PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22975449-11 2012 Our results suggest that growth-differentiation factor-15 is a new player in histamine-induced melanogenesis, which can help researchers to extend the knowledge of the role of the transforming growth factor beta family in melanogenesis and in skin pigment disorders such as vitiligo. Histamine 77-86 growth differentiation factor 15 Homo sapiens 25-57 25690161-4 2015 Also, GDF-15 is involved in skin biology and histamine-induced melanogenesis; it is overexpressed in melanoma cells and is associated with depth of tumor invasion and metastasis. Histamine 45-54 growth differentiation factor 15 Homo sapiens 6-12 22975449-0 2012 Histamine receptor 2-mediated growth-differentiation factor-15 expression is involved in histamine-induced melanogenesis. Histamine 89-98 growth differentiation factor 15 Homo sapiens 30-62 22975449-3 2012 However, the role and signaling mechanism of histamine are still unclear in melanogenesis, especially in relation to growth-differentiation factor-15, which is a protein belonging to transforming growth factor beta and found to be overexpressed in metastatic or malignant melanoma. Histamine 45-54 growth differentiation factor 15 Homo sapiens 117-149 22975449-4 2012 We found that histamine induces growth-differentiation factor-15 in melanoma cell lines such as SK-MEL-2, B16F10, and melan-a cells. Histamine 14-23 growth differentiation factor 15 Homo sapiens 32-64 22975449-5 2012 Therefore, in the present study, the role of growth-differentiation factor-15 in histamine-induced melanogenesis was investigated using gene silencing or overexpression of growth-differentiation factor-15 and histamine related compounds such as histamine, amthamine, and cimetidine. Histamine 81-90 growth differentiation factor 15 Homo sapiens 45-77 22975449-6 2012 Gene silencing of growth-differentiation factor-15 suppressed histamine-induced proliferation, melanin production, tyrosinase activity, and chemotactic migration of SK-MEL-2 cells. Histamine 62-71 growth differentiation factor 15 Homo sapiens 18-50 22975449-7 2012 Histamine-induced expression of tyrosinase, tyrosinase-related protein 1, and tyrosinase-related protein 2 was also suppressed by growth-differentiation factor-15 gene silencing. Histamine 0-9 growth differentiation factor 15 Homo sapiens 130-162