PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7955543-2 1994 On vascular endothelium, histamine mainly induces early effects: an increase in vasopermeability leading to oedema, a release of lipid mediators and a transient expression of P-selectin. Histamine 25-34 selectin P Homo sapiens 175-185 24735118-8 2014 RESULTS: G protein-coupled receptor kinase 2 depletion in HUVECs increases WPB exocytosis and P-selectin-dependent adhesion of THP-1 cells to the endothelial surface upon histamine stimulation, relative to controls. Histamine 171-180 selectin P Homo sapiens 94-104 24738138-8 2014 RESULTS: G protein-coupled receptor kinase 2 depletion in HUVECs increases WPB exocytosis and P-selectin-dependent adhesion of THP-1 cells to the endothelial surface upon histamine stimulation, relative to controls. Histamine 171-180 selectin P Homo sapiens 94-104 14676308-3 2003 We found that thrombin and histamine induced comparable exocytosis of P-selectin on endothelial cells. Histamine 27-36 selectin P Homo sapiens 70-80 9792213-8 1998 A model in which histamine provides a P-selectin-dependent rolling phenomenon is then postulated. Histamine 17-26 selectin P Homo sapiens 38-48 9618706-5 1998 Histamine interacts directly with the endothelial cells (EC) and induces permeability, a transient expression of P-selectin and the secretion of lipid mediators (e.g. PGI2, PAF and LTB4). Histamine 0-9 selectin P Homo sapiens 113-123 8906207-5 1996 Among mast-cell mediators, histamine was already known to induce a rapid and transient expression of P-selectin; we demonstrated that histamine also induced an IL-6 and IL-8 secretion by HUVEC, which was concentration-dependent and inhibited by H1 or H2 receptor antagonists. Histamine 27-36 selectin P Homo sapiens 101-111 8906207-5 1996 Among mast-cell mediators, histamine was already known to induce a rapid and transient expression of P-selectin; we demonstrated that histamine also induced an IL-6 and IL-8 secretion by HUVEC, which was concentration-dependent and inhibited by H1 or H2 receptor antagonists. Histamine 134-143 selectin P Homo sapiens 101-111 22322303-4 2012 We examined the role of the sphingosine kinase/sphingosine-1-phosphate (SK/S1P) pathway and showed that in human umbilical vein endothelial cells, histamine rapidly activates SK in an extracellular signal-regulated kinase (ERK) 1/2-dependent manner, concurrent with the induction of P-selectin expression. Histamine 147-156 selectin P Homo sapiens 283-293 18486135-12 2008 EC exposed to histamine demonstrated significantly increased (p<0.01) levels of P-selectin, abrogated (p<0.001) by pre-treatment with statin. Histamine 14-23 selectin P Homo sapiens 83-93 16877367-4 2006 The present in vitro analyses with human dermal microvascular endothelial cells (HDMECs) revealed that histamine rapidly induced P-selectin expression. Histamine 103-112 selectin P Homo sapiens 129-139 16172269-4 2005 Similar results were observed on endothelium treated with histamine, which induces P-selectin-dependent rolling and beta2-integrin-dependent adhesion. Histamine 58-67 selectin P Homo sapiens 83-93 11678636-3 2001 Surface expression of P-selectin was minimal in unstimulated HBMEC; however, it was significantly augmented upon stimulation with histamine (10(-7)-10(-3) M) and thrombin (0.01-1 U/ml). Histamine 130-139 selectin P Homo sapiens 22-32 11678636-7 2001 Histamine-induced surface expression of P-selectin was blocked by the histamine H2 receptor antagonist cimetidine. Histamine 0-9 selectin P Homo sapiens 40-50 10919613-2 2000 Redistribution of P-selectin to the endothelial cell surface occurs rapidly after challenge with several proinflammatory agents, for example, histamine, leucopterins, or lipopolysaccharide. Histamine 142-151 selectin P Homo sapiens 18-28 10080531-2 1999 P-selectin is stored in secretory granules (Weibel-Palade bodies) and is rapidly expressed on the endothelial surface after stimulation with histamine or thrombin. Histamine 141-150 selectin P Homo sapiens 0-10 10080531-6 1999 P-selectin surface expression increased significantly after histamine treatment and P-selectin immunostaining was concentrated along endothelial borders. Histamine 60-69 selectin P Homo sapiens 0-10 9383257-3 1997 Histamine is a potent activator of endothelial cells (EC): it induces the expression of P-selectin on the surface of endothelium and the secretion of IL-6 and IL-8. Histamine 0-9 selectin P Homo sapiens 88-98 9383257-5 1997 METHODS: HUVEC were stimulated in the presence of histamine at 10(-6) M, 10(-5) M and 10(-4) M. We assessed by ELISA the expression of P-selectin on EC surface, as well as cytokine production in EC supernatants of 24 h culture. Histamine 50-59 selectin P Homo sapiens 135-145 9168783-5 1997 A 15-minute histamine treatment of cells exposed to MM-LDL caused a 50% to 100% increase in P-selectin surface expression compared with cells not treated with the lipoprotein. Histamine 12-21 selectin P Homo sapiens 92-102 9168783-10 1997 Like histamine, highly oxidized low-density lipoprotein, especially the oxidized fatty acids, caused immediate redistribution of P-selectin to the cell surface followed by reinternalization. Histamine 5-14 selectin P Homo sapiens 129-139 8916955-4 1996 The increased PMN adherence to thrombin- or histamine-stimulated endothelium, which was blocked by an anti-P-selectin monoclonal antibody, was also significantly attenuated by preincubation of coronary segments with (100 nmol/L) ET-1. Histamine 44-53 selectin P Homo sapiens 107-117 8691152-7 1996 Under flow conditions, neutrophils rolled on P-selectin expressed by IL-4-treated HUVEC, and even more neutrophils rolled on P-selectin after IL-4-treated HUVEC were stimulated with histamine. Histamine 182-191 selectin P Homo sapiens 125-135 7955543-4 1994 Histamine did not modulate the expression of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin, but induced a transient expression of P-selectin as previously reported. Histamine 0-9 selectin P Homo sapiens 186-196 7919340-1 1994 It has been shown that histamine induces early changes on endothelial cells (EC), such as a transient expression of P-selectin and secretion and/or surface expression of early mediators (eg, prostacyclin [PG1(2)], platelet-activating factor [PAF], and leukotriene B4 [LTB4]). Histamine 23-32 selectin P Homo sapiens 116-126 7508745-1 1994 P-Selectin (CD62/GMP140/PADGEM) is an inducible cell-surface glycoprotein expressed by endothelial cells and platelets following stimulation by inflammatory mediators such as thrombin, histamine, or peroxides. Histamine 185-194 selectin P Homo sapiens 0-10 7508745-1 1994 P-Selectin (CD62/GMP140/PADGEM) is an inducible cell-surface glycoprotein expressed by endothelial cells and platelets following stimulation by inflammatory mediators such as thrombin, histamine, or peroxides. Histamine 185-194 selectin P Homo sapiens 12-16 7508745-1 1994 P-Selectin (CD62/GMP140/PADGEM) is an inducible cell-surface glycoprotein expressed by endothelial cells and platelets following stimulation by inflammatory mediators such as thrombin, histamine, or peroxides. Histamine 185-194 selectin P Homo sapiens 24-30 1689464-7 1990 Within minutes after stimulation with phorbol esters or histamine, human endothelial cells become adhesive for neutrophils; this interaction is inhibited by antibodies to GMP-140. Histamine 56-65 selectin P Homo sapiens 171-178 7816774-8 1994 At the side of endothelium, induction of P-selectin and PAF by histamine, thrombin and LTC4 contribute to the acute rolling of PMNs on endothelial surface. Histamine 63-72 selectin P Homo sapiens 41-51 1717159-1 1991 CD62, also called PADGEM protein, GMP-140, or P-selectin, is a granule membrane protein of endothelial cells and platelets that is mobilized to the plasma membrane following exposure to mediators such as thrombin, histamine, complement components, or peroxides. Histamine 214-223 selectin P Homo sapiens 0-4 1717159-1 1991 CD62, also called PADGEM protein, GMP-140, or P-selectin, is a granule membrane protein of endothelial cells and platelets that is mobilized to the plasma membrane following exposure to mediators such as thrombin, histamine, complement components, or peroxides. Histamine 214-223 selectin P Homo sapiens 18-24 1717159-1 1991 CD62, also called PADGEM protein, GMP-140, or P-selectin, is a granule membrane protein of endothelial cells and platelets that is mobilized to the plasma membrane following exposure to mediators such as thrombin, histamine, complement components, or peroxides. Histamine 214-223 selectin P Homo sapiens 34-41 1717159-1 1991 CD62, also called PADGEM protein, GMP-140, or P-selectin, is a granule membrane protein of endothelial cells and platelets that is mobilized to the plasma membrane following exposure to mediators such as thrombin, histamine, complement components, or peroxides. Histamine 214-223 selectin P Homo sapiens 46-56 1717478-0 1991 Coexpression of GMP-140 and PAF by endothelium stimulated by histamine or thrombin: a juxtacrine system for adhesion and activation of neutrophils. Histamine 61-70 selectin P Homo sapiens 16-23 1717478-3 1991 EC stimulated with histamine or thrombin coexpress two proadhesive molecules within minutes: granule membrane protein 140 (GMP-140), a member of the selectin family, and platelet-activating factor (PAF), a biologically active phospholipid. Histamine 19-28 selectin P Homo sapiens 93-121 1717478-3 1991 EC stimulated with histamine or thrombin coexpress two proadhesive molecules within minutes: granule membrane protein 140 (GMP-140), a member of the selectin family, and platelet-activating factor (PAF), a biologically active phospholipid. Histamine 19-28 selectin P Homo sapiens 123-130 7506064-0 1993 P-selectin mediates neutrophil rolling on histamine-stimulated endothelial cells. Histamine 42-51 selectin P Homo sapiens 0-10 7506064-3 1993 Here we demonstrate and characterize PMN rolling on monolayers of human umbilical vein endothelial cells (HUVECs) stimulated with histamine to induce surface expression of P-selectin. Histamine 130-139 selectin P Homo sapiens 172-182 7506064-10 1993 Rolling adhesion of PMNs on histamine-stimulated HUVECs therefore appears to be completely dependent on endothelial cell P-selectin, with a minor adhesion-stabilizing contribution from intercellular adhesion molecule 1 and beta 2 integrins. Histamine 28-37 selectin P Homo sapiens 121-131 8303310-3 1993 E-selectin is upregulated by cytokine stimulation of endothelial cells (ECs); P-selectin is upregulated by stimulation of ECs with agents such as thrombin and histamine; and L-selectin is resident on the surface of unstimulated neutrophils. Histamine 159-168 selectin P Homo sapiens 78-88 8513436-4 1993 E-selectin is synthesized by endothelial cells following cytokine stimulation, P-selectin is rapidly mobilized from Weibel-Palade bodies to the endothelial cell surface following stimulation with agents such as histamine, and L-selectin is constitutively expressed on the surface of leukocytes. Histamine 211-220 selectin P Homo sapiens 79-89 1914073-3 1991 Cytokines such as interleukin 1 induce the synthesis and surface expression of endothelial adhesion molecules such as ICAM-1 and ELAM-1, and stimuli such as thrombin and histamine induce the rapid mobilization to the endothelial surface of another adhesion molecule, GMP-140. Histamine 170-179 selectin P Homo sapiens 267-274 2472431-6 1989 When endothelial cells were stimulated with histamine, GMP-140 rapidly redistributed to the plasma membrane. Histamine 44-53 selectin P Homo sapiens 55-62 31092558-2 2019 Here we show that histamine evokes the release of the proinflammatory ligand, P-selectin, while diverting WPBs carrying non-inflammatory cargo away from the plasma membrane to the microtubule organizing center. Histamine 18-27 selectin P Homo sapiens 78-88 2470733-4 1989 For each agonist tested (histamine, thrombin, phorbol 12-myristate 13-acetate, and the calcium ionophore A23187) a dose-dependent redistribution of GMP-140 to the endothelial surface was observed which closely paralleled the dose-dependent secretion of vWF into the cell supernatant. Histamine 25-34 selectin P Homo sapiens 148-155 2470733-7 1989 In contrast, when histamine-stimulated cells were first fixed with paraformaldehyde or chilled to 4 degrees C before addition of antibody S12, only a transient increase in cell surface GMP-140 was detected. Histamine 18-27 selectin P Homo sapiens 185-192 2470733-8 1989 Under these conditions of arrested membrane turnover during antibody binding, cell surface GMP-140 was maximal 3 min after histamine stimulation and then declined to control levels by 20 min. Histamine 123-132 selectin P Homo sapiens 91-98 28566286-7 2017 Furthermore, knockdown of Rab35 and expression of a dominant-negative Rab35 mutant both inhibited histamine-evoked secretion of the WPB cargos von Willebrand factor and P-selectin. Histamine 98-107 selectin P Homo sapiens 169-179