PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15100264-4	2004	2) Fas or Fas ligand deficiency in mutant mice abolished the inhibitory effect of IL-12 plus IL-18 on IL-3-induced histamine production.	Histamine	115-124	interleukin 18	Mus musculus	93-98	
16959946-0	2007	IL-18 mediates the formation of stress-induced, histamine-dependent gastric lesions.	Histamine	48-57	interleukin 18	Mus musculus	0-5	
16959946-5	2007	In IL-18 KO mice, the WRS-induced elevation of gastric HDC activity and histamine levels was much less than that in wild-type mice, but it was augmented by prior administration of IL-18.	Histamine	72-81	interleukin 18	Mus musculus	3-8	
16959946-5	2007	In IL-18 KO mice, the WRS-induced elevation of gastric HDC activity and histamine levels was much less than that in wild-type mice, but it was augmented by prior administration of IL-18.	Histamine	72-81	interleukin 18	Mus musculus	180-185	
16959946-9	2007	These results indicate that IL-18 is involved in the induction of gastric lesions by WRS through augmentation of HDC activity and production of histamine in the stomach.	Histamine	144-153	interleukin 18	Mus musculus	28-33	
15362044-8	2004	Histamine suppressed the expression of IL-18 and tumor necrosis factor alpha in the liver, leading to the reduced plasma levels of cytokines including IL-18, TNF-alpha, IL-12, IFN-gamma, and IL-6.	Histamine	0-9	interleukin 18	Mus musculus	39-44	
15362044-8	2004	Histamine suppressed the expression of IL-18 and tumor necrosis factor alpha in the liver, leading to the reduced plasma levels of cytokines including IL-18, TNF-alpha, IL-12, IFN-gamma, and IL-6.	Histamine	0-9	interleukin 18	Mus musculus	151-156	
15100264-7	2004	IL-12 plus IL-18 rendered NK cells cytotoxic against Fas-transfected target cells and promoted their production of IFN-gamma and TNF-alpha, which are both essential for sensitizing histamine-producing cells to the Fas death pathway.	Histamine	181-190	interleukin 18	Mus musculus	11-16	
11298325-2	2001	IL-18 also exhibits biological activities related to allergic inflammation such as histamine or IL-4 release from basophils and accumulation of eosinophils in localized lesions in allergic model mice.	Histamine	83-92	interleukin 18	Mus musculus	0-5	
12890193-1	2003	BACKGROUND: Interleukin (IL)-18 has been shown to activate basophils to produce histamine and IL-4 and to induce naive T cells to differentiate into T-helper (Th) 2 cells.	Histamine	80-89	interleukin 18	Mus musculus	12-31	
11089902-9	2000	CONCLUSIONS: IL-18 may be involved in the stimulation of histamine synthesis during the course of immune responses, though an elevation of HDC activity is not itself the direct cause of the serious illness induced by IL-18+IL-12.	Histamine	57-66	interleukin 18	Mus musculus	13-18	
10570181-0	1999	IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils.	Histamine	79-88	interleukin 18	Mus musculus	0-5	
10570181-6	1999	Furthermore, injection of IL-18 alone enhances basophil production of IL-4 and histamine both in wild-type and IFN-gamma(-/-) mice.	Histamine	79-88	interleukin 18	Mus musculus	26-31