PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20691233-3	2010	In the present study, we investigated the roles of ghrelin and obestatin on mast cell degranulation and found that both ghrelin and obestatin induce the release of histamine from rat peritoneal mast cells.	Histamine	164-173	ghrelin and obestatin prepropeptide	Rattus norvegicus	51-58	
20571831-3	2010	In the present study, we compared desacyl and acyl ghrelin with regard to acid secretion and histamine production in the rat stomach.	Histamine	93-102	ghrelin and obestatin prepropeptide	Rattus norvegicus	51-58	
20571831-13	2010	CONCLUSIONS: The results indicate that acyl ghrelin stimulates gastric acid secretion via a mechanism involving activation of the vagus nerve and histamine release and synthesis and that desacyl ghrelin has no action on gastric acid secretion.	Histamine	146-155	ghrelin and obestatin prepropeptide	Rattus norvegicus	44-51	
20571831-14	2010	Furthermore, the results demonstrate synergism between gastrin and acyl ghrelin in terms of gastric acid secretion via a mechanism involving histamine release and synthesis.	Histamine	141-150	ghrelin and obestatin prepropeptide	Rattus norvegicus	72-79	
20691233-3	2010	In the present study, we investigated the roles of ghrelin and obestatin on mast cell degranulation and found that both ghrelin and obestatin induce the release of histamine from rat peritoneal mast cells.	Histamine	164-173	ghrelin and obestatin prepropeptide	Rattus norvegicus	120-127	
20691233-5	2010	Rat peritoneal mast cells and rat basophilic leukemia (RBL-2H3) cells did not express the ghrelin receptor GHSR1a, suggesting that histamine release induced by ghrelin occurs via a receptor-independent mechanism.	Histamine	131-140	ghrelin and obestatin prepropeptide	Rattus norvegicus	160-167	
19009648-8	2008	However, we have shown that famotidine completely inhibited ghrelin-induced acid secretion and histidine decarboxylase (HDC) mRNA was increased in gastric mucosa by ghrelin injection which is inhibited by vagotomy Our results indicate that histamine is involved in the action of ghrelin on acid secretion.	Histamine	240-249	ghrelin and obestatin prepropeptide	Rattus norvegicus	165-172	
18611393-1	2008	Gastrin and ghrelin are secreted from G cells and X/A-like cells in the stomach, respectively, and respective hormones stimulate gastric acid secretion by acting through histamine and the vagus nerve.	Histamine	170-179	ghrelin and obestatin prepropeptide	Rattus norvegicus	12-19	
19009648-4	2008	In the previous studies, the action of ghrelin on acid secretion was shown to be as strong as that of histamine and gastrin in in-vivo experiment.	Histamine	102-111	ghrelin and obestatin prepropeptide	Rattus norvegicus	39-46	
19009648-8	2008	However, we have shown that famotidine completely inhibited ghrelin-induced acid secretion and histidine decarboxylase (HDC) mRNA was increased in gastric mucosa by ghrelin injection which is inhibited by vagotomy Our results indicate that histamine is involved in the action of ghrelin on acid secretion.	Histamine	240-249	ghrelin and obestatin prepropeptide	Rattus norvegicus	165-172