PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26989676-2	2016	However, the relevance of polymorphisms in histamine-related genes, such as HRH2, HRH3, DAO, and HNMT, with CHF remains largely neglected.	Histamine	43-52	D-amino acid oxidase	Homo sapiens	88-91	
32178384-1	2020	Two members of the copper-containing amine oxidase family are physiologically important proteins: (1) Diamine oxidase (hDAO; AOC1) with a preference for diamines is involved in degradation of histamine and (2) Vascular adhesion protein-1 (hVAP-1; AOC3) with a preference for monoamines is a multifunctional cell-surface receptor and an enzyme.	Histamine	192-201	D-amino acid oxidase	Homo sapiens	119-123	
29187599-2	2018	Human diamine oxidase (hDAO), required for histamine catabolism, has multiple N-glycosylation sites, but their roles, for example in DAO secretion, are unclear.	Histamine	43-52	D-amino acid oxidase	Homo sapiens	24-27	
27401969-1	2016	Human diamine oxidase (hDAO, EC 1.4.3.22) is the key enzyme in the degradation of extracellular histamine.	Histamine	96-105	D-amino acid oxidase	Homo sapiens	23-27	
27063138-1	2016	Human diamine oxidase (hDAO) efficiently degrades polyamines and histamine.	Histamine	65-74	D-amino acid oxidase	Homo sapiens	23-27	
25982580-1	2015	BACKGROUND: Diamine oxidase (DAO) is a polyamine-degrading enzyme also implicated in histamine metabolism.	Histamine	85-94	D-amino acid oxidase	Homo sapiens	29-32	
20124708-3	2010	AOC1 encodes human diamine oxidase (hDAO), which is the frontline enzyme for histamine metabolism.	Histamine	77-86	D-amino acid oxidase	Homo sapiens	36-40	
25612138-2	2015	We investigated the possible association between functional single nucleotide polymorphisms (SNPs) in the diamine oxidase gene (DAO; chromosome 7q36.1, involved in histamine metabolism) and the risk for migraine.	Histamine	164-173	D-amino acid oxidase	Homo sapiens	128-131	
7542108-1	1995	We review a new technique--diamine oxidase (DAO)-gold ultrastructural enzyme-affinity labeling--which we developed to localize histamine in subcellular sites of mast cells.	Histamine	127-136	D-amino acid oxidase	Homo sapiens	16-42	
19764817-2	2009	The product of the AOC1 gene is a so-called diamine oxidase (hDAO), named for its substrate preference for diamines, particularly histamine.	Histamine	130-139	D-amino acid oxidase	Homo sapiens	61-65	
8728118-1	1996	Diamine oxidase (DAO) or histaminase is an enzyme which deaminates histamine and several aliphatic amines to their corresponding aldehydes.	Histamine	67-76	D-amino acid oxidase	Homo sapiens	17-20	
7542108-2	1995	The DAO-gold method showed that isolated human lung mast cells contained abundant histamine in their cytoplasmic granules, a conclusion which was verified by a large number of specificity controls.	Histamine	82-91	D-amino acid oxidase	Homo sapiens	4-7	
7542108-1	1995	We review a new technique--diamine oxidase (DAO)-gold ultrastructural enzyme-affinity labeling--which we developed to localize histamine in subcellular sites of mast cells.	Histamine	127-136	D-amino acid oxidase	Homo sapiens	44-47	
7542108-4	1995	The DAO-gold method demonstrated histamine in the electron-dense granules of mast cells in these lesions, but little or no histamine was detected in the swollen, empty granules of mast cells undergoing piecemeal degranulation.	Histamine	33-42	D-amino acid oxidase	Homo sapiens	4-7	
8396495-1	1993	We have reported the presence of a histamine synthesizing enzyme, histidine decarboxylase (HDC), and histamine degrading enzymes, histamine N-methyltransferase (HMT) and histaminase (diamine oxidase, DAO) in human nasal mucosa and the histamine content of the mucosa.	Histamine	35-44	D-amino acid oxidase	Homo sapiens	200-203	
34477104-3	2021	Human diamine oxidase (hDAO) can rapidly degrade histamine and therefore represents a promising new treatment strategy for conditions with pathological histamine concentrations.	Histamine	49-58	D-amino acid oxidase	Homo sapiens	23-27	
34477104-3	2021	Human diamine oxidase (hDAO) can rapidly degrade histamine and therefore represents a promising new treatment strategy for conditions with pathological histamine concentrations.	Histamine	152-161	D-amino acid oxidase	Homo sapiens	23-27	
34209583-11	2021	Alongside the dietary measures, DAO supplementation supporting the degradation of ingested histamine may be considered as subsidiary treatment for individuals with intestinal DAO deficiency.	Histamine	91-100	D-amino acid oxidase	Homo sapiens	32-35	
35303133-8	2022	Treatment with recombinant human DAO strongly reduced histamine-induced core body temperature loss, histamine concentrations and prevented the development of severe clinical symptoms.	Histamine	54-63	D-amino acid oxidase	Homo sapiens	33-36	
35303133-8	2022	Treatment with recombinant human DAO strongly reduced histamine-induced core body temperature loss, histamine concentrations and prevented the development of severe clinical symptoms.	Histamine	100-109	D-amino acid oxidase	Homo sapiens	33-36	
33921522-1	2021	Histamine intolerance (HIT) is assumed to be due to a deficiency of the gastrointestinal (GI) enzyme diamine oxidase (DAO) and, therefore, the food component histamine not being degraded and/or absorbed properly within the GI tract.	Histamine	0-9	D-amino acid oxidase	Homo sapiens	118-121