PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35163585-4 2022 METHODS: Here, we elucidated the role of histamine N-methyltransferase (HNMT), a histamine metabolism enzyme significantly upregulated in NSCLC and coexpressed with HER2. Histamine 81-90 histamine N-methyltransferase Homo sapiens 41-70 35163585-4 2022 METHODS: Here, we elucidated the role of histamine N-methyltransferase (HNMT), a histamine metabolism enzyme significantly upregulated in NSCLC and coexpressed with HER2. Histamine 81-90 histamine N-methyltransferase Homo sapiens 72-76 2898903-3 1988 The authors performed in vitro kinetic studies to determine the effect of vecuronium on histamine N-methyltransferase (HNMT), the primary catabolic enzyme for histamine in humans. Histamine 88-97 histamine N-methyltransferase Homo sapiens 119-123 2898903-7 1988 Vecuronium, in doses greater than or equal to 0.1 mg/kg, may delay the metabolism of histamine by HNMT in vitro. Histamine 85-94 histamine N-methyltransferase Homo sapiens 98-102 3112138-5 1987 Initially, the cells" endogenous histamine N-methyltransferase activity mediates conversion of cell-associated [3H]histamine to tele-methylhistamine with retention of this intermediate metabolite. Histamine 111-124 histamine N-methyltransferase Homo sapiens 33-62 3345617-1 1988 Histamine N-methyltransferase (HNMT) catalyzes the N tau-methylation of histamine. Histamine 72-81 histamine N-methyltransferase Homo sapiens 0-29 3345617-1 1988 Histamine N-methyltransferase (HNMT) catalyzes the N tau-methylation of histamine. Histamine 72-81 histamine N-methyltransferase Homo sapiens 31-35 3370823-0 1988 Optimization of histamine radio enzyme assay with purified histamine-N-methyltransferase. Histamine 16-25 histamine N-methyltransferase Homo sapiens 59-88 3370823-1 1988 The radio enzyme assay for histamine based on the transmethylation with purified histamine-N-methyltransferase and utilizing [3H-methyl]-S-adenosylmethionine as the methyl donor has been optimized to measure low histamine concentrations, for example in plasma. Histamine 27-36 histamine N-methyltransferase Homo sapiens 81-110 3836703-2 1985 This assay is based on the incubation of tissue histamine with a partially purified preparation of histamine-N-methyltransferase (S-adenosyl-L-methionine: histamine N-methyltransferase, E.C. Histamine 48-57 histamine N-methyltransferase Homo sapiens 99-128 4083176-1 1985 On the basis of previous findings that histamine-N-methyltransferase (HMT) activity can be significantly enhanced or inhibited by a number of analogues of histamine and drugs containing dialkylaminoalkyl moieties, we investigated whether the neuromuscular blocking drugs alcuronium, d-tubocurarine, decamethonium, succinylcholine, gallamine and pancuronium each of which contain quaternary ammonium groups, influence the activity of HMT. Histamine 39-48 histamine N-methyltransferase Homo sapiens 70-73 3111193-0 1987 Histamine levels and activity of histidine decarboxylase (HD) and histamine-methyltransferase (HMT) in neonate and adult human brain. Histamine 0-9 histamine N-methyltransferase Homo sapiens 66-93 3111193-0 1987 Histamine levels and activity of histidine decarboxylase (HD) and histamine-methyltransferase (HMT) in neonate and adult human brain. Histamine 0-9 histamine N-methyltransferase Homo sapiens 95-98 4019656-2 1985 Urine appears to inhibit the methylation of histamine by histamine N-methyltransferase such that the radioenzymatic assay underestimates the concentration of histamine present in urine. Histamine 44-53 histamine N-methyltransferase Homo sapiens 57-86 7337069-1 1981 Enzymatic methylation of histamine and analogues by histamine methyltransferase (HMT) was studied. Histamine 25-34 histamine N-methyltransferase Homo sapiens 52-79 6476381-0 1984 The differential reaction of histamine and N tau-methylhistamine with Pauly"s diazo reagent: application to assay of histamine N-methyltransferase activity. Histamine 29-38 histamine N-methyltransferase Homo sapiens 117-146 6476381-2 1984 After termination of the HMT reaction, the remaining excess substrate, histamine, was degraded by Pauly "s diazo reagent, whereas the product, N tau-methylhistamine (N- MeHA ), was not degraded by the reagent. Histamine 71-80 histamine N-methyltransferase Homo sapiens 25-28 6415051-2 1983 Histamine N-methyltransferase is a major enzyme for inactivating histamine in mammalian tissues. Histamine 65-74 histamine N-methyltransferase Homo sapiens 0-29 6343748-0 1983 A new radioenzymatic assay for histamine using purified histamine N-methyltransferase. Histamine 31-40 histamine N-methyltransferase Homo sapiens 56-85 7126242-0 1982 Sidechain-modified histamine analogues as substrates for histamine N-methyltransferase. Histamine 19-28 histamine N-methyltransferase Homo sapiens 57-86 6748851-1 1984 The specificity of the histamine N-methyltransferase (HNMT) based radioenzymatic assay for histamine has been questioned since N-alpha-methylhistamine is also a substrate for this enzyme. Histamine 23-32 histamine N-methyltransferase Homo sapiens 54-58 7033328-1 1982 The concentration of plasma histamine may provide an index of mast cell activation (degranulation) and can be measured by a sensitive radioenzymatic assay based on its specific conversion to (3H)-methylhistamine in the presence of histamine-N-methyltransferase and (3H)-S-adenosyl-L-methionine. Histamine 28-37 histamine N-methyltransferase Homo sapiens 231-260 7337069-1 1981 Enzymatic methylation of histamine and analogues by histamine methyltransferase (HMT) was studied. Histamine 25-34 histamine N-methyltransferase Homo sapiens 81-84 7337069-2 1981 Incubation of histamine or alpha-methylhistamine with HMT and S-adenosylmethionine was shown by GC-MS to yield tele-methyl and alpha-methyl-tele-methyl-histamine, respectively. Histamine 14-23 histamine N-methyltransferase Homo sapiens 54-57 7337069-2 1981 Incubation of histamine or alpha-methylhistamine with HMT and S-adenosylmethionine was shown by GC-MS to yield tele-methyl and alpha-methyl-tele-methyl-histamine, respectively. Histamine 39-48 histamine N-methyltransferase Homo sapiens 54-57 7337069-4 1981 These results indicate that alpha-methylhistamine can be methylated as effectively as histamine, and may be a useful tool in further studies of HMT. Histamine 40-49 histamine N-methyltransferase Homo sapiens 144-147 871095-6 1977 According to these results the low gastric HMT-activity of duodenal ulcer patients could play a role in the pathogenesis of a chronic peptic ulcer by being responsible for reduced histamine inactivation and - as a consequence - enhanced acid secretion. Histamine 180-189 histamine N-methyltransferase Homo sapiens 43-46 456139-1 1979 In a control group (n = 12) the histamine content of the liver was 1.42 microgram/g tissue and the activity of the histamine-degradating enzyme, HMT, 421.5 pmol/(min . Histamine 115-124 histamine N-methyltransferase Homo sapiens 145-148 697892-0 1978 Elevation of brain histamine levels by diaminopyrimidine inhibitors of histamine N-methyl transferase. Histamine 19-28 histamine N-methyltransferase Homo sapiens 71-101 907871-2 1977 Degradation of histamine by homogenized human skin in vitro, in the presence of the cofactor S-adenosyl methionine, indicates the presence of the histamine metabolizing enzyme histamine-N-methyl transferase in human skin. Histamine 15-24 histamine N-methyltransferase Homo sapiens 176-206 907871-9 1977 The presence of a potent histamine degrading mechanism raises the possibility that histamine-N-methyl transferase activity may be an important modulating factor in histamine-mediated skin disorders. Histamine 25-34 histamine N-methyltransferase Homo sapiens 83-113 33310825-2 2020 The histamine N-methyltransferase (HNMT) enzyme is the only pathway for termination of histamine neurotransmission in the central nervous system. Histamine 4-13 histamine N-methyltransferase Homo sapiens 35-39 29506638-6 2018 What"s more, we found for the first time that one of the major histamine degradation enzymes, histamine-N-methyltransferase (HNMT), was increased in AD patients and AD model mice. Histamine 63-72 histamine N-methyltransferase Homo sapiens 94-123 30744146-3 2019 Histamine N-methyltransferase (HNMT) is a histamine-metabolising enzyme expressed in the brain. Histamine 42-51 histamine N-methyltransferase Homo sapiens 0-29 30744146-3 2019 Histamine N-methyltransferase (HNMT) is a histamine-metabolising enzyme expressed in the brain. Histamine 42-51 histamine N-methyltransferase Homo sapiens 31-35 30744146-6 2019 Hnmt disruption resulted in a robust increase in brain histamine concentration, demonstrating the essential role of HNMT in the brain histamine system. Histamine 55-64 histamine N-methyltransferase Homo sapiens 0-4 30744146-6 2019 Hnmt disruption resulted in a robust increase in brain histamine concentration, demonstrating the essential role of HNMT in the brain histamine system. Histamine 55-64 histamine N-methyltransferase Homo sapiens 116-120 30744146-6 2019 Hnmt disruption resulted in a robust increase in brain histamine concentration, demonstrating the essential role of HNMT in the brain histamine system. Histamine 134-143 histamine N-methyltransferase Homo sapiens 0-4 30744146-6 2019 Hnmt disruption resulted in a robust increase in brain histamine concentration, demonstrating the essential role of HNMT in the brain histamine system. Histamine 134-143 histamine N-methyltransferase Homo sapiens 116-120 30744146-9 2019 These findings emphasise that an increase in brain histamine levels by novel HNMT inhibitors could contribute to the improvement of brain disorders. Histamine 51-60 histamine N-methyltransferase Homo sapiens 77-81 29506638-6 2018 What"s more, we found for the first time that one of the major histamine degradation enzymes, histamine-N-methyltransferase (HNMT), was increased in AD patients and AD model mice. Histamine 63-72 histamine N-methyltransferase Homo sapiens 125-129 29506638-8 2018 Taken together, it suggested that miR-223 participates in AD through upregulating HNMT indirectly to degrade the excessive histamine. Histamine 123-132 histamine N-methyltransferase Homo sapiens 82-86 27769936-1 2017 The degradation of histamine catalyzed by the SAM-dependent histamine N-methyltransferase (HNMT) is critically important for the maintenance of neurological processes. Histamine 19-28 histamine N-methyltransferase Homo sapiens 60-89 27769936-1 2017 The degradation of histamine catalyzed by the SAM-dependent histamine N-methyltransferase (HNMT) is critically important for the maintenance of neurological processes. Histamine 19-28 histamine N-methyltransferase Homo sapiens 91-95 25768024-2 2015 Since elevated histamine levels in the brain have been associated with PD and SCZ, we wanted to explore whether the Thr105Ile substitution in the histamine N-methyltransferase gene (HNMT-Thr105Ile), which impairs histamine degradation, is associated with either disease. Histamine 15-24 histamine N-methyltransferase Homo sapiens 146-175 27679412-2 2017 Histamine N-methyltransferase, which is an enzyme in the central nervous system that metabolizes histamine, is localized to the cytosol. Histamine 97-106 histamine N-methyltransferase Homo sapiens 0-29 25909280-5 2015 Genotyping was performed to detect known SNPs (n = 10) among genes (HDC, HNMT, ABP1, HRH1, and HRH4) within the histamine pathway. Histamine 112-121 histamine N-methyltransferase Homo sapiens 73-77 26966348-4 2016 In mammals, histamine N-methyltransferase (HMT) is the sole enzyme responsible for degrading histamine in the brain. Histamine 12-21 histamine N-methyltransferase Homo sapiens 43-46 26966348-5 2016 Metoprine, one of the most potent HMT inhibitors, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT. Histamine 103-112 histamine N-methyltransferase Homo sapiens 34-37 26989676-2 2016 However, the relevance of polymorphisms in histamine-related genes, such as HRH2, HRH3, DAO, and HNMT, with CHF remains largely neglected. Histamine 43-52 histamine N-methyltransferase Homo sapiens 97-101 25768024-2 2015 Since elevated histamine levels in the brain have been associated with PD and SCZ, we wanted to explore whether the Thr105Ile substitution in the histamine N-methyltransferase gene (HNMT-Thr105Ile), which impairs histamine degradation, is associated with either disease. Histamine 15-24 histamine N-methyltransferase Homo sapiens 182-186 25768024-2 2015 Since elevated histamine levels in the brain have been associated with PD and SCZ, we wanted to explore whether the Thr105Ile substitution in the histamine N-methyltransferase gene (HNMT-Thr105Ile), which impairs histamine degradation, is associated with either disease. Histamine 146-155 histamine N-methyltransferase Homo sapiens 182-186 24404388-6 2014 Genetic polymorphisms in histamine-related genes, including FcepsilonRI and HNMT, were suggested to be involved in mast cell activation and histamine metabolism. Histamine 25-34 histamine N-methyltransferase Homo sapiens 76-80 23578781-0 2014 Influence of iodinated contrast media on the activities of histamine inactivating enzymes diamine oxidase and histamine N-methyltransferase in vitro. Histamine 59-68 histamine N-methyltransferase Homo sapiens 110-139 24404388-6 2014 Genetic polymorphisms in histamine-related genes, including FcepsilonRI and HNMT, were suggested to be involved in mast cell activation and histamine metabolism. Histamine 140-149 histamine N-methyltransferase Homo sapiens 76-80 22118942-4 2012 In addition, significantly increased mRNA levels of histamine methyltransferase (HMT), a key enzyme involved in histamine metabolism, were found in the SN and in the PU in PD. Histamine 52-61 histamine N-methyltransferase Homo sapiens 81-84 23932992-1 2013 INTRODUCTION: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine. Histamine 86-95 histamine N-methyltransferase Homo sapiens 14-43 23932992-1 2013 INTRODUCTION: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine. Histamine 86-95 histamine N-methyltransferase Homo sapiens 45-49 23505051-4 2013 We detected histamine N-methyltransferase (HNMT), a histamine-metabolizing enzyme, in primary human astrocytes and the astrocytes of human brain specimens. Histamine 12-21 histamine N-methyltransferase Homo sapiens 43-47 23505051-5 2013 Immunocytochemical analysis and subcellular fractionation assays revealed that active HNMT localized to the cytosol, suggesting that histamine transport into the cytosol is crucial for histamine inactivation. Histamine 133-142 histamine N-methyltransferase Homo sapiens 86-90 23505051-5 2013 Immunocytochemical analysis and subcellular fractionation assays revealed that active HNMT localized to the cytosol, suggesting that histamine transport into the cytosol is crucial for histamine inactivation. Histamine 185-194 histamine N-methyltransferase Homo sapiens 86-90 23505051-14 2013 These findings might indicate that PMAT, OCT3 and HNMT in human astrocytes play a role in the regulation of extraneuronal histamine concentration and the activities of histaminergic neurons. Histamine 122-131 histamine N-methyltransferase Homo sapiens 50-54 22118942-4 2012 In addition, significantly increased mRNA levels of histamine methyltransferase (HMT), a key enzyme involved in histamine metabolism, were found in the SN and in the PU in PD. Histamine 112-121 histamine N-methyltransferase Homo sapiens 81-84 22211168-1 2012 PURPOSE: Histamine N-methyltransferase (HNMT) catalyzes one of two major histamine metabolic pathways. Histamine 73-82 histamine N-methyltransferase Homo sapiens 9-38 21794955-1 2012 Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Histamine 0-9 histamine N-methyltransferase Homo sapiens 52-81 21794955-1 2012 Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Histamine 0-9 histamine N-methyltransferase Homo sapiens 83-87 22211168-1 2012 PURPOSE: Histamine N-methyltransferase (HNMT) catalyzes one of two major histamine metabolic pathways. Histamine 73-82 histamine N-methyltransferase Homo sapiens 40-44 21138759-2 2011 Histamine is a central neurotransmitter with several functions in brain including regulation of memory, cognition, locomotion, and is degraded in part by histamine N-methyltransferase (HNMT). Histamine 0-9 histamine N-methyltransferase Homo sapiens 154-183 21138759-2 2011 Histamine is a central neurotransmitter with several functions in brain including regulation of memory, cognition, locomotion, and is degraded in part by histamine N-methyltransferase (HNMT). Histamine 0-9 histamine N-methyltransferase Homo sapiens 185-189 20551163-6 2010 RESULTS: The adverse effect of food additives on ADHD symptoms was moderated by histamine degradation gene polymorphisms HNMT T939C and HNMT Thr105Ile in 3- and 8/9-year-old children and by a DAT1 polymorphism (short versus long) in 8/9-year-old children only. Histamine 80-89 histamine N-methyltransferase Homo sapiens 121-125 20608921-1 2010 BACKGROUND: Nonsynonymous polymorphisms in genes coding for histamine-metabolizing enzymes, diamine oxidase and histamine N-methyltransferase are related to the risk of developing allergic diseases. Histamine 60-69 histamine N-methyltransferase Homo sapiens 112-141 20551163-6 2010 RESULTS: The adverse effect of food additives on ADHD symptoms was moderated by histamine degradation gene polymorphisms HNMT T939C and HNMT Thr105Ile in 3- and 8/9-year-old children and by a DAT1 polymorphism (short versus long) in 8/9-year-old children only. Histamine 80-89 histamine N-methyltransferase Homo sapiens 136-140 19538200-1 2010 BACKGROUND: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. Histamine 84-93 histamine N-methyltransferase Homo sapiens 12-41 19538200-1 2010 BACKGROUND: Histamine N-methyltransferase (HNMT) is the main metabolizing enzyme of histamine (a mediator of inflammation implicated in the pathogenesis of multiple sclerosis-MS) in the CNS. Histamine 84-93 histamine N-methyltransferase Homo sapiens 43-47 16205835-2 2005 A major pathway of histamine biotransformation in the lungs is mediated by histamine N-methyltransferase (HNMT). Histamine 19-28 histamine N-methyltransferase Homo sapiens 75-104 19178400-2 2009 Histamine levels are regulated by histamine N-methyltransferase (HNMT). Histamine 0-9 histamine N-methyltransferase Homo sapiens 34-63 19178400-2 2009 Histamine levels are regulated by histamine N-methyltransferase (HNMT). Histamine 0-9 histamine N-methyltransferase Homo sapiens 65-69 19178400-11 2009 CONCLUSION: The HNMT 939A>G polymorphism lowers HNMT enzymatic activity by decreasing HNMT mRNA stability, which leads to an increase in the histamine level and contributes to the development of AICU. Histamine 141-150 histamine N-methyltransferase Homo sapiens 16-20 19178400-11 2009 CONCLUSION: The HNMT 939A>G polymorphism lowers HNMT enzymatic activity by decreasing HNMT mRNA stability, which leads to an increase in the histamine level and contributes to the development of AICU. Histamine 141-150 histamine N-methyltransferase Homo sapiens 48-52 19178400-11 2009 CONCLUSION: The HNMT 939A>G polymorphism lowers HNMT enzymatic activity by decreasing HNMT mRNA stability, which leads to an increase in the histamine level and contributes to the development of AICU. Histamine 141-150 histamine N-methyltransferase Homo sapiens 48-52 19025430-10 2008 CONCLUSION: Increased histamine levels in patients with atopic dermatitis may result, at least in part, from reduced enzymatic inactivation via HNMT. Histamine 22-31 histamine N-methyltransferase Homo sapiens 144-148 17562176-2 2008 In humans, histamine can be catabolized either by oxidative deamination by diamine oxidase (DAO) or by ring methylation by histamine N-methyltransferase (HNMT). Histamine 11-20 histamine N-methyltransferase Homo sapiens 123-152 17562176-2 2008 In humans, histamine can be catabolized either by oxidative deamination by diamine oxidase (DAO) or by ring methylation by histamine N-methyltransferase (HNMT). Histamine 11-20 histamine N-methyltransferase Homo sapiens 154-158 18154359-1 2008 Histamine N-methyltransferase (HNMT) is the primary enzyme responsible for inactivating histamine in the mammalian brain. Histamine 88-97 histamine N-methyltransferase Homo sapiens 0-29 18154359-1 2008 Histamine N-methyltransferase (HNMT) is the primary enzyme responsible for inactivating histamine in the mammalian brain. Histamine 88-97 histamine N-methyltransferase Homo sapiens 31-35 17490952-6 2007 Conversely, histamine N-methyltransferase, the other important enzyme inactivating histamine, is a cytosolic protein that can convert histamine only in the intracellular space of cells. Histamine 83-92 histamine N-methyltransferase Homo sapiens 12-41 16669609-0 2006 Endogenous histamine and cortisol levels in subjects with different histamine N-methyltransferase C314T genotypes : a pilot study. Histamine 11-20 histamine N-methyltransferase Homo sapiens 68-97 16669609-1 2006 BACKGROUND: Histamine N-methyltransferase (HNMT) catalyzes the methylation of histamine and plays an important role in histamine biotransformation in bronchial epithelium. Histamine 78-87 histamine N-methyltransferase Homo sapiens 12-41 16669609-1 2006 BACKGROUND: Histamine N-methyltransferase (HNMT) catalyzes the methylation of histamine and plays an important role in histamine biotransformation in bronchial epithelium. Histamine 78-87 histamine N-methyltransferase Homo sapiens 43-47 16669609-1 2006 BACKGROUND: Histamine N-methyltransferase (HNMT) catalyzes the methylation of histamine and plays an important role in histamine biotransformation in bronchial epithelium. Histamine 119-128 histamine N-methyltransferase Homo sapiens 12-41 16669609-1 2006 BACKGROUND: Histamine N-methyltransferase (HNMT) catalyzes the methylation of histamine and plays an important role in histamine biotransformation in bronchial epithelium. Histamine 119-128 histamine N-methyltransferase Homo sapiens 43-47 16669609-15 2006 CONCLUSION: Wide variability of plasma and whole-blood histamine levels was observed in subjects with different HNMT C314T genotypes. Histamine 55-64 histamine N-methyltransferase Homo sapiens 112-116 16307217-3 2005 Termination of the multiple actions of histamine is dependent on particular amine oxidases and histamine-N-methyltransferase. Histamine 39-48 histamine N-methyltransferase Homo sapiens 95-124 19773194-1 2010 A functional variant in the Histamine N-Methyltransferase gene (HNMT - rs11558538) resulting in a threonine to isoleucine substitution (Thr105Ile) has been shown to impair histamine degradation. Histamine 172-181 histamine N-methyltransferase Homo sapiens 28-57 19773194-1 2010 A functional variant in the Histamine N-Methyltransferase gene (HNMT - rs11558538) resulting in a threonine to isoleucine substitution (Thr105Ile) has been shown to impair histamine degradation. Histamine 172-181 histamine N-methyltransferase Homo sapiens 64-68 19450133-2 2009 Initial reports on polymorphisms of histamine-related genes including those coding for the enzymes histidine decarboxylase (HDC), diamine oxidase (ABP1) and histamine N-methyltransferase (HNMT), as well as histamine receptor genes, often have pointed to polymorphisms that occur with extremely low frequencies or that could not be verified by later studies. Histamine 36-45 histamine N-methyltransferase Homo sapiens 157-186 19450133-2 2009 Initial reports on polymorphisms of histamine-related genes including those coding for the enzymes histidine decarboxylase (HDC), diamine oxidase (ABP1) and histamine N-methyltransferase (HNMT), as well as histamine receptor genes, often have pointed to polymorphisms that occur with extremely low frequencies or that could not be verified by later studies. Histamine 36-45 histamine N-methyltransferase Homo sapiens 188-192 19201365-3 2009 In humans, histamine can be inactivated either by diamine oxidase (DAO) or by histamine N-methyltransferase (HMT), and numerous drugs are known to inhibit these enzymes. Histamine 11-20 histamine N-methyltransferase Homo sapiens 78-107 19201365-3 2009 In humans, histamine can be inactivated either by diamine oxidase (DAO) or by histamine N-methyltransferase (HMT), and numerous drugs are known to inhibit these enzymes. Histamine 11-20 histamine N-methyltransferase Homo sapiens 109-112 18266724-2 2008 In the CNS, histamine is almost exclusively metabolized by the polymorphic enzyme histamine N-methyltransferase (HNMT). Histamine 12-21 histamine N-methyltransferase Homo sapiens 82-111 18266724-2 2008 In the CNS, histamine is almost exclusively metabolized by the polymorphic enzyme histamine N-methyltransferase (HNMT). Histamine 12-21 histamine N-methyltransferase Homo sapiens 113-117 18086566-2 2008 Histamine is metabolized by both histamine N-methyltransferase (HNMT) and diamine oxidase, and its local action is terminated primarily by methylation which is catalyzed by HNMT. Histamine 0-9 histamine N-methyltransferase Homo sapiens 33-62 18086566-2 2008 Histamine is metabolized by both histamine N-methyltransferase (HNMT) and diamine oxidase, and its local action is terminated primarily by methylation which is catalyzed by HNMT. Histamine 0-9 histamine N-methyltransferase Homo sapiens 64-68 18086566-2 2008 Histamine is metabolized by both histamine N-methyltransferase (HNMT) and diamine oxidase, and its local action is terminated primarily by methylation which is catalyzed by HNMT. Histamine 0-9 histamine N-methyltransferase Homo sapiens 173-177 18543121-5 2008 CONCLUSION: These results, combined with previous findings indicating alterations in the frequency for the HNMT Thr105Ile polymorphism in patients with PD, suggest that alterations of histamine homeostasis in the SNC are associated with the risk of movement disorders. Histamine 184-193 histamine N-methyltransferase Homo sapiens 107-111 16950574-2 2007 Histamine N-methyltransferase (HNMT) is believed to be the sole pathway for termination of the neurotransmitter action of histamine in mammalian brain. Histamine 122-131 histamine N-methyltransferase Homo sapiens 0-29 16950574-2 2007 Histamine N-methyltransferase (HNMT) is believed to be the sole pathway for termination of the neurotransmitter action of histamine in mammalian brain. Histamine 122-131 histamine N-methyltransferase Homo sapiens 31-35 16168438-1 2005 In mammals, histamine action is terminated through metabolic inactivation by histamine N-methyltransferase (HNMT) and diamine oxidase. Histamine 12-21 histamine N-methyltransferase Homo sapiens 77-106 16168438-1 2005 In mammals, histamine action is terminated through metabolic inactivation by histamine N-methyltransferase (HNMT) and diamine oxidase. Histamine 12-21 histamine N-methyltransferase Homo sapiens 108-112 15770103-3 2005 Histamine N-methyltransferase (HNMT) catalyzes the Ntau methylation of histamine, the sole pathway for termination of the neurotransmitter action of histamine in mammalian brain. Histamine 71-80 histamine N-methyltransferase Homo sapiens 0-29 15770103-3 2005 Histamine N-methyltransferase (HNMT) catalyzes the Ntau methylation of histamine, the sole pathway for termination of the neurotransmitter action of histamine in mammalian brain. Histamine 71-80 histamine N-methyltransferase Homo sapiens 31-35 15770103-3 2005 Histamine N-methyltransferase (HNMT) catalyzes the Ntau methylation of histamine, the sole pathway for termination of the neurotransmitter action of histamine in mammalian brain. Histamine 149-158 histamine N-methyltransferase Homo sapiens 0-29 15770103-3 2005 Histamine N-methyltransferase (HNMT) catalyzes the Ntau methylation of histamine, the sole pathway for termination of the neurotransmitter action of histamine in mammalian brain. Histamine 149-158 histamine N-methyltransferase Homo sapiens 31-35 15693910-2 2005 Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. Histamine 67-76 histamine N-methyltransferase Homo sapiens 0-28 15693910-2 2005 Histamin N-Methyltransferase (HNMT) catalyses the major pathway of histamine metabolism in the human lung. Histamine 67-76 histamine N-methyltransferase Homo sapiens 30-34 16205835-2 2005 A major pathway of histamine biotransformation in the lungs is mediated by histamine N-methyltransferase (HNMT). Histamine 19-28 histamine N-methyltransferase Homo sapiens 106-110 11880199-1 2002 Histamine-N-methyltransferase (HMT) inactivates the neurotransmitter histamine. Histamine 69-78 histamine N-methyltransferase Homo sapiens 0-29 15551002-2 2004 Histamine N-methyltransferase (HNMT) is the major metabolizing enzyme for histamine inactivation in human stomach. Histamine 74-83 histamine N-methyltransferase Homo sapiens 0-29 15551002-2 2004 Histamine N-methyltransferase (HNMT) is the major metabolizing enzyme for histamine inactivation in human stomach. Histamine 74-83 histamine N-methyltransferase Homo sapiens 31-35 15054605-0 2004 Both catabolic pathways of histamine via histamine-N-methyltransferase and diamine oxidase are diminished in the colonic mucosa of patients with food allergy. Histamine 27-36 histamine N-methyltransferase Homo sapiens 41-70 14667820-1 2004 Histamine N-methyltransferase (HNMT), a cytosolic histamine-metabolizing enzyme, is the only known product of the 50-kb human HNMT. Histamine 50-59 histamine N-methyltransferase Homo sapiens 0-29 14667820-1 2004 Histamine N-methyltransferase (HNMT), a cytosolic histamine-metabolizing enzyme, is the only known product of the 50-kb human HNMT. Histamine 50-59 histamine N-methyltransferase Homo sapiens 31-35 14667820-1 2004 Histamine N-methyltransferase (HNMT), a cytosolic histamine-metabolizing enzyme, is the only known product of the 50-kb human HNMT. Histamine 50-59 histamine N-methyltransferase Homo sapiens 126-130 12755414-0 2003 Simultaneous purification of the histamine degrading enzymes diamine oxidase and histamine N-methyltransferase from the same tissue. Histamine 33-42 histamine N-methyltransferase Homo sapiens 81-110 12167489-1 2002 Histamine N-methyltransferase (HNMT) catalyzes one of two major metabolic pathways for histamine. Histamine 87-96 histamine N-methyltransferase Homo sapiens 0-29 12167489-1 2002 Histamine N-methyltransferase (HNMT) catalyzes one of two major metabolic pathways for histamine. Histamine 87-96 histamine N-methyltransferase Homo sapiens 31-35 12417108-1 2002 BACKGROUND: Histamine N-methyltransferase (HNMT) plays an important role in the metabolism of histamine, a biogenic amine that has many physiologic and pathological roles in human tissues. Histamine 94-103 histamine N-methyltransferase Homo sapiens 12-41 12417108-1 2002 BACKGROUND: Histamine N-methyltransferase (HNMT) plays an important role in the metabolism of histamine, a biogenic amine that has many physiologic and pathological roles in human tissues. Histamine 94-103 histamine N-methyltransferase Homo sapiens 43-47 11880199-1 2002 Histamine-N-methyltransferase (HMT) inactivates the neurotransmitter histamine. Histamine 69-78 histamine N-methyltransferase Homo sapiens 31-34 11880199-7 2002 Elevated HMT in PiD could lead to increased histamine degradation that in turn would be in agreement with impaired cognitive functions of PiD. Histamine 44-53 histamine N-methyltransferase Homo sapiens 9-12 10898922-2 2000 Histamine N-methyltransferase (HNMT) terminates the neurotransmitter actions of histamine in the mammalian CNS, and levels of HNMT activity in human tissues are controlled, in part, by inheritance. Histamine 80-89 histamine N-methyltransferase Homo sapiens 0-29 11566133-4 2001 RESULTS: Two ternary structures of human HNMT have been determined: the Thr105 variant complexed with its substrate histamine and reaction product AdoHcy and the Ile105 variant complexed with an inhibitor (quinacrine) and AdoHcy. Histamine 116-125 histamine N-methyltransferase Homo sapiens 41-45 11566133-8 2001 CONCLUSIONS: HNMT has a 2 domain structure including a consensus AdoMet binding domain, where the residue 105 is located on the surface, consistent with the kinetic data that the polymorphism does not affect overall protein stability at physiological temperatures but lowers K(M) values for AdoMet and histamine. Histamine 302-311 histamine N-methyltransferase Homo sapiens 13-17 11549275-1 2001 Histamine N-methyltransferase (HNMT) catalyzes the N-methylation of histamine in mammals. Histamine 68-77 histamine N-methyltransferase Homo sapiens 0-29 11549275-1 2001 Histamine N-methyltransferase (HNMT) catalyzes the N-methylation of histamine in mammals. Histamine 68-77 histamine N-methyltransferase Homo sapiens 31-35 10898922-2 2000 Histamine N-methyltransferase (HNMT) terminates the neurotransmitter actions of histamine in the mammalian CNS, and levels of HNMT activity in human tissues are controlled, in part, by inheritance. Histamine 80-89 histamine N-methyltransferase Homo sapiens 31-35 10803682-1 2000 Histamine is involved in the pathophysiology of asthma, and histamine N-methyltransferase (HNMT) plays the dominant role in histamine metabolism in human bronchial epithelium. Histamine 60-69 histamine N-methyltransferase Homo sapiens 91-95 10803682-7 2000 The association between a common, functionally significant genetic polymorphism for HNMT and asthma suggests that individual variation in histamine metabolism might contribute to the pathophysiology and/or response to therapy of this disease. Histamine 138-147 histamine N-methyltransferase Homo sapiens 84-88 8780048-1 1996 In mammalian brain, histamine is known to be metabolized solely by histamine methyltransferase (HMT), forming tele-methylhistamine (t-MH), then tele-methylimidazoleacetic acid (t-MIAA). Histamine 20-29 histamine N-methyltransferase Homo sapiens 67-94 10051705-2 1999 Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT). Histamine 0-9 histamine N-methyltransferase Homo sapiens 112-141 10051705-2 1999 Histamine is synthesized by L-histidine, catalysed by L-histidine decarboxylase (HDC) and metabolized mainly by histamine N-methyltransferase (HMT). Histamine 0-9 histamine N-methyltransferase Homo sapiens 143-146 9547362-1 1998 Histamine N-methyltransferase (HNMT) catalyzes a major pathway in histamine metabolism. Histamine 66-75 histamine N-methyltransferase Homo sapiens 0-29 9547362-1 1998 Histamine N-methyltransferase (HNMT) catalyzes a major pathway in histamine metabolism. Histamine 66-75 histamine N-methyltransferase Homo sapiens 31-35 9241692-0 1997 HMT regulates histamine-induced glycoconjugate secretion from human airways in vitro. Histamine 14-23 histamine N-methyltransferase Homo sapiens 0-3 8780048-1 1996 In mammalian brain, histamine is known to be metabolized solely by histamine methyltransferase (HMT), forming tele-methylhistamine (t-MH), then tele-methylimidazoleacetic acid (t-MIAA). Histamine 20-29 histamine N-methyltransferase Homo sapiens 96-99 7822670-1 1995 BACKGROUND: Histamine is metabolized mainly by histamine N-methyltransferase (HMT) to N tau-methylhistamine in human nasal mucosa. Histamine 12-21 histamine N-methyltransferase Homo sapiens 47-76 8605025-1 1996 Histamine N-methyltransferase (HNMT) catalyzes the N(tau)-methylation of histamine. Histamine 73-82 histamine N-methyltransferase Homo sapiens 0-29 8605025-1 1996 Histamine N-methyltransferase (HNMT) catalyzes the N(tau)-methylation of histamine. Histamine 73-82 histamine N-methyltransferase Homo sapiens 31-35 8838085-7 1996 Histamine N-methyltransferase (HMT) is a principal enzyme of histamine degradation in the airway. Histamine 61-70 histamine N-methyltransferase Homo sapiens 0-29 8838085-7 1996 Histamine N-methyltransferase (HMT) is a principal enzyme of histamine degradation in the airway. Histamine 61-70 histamine N-methyltransferase Homo sapiens 31-34 8838085-11 1996 A specific inhibitor of HMT, SKF91488 augments airway contractile response to histamine, suggesting that the level of HMT activity is one of the important factors determining airway hyperresponsiveness. Histamine 78-87 histamine N-methyltransferase Homo sapiens 24-27 8838085-11 1996 A specific inhibitor of HMT, SKF91488 augments airway contractile response to histamine, suggesting that the level of HMT activity is one of the important factors determining airway hyperresponsiveness. Histamine 78-87 histamine N-methyltransferase Homo sapiens 118-121 8750789-1 1995 Histamine N-methyltransferase (HMT) expressed in the epithelial and endothelial cells of the airways is a principal enzyme degrading histamine in the body. Histamine 133-142 histamine N-methyltransferase Homo sapiens 0-29 8750789-1 1995 Histamine N-methyltransferase (HMT) expressed in the epithelial and endothelial cells of the airways is a principal enzyme degrading histamine in the body. Histamine 133-142 histamine N-methyltransferase Homo sapiens 31-34 7616240-1 1995 It is generally accepted that in mammalian brain histamine is metabolized solely by histamine methyltransferase (HMT), to form tele-methylhistamine, then oxidized to tele-methylimidazoleacetic acid. Histamine 49-58 histamine N-methyltransferase Homo sapiens 84-111 7616240-1 1995 It is generally accepted that in mammalian brain histamine is metabolized solely by histamine methyltransferase (HMT), to form tele-methylhistamine, then oxidized to tele-methylimidazoleacetic acid. Histamine 49-58 histamine N-methyltransferase Homo sapiens 113-116 7822670-1 1995 BACKGROUND: Histamine is metabolized mainly by histamine N-methyltransferase (HMT) to N tau-methylhistamine in human nasal mucosa. Histamine 12-21 histamine N-methyltransferase Homo sapiens 78-81 35149385-2 2022 Food-derived histamine is degraded by intestinal diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT), while the organic cation transporter 3 (OCT3) contributes to the transcellular flux of histamine. Histamine 200-209 histamine N-methyltransferase Homo sapiens 106-110 7943261-1 1994 In mammals, histamine is inactivated principally by two enzymes: histamine N-methyltransferase (HMT; EC 2.1.1.8) and diamine oxidase (DAO; EC 1.4.3.6.). Histamine 12-21 histamine N-methyltransferase Homo sapiens 65-94 7943261-1 1994 In mammals, histamine is inactivated principally by two enzymes: histamine N-methyltransferase (HMT; EC 2.1.1.8) and diamine oxidase (DAO; EC 1.4.3.6.). Histamine 12-21 histamine N-methyltransferase Homo sapiens 96-99 7943261-7 1994 In addition, the contractile response of isolated human bronchi to histamine was potentiated in the presence of an HMT inhibitor, SKF 91488, but a DAO inhibitor, aminoguanidine, was without effect. Histamine 67-76 histamine N-methyltransferase Homo sapiens 115-118 7943261-8 1994 These results suggest that HMT plays an important role in degrading histamine and in regulating the airway response to histamine. Histamine 68-77 histamine N-methyltransferase Homo sapiens 27-30 7943261-8 1994 These results suggest that HMT plays an important role in degrading histamine and in regulating the airway response to histamine. Histamine 119-128 histamine N-methyltransferase Homo sapiens 27-30 7943261-9 1994 Therefore, the level of HMT gene expression in human airway may be one of the critical factors determining the airway responsiveness to histamine. Histamine 136-145 histamine N-methyltransferase Homo sapiens 24-27 8339926-2 1993 Histamine N-methyltransferase (HNMT) catalyzes the N tau-methylation of histamine and structurally related compounds. Histamine 72-81 histamine N-methyltransferase Homo sapiens 0-29 8339926-2 1993 Histamine N-methyltransferase (HNMT) catalyzes the N tau-methylation of histamine and structurally related compounds. Histamine 72-81 histamine N-methyltransferase Homo sapiens 31-35 1706093-4 1990 Histamine was assayed with isotope-enzymatic technique according to Shaff and Beaven with histamine N-methyltransferase. Histamine 0-9 histamine N-methyltransferase Homo sapiens 90-119 1968337-5 1990 In humans, histamine N-methyl-transferase (HNMT) is the enzyme primarily degrading for histamine. Histamine 11-20 histamine N-methyltransferase Homo sapiens 43-47 1968337-10 1990 Our data suggest that HNMT-based radioenzymatic assays for histamine should be susceptible to inhibition by concurrent use of NMRs, particularly vecuronium. Histamine 59-68 histamine N-methyltransferase Homo sapiens 22-26 34680041-6 2021 The increase of histamine levels can be achieved by inhibiting its degrading enzyme, histamine N-methyltransferase (HNMT), a cytoplasmatic enzyme located in astrocytes. Histamine 16-25 histamine N-methyltransferase Homo sapiens 85-114 34680041-6 2021 The increase of histamine levels can be achieved by inhibiting its degrading enzyme, histamine N-methyltransferase (HNMT), a cytoplasmatic enzyme located in astrocytes. Histamine 16-25 histamine N-methyltransferase Homo sapiens 116-120 8145732-1 1994 Histamine N-methyltransferase (HNMT) catalyzes the NT-methylation of histamine. Histamine 69-78 histamine N-methyltransferase Homo sapiens 0-29 8145732-1 1994 Histamine N-methyltransferase (HNMT) catalyzes the NT-methylation of histamine. Histamine 69-78 histamine N-methyltransferase Homo sapiens 31-35 8145732-12 1994 Human renal cortical HNMT, partially purified human renal cortical HNMT, and partially purified transfected COS-1 cell HNMT had Km values for histamine and S-adenosyl-L-methionine, the two cosubstrates for the enzyme reaction, of 20, 13, and 14 microM and 2.0, 3.0, and 6.2 microM, respectively. Histamine 142-151 histamine N-methyltransferase Homo sapiens 21-25 18472930-2 1994 Pretreatment of tissues with the histamine N-methyltransferase (HMT) inhibitor SKF 91488 specifically potentiated the contractile responses to histamine, causing a leftward displacement of the concentration response curves, whereas the diamine oxidase inhibitor aminoguanidine had no effect. Histamine 33-42 histamine N-methyltransferase Homo sapiens 64-67 18472930-5 1994 These results suggest that HMT localized to the airway epithelium may play a protective role against histamine-mediated bronchoconstriction in humans. Histamine 101-110 histamine N-methyltransferase Homo sapiens 27-30 8147263-1 1993 Histamine N-methyltransferase (HNMT) catalyzes the N tau-methylation of histamine. Histamine 72-81 histamine N-methyltransferase Homo sapiens 0-29 8147263-1 1993 Histamine N-methyltransferase (HNMT) catalyzes the N tau-methylation of histamine. Histamine 72-81 histamine N-methyltransferase Homo sapiens 31-35 8448680-8 1993 Activities of HMT and histaminase, including their kinetic constants (Km and Vmax values for histamine) indicated that HMT has a greater potential than histaminase for histamine degradation in the human nasal mucosa. Histamine 93-102 histamine N-methyltransferase Homo sapiens 14-17 8448680-8 1993 Activities of HMT and histaminase, including their kinetic constants (Km and Vmax values for histamine) indicated that HMT has a greater potential than histaminase for histamine degradation in the human nasal mucosa. Histamine 93-102 histamine N-methyltransferase Homo sapiens 119-122 8448680-8 1993 Activities of HMT and histaminase, including their kinetic constants (Km and Vmax values for histamine) indicated that HMT has a greater potential than histaminase for histamine degradation in the human nasal mucosa. Histamine 168-177 histamine N-methyltransferase Homo sapiens 14-17 8448680-8 1993 Activities of HMT and histaminase, including their kinetic constants (Km and Vmax values for histamine) indicated that HMT has a greater potential than histaminase for histamine degradation in the human nasal mucosa. Histamine 168-177 histamine N-methyltransferase Homo sapiens 119-122 1588129-2 1992 Histamine is synthesized by multiple isozymes of histidine decarboxylase, and catabolized by either diamine oxidase or histamine-N-methyltransferase. Histamine 0-9 histamine N-methyltransferase Homo sapiens 119-148 34225943-3 2021 Brain histamine is reduced to an inactivated form, tele-methylhistamine (t-MeHA), by histamine N-methyltransferase (HMT). Histamine 6-15 histamine N-methyltransferase Homo sapiens 85-114 34225943-3 2021 Brain histamine is reduced to an inactivated form, tele-methylhistamine (t-MeHA), by histamine N-methyltransferase (HMT). Histamine 6-15 histamine N-methyltransferase Homo sapiens 116-119 35149385-2 2022 Food-derived histamine is degraded by intestinal diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT), while the organic cation transporter 3 (OCT3) contributes to the transcellular flux of histamine. Histamine 13-22 histamine N-methyltransferase Homo sapiens 75-104 35149385-2 2022 Food-derived histamine is degraded by intestinal diamine oxidase (DAO) and histamine-N-methyltransferase (HNMT), while the organic cation transporter 3 (OCT3) contributes to the transcellular flux of histamine. Histamine 13-22 histamine N-methyltransferase Homo sapiens 106-110