-76 19483309-10 2009 In addition, the effect of Columbianetin was investigated on the histamine release from HMC-1 stimulated by substance P, which promotes histamine release. Histamine 136-145 tachykinin precursor 1 Homo sapiens 108-119 19483309-11 2009 Columbianetin also inhibited the histamine release by substance P. Histamine 33-42 tachykinin precursor 1 Homo sapiens 54-65 19032907-7 2008 In addition, we found that HCBMCs generate the transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, after SP treatment. Histamine 140-149 tachykinin precursor 1 Homo sapiens 172-174