PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14521154-2 2003 In this report,we show that this compound also inhibits histidine decarboxylase, the enzymic activity responsible for histamine biosynthesis. Histamine 118-127 histidine decarboxylase Homo sapiens 56-79 11790728-1 2002 Histidine decarboxylase (HDC) is the key enzyme for gastric histamine synthesis, and enhanced HDC expression is critically involved in the pathogenesis of gastric disorders, including gastroduodenal ulcer disease. Histamine 60-69 histidine decarboxylase Homo sapiens 25-28 12875237-3 2003 We have studied histidine decarboxylase (HDC), the rate-limiting enzyme for mammalian histamine synthesis. Histamine 86-95 histidine decarboxylase Homo sapiens 16-39 12875237-3 2003 We have studied histidine decarboxylase (HDC), the rate-limiting enzyme for mammalian histamine synthesis. Histamine 86-95 histidine decarboxylase Homo sapiens 41-44 12777977-4 2003 In the present study, the activities of the histamine-forming enzyme HDC and of the degrading enzymes diamine oxidase (DAO) and histamine N-methyltransferase (HNMT) were measured in primary (WM35 and WM983) and metastatic (M1 and HT168) human melanoma cell lines. Histamine 44-53 histidine decarboxylase Homo sapiens 69-72 12132991-2 2002 Histidine decarboxylase inhibitor decreases the histamine level, and its intracellular antagonist decreases the histamine effect. Histamine 48-57 histidine decarboxylase Homo sapiens 0-23 12132991-2 2002 Histidine decarboxylase inhibitor decreases the histamine level, and its intracellular antagonist decreases the histamine effect. Histamine 112-121 histidine decarboxylase Homo sapiens 0-23 12832849-5 2003 Histamine is synthesized in monocytes and T cells by the induction of histidine decarboxylase. Histamine 0-9 histidine decarboxylase Homo sapiens 70-93 12140379-1 2002 Histamine is produced by many cells expressing histidine decarboxylase (HDC), the enzyme responsible for the synthesis of histamine. Histamine 0-9 histidine decarboxylase Homo sapiens 47-70 12140379-1 2002 Histamine is produced by many cells expressing histidine decarboxylase (HDC), the enzyme responsible for the synthesis of histamine. Histamine 0-9 histidine decarboxylase Homo sapiens 72-75 12140379-1 2002 Histamine is produced by many cells expressing histidine decarboxylase (HDC), the enzyme responsible for the synthesis of histamine. Histamine 122-131 histidine decarboxylase Homo sapiens 47-70 12140379-1 2002 Histamine is produced by many cells expressing histidine decarboxylase (HDC), the enzyme responsible for the synthesis of histamine. Histamine 122-131 histidine decarboxylase Homo sapiens 72-75 11834241-3 2002 In addition, troglitazone caused a decrease in histamine secretion due to the reduced expression of histidine decarboxylase mRNA. Histamine 47-56 histidine decarboxylase Homo sapiens 100-123 12371609-3 2002 We detected mRNA and protein expression of histidine decarboxylase (HDC), the only enzyme responsible for histamine synthesis both in normal bone marrow progenitor cells and in leukaemic progenitors. Histamine 106-115 histidine decarboxylase Homo sapiens 43-66 12371609-3 2002 We detected mRNA and protein expression of histidine decarboxylase (HDC), the only enzyme responsible for histamine synthesis both in normal bone marrow progenitor cells and in leukaemic progenitors. Histamine 106-115 histidine decarboxylase Homo sapiens 68-71 12371609-4 2002 The significance of in situ generated histamine was shown on colony formation by inhibitory action of alphaFMH (blocking HDC activity, i.e. de novo histamine formation) and by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl (DPPE) disturbing the interference of histamine with intracellular binding sites. Histamine 38-47 histidine decarboxylase Homo sapiens 121-124 12371609-4 2002 The significance of in situ generated histamine was shown on colony formation by inhibitory action of alphaFMH (blocking HDC activity, i.e. de novo histamine formation) and by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl (DPPE) disturbing the interference of histamine with intracellular binding sites. Histamine 148-157 histidine decarboxylase Homo sapiens 121-124 12371609-4 2002 The significance of in situ generated histamine was shown on colony formation by inhibitory action of alphaFMH (blocking HDC activity, i.e. de novo histamine formation) and by N,N-diethyl-2-[4-(phenylmethyl)phenoxy]-ethanamine-HCl (DPPE) disturbing the interference of histamine with intracellular binding sites. Histamine 148-157 histidine decarboxylase Homo sapiens 121-124 12469348-0 2002 L-histidine decarboxylase as a probe in studies on histamine. Histamine 51-60 histidine decarboxylase Homo sapiens 0-25 12469348-12 2002 In summary, HDC has been and will be useful in studies on functions of histamine. Histamine 71-80 histidine decarboxylase Homo sapiens 12-15 11442763-1 2001 Histidine decarboxylase (HDC) is expressed by the cells of melanoma, in which the histamine content tends to be relatively high. Histamine 82-91 histidine decarboxylase Homo sapiens 0-23 11566179-1 2001 We investigated the localization of histidine decarboxylase (HDC), which is the rate-limiting enzyme that generates histamine from histidine, in human aorta/coronary artery. Histamine 116-125 histidine decarboxylase Homo sapiens 36-59 11566179-1 2001 We investigated the localization of histidine decarboxylase (HDC), which is the rate-limiting enzyme that generates histamine from histidine, in human aorta/coronary artery. Histamine 116-125 histidine decarboxylase Homo sapiens 61-64 11556524-1 2001 OBJECTIVE: In this study the expression of histidine decarboxylase (HDC), the pivotal enzyme in histamine formation and the effect of endogenously produced histamine on differentiation antigens was examined during in vitro differentiation of human monocytes. Histamine 96-105 histidine decarboxylase Homo sapiens 43-66 11556524-1 2001 OBJECTIVE: In this study the expression of histidine decarboxylase (HDC), the pivotal enzyme in histamine formation and the effect of endogenously produced histamine on differentiation antigens was examined during in vitro differentiation of human monocytes. Histamine 96-105 histidine decarboxylase Homo sapiens 68-71 11442763-1 2001 Histidine decarboxylase (HDC) is expressed by the cells of melanoma, in which the histamine content tends to be relatively high. Histamine 82-91 histidine decarboxylase Homo sapiens 25-28 11442763-4 2001 Moreover, the decrease in proliferation caused by HDC antisense oligonucleotides indicates considerable functional relevance of histamine synthesis in melanoma growth and suggests a possible in situ application of specific antisense oligonucleotides for HDC in melanoma therapy. Histamine 128-137 histidine decarboxylase Homo sapiens 50-53 11442763-4 2001 Moreover, the decrease in proliferation caused by HDC antisense oligonucleotides indicates considerable functional relevance of histamine synthesis in melanoma growth and suggests a possible in situ application of specific antisense oligonucleotides for HDC in melanoma therapy. Histamine 128-137 histidine decarboxylase Homo sapiens 254-257 9813077-1 1998 L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine, and in hematopoietic cell lineages the gene is expressed only in mast cells and basophils. Histamine 59-68 histidine decarboxylase Homo sapiens 0-25 11496827-5 2001 The histamine newly formed via the induction of HDC is released immediately and may be involved in a variety of immune responses. Histamine 4-13 histidine decarboxylase Homo sapiens 48-51 11496827-6 2001 Reviewing our work and that of Schayer and Kahlson, the pioneers in this field, lead us to the conclusion that nowadays we need to understand that histamine can be produced via the induction of HDC by a mechanism coupled with the cytokine network. Histamine 147-156 histidine decarboxylase Homo sapiens 194-197 11356560-7 2001 It is now possible to detect the presence of undesirable histamine-producing strains by PCR test or DNA probe based on the presence of the gene encoding histidine decarboxylase. Histamine 57-66 histidine decarboxylase Homo sapiens 153-176 10951267-2 2000 Histidine decarboxylase, the only enzyme that catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine levels. Histamine 73-82 histidine decarboxylase Homo sapiens 0-23 10951267-2 2000 Histidine decarboxylase, the only enzyme that catalyzes the formation of histamine from L-histidine, is an essential regulator of histamine levels. Histamine 130-139 histidine decarboxylase Homo sapiens 0-23 10652359-3 2000 Histidine decarboxylase (HDC) is the rate-limiting enzyme for histamine production, and its activity is regulated through transcriptional mechanisms. Histamine 62-71 histidine decarboxylase Homo sapiens 25-28 10888270-1 2000 Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. Histamine 0-9 histidine decarboxylase Homo sapiens 40-63 10888270-1 2000 Histamine is produced from histidine by histidine decarboxylase (HDC) in many cells including normal and malignant lymphocytes. Histamine 0-9 histidine decarboxylase Homo sapiens 65-68 10564076-5 1999 Histamine release occurs from different cellular pools: preexisting vacuolar histamine immediately released by Ca(2+) entry or newly synthesized histamine following induction of histidine decarboxylase (HDC) by gastrin stimulation. Histamine 0-9 histidine decarboxylase Homo sapiens 178-201 10564076-5 1999 Histamine release occurs from different cellular pools: preexisting vacuolar histamine immediately released by Ca(2+) entry or newly synthesized histamine following induction of histidine decarboxylase (HDC) by gastrin stimulation. Histamine 0-9 histidine decarboxylase Homo sapiens 203-206 10564076-6 1999 Histamine is synthesized by cytoplasmic HDC and accumulated in secretory vesicles by proton-histamine countertransport via the vesicular monoamine transporter subtype 2 (VMAT-2). Histamine 0-9 histidine decarboxylase Homo sapiens 40-43 10051705-2 1999 Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT). Histamine 0-9 histidine decarboxylase Homo sapiens 54-79 10051705-2 1999 Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT). Histamine 0-9 histidine decarboxylase Homo sapiens 81-84 11306145-1 2001 Histamine, a principal mediator in various physiological and pathological cell functions is synthesized from L-histidine exclusively by histidine decarboxylase, an enzyme, which is expressed in many tissues of mammalian organism. Histamine 0-9 histidine decarboxylase Homo sapiens 136-159 11246041-5 2001 Gastrin acts on CCK2 receptors to control the synthesis of ECL-cell histamine, accelerating the expression of the histamine-forming enzyme histidine decarboxylase (HDC) at both the transcription and the translation/posttranslation levels. Histamine 68-77 histidine decarboxylase Homo sapiens 139-162 11246041-5 2001 Gastrin acts on CCK2 receptors to control the synthesis of ECL-cell histamine, accelerating the expression of the histamine-forming enzyme histidine decarboxylase (HDC) at both the transcription and the translation/posttranslation levels. Histamine 68-77 histidine decarboxylase Homo sapiens 164-167 11246041-6 2001 Depletion of histamine by alpha-fluoromethylhistidine (an irreversible inhibitor of HDC) prevents gastrin-induced but not histamine-induced gastric acid secretion. Histamine 13-22 histidine decarboxylase Homo sapiens 84-87 11028755-2 2000 Histidine decarboxylase (HDC), the enzyme solely responsible for generation of histamine is expressed in many cells including regenerating and tumour cells. Histamine 79-88 histidine decarboxylase Homo sapiens 0-23 11028755-2 2000 Histidine decarboxylase (HDC), the enzyme solely responsible for generation of histamine is expressed in many cells including regenerating and tumour cells. Histamine 79-88 histidine decarboxylase Homo sapiens 25-28 10096452-12 1999 On the basis of these and previous results and the known actions of histamine, we propose that the histamine newly formed following the induction of HDC activity, which is itself mediated by IL-1, may be involved in inducing pain and, possibly, stiffness in muscles in temporomandibular disorders. Histamine 68-77 histidine decarboxylase Homo sapiens 149-152 10096452-12 1999 On the basis of these and previous results and the known actions of histamine, we propose that the histamine newly formed following the induction of HDC activity, which is itself mediated by IL-1, may be involved in inducing pain and, possibly, stiffness in muscles in temporomandibular disorders. Histamine 99-108 histidine decarboxylase Homo sapiens 149-152 9813077-1 1998 L-Histidine decarboxylase (HDC) catalyzes the formation of histamine from L-histidine, and in hematopoietic cell lineages the gene is expressed only in mast cells and basophils. Histamine 59-68 histidine decarboxylase Homo sapiens 27-30 9865502-3 1998 Histamine was quantitated by RIA, HDC activity by the formation of histamine. Histamine 67-76 histidine decarboxylase Homo sapiens 34-37 8396495-1 1993 We have reported the presence of a histamine synthesizing enzyme, histidine decarboxylase (HDC), and histamine degrading enzymes, histamine N-methyltransferase (HMT) and histaminase (diamine oxidase, DAO) in human nasal mucosa and the histamine content of the mucosa. Histamine 35-44 histidine decarboxylase Homo sapiens 91-94 9657253-7 1998 RESULTS: Human platelets contain 72.5 +/- 9.6pmoles of histamine x 10(9) platelets, and their capacity to form histamine is 18.7 +/- 3.5pmoles h(-1)g(-1) protein, which is reduced by alpha-fluoromethylhistidine (10(-5) M) a selective inhibitor of the specific histidine decarboxylase. Histamine 111-120 histidine decarboxylase Homo sapiens 260-283 9546316-2 1998 Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC). Histamine 49-58 histidine decarboxylase Homo sapiens 96-119 9546316-2 1998 Basophils and mast cells are the main sources of histamine, which is formed from L-histidine by histidine decarboxylase (HDC). Histamine 49-58 histidine decarboxylase Homo sapiens 121-124 9654597-1 1998 Histidine decarboxylase (HDC), the only enzyme capable of synthetizing histamine, has been found in many proliferating cells and tissues suggesting a role of histamine in cellular proliferation. Histamine 71-80 histidine decarboxylase Homo sapiens 0-23 9654597-1 1998 Histidine decarboxylase (HDC), the only enzyme capable of synthetizing histamine, has been found in many proliferating cells and tissues suggesting a role of histamine in cellular proliferation. Histamine 71-80 histidine decarboxylase Homo sapiens 25-28 9654597-1 1998 Histidine decarboxylase (HDC), the only enzyme capable of synthetizing histamine, has been found in many proliferating cells and tissues suggesting a role of histamine in cellular proliferation. Histamine 158-167 histidine decarboxylase Homo sapiens 0-23 9654597-1 1998 Histidine decarboxylase (HDC), the only enzyme capable of synthetizing histamine, has been found in many proliferating cells and tissues suggesting a role of histamine in cellular proliferation. Histamine 158-167 histidine decarboxylase Homo sapiens 25-28 9654597-7 1998 The observations suggest that HDC has functional relevance in lymphocytes, since mitogen induced lymphocyte proliferation of healthy donors is mainly enhanced by de novo synthesis and subsequent action of intracellular histamine. Histamine 219-228 histidine decarboxylase Homo sapiens 30-33 8757788-9 1996 Recent work indicates physiological regulation of the expression of genes encoding cytosolic enzymes such as histidine decarboxylase, which converts histidine to histamine, and of secretory granule transporters such as vesicular monoamine transporter type 2, which concentrates amines in secretory vesicles. Histamine 162-171 histidine decarboxylase Homo sapiens 109-132 8838085-2 1996 L-Histidine decarboxylase (HDC) is a unique enzyme in mammals which catalyzes histamine formation from L-histidine. Histamine 78-87 histidine decarboxylase Homo sapiens 0-25 8838085-2 1996 L-Histidine decarboxylase (HDC) is a unique enzyme in mammals which catalyzes histamine formation from L-histidine. Histamine 78-87 histidine decarboxylase Homo sapiens 27-30 1425659-1 1992 L-Histidine decarboxylase (HisDC) is the enzyme catalyzing the formation of histamine from L-histidine. Histamine 76-85 histidine decarboxylase Homo sapiens 2-25 1319204-2 1992 With histidine decarboxylase (pyruvoyl) it is found that the presence of CO2 is required for T-exchange between histamine and water. Histamine 112-121 histidine decarboxylase Homo sapiens 5-28 1768863-2 1991 The biosynthesis of histamine is catalyzed by the enzyme, L-histidine decarboxylase (HDC). Histamine 20-29 histidine decarboxylase Homo sapiens 58-83 1588129-2 1992 Histamine is synthesized by multiple isozymes of histidine decarboxylase, and catabolized by either diamine oxidase or histamine-N-methyltransferase. Histamine 0-9 histidine decarboxylase Homo sapiens 49-72 1721655-1 1991 We investigated whether production of histamine by bacteria isolated from sputum of patients with infective lung diseases could be attributed to the presence of histidine decarboxylase (HD). Histamine 38-47 histidine decarboxylase Homo sapiens 161-184 1721655-1 1991 We investigated whether production of histamine by bacteria isolated from sputum of patients with infective lung diseases could be attributed to the presence of histidine decarboxylase (HD). Histamine 38-47 histidine decarboxylase Homo sapiens 186-188 1834679-4 1991 We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine. Histamine 106-115 histidine decarboxylase Homo sapiens 166-189 1834679-4 1991 We further provide evidence that this phenomenon is completely abolished: i) by preventing GM-CSF-induced histamine synthesis by alpha-FMH, the specific inhibitor of histidine decarboxylase (HDC), or ii) by blocking the binding sites of H2 histamine receptors with their specific antagonist oxmetidine. Histamine 106-115 histidine decarboxylase Homo sapiens 191-194 1768863-2 1991 The biosynthesis of histamine is catalyzed by the enzyme, L-histidine decarboxylase (HDC). Histamine 20-29 histidine decarboxylase Homo sapiens 85-88 2146139-3 1990 It results from an increase in histamine synthesis because of 1) the low level of histamine cell content before any incubation, 2) the parallel increase in both extra- and intracellular histamine levels in response to rhIL-3, and 3) the early IL-3-induced increase in L-histidine decarboxylase (HDC; EC 4.1.1.22) activity. Histamine 31-40 histidine decarboxylase Homo sapiens 268-293 2146139-3 1990 It results from an increase in histamine synthesis because of 1) the low level of histamine cell content before any incubation, 2) the parallel increase in both extra- and intracellular histamine levels in response to rhIL-3, and 3) the early IL-3-induced increase in L-histidine decarboxylase (HDC; EC 4.1.1.22) activity. Histamine 31-40 histidine decarboxylase Homo sapiens 295-298 34734351-0 2021 Histamine Deficiency Promotes Myofibroblasts Transformation from HDC-Expressing CD11b+ Myeloid Cells in Injured Hearts Post Myocardial Infarction. Histamine 0-9 histidine decarboxylase Homo sapiens 65-68 2238092-1 1990 alpha-Fluoromethyl-[S]-histidine (FMH) is a specific and potent inhibitor of histidine decarboxylase, which forms histamine from histidine. Histamine 114-123 histidine decarboxylase Homo sapiens 77-100 2104768-5 1990 Inhibitors of histidine decarboxylase (HDC) block both aggregation and histamine synthesis in parallel. Histamine 71-80 histidine decarboxylase Homo sapiens 14-37 2104768-5 1990 Inhibitors of histidine decarboxylase (HDC) block both aggregation and histamine synthesis in parallel. Histamine 71-80 histidine decarboxylase Homo sapiens 39-42 2104768-8 1990 The effects of DPPE and HDC inhibitors are significantly reversed by the addition of histamine (0.1 to 10 mumol/L) to saponin-permeabilized platelets, though histamine alone has no pro-aggregatory effects. Histamine 85-94 histidine decarboxylase Homo sapiens 24-27 34941436-1 2022 Aerobic exercise induces mast cell degranulation and increases histamine formation by histidine decarboxylase, resulting in an ~150% increase in intramuscular histamine. Histamine 63-72 histidine decarboxylase Homo sapiens 86-109 34941436-1 2022 Aerobic exercise induces mast cell degranulation and increases histamine formation by histidine decarboxylase, resulting in an ~150% increase in intramuscular histamine. Histamine 159-168 histidine decarboxylase Homo sapiens 86-109 34941436-8 2022 However, this thermal effect is most likely due to changes in de novo histamine formation via histidine decarboxylase and not due to degranulation of mast cells. Histamine 70-79 histidine decarboxylase Homo sapiens 94-117 34734351-2 2021 Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells. Histamine 78-87 histidine decarboxylase Homo sapiens 0-23 34734351-2 2021 Histidine decarboxylase (HDC), the unique enzyme that converts L-histidine to histamine, is highly expressed in CD11b+ immature myeloid cells. Histamine 78-87 histidine decarboxylase Homo sapiens 25-28 35632808-15 2022 An immunohistochemistry (IHC) was strongly positive for HDC in the DRG neurons of the PRV-infected mice, which led to the high expression of histamine at the injected sites. Histamine 141-150 histidine decarboxylase Homo sapiens 56-59 34471328-0 2021 Rapid identification of histamine-producing bacteria isolated from fish using MALDI-TOF MS. Histamine-producing bacteria (HPB) produce histamine from histidine contained in food through the action of histidine decarboxylase. Histamine 24-33 histidine decarboxylase Homo sapiens 200-223 34471328-0 2021 Rapid identification of histamine-producing bacteria isolated from fish using MALDI-TOF MS. Histamine-producing bacteria (HPB) produce histamine from histidine contained in food through the action of histidine decarboxylase. Histamine 92-101 histidine decarboxylase Homo sapiens 200-223 34471328-0 2021 Rapid identification of histamine-producing bacteria isolated from fish using MALDI-TOF MS. Histamine-producing bacteria (HPB) produce histamine from histidine contained in food through the action of histidine decarboxylase. Histamine 135-144 histidine decarboxylase Homo sapiens 200-223 34225943-2 2021 The histamine neurons in it synthesize histamine by means of the key enzyme histidine decarboxylase (HDC) and from the TMN, innervate a large number of brain areas, such as the cerebral cortex, hippocampus, amygdala as well as the thalamus, hypothalamus, and basal ganglia. Histamine 4-13 histidine decarboxylase Homo sapiens 76-99 34225943-2 2021 The histamine neurons in it synthesize histamine by means of the key enzyme histidine decarboxylase (HDC) and from the TMN, innervate a large number of brain areas, such as the cerebral cortex, hippocampus, amygdala as well as the thalamus, hypothalamus, and basal ganglia. Histamine 4-13 histidine decarboxylase Homo sapiens 101-104 34225943-2 2021 The histamine neurons in it synthesize histamine by means of the key enzyme histidine decarboxylase (HDC) and from the TMN, innervate a large number of brain areas, such as the cerebral cortex, hippocampus, amygdala as well as the thalamus, hypothalamus, and basal ganglia. Histamine 39-48 histidine decarboxylase Homo sapiens 76-99 34225943-2 2021 The histamine neurons in it synthesize histamine by means of the key enzyme histidine decarboxylase (HDC) and from the TMN, innervate a large number of brain areas, such as the cerebral cortex, hippocampus, amygdala as well as the thalamus, hypothalamus, and basal ganglia. Histamine 39-48 histidine decarboxylase Homo sapiens 101-104 35411649-5 2022 Histamine was evaluated by the expression of L-histidine decarboxylase (HDC). Histamine 0-9 histidine decarboxylase Homo sapiens 45-70 35411649-5 2022 Histamine was evaluated by the expression of L-histidine decarboxylase (HDC). Histamine 0-9 histidine decarboxylase Homo sapiens 72-75 35632808-18 2022 Taken together, the histamine synthesized by the HDC in the DRG neurons was responsible for the PRV-induced itch in the mice. Histamine 20-29 histidine decarboxylase Homo sapiens 49-52 4052109-1 1985 A microassay procedure for mammalian histidine decarboxylase based on the conversion of L-[3H]histidine to [3H]histamine, which were separated by an alkaline butanol extraction followed by thin-layer chromatography, is described. Histamine 107-120 histidine decarboxylase Homo sapiens 37-60 2918844-2 1989 In the present study, we have measured: (a) plasma histamine concentrations; (b) leucocyte and platelet histidine decarboxylase (the enzyme responsible for the biosynthesis of histamine) in patients with diabetes mellitus (Types I and II) and peripheral vascular disease; and (c) platelet and leucocyte histamine content. Histamine 176-185 histidine decarboxylase Homo sapiens 104-127 2918844-2 1989 In the present study, we have measured: (a) plasma histamine concentrations; (b) leucocyte and platelet histidine decarboxylase (the enzyme responsible for the biosynthesis of histamine) in patients with diabetes mellitus (Types I and II) and peripheral vascular disease; and (c) platelet and leucocyte histamine content. Histamine 176-185 histidine decarboxylase Homo sapiens 104-127 35529437-9 2022 Histidine can be decarboxylated to histamine by histidine decarboxylase. Histamine 35-44 histidine decarboxylase Homo sapiens 48-71 2928797-3 1989 Inhibitors of histidine decarboxylase (HDC) suppressed both aggregation and the elevation of histamine content, whereas DPPE inhibited aggregation only. Histamine 93-102 histidine decarboxylase Homo sapiens 14-37 2928797-3 1989 Inhibitors of histidine decarboxylase (HDC) suppressed both aggregation and the elevation of histamine content, whereas DPPE inhibited aggregation only. Histamine 93-102 histidine decarboxylase Homo sapiens 39-42 2928797-4 1989 In saponin-permeabilized platelets, added histamine reversed the inhibition by DPPE or HDC inhibitors on aggregation induced by PMA or collagen. Histamine 42-51 histidine decarboxylase Homo sapiens 87-90 3263349-2 1988 A specific inhibitor of histidine decarboxylase, the enzyme which catalyses the synthesis of histamine, reduced ampullar nerve firing in a dose-dependent manner. Histamine 93-102 histidine decarboxylase Homo sapiens 24-47 4052109-4 1985 This report includes information on histidine decarboxylase activity at various pH levels, in different buffers, and in the presence of selected histamine active drugs. Histamine 145-154 histidine decarboxylase Homo sapiens 36-59 3994743-1 1985 An irreversible inhibitor of histidine decarboxylase, alpha-fluoromethylhistidine (FMH), was used to inhibit histamine formation by mast cells in vivo. Histamine 109-118 histidine decarboxylase Homo sapiens 29-52 4052095-1 1985 Histidine decarboxylase (HDC) activity in Ficoll-Hypaque purified human peripheral blood leukocytes (PBL) was determined by measuring the formation of [3H]histamine from L-[3H]histidine. Histamine 151-164 histidine decarboxylase Homo sapiens 0-23 4052095-1 1985 Histidine decarboxylase (HDC) activity in Ficoll-Hypaque purified human peripheral blood leukocytes (PBL) was determined by measuring the formation of [3H]histamine from L-[3H]histidine. Histamine 151-164 histidine decarboxylase Homo sapiens 25-28 6094908-8 1984 The increase in histamine levels in glomeruli was abolished by the histidine decarboxylase inhibitor bromocresine. Histamine 16-25 histidine decarboxylase Homo sapiens 67-90 3994269-3 1985 The histamine value was determined by the amount of carbon dioxide produced in histidine decarboxylase activity (HDCA); the measurement of 5-hydroxytryptamine (5-HT) was done by the Ninhydrin method. Histamine 4-13 histidine decarboxylase Homo sapiens 79-102 6529603-1 1984 Further studies of the histamine metabolism in the M-2 adenocarcinoma have shown that the tumor and the intestinal histidine decarboxylase should have similar conformations, since both enzymes exhibit superimposable curves of activity vs. pH as well as nearly identical 50% inhibitory concentrations for the specific inhibitor NSD-1015. Histamine 23-32 histidine decarboxylase Homo sapiens 115-138 6641910-0 1983 Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations. Histamine 68-77 histidine decarboxylase Homo sapiens 34-57 6641910-1 1983 In rats, chronic infusion of alpha-fluoromethyl histidine, a selective irreversible inhibitor of mammalian histidine decarboxylase, caused a marked depletion of histamine in all tissues examined. Histamine 161-170 histidine decarboxylase Homo sapiens 107-130 7452264-4 1980 The data indicate that histamine synthesis in the human brain involves the "specific" histidine decarboxylase (HD, EC 4.1.1.22) and not the aromatic L-amino acid decarboxylase: (1) the optimum pH is 7.4 at 10(-6) M-L-histidine; (2) the apparent Km is about 3.10(-5) M; (3) it is inhibited by alpha-hydrazino histidine and brocresine but not affected by alpha-methyl DOPA. Histamine 23-32 histidine decarboxylase Homo sapiens 86-109 6621397-0 1983 A simple method for the determination of polyamines and histamine and its application to the assay of ornithine and histidine decarboxylase activities. Histamine 56-65 histidine decarboxylase Homo sapiens 116-139 7044070-6 1982 Reaction kinetics of histamine formation were linear over an incubation period of at least 3 h. Histidine decarboxylase activity as a rather low pH and substrate concentration, which is characteristic for the acid (specific) histidine decarboxylase, was demonstrated inthe gastric mucosa of human subjects, dogs, rabbits and guinea-pigs, always using the same incubation conditions for all species investigated. Histamine 21-30 histidine decarboxylase Homo sapiens 96-119 7044070-6 1982 Reaction kinetics of histamine formation were linear over an incubation period of at least 3 h. Histidine decarboxylase activity as a rather low pH and substrate concentration, which is characteristic for the acid (specific) histidine decarboxylase, was demonstrated inthe gastric mucosa of human subjects, dogs, rabbits and guinea-pigs, always using the same incubation conditions for all species investigated. Histamine 21-30 histidine decarboxylase Homo sapiens 225-248 1221981-3 1975 It is hypothesized that the increase in the histamine level can be explained by admitting an increase in histidine-decarboxylase activity at tissue level with consequent synthesis of a greater quantity of histamine. Histamine 44-53 histidine decarboxylase Homo sapiens 105-128 6253362-17 1980 welchii from NE cases had significantly higher histidine decarboxylase activity than strains from control sources; it is possible that the resultant histamine production could act as a promoting factor in stage 1. Histamine 149-158 histidine decarboxylase Homo sapiens 47-70 499547-0 1979 Stereochemical study of formation of histamine from (2S)-histidine by mammalian histidine decarboxylase. Histamine 37-46 histidine decarboxylase Homo sapiens 80-103 1221981-3 1975 It is hypothesized that the increase in the histamine level can be explained by admitting an increase in histidine-decarboxylase activity at tissue level with consequent synthesis of a greater quantity of histamine. Histamine 205-214 histidine decarboxylase Homo sapiens 105-128 6017372-0 1967 Histamine formation: histidine decarboxylase determination using carboxyl-14-C-labeled histidine. Histamine 0-9 histidine decarboxylase Homo sapiens 21-44 32871134-1 2020 Histidine decarboxylase (HDC; EC 4.1.1.22), an enzyme that catalyzes histamine synthesis with high substrate specificity, is a member of the group II pyridoxal 5"-phosphate (PLP) -dependent decarboxylase family. Histamine 69-78 histidine decarboxylase Homo sapiens 0-23 33340761-1 2021 Histamine-producing cells include storage-type cells (e.g., mast cells and basophils), which store histamine intracellularly, and inducible-type cells (e.g., keratinocytes and macrophages), which induce histidine decarboxylase (HDC, a key enzyme for histamine biosynthesis) activity but do not have a storage pool of histamine. Histamine 0-9 histidine decarboxylase Homo sapiens 203-226 33340761-1 2021 Histamine-producing cells include storage-type cells (e.g., mast cells and basophils), which store histamine intracellularly, and inducible-type cells (e.g., keratinocytes and macrophages), which induce histidine decarboxylase (HDC, a key enzyme for histamine biosynthesis) activity but do not have a storage pool of histamine. Histamine 0-9 histidine decarboxylase Homo sapiens 228-231 33261109-1 2020 Allergy is an immunological disorder that develops in response to exposure to an allergen, and histamines mediate these effects via histidine decarboxylase (HDC) activity at the intracellular level. Histamine 95-105 histidine decarboxylase Homo sapiens 157-160 4382888-0 1967 [Influence of histidine decarboxylase inhibitor 554 L (Hypostamine) on the behavior of certain indices of histamine and serotonin metabolism]. Histamine 106-115 histidine decarboxylase Homo sapiens 14-37 14311532-0 1965 [THE INFLUENCE OF AN INHIBITOR OF HISTIDINE DECARBOXYLASE ON HISTAMINE LIBERATION PRODUCED IN MAN BY THE INTRADERMAL INJECTION OF L 1935 AND THE LOCAL ANAPHYLACTIC REACTION]. Histamine 62-71 histidine decarboxylase Homo sapiens 34-57 33788304-6 2021 Additionally, we examined the expression of histidine decarboxylase and diamine oxidase, critical enzymes in the metabolism of histamine, under allergen challenge. Histamine 127-136 histidine decarboxylase Homo sapiens 44-67 33788304-10 2021 Interestingly, allergen-specific immunotherapy canceled the histamine release through the downregulation of histidine decarboxylase expression. Histamine 60-69 histidine decarboxylase Homo sapiens 108-131 33505099-1 2021 Histamine is a degradation product of the bacterial decarboxylation of the amino acid histidine; such activity is determined by histidine decarboxylase encoded by a gene cluster, carried by some Gram-positive bacteria, that includes the hdcA gene. Histamine 0-9 histidine decarboxylase Homo sapiens 128-151 33402532-9 2021 We also observed elevated levels of Hdc transcripts, which might affect histamine metabolism with consequences for circadian rhythm. Histamine 72-81 histidine decarboxylase Homo sapiens 36-39 33261109-3 2020 A computational and in vitro study using K. pneumonia revealed that CA binds to HDC nearby the pyridoxal-5"-phosphate (PLP) binding site and inhibited histamine synthesis in a bacterial model. Histamine 151-160 histidine decarboxylase Homo sapiens 80-83 32871134-1 2020 Histidine decarboxylase (HDC; EC 4.1.1.22), an enzyme that catalyzes histamine synthesis with high substrate specificity, is a member of the group II pyridoxal 5"-phosphate (PLP) -dependent decarboxylase family. Histamine 69-78 histidine decarboxylase Homo sapiens 25-28 32054995-2 2020 Multidrug resistance-2 gene knockout (Mdr2-/-) mice and PSC patients have increased histamine (HA) levels (synthesized by l-histidine decarboxylase, HDC) and HA receptor (HR) expression. Histamine 95-97 histidine decarboxylase Homo sapiens 149-152 33000155-11 2020 Histidine can be decarboxylated to histamine by histidine decarboxylase. Histamine 35-44 histidine decarboxylase Homo sapiens 48-71 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histamine 209-218 histidine decarboxylase Homo sapiens 167-170 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histamine 209-218 histidine decarboxylase Homo sapiens 142-165 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histamine 220-224 histidine decarboxylase Homo sapiens 142-165 31730800-1 2020 Bile acid (BA) imbalance may be directly associated with gastric cancer and indirectly influence stomach carcinogenesis via overexpression of histidine decarboxylase (HDC), which converts histidine (His) into histamine (HIST). Histamine 220-224 histidine decarboxylase Homo sapiens 167-170 31600036-1 2019 Histidine decarboxylase (HDC) catalyses the formation of histamine from L-histidine. Histamine 57-66 histidine decarboxylase Homo sapiens 0-23 31600036-1 2019 Histidine decarboxylase (HDC) catalyses the formation of histamine from L-histidine. Histamine 57-66 histidine decarboxylase Homo sapiens 25-28 31009260-14 2019 This warns for the presence of HPB carrying hdc gene in retail sardine and mackerel, which is associated with a relatively high level of histamine. Histamine 137-146 histidine decarboxylase Homo sapiens 44-47 31009260-10 2019 Fish muscles that contain hdc-positive bacteria exhibit higher levels of histamine (median 86; IQR 80-1112 mg/kg) than those with hdc-negative bacteria (48; 75-223 mg/kg). Histamine 73-82 histidine decarboxylase Homo sapiens 26-29 30346159-1 2018 Histidine decarboxylase is a pyridoxal 5"-phosphate enzyme catalyzing the conversion of histidine to histamine, a bioactive molecule exerting its role in many modulatory processes. Histamine 101-110 histidine decarboxylase Homo sapiens 0-23 30472035-7 2019 Finally, we found that IP injection of compound 48/80 reduced mRNA expression of histidine decarboxylase, a rate-limiting enzyme for histamine synthesis, in the esophagus and proventriculus at 1 h and the proventriculus and duodenum at 3 h after the injection. Histamine 133-142 histidine decarboxylase Homo sapiens 81-104 30654600-5 2019 The histamine producing enzyme, histidine decarboxylase (HDC), is commonly induced at inflammatory sites during the late and chronic phases of both allergic and non-allergic inflammation. Histamine 4-13 histidine decarboxylase Homo sapiens 32-55 30654600-5 2019 The histamine producing enzyme, histidine decarboxylase (HDC), is commonly induced at inflammatory sites during the late and chronic phases of both allergic and non-allergic inflammation. Histamine 4-13 histidine decarboxylase Homo sapiens 57-60 29973935-2 2018 Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Histamine 0-9 histidine decarboxylase Homo sapiens 110-133 29884090-0 2018 Repurposing a Histamine Detection Platform for High-Throughput Screening of Histidine Decarboxylase. Histamine 14-23 histidine decarboxylase Homo sapiens 76-99 29884090-1 2018 Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine. Histamine 98-107 histidine decarboxylase Homo sapiens 0-23 29884090-1 2018 Histidine decarboxylase (HDC) is the primary enzyme that catalyzes the conversion of histidine to histamine. Histamine 98-107 histidine decarboxylase Homo sapiens 25-28 29884090-2 2018 HDC contributes to many physiological responses as histamine plays important roles in allergic reaction, neurological response, gastric acid secretion, and cell proliferation and differentiation. Histamine 51-60 histidine decarboxylase Homo sapiens 0-3 29884090-3 2018 Small-molecule modulation of HDC represents a potential therapeutic strategy for a range of histamine-associated diseases, including inflammatory disease, neurological disorders, gastric ulcers, and select cancers. Histamine 92-101 histidine decarboxylase Homo sapiens 29-32 29884090-6 2018 The assay is based on competition between HDC-generated histamine and fluorophore-labeled histamine for binding to a Europium cryptate (EuK)-labeled anti-histamine antibody. Histamine 56-65 histidine decarboxylase Homo sapiens 42-45 29973935-2 2018 Histamine is a monoamine synthesized from the amino acid histidine through a reaction catalyzed by the enzyme histidine decarboxylase (HDC), which removes carboxyl group from histidine. Histamine 0-9 histidine decarboxylase Homo sapiens 135-138 28584117-2 2017 A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS). Histamine 44-53 histidine decarboxylase Homo sapiens 85-88 29523718-1 2018 Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. Histamine 0-9 histidine decarboxylase Homo sapiens 74-97 29523718-1 2018 Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. Histamine 0-9 histidine decarboxylase Homo sapiens 99-102 29523718-1 2018 Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. Histamine 11-13 histidine decarboxylase Homo sapiens 74-97 29523718-1 2018 Histamine (HA) is a pleiotropic biogenic amine synthesized exclusively by histidine decarboxylase (HDC) in most mammalian tissues. Histamine 11-13 histidine decarboxylase Homo sapiens 99-102 28917668-2 2017 Histidine decarboxylase (HDC) deficiency has been shown to promote inflammation-associated colorectal cancer by accumulation of CD11b+Gr-1+ immature myeloid cells, indicating a potential antitumorigenic effect of histamine. Histamine 213-222 histidine decarboxylase Homo sapiens 0-23 28917668-2 2017 Histidine decarboxylase (HDC) deficiency has been shown to promote inflammation-associated colorectal cancer by accumulation of CD11b+Gr-1+ immature myeloid cells, indicating a potential antitumorigenic effect of histamine. Histamine 213-222 histidine decarboxylase Homo sapiens 25-28 28690192-8 2017 However, histidine decarboxylase, a key enzyme in histamine production, did not change significantly after famotidine addition. Histamine 50-59 histidine decarboxylase Homo sapiens 9-32 28600950-1 2017 BACKGROUND AND AIMS: The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b+Gr-1+ myeloid cells that play a critical role in infection, inflammation and tumorigenesis. Histamine 79-88 histidine decarboxylase Homo sapiens 32-55 28600950-1 2017 BACKGROUND AND AIMS: The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b+Gr-1+ myeloid cells that play a critical role in infection, inflammation and tumorigenesis. Histamine 79-88 histidine decarboxylase Homo sapiens 57-60 28584117-2 2017 A rare mutation in the enzyme that produces histamine (HA), histidine decarboxylase (HDC), has been identified in patients with Tourette syndrome (TS). Histamine 44-53 histidine decarboxylase Homo sapiens 60-83 29198940-3 2017 Committed Hdc+ myeloid cells lie in close anatomical proximity to MB-HSCs and produce histamine, which activates the H2 receptor on MB-HSCs to promote their quiescence and self-renewal. Histamine 86-95 histidine decarboxylase Homo sapiens 10-13 28228363-1 2017 Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine. Histamine 70-79 histidine decarboxylase Homo sapiens 0-23 28228363-1 2017 Histidine decarboxylase (HDC) is an enzyme that converts histidine to histamine. Histamine 70-79 histidine decarboxylase Homo sapiens 25-28 27752845-5 2017 Generally, the good quality of raw material and hygienic practices during food processing as well as the use of histidine decarboxylase-negative starter cultures can minimize the occurrence of histamine. Histamine 193-202 histidine decarboxylase Homo sapiens 112-135 25524476-7 2015 Through the colocalized enzymatic activity of Histidine decarboxylase in the histaminergic neurons, the resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and physiological function. Histamine 77-86 histidine decarboxylase Homo sapiens 46-69 26164497-1 2015 Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histamine 60-69 histidine decarboxylase Homo sapiens 0-23 26164497-1 2015 Histidine decarboxylase (HDC) catalyzes the biosynthesis of histamine from L-histidine and is expressed throughout the mammalian nervous system by histaminergic neurons. Histamine 60-69 histidine decarboxylase Homo sapiens 25-28 25846768-1 2015 Histidine decarboxylase (HDC) is a key determinant of the levels of endogenous histamine that has long been recognized to play important pathophysiological roles during development of chronic heart failure (CHF). Histamine 79-88 histidine decarboxylase Homo sapiens 0-23 25846768-1 2015 Histidine decarboxylase (HDC) is a key determinant of the levels of endogenous histamine that has long been recognized to play important pathophysiological roles during development of chronic heart failure (CHF). Histamine 79-88 histidine decarboxylase Homo sapiens 25-28 25846768-2 2015 Meanwhile, certain genetic variants in HDC gene were reported to affect the function of HDC and associated with histamine-related diseases. Histamine 112-121 histidine decarboxylase Homo sapiens 39-42 25846768-2 2015 Meanwhile, certain genetic variants in HDC gene were reported to affect the function of HDC and associated with histamine-related diseases. Histamine 112-121 histidine decarboxylase Homo sapiens 88-91 25805997-9 2015 Based on that, histidine decarboxylase expression was studied by quantitative PCR in AGS cells and its levels were increased by famotidine as well as by histamine and amthamine. Histamine 153-162 histidine decarboxylase Homo sapiens 15-38 27769832-1 2016 Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. Histamine 154-163 histidine decarboxylase Homo sapiens 6-29 27769832-1 2016 Human histidine decarboxylase (HDC) and dopa decarboxilase (DDC) are highly homologous enzymes responsible for the synthesis of biogenic amines (BA) like histamine, and serotonin and dopamine, respectively. Histamine 154-163 histidine decarboxylase Homo sapiens 31-34 26715806-1 2015 AIM: To study histidine decarboxylase (HDC) expression in normal and neoplastic gastric neuroendocrine cells in relationship to the main histamine metabolite. Histamine 137-146 histidine decarboxylase Homo sapiens 14-37 26715806-1 2015 AIM: To study histidine decarboxylase (HDC) expression in normal and neoplastic gastric neuroendocrine cells in relationship to the main histamine metabolite. Histamine 137-146 histidine decarboxylase Homo sapiens 39-42 26715806-12 2015 Co-expression of VMAT-2 and HDC might be required for increased histamine production in patients with GNETs. Histamine 64-73 histidine decarboxylase Homo sapiens 28-31 25961682-4 2015 Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production. Histamine 0-9 histidine decarboxylase Homo sapiens 163-186 25961682-4 2015 Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production. Histamine 0-9 histidine decarboxylase Homo sapiens 188-191 25961682-4 2015 Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production. Histamine 217-226 histidine decarboxylase Homo sapiens 163-186 25961682-4 2015 Histamine concentration in breast cancer tissues was found to be higher than that in normal tissues of healthy controls by means of an increase in the activity of histidine decarboxylase (HDC), the enzyme involved in histamine production. Histamine 217-226 histidine decarboxylase Homo sapiens 188-191 24415870-0 2014 Bile acid increases expression of the histamine-producing enzyme, histidine decarboxylase, in gastric cells. Histamine 38-47 histidine decarboxylase Homo sapiens 66-89 24508257-1 2014 In the mammalian species studied so far, the L-histidine decarboxylase (HDC) enzyme responsible for histamine biosynthesis has been shown to undergo post-translational processing. Histamine 100-109 histidine decarboxylase Homo sapiens 45-70 24508257-1 2014 In the mammalian species studied so far, the L-histidine decarboxylase (HDC) enzyme responsible for histamine biosynthesis has been shown to undergo post-translational processing. Histamine 100-109 histidine decarboxylase Homo sapiens 72-75 24129980-0 2014 Aminooxy analog of histamine is an efficient inhibitor of mammalian L-histidine decarboxylase: combined in silico and experimental evidence. Histamine 19-28 histidine decarboxylase Homo sapiens 70-93 24129980-2 2014 In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5"-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). Histamine 12-21 histidine decarboxylase Homo sapiens 128-151 24129980-2 2014 In mammals, histamine is formed by decarboxylation of L-histidine, which is catalyzed by pyridoxal-5"-phosphate (PLP) dependent histidine decarboxylase (HDC, EC 4.1.1.22). Histamine 12-21 histidine decarboxylase Homo sapiens 153-156 24415870-8 2014 Here, we show that bile acid increased the expression of HDC, which is a rate-limiting enzyme of the histamine production pathway. Histamine 101-110 histidine decarboxylase Homo sapiens 57-60 24415870-1 2014 AIM: To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon cooperative activation. Histamine 132-141 histidine decarboxylase Homo sapiens 65-88 24415870-1 2014 AIM: To investigate the effect of bile acid on the expression of histidine decarboxylase (HDC), which is a major enzyme involved in histamine production, and gene expression of gastric transcription factors upon cooperative activation. Histamine 132-141 histidine decarboxylase Homo sapiens 90-93 23825391-3 2013 The recent implication of the histamine decarboxylase (HDC) gene, the key enzyme in histamine production, raises the intriguing hypothesis of a possible role of histaminergic dysfunction leading to TS onset. Histamine 30-39 histidine decarboxylase Homo sapiens 55-58 25158972-11 2014 A tissue carnosine-degrading enzyme (CN2) colocalized with the activity of histidine decarboxylase to histamine neurons in the hypothalamic tuberomammillary nucleus (TMN) plays a key role in the neuro-transmission and neuroregulation roles of imidazole-containing based dipeptides. Histamine 102-111 histidine decarboxylase Homo sapiens 75-98 23572231-9 2013 Basal expression of histidine decarboxylase, the rate-limiting enzyme in histamine production, is higher in neutrophils from patients with allergies than from healthy donors. Histamine 73-82 histidine decarboxylase Homo sapiens 20-43 23239191-4 2013 In this study, we evaluated the histamine positive microvessels with the specific marker for biosynthesis of histamine L-histidine decarboxylase (HDC) in the CRC tumor microenvironment. Histamine 32-41 histidine decarboxylase Homo sapiens 119-144 23026128-2 2013 METHODS: We determined, therefore, in postmortem tissue of 12 mood disorder patients (8 major depression disorder (MDD) and 4 bipolar disorder (BD)) and 12 well matched controls the expression of the rate-limiting enzyme for histamine production and histidine decarboxylase in the tuberomamillary nucleus (TMN) by quantitative in situ hybridization. Histamine 225-234 histidine decarboxylase Homo sapiens 250-273 23411280-1 2013 Histidine decarboxylase (HDC) catalyses the formation of histamine, a bioactive amine. Histamine 57-66 histidine decarboxylase Homo sapiens 0-23 23239191-4 2013 In this study, we evaluated the histamine positive microvessels with the specific marker for biosynthesis of histamine L-histidine decarboxylase (HDC) in the CRC tumor microenvironment. Histamine 32-41 histidine decarboxylase Homo sapiens 146-149 22940786-0 2012 Enhanced histamine production through the induction of histidine decarboxylase expression by phorbol ester in Jurkat cells. Histamine 9-18 histidine decarboxylase Homo sapiens 55-78 22940786-1 2012 Histamine (HA), a mediator of inflammation, type I allergic responses and neurotransmission, is synthesized from L-histidine, the reaction of which is catalyzed by histidine decarboxylase (HDC). Histamine 0-9 histidine decarboxylase Homo sapiens 188-211 22940786-1 2012 Histamine (HA), a mediator of inflammation, type I allergic responses and neurotransmission, is synthesized from L-histidine, the reaction of which is catalyzed by histidine decarboxylase (HDC). Histamine 0-9 histidine decarboxylase Homo sapiens 213-216 22940786-1 2012 Histamine (HA), a mediator of inflammation, type I allergic responses and neurotransmission, is synthesized from L-histidine, the reaction of which is catalyzed by histidine decarboxylase (HDC). Histamine 11-13 histidine decarboxylase Homo sapiens 188-211 22940786-1 2012 Histamine (HA), a mediator of inflammation, type I allergic responses and neurotransmission, is synthesized from L-histidine, the reaction of which is catalyzed by histidine decarboxylase (HDC). Histamine 11-13 histidine decarboxylase Homo sapiens 213-216 22767596-2 2012 L-histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction. Histamine 70-79 histidine decarboxylase Homo sapiens 0-25 22284987-2 2012 We studied its involvement in Alzheimer"s disease (AD) by in situ hybridization of histidine decarboxylase (HDC), the key enzyme of histamine production, in 9 AD patients and 9 controls. Histamine 132-141 histidine decarboxylase Homo sapiens 83-106 22284987-2 2012 We studied its involvement in Alzheimer"s disease (AD) by in situ hybridization of histidine decarboxylase (HDC), the key enzyme of histamine production, in 9 AD patients and 9 controls. Histamine 132-141 histidine decarboxylase Homo sapiens 108-111 24639917-11 2012 Histamine is produced from numerous cells such as basophils and mast cells and is synthesized from the enzyme histidine decarboxylase (HDC). Histamine 0-9 histidine decarboxylase Homo sapiens 110-133 24639917-11 2012 Histamine is produced from numerous cells such as basophils and mast cells and is synthesized from the enzyme histidine decarboxylase (HDC). Histamine 0-9 histidine decarboxylase Homo sapiens 135-138 24639917-12 2012 In this review we will prominently discuss the function of mast cells and HDC in histamine expression in various gastrointestinal carcinomas. Histamine 81-90 histidine decarboxylase Homo sapiens 74-77 22767596-2 2012 L-histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction. Histamine 70-79 histidine decarboxylase Homo sapiens 27-30 22767596-2 2012 L-histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction. Histamine 103-112 histidine decarboxylase Homo sapiens 0-25 22767596-2 2012 L-histidine decarboxylase (HDC) is the primary enzyme responsible for histamine synthesis and produces histamine from histidine in a one-step reaction. Histamine 103-112 histidine decarboxylase Homo sapiens 27-30 21371786-2 2012 We measured the messenger ribonucleic acid (mRNA) levels of histidine decarboxylase (HDC), the key enzyme of histamine production, and the amount of LBs/LNs in the TMN by quantitative in situ hybridization and immunocytochemistry in postmortem human brain material of clinical PD (CPD), preclinical PD, and control subjects. Histamine 109-118 histidine decarboxylase Homo sapiens 85-88 21930594-4 2011 We found that Ahr-Sp1 complex, independent of Stat1, represses histidine decarboxylase expression by inhibiting LPS-induced Sp1 phosphorylation on Ser residues in macrophages; this leads to suppression of histamine production. Histamine 205-214 histidine decarboxylase Homo sapiens 63-86 21873469-14 2012 CONCLUSION: The novel concept that an autocrine loop (consisting of enhanced histamine synthesis by HDC) sustains cholangiocarcinoma growth is proposed. Histamine 77-86 histidine decarboxylase Homo sapiens 100-103 23123711-11 2012 The increase in histamine release may be attributable to the activation of HDC in epidermal keratinocytes. Histamine 16-25 histidine decarboxylase Homo sapiens 75-78 21873469-0 2012 Inhibition of histidine decarboxylase ablates the autocrine tumorigenic effects of histamine in human cholangiocarcinoma. Histamine 83-92 histidine decarboxylase Homo sapiens 14-37 21873469-1 2012 BACKGROUND: In several tumours the endogenous activity of histidine decarboxylase (HDC), the enzyme stimulating histamine synthesis, sustains the autocrine trophic effect of histamine on cancer progression. Histamine 112-121 histidine decarboxylase Homo sapiens 58-81 21873469-1 2012 BACKGROUND: In several tumours the endogenous activity of histidine decarboxylase (HDC), the enzyme stimulating histamine synthesis, sustains the autocrine trophic effect of histamine on cancer progression. Histamine 112-121 histidine decarboxylase Homo sapiens 83-86 21873469-1 2012 BACKGROUND: In several tumours the endogenous activity of histidine decarboxylase (HDC), the enzyme stimulating histamine synthesis, sustains the autocrine trophic effect of histamine on cancer progression. Histamine 174-183 histidine decarboxylase Homo sapiens 58-81 21873469-1 2012 BACKGROUND: In several tumours the endogenous activity of histidine decarboxylase (HDC), the enzyme stimulating histamine synthesis, sustains the autocrine trophic effect of histamine on cancer progression. Histamine 174-183 histidine decarboxylase Homo sapiens 83-86 21873469-4 2012 OBJECTIVE: To determine the effects of histamine stimulation and inhibition of histamine synthesis (by modulation of HDC) on cholangiocarcinoma growth. Histamine 79-88 histidine decarboxylase Homo sapiens 117-120 21873469-10 2012 Inhibition of HDC and antagonising H1HR decreased histamine secretion in Mz-ChA-1 cells. Histamine 50-59 histidine decarboxylase Homo sapiens 14-17 21873469-11 2012 Long-term treatment with histamine increased proliferation and VEGF expression in cholangiocarcinoma that was blocked by HDC inhibitor and the H1HR antagonist. Histamine 25-34 histidine decarboxylase Homo sapiens 121-124 22547898-0 2012 Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases. Histamine 88-97 histidine decarboxylase Homo sapiens 23-46 22547898-3 2012 DESIGN: Quantitative in situ hybridization was used to study the mRNA expression of histidine decarboxylase (HDC), the key enzyme of histamine production in the tuberomammillary nucleus (TMN) in postmortem human hypothalamic tissue, obtained from 33 controls and 31 patients with a neurodegenerative disease-PD (n = 15), AD (n = 9), and HD (n = 8)-and covering the full 24-h cycle with respect to clock time of death. Histamine 133-142 histidine decarboxylase Homo sapiens 84-107 22547898-3 2012 DESIGN: Quantitative in situ hybridization was used to study the mRNA expression of histidine decarboxylase (HDC), the key enzyme of histamine production in the tuberomammillary nucleus (TMN) in postmortem human hypothalamic tissue, obtained from 33 controls and 31 patients with a neurodegenerative disease-PD (n = 15), AD (n = 9), and HD (n = 8)-and covering the full 24-h cycle with respect to clock time of death. Histamine 133-142 histidine decarboxylase Homo sapiens 109-112 22547898-6 2012 CONCLUSION: The diurnal fluctuation of HDC-mRNA expression in human TMN supports a role for neuronal histamine in regulating day-night rhythms. Histamine 101-110 histidine decarboxylase Homo sapiens 39-42 22547898-9 2012 Diurnal fluctuation in histidine decarboxylase expression, the rate limiting enzyme for histamine production, and its disorder in neurodegenerative diseases. Histamine 88-97 histidine decarboxylase Homo sapiens 23-46 19450133-2 2009 Initial reports on polymorphisms of histamine-related genes including those coding for the enzymes histidine decarboxylase (HDC), diamine oxidase (ABP1) and histamine N-methyltransferase (HNMT), as well as histamine receptor genes, often have pointed to polymorphisms that occur with extremely low frequencies or that could not be verified by later studies. Histamine 36-45 histidine decarboxylase Homo sapiens 99-122 20652470-9 2010 In fact, EGCG has been shown to have potent anti-inflammatory, anti-tumoral, and anti-angiogenic effects and to be a potent inhibitor of the histamine-producing enzyme, histidine decarboxylase. Histamine 141-150 histidine decarboxylase Homo sapiens 169-192 20445167-3 2010 Here, we describe an analysis of linkage in a two-generation pedigree leading to the identification of a rare functional mutation in the HDC gene encoding L-histidine decarboxylase, the rate-limiting enzyme in histamine biosynthesis. Histamine 210-219 histidine decarboxylase Homo sapiens 137-140 19413567-1 2009 For a long time the structural and molecular features of mammalian histidine decarboxylase (EC 4.1.1.22), the enzyme that produces histamine, have evaded characterization. Histamine 131-140 histidine decarboxylase Homo sapiens 67-90 19413567-2 2009 We overcome the experimental problems for the study of this enzyme by using a computer-based modelling and simulation approach, and have now the conditions to use histidine decarboxylase as a target in histamine pharmacology. Histamine 202-211 histidine decarboxylase Homo sapiens 163-186 19375125-8 2009 The concentration of histamine in cancerous tissues of the breast and the metabolism of histamine enzymes, specially histidine decarboxylase, decarboxylase of aromatic L-amino acids, N-histamine methyltransferase, monoamine oxydase B, and diamine oxydase, were determined using isotope technique. Histamine 21-30 histidine decarboxylase Homo sapiens 117-140 19450133-2 2009 Initial reports on polymorphisms of histamine-related genes including those coding for the enzymes histidine decarboxylase (HDC), diamine oxidase (ABP1) and histamine N-methyltransferase (HNMT), as well as histamine receptor genes, often have pointed to polymorphisms that occur with extremely low frequencies or that could not be verified by later studies. Histamine 36-45 histidine decarboxylase Homo sapiens 124-127 19266161-1 2009 Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histamine 57-66 histidine decarboxylase Homo sapiens 0-23 19266161-1 2009 Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histamine 57-66 histidine decarboxylase Homo sapiens 25-28 18790006-7 2008 We found that CN2-immunoreactivity was colocalized with that of histidine decarboxylase, which is the key enzyme for histamine biosynthesis specifically expressed in the histaminergic neurons of the tuberomammillary nucleus. Histamine 117-126 histidine decarboxylase Homo sapiens 64-87 19032907-7 2008 In addition, we found that HCBMCs generate the transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, after SP treatment. Histamine 140-149 histidine decarboxylase Homo sapiens 64-87 19032907-7 2008 In addition, we found that HCBMCs generate the transcription of histidine decarboxylase (HDC), the enzyme responsible for the generation of histamine from histidine, after SP treatment. Histamine 140-149 histidine decarboxylase Homo sapiens 89-92 18756395-3 2008 In most histamine-containing foods the majority of the histamine is generated by decarboxylation of the histidine through histidine decarboxylase enzymes derived from the bacteria present in food. Histamine 8-17 histidine decarboxylase Homo sapiens 122-145 19009648-8 2008 However, we have shown that famotidine completely inhibited ghrelin-induced acid secretion and histidine decarboxylase (HDC) mRNA was increased in gastric mucosa by ghrelin injection which is inhibited by vagotomy Our results indicate that histamine is involved in the action of ghrelin on acid secretion. Histamine 240-249 histidine decarboxylase Homo sapiens 95-118 19009648-8 2008 However, we have shown that famotidine completely inhibited ghrelin-induced acid secretion and histidine decarboxylase (HDC) mRNA was increased in gastric mucosa by ghrelin injection which is inhibited by vagotomy Our results indicate that histamine is involved in the action of ghrelin on acid secretion. Histamine 240-249 histidine decarboxylase Homo sapiens 120-123 18756395-3 2008 In most histamine-containing foods the majority of the histamine is generated by decarboxylation of the histidine through histidine decarboxylase enzymes derived from the bacteria present in food. Histamine 55-64 histidine decarboxylase Homo sapiens 122-145 18234316-6 2008 The amounts of histamine/serotonin stored were reflected by the expression levels of histidine decarboxylase and tryptophan hydroxylase 1, respectively. Histamine 15-24 histidine decarboxylase Homo sapiens 85-108 18450547-3 2008 METHODS: Histidine decarboxylase is the only enzyme capable for histamine synthesis having significance in cell proliferation. Histamine 64-73 histidine decarboxylase Homo sapiens 9-32 18450547-6 2008 CONCLUSIONS: Authors conclude that the histidine decarboxylase loss would serve as an evidence for the dedifferentiation of epidermoinvasive cells as being the result of fundamental changes in histamine metabolism. Histamine 193-202 histidine decarboxylase Homo sapiens 39-62 17965265-1 2008 Histamine, a biogenic amine with important biological functions, is produced from histidine by histidine decarboxylase (HDC), a pyridoxal 5"-phosphate-dependent enzyme. Histamine 0-9 histidine decarboxylase Homo sapiens 95-118 17965265-2 2008 HDC is thus a potential target to attenuate histamine production in certain pathological states. Histamine 44-53 histidine decarboxylase Homo sapiens 0-3 17965265-1 2008 Histamine, a biogenic amine with important biological functions, is produced from histidine by histidine decarboxylase (HDC), a pyridoxal 5"-phosphate-dependent enzyme. Histamine 0-9 histidine decarboxylase Homo sapiens 120-123 16960050-2 2006 The enzyme histidine decarboxylase catalyzes the decarboxylation of histidine to histamine, the biogenic amine most frequently involved in food poisoning. Histamine 81-90 histidine decarboxylase Homo sapiens 11-34 17227057-1 2007 Histidine decarboxylase (HDC) catalyzes histamine formation from histidine. Histamine 40-49 histidine decarboxylase Homo sapiens 0-23 17227057-1 2007 Histidine decarboxylase (HDC) catalyzes histamine formation from histidine. Histamine 40-49 histidine decarboxylase Homo sapiens 25-28 17227057-10 2007 Therefore, those food components exhibiting HDC inhibitory activity might be potentially useful in controlling histamine-induced biological actions. Histamine 111-120 histidine decarboxylase Homo sapiens 44-47 16959953-4 2006 Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK(2) receptors on the ECL cells. Histamine 0-9 histidine decarboxylase Homo sapiens 43-66 16959953-4 2006 Histamine in the stomach is synthesized by histidine decarboxylase (HDC), stored in enterochromaffin-like (ECL) cells, and released in response to gastrin, acting on CCK(2) receptors on the ECL cells. Histamine 0-9 histidine decarboxylase Homo sapiens 68-71 16923847-3 2006 Histamine serum levels are regulated mainly by the activity of the histamine-synthesizing enzyme histidine decarboxylase (HDC). Histamine 0-9 histidine decarboxylase Homo sapiens 97-120 16923847-3 2006 Histamine serum levels are regulated mainly by the activity of the histamine-synthesizing enzyme histidine decarboxylase (HDC). Histamine 0-9 histidine decarboxylase Homo sapiens 122-125 17713357-6 2007 We also found increased histidine decarboxylase (HDC) expression in activated HUCMC after 6 h of incubation, a rate-limiting enzyme responsible for the generation of histamine from histidine. Histamine 166-175 histidine decarboxylase Homo sapiens 24-47 17713357-6 2007 We also found increased histidine decarboxylase (HDC) expression in activated HUCMC after 6 h of incubation, a rate-limiting enzyme responsible for the generation of histamine from histidine. Histamine 166-175 histidine decarboxylase Homo sapiens 49-52 16790022-0 2006 Histamine, histidine, and growth-phase mediated regulation of the histidine decarboxylase gene in lactic acid bacteria isolated from wine. Histamine 0-9 histidine decarboxylase Homo sapiens 66-89 16517981-1 2006 Histidine decarboxylase (HDC) and vesicular monoamine transporter 2 (v-MAT2) are involved in the biosynthesis and storage of histamine. Histamine 125-134 histidine decarboxylase Homo sapiens 0-23 16517981-1 2006 Histidine decarboxylase (HDC) and vesicular monoamine transporter 2 (v-MAT2) are involved in the biosynthesis and storage of histamine. Histamine 125-134 histidine decarboxylase Homo sapiens 25-28 16790022-1 2006 Fermented foods are frequently contaminated by histamine that is generated by microorganisms with histidine decarboxylase activity. Histamine 47-56 histidine decarboxylase Homo sapiens 98-121 16564918-2 2006 We therefore asked whether the key enzyme involved in histamine production, histidine decarboxylase (HDC), can be used as an immunohistochemical marker for the detection of immature neoplastic mast cells (MC) in patients with MC-proliferative disorders. Histamine 54-63 histidine decarboxylase Homo sapiens 76-99 16357063-1 2006 Histidine decarboxylase (HDC) is the enzyme that converts histidine to histamine, a bioamine that plays an important role in many physiological aspects including allergic responses, inflammation, neurotransmission, and gastric acid secretion. Histamine 71-80 histidine decarboxylase Homo sapiens 0-23 16357063-1 2006 Histidine decarboxylase (HDC) is the enzyme that converts histidine to histamine, a bioamine that plays an important role in many physiological aspects including allergic responses, inflammation, neurotransmission, and gastric acid secretion. Histamine 71-80 histidine decarboxylase Homo sapiens 25-28 16564918-2 2006 We therefore asked whether the key enzyme involved in histamine production, histidine decarboxylase (HDC), can be used as an immunohistochemical marker for the detection of immature neoplastic mast cells (MC) in patients with MC-proliferative disorders. Histamine 54-63 histidine decarboxylase Homo sapiens 101-104 17191019-6 2006 Moreover, using RT-PCR quercetin inhibited the transcription of histidine decarboxylase, the rate-limiting enzyme responsible for the generation of histamine from histidine, and MCP-1. Histamine 148-157 histidine decarboxylase Homo sapiens 64-87 16434984-1 2006 Histamine (HDC) inhibits formation and release of phagocyte-derived reactive oxygen species, and thereby protects natural killer (NK) and T cells against oxidative damage. Histamine 0-9 histidine decarboxylase Homo sapiens 11-14 16328055-2 2006 Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histamine 57-66 histidine decarboxylase Homo sapiens 0-23 16328055-2 2006 Histidine decarboxylase (HDC) catalyzes the formation of histamine from histidine. Histamine 57-66 histidine decarboxylase Homo sapiens 25-28 15799559-1 2004 Fermented foods are frequently contaminated by histamine generated by microorganisms possessing histidine decarboxylase activity. Histamine 47-56 histidine decarboxylase Homo sapiens 96-119 16203768-1 2005 PURPOSE: Activity of histidine decarboxylase, the key enzyme in the synthesis of histamine, has been shown to be increased in several types of human tumors. Histamine 81-90 histidine decarboxylase Homo sapiens 21-44 15935495-3 2005 A set of consensual primers based on histidine decarboxylase gene (hdc) sequences of different bacteria was designed for the detection of histamine-producing Gram-positive bacteria. Histamine 138-147 histidine decarboxylase Homo sapiens 37-60 15935495-3 2005 A set of consensual primers based on histidine decarboxylase gene (hdc) sequences of different bacteria was designed for the detection of histamine-producing Gram-positive bacteria. Histamine 138-147 histidine decarboxylase Homo sapiens 67-70 16297195-5 2005 In this study, we investigated the expression of CRH-R1, the main CRH-R subtype in human skin, and the mast cell related gene histidine decarboxylase (HDC), which regulates the production of histamine, in normal and pathological skin biopsies. Histamine 191-200 histidine decarboxylase Homo sapiens 126-149 16297195-5 2005 In this study, we investigated the expression of CRH-R1, the main CRH-R subtype in human skin, and the mast cell related gene histidine decarboxylase (HDC), which regulates the production of histamine, in normal and pathological skin biopsies. Histamine 191-200 histidine decarboxylase Homo sapiens 151-154 15927833-1 2005 The aim of this study was to evaluate the concentration of histamine (HA) and the activities of their enzymes, namely histidine decarboxylase (HDC) and diaminooxydase (DAO) in 95 women with ductal breast cancer and in healthy women. Histamine 59-68 histidine decarboxylase Homo sapiens 118-141 15927833-1 2005 The aim of this study was to evaluate the concentration of histamine (HA) and the activities of their enzymes, namely histidine decarboxylase (HDC) and diaminooxydase (DAO) in 95 women with ductal breast cancer and in healthy women. Histamine 59-68 histidine decarboxylase Homo sapiens 143-146 15612036-2 2005 Histamine biosynthesis depends on a single decarboxylation step, carried out by a PLP-dependent histidine decarboxylase activity (EC 4.1.1.22), an enzyme that still remains to be fully characterized. Histamine 0-9 histidine decarboxylase Homo sapiens 96-119 15167966-1 2004 OBJECTIVE: The objective of this study was to investigate histamine synthesis capability of human vascular smooth muscle and endothelial cells by detecting histidine decarboxylase (HDC) mRNA. Histamine 58-67 histidine decarboxylase Homo sapiens 156-179 15189499-1 2004 Previously we demonstrated that histidine decarboxylase (HDC), which produces histamine from l-histidine, was detected in monocytes/macrophages located in human atherosclerotic lesions. Histamine 78-87 histidine decarboxylase Homo sapiens 32-55 15189499-1 2004 Previously we demonstrated that histidine decarboxylase (HDC), which produces histamine from l-histidine, was detected in monocytes/macrophages located in human atherosclerotic lesions. Histamine 78-87 histidine decarboxylase Homo sapiens 57-60 15450254-3 2004 Indeed, cytokines not only modulate the degranulation process of histamine but also control its neosynthesis by the histamine-forming enzyme, histidine decarboxylase (HDC), at transcriptional and post-transcriptional levels. Histamine 65-74 histidine decarboxylase Homo sapiens 142-165 15450254-3 2004 Indeed, cytokines not only modulate the degranulation process of histamine but also control its neosynthesis by the histamine-forming enzyme, histidine decarboxylase (HDC), at transcriptional and post-transcriptional levels. Histamine 65-74 histidine decarboxylase Homo sapiens 167-170 15167966-1 2004 OBJECTIVE: The objective of this study was to investigate histamine synthesis capability of human vascular smooth muscle and endothelial cells by detecting histidine decarboxylase (HDC) mRNA. Histamine 58-67 histidine decarboxylase Homo sapiens 181-184 15167966-2 2004 METHODS: HDC catalyzes exclusively the formation of histamine in mammalian cells. Histamine 52-61 histidine decarboxylase Homo sapiens 9-12 15144399-1 2004 Histidine decarboxylase (HDC) is an enzyme for decarboxylating l-histidine to histamine and is expressed in various types of cells including neuroendocrine tumors. Histamine 78-87 histidine decarboxylase Homo sapiens 0-23 15144399-1 2004 Histidine decarboxylase (HDC) is an enzyme for decarboxylating l-histidine to histamine and is expressed in various types of cells including neuroendocrine tumors. Histamine 78-87 histidine decarboxylase Homo sapiens 25-28 14961766-1 2004 HDC (L-histidine decarboxylase), the enzyme responsible for the catalytic production of histamine from L-histidine, belongs to an evolutionarily conserved family of vitamin B6-dependent enzymes known as the group II decarboxylases. Histamine 88-97 histidine decarboxylase Homo sapiens 0-3 14961766-1 2004 HDC (L-histidine decarboxylase), the enzyme responsible for the catalytic production of histamine from L-histidine, belongs to an evolutionarily conserved family of vitamin B6-dependent enzymes known as the group II decarboxylases. Histamine 88-97 histidine decarboxylase Homo sapiens 5-30 14961766-8 2004 This is the most extensive mutagenesis study yet to identify catalytically important residues in a mammalian HDC protein sequence and it provides a number of novel insights into the mechanism of histamine biosynthesis. Histamine 195-204 histidine decarboxylase Homo sapiens 109-112 12972479-7 2003 The addition of alpha-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase (the enzyme responsible for histamine production), reduced the rate of proliferation of HAC. Histamine 121-130 histidine decarboxylase Homo sapiens 69-92 12972479-9 2003 CONCLUSION: Changes induced by histamine in the proliferative rate of HAC may contribute to the formation of chondrocyte clusters associated with OA cartilage; an observation supported by the demonstration of histamine and HDC expression by chondrocytes of OA cartilage in situ. Histamine 31-40 histidine decarboxylase Homo sapiens 223-226