PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15668925-1 2005 We previously demonstrated that histamine synthesis is drastically induced upon sensitization with an anti-DNP IgE clone, SPE-7, in IL-3-dependent mouse bone marrow derived mast cells (BMMC). Histamine 32-41 interleukin 3 Mus musculus 132-136 19562674-0 2009 Polyamines affect histamine synthesis during early stages of IL-3-induced bone marrow cell differentiation. Histamine 18-27 interleukin 3 Mus musculus 61-65 16061728-7 2005 Intracellular histamine levels were increased strongly in IL-3-induced OCT3-/- bone marrow basophils, and explained why they generated fewer cytokines than their wild-type counterpart. Histamine 14-23 interleukin 3 Mus musculus 58-62 10219657-6 1999 Granulocyte/macrophage colony-stimulating factor (GM-CSF) or IL-3 strongly enhanced the Con A-induced histamine formation. Histamine 102-111 interleukin 3 Mus musculus 61-65 11934874-9 2002 These findings suggest that the effect of histamine on the IL-3-dependent development of bone marrow-derived mast cell differentiation during the early period is crucial and irreplaceable. Histamine 42-51 interleukin 3 Mus musculus 59-63 15100264-1 2004 We have previously characterized immature hemopoietic cells of the basophil lineage as a lin(-)c-kit(-) population, which responds to IL-3 by enhancing its histamine synthesis through histidine decarboxylase activation. Histamine 156-165 interleukin 3 Mus musculus 134-138 15100264-4 2004 2) Fas or Fas ligand deficiency in mutant mice abolished the inhibitory effect of IL-12 plus IL-18 on IL-3-induced histamine production. Histamine 115-124 interleukin 3 Mus musculus 102-106 10219657-10 1999 CONCLUSIONS: These results suggest that GM-CSF and IL-3 enhance histamine synthesis in CD4+ T cells and CD8+ T cells. Histamine 64-73 interleukin 3 Mus musculus 51-55 8799721-1 1996 Mast cells cultured from bone marrow of BALB/c and SJL/J inbred strains of mice using IL-3 showed distinct patterns of growth and marked differences in their content of TNF-alpha and histamine. Histamine 183-192 interleukin 3 Mus musculus 86-90 9694512-1 1998 In the present study we investigated the effect of anti-CD3 stimulation on IL-3-induced histamine, IL-6, and IL-4 synthesis by murine hematopoietic precursor cells. Histamine 88-97 interleukin 3 Mus musculus 75-79 9062350-2 1997 We describe studies of its biological activity in vitro to induce chemotaxis of peripheral blood eosinophils and to induce histamine release from IL-3-primed peripheral blood basophils. Histamine 123-132 interleukin 3 Mus musculus 146-150 8764989-1 1996 Murine hematopoietic progenitor cells synthesize substantial amounts of histamine in response to IL-3 or calcium ionophore. Histamine 72-81 interleukin 3 Mus musculus 97-101 8764989-5 1996 These compounds also inhibit the release of histamine which has been newly synthesized by hematopoietic progenitors in response to IL-3 or calcium ionophore, as assessed by the accumulation of the mediator inside the cells in the presence of the antagonists. Histamine 44-53 interleukin 3 Mus musculus 131-135 8605330-0 1996 Hematopoietic progenitors and interleukin-3-dependent cell lines synthesize histamine in response to calcium ionophore. Histamine 76-85 interleukin 3 Mus musculus 30-43 8605330-2 1996 The cells responsible for this biological activity copurify with hematopoietic progenitors in terms of density, light scatter characteristics, and rhodamine retention, similar to interleukin (IL) 3-induced histamine-producing cells. Histamine 206-215 interleukin 3 Mus musculus 179-197 8605330-6 1996 The finding that all IL-3-dependent cell lines tested so far exhibit increased histamine production and HDC mRNA expression in response to calcium influx lends further support to this notion. Histamine 79-88 interleukin 3 Mus musculus 21-25 8605330-9 1996 It might, therefore, be suggested that the pathway transducing the signal for increased histamine synthesis after IL-3 receptor binding in normal hematopoietic progenitors is modified in these cell lines. Histamine 88-97 interleukin 3 Mus musculus 114-118 9694512-10 1998 Together, our data support the notion that the decrease in IL-3-induced histamine and IL-6 production by splenocytes pretreated with anti-CD3 is mediated, at least in part, by Fas/FasL interactions, suggesting that the activity of extramedullary myeloid precursor cells can be modulated by molecules involved in apoptosis. Histamine 72-81 interleukin 3 Mus musculus 59-63 9090792-7 1997 Furthermore, the responsiveness of these splenocytes to IL-3, in terms of histamine synthesis, was enhanced. Histamine 74-83 interleukin 3 Mus musculus 56-60 8543833-4 1996 Granulocyte/macrophage CSF (GM-CSF) or IL-3 strongly enhanced LPS-induced histamine formation and expression of CD14 on bone marrow-derived macrophages, without affecting the expression of Mac-1 Ag. Histamine 74-83 interleukin 3 Mus musculus 39-43 8543833-6 1996 Macrophage CSF and IL-1-alpha also potentiated LPS-dependent histamine formation when it was stimulated with GM-CSF or IL-3. Histamine 61-70 interleukin 3 Mus musculus 119-123 8543833-9 1996 These results suggest that GM-CSF and IL-3 enhance LPS-induced histamine production in bone marrow-derived macrophages and that macrophage CSF and IL-1 alpha augment the actions of GM-CSF and IL-3. Histamine 63-72 interleukin 3 Mus musculus 38-42 8550082-8 1995 In contrast, murine interleukin-3 (IL-3) in combination with MCP-1 (200 and 100 nM) provoked a greater release of histamine and [3H]5HT than the compounds alone. Histamine 114-123 interleukin 3 Mus musculus 20-33 8550082-8 1995 In contrast, murine interleukin-3 (IL-3) in combination with MCP-1 (200 and 100 nM) provoked a greater release of histamine and [3H]5HT than the compounds alone. Histamine 114-123 interleukin 3 Mus musculus 35-39 8750790-7 1995 Granulocyte/macrophage colony-stimulating factor (rmGM-CSF) or interleukin 3 (rmIL-3) potently increased lipopolysaccharide-induced histamine formation. Histamine 132-141 interleukin 3 Mus musculus 50-76 7605988-10 1995 Furthermore, in all sorting procedures used here, the cells capable of histamine uptake coenrich with those producing histamine in response to interleukin-3, indicating at least a partial identity between these cells. Histamine 118-127 interleukin 3 Mus musculus 143-156 8049426-0 1994 Aggregated IgE mimic interleukin-3-induced histamine synthesis by murine hematopoietic progenitors. Histamine 43-52 interleukin 3 Mus musculus 21-34 7530742-4 1995 ET-1 induced a very rapid (< or = 1 min) and dose-dependent release of histamine and serotonin from BMMC cultured in the presence of both IL-3 and IL-4. Histamine 74-83 interleukin 3 Mus musculus 141-145 8049426-9 1994 The target cells of IL-3 and IgE in terms of histamine synthesis do not belong to mature bone marrow populations, especially mast cells. Histamine 45-54 interleukin 3 Mus musculus 20-24 1826367-7 1991 The Fc epsilon R+ cells synthesize histamine during a 60-hr culture with IL-3, while the Fc epsilon R- cells do not. Histamine 35-44 interleukin 3 Mus musculus 73-77 7505757-4 1993 IL3-CM enhanced antigen-induced histamine release from P-cells, although IL3-CM did not affect spontaneous histamine release. Histamine 32-41 interleukin 3 Mus musculus 0-3 7505757-6 1993 TYB-2285 inhibited antigen-induced histamine release in the presence of IL3-CM, although it did not inhibit histamine release in the absence of IL3-CM. Histamine 35-44 interleukin 3 Mus musculus 72-75 7505757-8 1993 The enhancement of histamine release by IL3-CM was reproduced by recombinant IL-3 (1-100 U/ml). Histamine 19-28 interleukin 3 Mus musculus 40-43 7505757-8 1993 The enhancement of histamine release by IL3-CM was reproduced by recombinant IL-3 (1-100 U/ml). Histamine 19-28 interleukin 3 Mus musculus 77-81 7505757-10 1993 These results demonstrate that TYB-2285 inhibits the histamine release primed with IL-3 and also suggests that TYB-2285 might regulate allergic inflammation in vivo by the suppression of mediator release primed with IL-3. Histamine 53-62 interleukin 3 Mus musculus 83-87 8476418-0 1993 Interleukin 3 promotes histamine synthesis in hematopoietic progenitors by increasing histidine decarboxylase mRNA expression. Histamine 23-32 interleukin 3 Mus musculus 0-13 8476418-1 1993 Interleukin 3 (IL-3) is a potent stimulator of histamine production by cells from murine hematopoietic organs. Histamine 47-56 interleukin 3 Mus musculus 0-19 8443378-1 1993 In the present study we investigate the nature of the murine bone marrow cell subset responsible for the marked increase in histamine synthesis induced by interleukin-3 (IL-3). Histamine 124-133 interleukin 3 Mus musculus 155-168 8443378-1 1993 In the present study we investigate the nature of the murine bone marrow cell subset responsible for the marked increase in histamine synthesis induced by interleukin-3 (IL-3). Histamine 124-133 interleukin 3 Mus musculus 170-174 8443378-4 1993 Starting from these findings, we further characterized the immature hematopoietic compartment responsible for IL-3-induced histamine synthesis using fluorescence-activated cell sorter (FACS) sorting based on rhodamine retention or wheat germ agglutinin (WGA) affinity. Histamine 123-132 interleukin 3 Mus musculus 110-114 1382745-0 1992 Mouse IL-3 induces histamine release from mouse peritoneal mast cells. Histamine 19-28 interleukin 3 Mus musculus 6-10 1382745-1 1992 In this study, we have attempted to determine whether mouse peritoneal mast cells released histamine in response to IL-3. Histamine 91-100 interleukin 3 Mus musculus 116-120 1382745-2 1992 Recombinant mouse (m)IL-3 induced histamine release from mouse peritoneal mast cells in a dose-dependent fashion. Histamine 34-43 interleukin 3 Mus musculus 21-25 1382745-7 1992 IL-3-induced histamine release reached a peak within 15 min, while that by anti-IgE reached 80% of the maximum in 3 min. Histamine 13-22 interleukin 3 Mus musculus 0-4 1832645-0 1991 Concomitant histamine, interleukin 4, and interleukin 6 production by hematopoietic progenitor subsets in response to interleukin 3. Histamine 12-21 interleukin 3 Mus musculus 118-131 1832645-1 1991 Murine interleukin 3 (IL-3) induces a strong, concomitant increase in histamine, interleukin 6 (IL-6), and interleukin 4 (IL-4) synthesis by progenitor-enriched bone marrow cell populations, whereas interleukin 2 (IL-2) or interferon-gamma (IFN-gamma) are undetectable. Histamine 70-79 interleukin 3 Mus musculus 7-26 1711569-6 1991 The histamine content of BMCMC maintained by IL-3 was also increased by addition of NGF. Histamine 4-13 interleukin 3 Mus musculus 45-49 2380556-0 1990 Antigenic challenge of immunized mice induces endogeneous production of IL-3 that increases histamine synthesis in hematopoietic organs. Histamine 92-101 interleukin 3 Mus musculus 72-76 1646366-4 1991 Conversely, histamine synthesis promoted by Interleukin 3 (IL-3), the unique cytokine sharing this property with GM-CSF, is not modulated by PGE2 or cAMP, suggesting two distinct mechanisms for the induction of this biological activity in hematopoietic cells. Histamine 12-21 interleukin 3 Mus musculus 44-57 1646366-4 1991 Conversely, histamine synthesis promoted by Interleukin 3 (IL-3), the unique cytokine sharing this property with GM-CSF, is not modulated by PGE2 or cAMP, suggesting two distinct mechanisms for the induction of this biological activity in hematopoietic cells. Histamine 12-21 interleukin 3 Mus musculus 59-63 2380556-9 1990 Taken together these results support the conclusion that antigenic challenge of immunized mice induces endogeneous IL-3 which, in turn, promotes a rapid increase in histamine synthesis in hematopoietic organs. Histamine 165-174 interleukin 3 Mus musculus 115-119 34440939-3 2021 IgE could protect murine cultured mast cells from apoptotic cell death induced by the deprivation of interleukin-3 and a certain kind of IgE could activate immature mast cells in the absence of antigens, leading to the release of pro-inflammatory cytokines and a transient increase in histamine synthesis. Histamine 285-294 interleukin 3 Mus musculus 101-114 1970573-0 1990 New role for histamine in interleukin-3-induced proliferation of hematopoietic stem cells. Histamine 13-22 interleukin 3 Mus musculus 26-39 1970573-1 1990 This study investigated the effect of histamine generated by murine bone marrow cells in response to IL-3 on one particular biological activity of this growth factor, i.e., triggering of cells forming colonies in spleen (CFU-S) into S phase. Histamine 38-47 interleukin 3 Mus musculus 101-105 1970573-5 1990 injection of recombinant (r)IL-3 results within 2 hr in a substantial increase in bone marrow cell histamine synthesis together with triggering of day-8 CFU-S into cycle, the latter being completely abolished by a simultaneous injection of the H2 histamine receptor antagonist oxmetidine. Histamine 99-108 interleukin 3 Mus musculus 28-32 1970573-6 1990 Thus, our findings support the notion that both in vitro and in vivo the proliferation of early CFU-S in response to IL-3 is modulated by histamine via its H2 receptors. Histamine 138-147 interleukin 3 Mus musculus 117-121 2824613-2 1987 Both interleukin 3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF) induce increased histamine production by murine hemopoietic cells. Histamine 105-114 interleukin 3 Mus musculus 5-24 2524246-1 1989 Interleukin-3 induces an increase in histamine synthesis, in the murine hematopoietic system. Histamine 37-46 interleukin 3 Mus musculus 0-13 2689185-4 1989 Conversely, histamine synthesis promoted by IL 3, the unique cytokine sharing this property with GM-CSF, cannot be modulated by IL 1, TNF-alpha or PGE2, suggesting two distinct mechanisms for the induction of this biological activity in hematopoietic progenitor cells. Histamine 12-21 interleukin 3 Mus musculus 44-48 2824613-11 1987 In addition, maximal increase in histamine production in response to IL-3 is always higher than in response to GM-CSF. Histamine 33-42 interleukin 3 Mus musculus 69-73 2824613-14 1987 However, both mediators act by inducing the transcription of the HDC gene and de novo synthesis of this enzyme since actinomycin D or cycloheximide abolish GM-CSF-or IL-3-induced histamine-producing cell-stimulating activity. Histamine 179-188 interleukin 3 Mus musculus 166-170 2824613-16 1987 Finally, the observation that cholera toxin, prostaglandin E2, and N6,2"-O-dibutyryl adenosine 3",5"-cyclic monophosphate mimic the effects of IL-3 and GM-CSF on bone marrow cell HDC suggests an involvement of cyclic adenosine monophosphate in factor-induced histamine-producing cell-stimulating activity. Histamine 259-268 interleukin 3 Mus musculus 143-147 3549363-7 1987 Thus, interleukin 3-dependent mouse BMMC can be induced to undergo phenotypic changes in staining characteristics, histamine content, glycosaminoglycan structure, and metabolism of arachidonic acid to resemble heparin-containing CTMC. Histamine 115-124 interleukin 3 Mus musculus 6-19 2957431-0 1987 Interleukin 3-dependent mouse mast cells express the cholera toxin-binding acidic glycosphingolipid, ganglioside GM1, and increase their histamine content in response to toxin. Histamine 137-146 interleukin 3 Mus musculus 0-13 3158382-1 1985 Since homogeneously purified Interleukin 3 can induce an increase in histamine synthesis by normal bone marrow cells (HCSF activity), it has been suggested that HCSF and IL3 could be identical. Histamine 69-78 interleukin 3 Mus musculus 29-42 2434985-4 1987 The IL-3-induced mast cells were IL-3-dependent, did not express Ia, T-cell, B-cell or macrophage markers, and released histamine in response to Ca ionophore, but not in response to compound 48/80. Histamine 120-129 interleukin 3 Mus musculus 4-8 29777594-6 2018 RESULTS: We show that BMRB and basophils previously exposed to IL-3 differ in their ability to generate cytokines (IL-4, IL-6, IL-13, and GM-CSF) and histamine in response to FcepsilonRI crosslinking, reflecting two stages of maturation. Histamine 150-159 interleukin 3 Mus musculus 63-67 29777594-7 2018 Exposure to IL-3 initiated an autocrine loop of endogenous IL-3 production that enhanced histamine and cytokine production upon FcepsilonRI crosslinking. Histamine 89-98 interleukin 3 Mus musculus 12-16 29777594-7 2018 Exposure to IL-3 initiated an autocrine loop of endogenous IL-3 production that enhanced histamine and cytokine production upon FcepsilonRI crosslinking. Histamine 89-98 interleukin 3 Mus musculus 59-63