PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 18360087-4 2008 Histamine induced increase in histamine H(1) receptor gene expression in vitro, and the protein kinase C-delta isoform was suggested to mediate the gene expression. Histamine 0-9 histamine receptor H 1 Rattus norvegicus 30-53 16648669-0 2006 Recent advances in molecular pharmacology of the histamine systems: regulation of histamine H1 receptor signaling by changing its expression level. Histamine 49-58 histamine receptor H 1 Rattus norvegicus 82-103 16337938-3 2006 Histamine-induced vasodilation was attenuated by L-NAME (nitric oxide (NO) synthase inhibitor, 100 microM) and olopatadine (histamine H(1) receptor antagonist, 1 microM) but not by lafutidine (histamine H(2) receptor antagonist, 1 microM). Histamine 0-9 histamine receptor H 1 Rattus norvegicus 124-147 15513549-9 2004 CONCLUSION: As shown in TDI-sensitized rats, our findings suggest that the upregulation of H1R in the nasal mucosa is one of the mechanisms responsible for nasal hypersensitivity behavior and nasal hypersensitivity to histamine and that the therapeutic effects of dexamethasone are, in part, due to its inhibitory action on the upregulation of H1R. Histamine 218-227 histamine receptor H 1 Rattus norvegicus 91-94 9550146-0 1998 In situ detection of H1-receptor mRNA and absence of apoptosis in the transient histamine system of the embryonic rat brain. Histamine 80-89 histamine receptor H 1 Rattus norvegicus 21-32 15167971-7 2004 RESULTS: Histamine H(1)-receptor agonists (histamine, selected histaprodifens) increased the secretion of NGF from cultured astrocytes in a concentration-dependent manner. Histamine 43-52 histamine receptor H 1 Rattus norvegicus 9-32 12650837-5 2003 Administration of histamine (5-20 microg/rat) reduced, but the histamine H(1) receptor antagonist, pyrilamine (10-50 microg/rat), and the histamine H(2) receptor antagonist, cimetidine (1-50 microg/rat), increased memory retention in rats. Histamine 18-27 histamine receptor H 1 Rattus norvegicus 63-86 14575794-5 2003 Administration of histamine (40-80 microg/rat) and naloxone (0.5-1 microg/rat) increased, while morphine (2.5 microg/rat), pyrilamine (25-50 microg/rat), the histamine H1 receptor antagonist, and ranitidine (10-20 microg/rat), the histamine H2 receptor antagonist, decreased water intake in isolated rats. Histamine 18-27 histamine receptor H 1 Rattus norvegicus 158-179 12354569-4 2002 Administration of histamine (20 micro g/rat) reduced, but the histamine H(1) receptor antagonist, pyrilamine (20 and 50 micro g/rat), and the histamine H(2) receptor antagonist, cimetidine (10 and 50 micro g/rat), increased memory retention in rats. Histamine 18-27 histamine receptor H 1 Rattus norvegicus 62-85 9550146-9 1998 H1R mRNA could be detected in rat brain and in spinal cord on embryonic day (E) 14, and the expression pattern seemed to partially localize in areas containing histamine-immunoreactive nerve fibers through E14-E20. Histamine 160-169 histamine receptor H 1 Rattus norvegicus 0-3 9550146-13 1998 The presence of H1R mRNA during the embryonic development renders it possible that histamine could exert an H1R-specific function at the time of the embryonic histamine peak. Histamine 83-92 histamine receptor H 1 Rattus norvegicus 16-19 9550146-13 1998 The presence of H1R mRNA during the embryonic development renders it possible that histamine could exert an H1R-specific function at the time of the embryonic histamine peak. Histamine 83-92 histamine receptor H 1 Rattus norvegicus 108-111 9550146-13 1998 The presence of H1R mRNA during the embryonic development renders it possible that histamine could exert an H1R-specific function at the time of the embryonic histamine peak. Histamine 159-168 histamine receptor H 1 Rattus norvegicus 16-19 9550146-13 1998 The presence of H1R mRNA during the embryonic development renders it possible that histamine could exert an H1R-specific function at the time of the embryonic histamine peak. Histamine 159-168 histamine receptor H 1 Rattus norvegicus 108-111 9085361-4 1996 Relaxant responses to histamine were not influenced by cimetidine, histamine H2-receptor antagonist, but were significantly decreased or abolished by treatment with chlorphenyramine or diphenhydramine, histamine H1-receptor antagonists. Histamine 22-31 histamine receptor H 1 Rattus norvegicus 202-223 8098142-7 1993 The enhancement of the depolarizing afterpotential by histamine was mimicked by the histamine H1-receptor agonist 2-thiazolylethylamine and was reduced or blocked by the H1-receptor antagonist promethazine, but was not blocked or reduced in the presence of the histamine H2-receptor antagonist, cimetidine. Histamine 54-63 histamine receptor H 1 Rattus norvegicus 84-105 7515820-2 1994 Intracerebroventricular administration of histamine decreased 5-hydroxytryptamine (5-HT) and increased 5-hydroxyindoleacetic acid (5-HIAA) concentrations in several hypothalamic nuclei; these effects were blocked by the histamine H1 receptor antagonist mepyramine but not the histamine H2 receptor antagonist zolantidine. Histamine 42-51 histamine receptor H 1 Rattus norvegicus 220-241 2531971-5 1989 Histamine, 2-pyridylethylamine (PEA), a histamine H1-receptor agonist, and 4-methylhistamine (MeHA) and dimaprit, H2-receptor agonists, significantly intensified the stress-induced increase in serum corticosterone levels. Histamine 0-9 histamine receptor H 1 Rattus norvegicus 40-61 35050802-4 2022 Rupatadine is a potent histamine receptor 1 (H1R) and platelet-activating factor (PAF) blocker. Histamine 23-32 histamine receptor H 1 Rattus norvegicus 45-48 2839961-3 1988 Histamine, 2-pyridylethylamine (PEA), a histamine H1-receptor agonist, and 4-methyl-histamine (MeHA) and dimaprit, the H2-receptor agonists, considerably increased the serum corticosterone levels 1 h after administration. Histamine 0-9 histamine receptor H 1 Rattus norvegicus 40-61 2564258-5 1989 These results suggest that feeding induced by histamine H1-receptor antagonists is due to blockade of neuronal histamine at the site of histamine H1-receptors, at least in part, in the ventromedial hypothalamus and that diurnal fluctuation of feeding behavior may reflect circadian variation of neuronal histamine level. Histamine 111-120 histamine receptor H 1 Rattus norvegicus 46-67 2829906-4 1987 The specificity of the sites for various histamine antagonists indicated that the high-affinity [3H]pyrilamine binding site is representative of the histamine H1 receptor. Histamine 41-50 histamine receptor H 1 Rattus norvegicus 149-170 26980430-1 2016 Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. Histamine 4-13 histamine receptor H 1 Rattus norvegicus 55-76 6113741-3 1981 Histamine H1-receptor antagonists, mepyramine and chloropyramine, when injected 2 h prior to histamine, abolished considerably hyperlipaemic responses to histamine. Histamine 93-102 histamine receptor H 1 Rattus norvegicus 0-21 6104420-0 1980 Regulation of histamine synthesis: altered synthesis and level of histamine in the hypothalamus of rats by repeated administration of histamine H1 and H2 receptor antagonists. Histamine 14-23 histamine receptor H 1 Rattus norvegicus 134-162 6104420-0 1980 Regulation of histamine synthesis: altered synthesis and level of histamine in the hypothalamus of rats by repeated administration of histamine H1 and H2 receptor antagonists. Histamine 66-75 histamine receptor H 1 Rattus norvegicus 134-162 29311766-3 2017 Histamine is a neurogenic factor for cortical neural stem cells in vitro through H1 receptor (H1R) which is highly expressed during corticogenesis in rats and mice. Histamine 0-9 histamine receptor H 1 Rattus norvegicus 94-97 25682263-5 2016 In the present study, we show that histamine evokes a concentration- and calcium-dependent release of MMP-9 from human astrocytic U373 cells and primary cultures of human and rat astrocytes through the H1R subtype. Histamine 35-44 histamine receptor H 1 Rattus norvegicus 202-205 3330786-5 1987 The histamine-induced expression of the c-fos gene was blocked by the histamine H1-receptor antagonist pyrilamine but not by H2-receptor antagonists ranitidine and cimetidine. Histamine 4-13 histamine receptor H 1 Rattus norvegicus 70-91 6207886-8 1984 The spasmogenic activity displayed by most of the SP antagonists tested is likely to be related to their ability to release histamine since the contractile response was reduced by mepyramine, a histamine H1-receptor antagonist. Histamine 124-133 histamine receptor H 1 Rattus norvegicus 194-215 6759742-3 1982 Since the histamine-induced contraction was inhibited by tripelennamine, the contraction seems to be mediated by histamine H1-receptor. Histamine 10-19 histamine receptor H 1 Rattus norvegicus 113-134 7238574-6 1981 Furthermore, all the H1-histamine antagonists tested display micromolar potency at the low-affinity doxepin sites but nanomolar potency at the high-affinity doxepin sites associated with a physiological histamine H1-receptor. Histamine 24-33 histamine receptor H 1 Rattus norvegicus 203-224 30282868-5 2018 WGE suppressed histamine/PMA-induced H1R gene up-regulation in HeLa cells. Histamine 15-24 histamine receptor H 1 Rattus norvegicus 37-40 26980430-1 2016 Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. Histamine 4-13 histamine receptor H 1 Rattus norvegicus 78-81 26980430-1 2016 Antihistamines inhibit histamine signaling by blocking histamine H1 receptor (H1R) or suppressing H1R signaling as inverse agonists. Histamine 4-13 histamine receptor H 1 Rattus norvegicus 98-101 19596986-0 2009 Suplatast tosilate inhibits histamine signaling by direct and indirect down-regulation of histamine H1 receptor gene expression through suppression of histidine decarboxylase and IL-4 gene transcriptions. Histamine 28-37 histamine receptor H 1 Rattus norvegicus 90-111 26619301-5 2016 MBCA suppressed PMA- and histamine-induced upregulation of H1R expression at both mRNA and protein levels and inhibited PMA-induced phosphorylation of PKCdelta at Tyr(311) and subsequent translocation to the Golgi. Histamine 25-34 histamine receptor H 1 Rattus norvegicus 59-62 25443720-0 2014 Rupatadine effectively prevents the histamine-induced up regulation of histamine H1R and bradykinin B2R receptor gene expression in the rat paw. Histamine 36-45 histamine receptor H 1 Rattus norvegicus 81-84 25443720-3 2014 Here we use an experimental model of rat paw oedema formation to examine the effect of exogenously added histamine on the gene expression of H1R and bradykinin receptors B1R and B2R, alone or in combination to rupatadine, a second generation antihistamine agent. Histamine 105-114 histamine receptor H 1 Rattus norvegicus 141-144 25443720-8 2014 RESULTS: Histamine injection into the paw resulted in significant up regulation of H1R and B2R without inducing significant cellular infiltration, but appears to affect less the expression of B1R. Histamine 9-18 histamine receptor H 1 Rattus norvegicus 83-94 24805361-8 2014 These data suggest that estrogen can amplify histamine signaling by enhancing H1R expression in the vl VMN. Histamine 45-54 histamine receptor H 1 Rattus norvegicus 78-81 23982898-7 2013 Using these procedures to assess the receptors mediating histamine"s effects, the histamine H1 -receptor antagonists, pyrilamine and ketotifen, antagonized the punishing effect of histamine, but the histamine H2 -receptor antagonist ranitidine did not. Histamine 57-66 histamine receptor H 1 Rattus norvegicus 82-104 23333628-3 2013 Recently, we demonstrated that histamine or phorbol-12-myristate-13-acetate (PMA) stimulation induced the up-regulation of H1R gene expression through the protein kinase Cdelta (PKCdelta)/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 signaling pathway in HeLa cells expressing H1R endogenously. Histamine 31-40 histamine receptor H 1 Rattus norvegicus 299-302 22314222-1 2012 A previous report showed that histamine in denuded mesenteric vascular beds produced a triphasic response; an initial small histamine H(2) receptor-mediated vasodilation, a transient histamine H(1) receptor-mediated vasoconstriction, and finally a long-lasting vasodilation. Histamine 30-39 histamine receptor H 1 Rattus norvegicus 183-206 26874672-2 2016 Antihistamines are widely used as allergy treatments because they inhibit histamine signaling by blocking H1R or suppressing H1R signaling as inverse agonists. Histamine 4-13 histamine receptor H 1 Rattus norvegicus 106-109 26874672-2 2016 Antihistamines are widely used as allergy treatments because they inhibit histamine signaling by blocking H1R or suppressing H1R signaling as inverse agonists. Histamine 4-13 histamine receptor H 1 Rattus norvegicus 125-128 19393269-6 2009 These results suggest that chewing-induced histamine release in the hippocampus and the subsequent H1 receptor activation may be essential to rescue stress-suppressed synaptic plasticity. Histamine 43-52 histamine receptor H 1 Rattus norvegicus 99-110 19352071-7 2009 These data suggest that oral administration of Kujin showed anti-allergic activity through suppression of histamine signaling by the inhibition of TDI-induced H1R and HDC mRNA elevations followed by decrease in H1R, HDC protein level, and histamine content in the nasal mucosa of TDI-sensitized rats. Histamine 106-115 histamine receptor H 1 Rattus norvegicus 159-162 19050374-13 2009 CONCLUSIONS: These results demonstrate that SST alleviates nasal symptoms by the inhibition of histamine signaling through suppression of TDI-induced H1R and HDC gene up-regulation. Histamine 95-104 histamine receptor H 1 Rattus norvegicus 150-161