PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25690161-4	2015	Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis.	Histamine	45-54	growth differentiation factor 15	Homo sapiens	6-12	
22975449-0	2012	Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis.	Histamine	89-98	growth differentiation factor 15	Homo sapiens	30-62	
22975449-3	2012	However, the role and signaling mechanism of histamine are still unclear in melanogenesis, especially in relation to growth-differentiation factor-15, which is a protein belonging to transforming growth factor beta and found to be overexpressed in metastatic or malignant melanoma.	Histamine	45-54	growth differentiation factor 15	Homo sapiens	117-149	
22975449-4	2012	We found that histamine induces growth-differentiation factor-15 in melanoma cell lines such as SK-MEL-2, B16F10, and melan-a cells.	Histamine	14-23	growth differentiation factor 15	Homo sapiens	32-64	
22975449-5	2012	Therefore, in the present study, the role of growth-differentiation factor-15 in histamine-induced melanogenesis was investigated using gene silencing or overexpression of growth-differentiation factor-15 and histamine related compounds such as histamine, amthamine, and cimetidine.	Histamine	81-90	growth differentiation factor 15	Homo sapiens	45-77	
22975449-6	2012	Gene silencing of growth-differentiation factor-15 suppressed histamine-induced proliferation, melanin production, tyrosinase activity, and chemotactic migration of SK-MEL-2 cells.	Histamine	62-71	growth differentiation factor 15	Homo sapiens	18-50	
22975449-7	2012	Histamine-induced expression of tyrosinase, tyrosinase-related protein 1, and tyrosinase-related protein 2 was also suppressed by growth-differentiation factor-15 gene silencing.	Histamine	0-9	growth differentiation factor 15	Homo sapiens	130-162	
22975449-11	2012	Our results suggest that growth-differentiation factor-15 is a new player in histamine-induced melanogenesis, which can help researchers to extend the knowledge of the role of the transforming growth factor beta family in melanogenesis and in skin pigment disorders such as vitiligo.	Histamine	77-86	growth differentiation factor 15	Homo sapiens	25-57