PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7605251-1 1995 Bradykinin and thrombin caused a time- and dose-dependent stimulation of prostanoid biosynthesis in human dental-pulp fibroblasts, as assessed by the release of prostaglandin E2 (PGE2) and 6-keto-prostaglandin F1 alpha (the stable breakdown product of prostacyclin). 6-Ketoprostaglandin F1 alpha 189-218 coagulation factor II, thrombin Homo sapiens 15-23 9372311-9 1997 In contrast to hydrocortisone and 5-aminosalicylic acid, ropivacaine only weakly affected the release of 6-keto PGF1 alpha after stimulation with thrombin. 6-Ketoprostaglandin F1 alpha 105-122 coagulation factor II, thrombin Homo sapiens 146-154 8647949-6 1996 Release of 6-keto PGF1alpha by the NO donors increased the ability of these compounds to inhibit thrombin-induced human platelet aggregation by at least 10 times; this potentiation was inhibited by hemoglobin but not by MeB. 6-Ketoprostaglandin F1 alpha 11-27 coagulation factor II, thrombin Homo sapiens 97-105 9403612-4 1997 METHODS AND RESULTS: Thrombin receptor expression was assessed by Northern and Western blot analyses and functionally by measuring the release of 6-keto prostaglandin F1alpha. 6-Ketoprostaglandin F1 alpha 146-174 coagulation factor II, thrombin Homo sapiens 21-29 9403612-8 1997 Pretreatment of VSMCs with either acidified PDP, or TGF-beta1 increased the alpha-thrombin-stimulated release of 6-keto prostaglandin F1alpha. 6-Ketoprostaglandin F1 alpha 113-141 coagulation factor II, thrombin Homo sapiens 82-90 1315648-15 1992 In all groups the addition of thrombin to intact endothelial cells increased 6-keto-prostaglandin F1 alpha production approximately 15-30-fold over basal levels, but only three- to five-fold in damaged endothelial cells. 6-Ketoprostaglandin F1 alpha 77-106 coagulation factor II, thrombin Homo sapiens 30-38 2671341-1 1989 Thrombin and bradykinin stimulate production of prostaglandin E2 (PGE2), and 6-keto-prostaglandin F1 alpha (the stable breakdown product of prostacyclin) in isolated human peripheral blood monocytes in a dose- and time-dependent manner. 6-Ketoprostaglandin F1 alpha 77-106 coagulation factor II, thrombin Homo sapiens 0-8 3291862-12 1988 Total accumulated amounts of 6-oxo-prostaglandin F1 alpha on stimulation with thrombin without extracellular Ca2+ were only 65% of those accumulated with extracellular Ca2+ present. 6-Ketoprostaglandin F1 alpha 29-57 coagulation factor II, thrombin Homo sapiens 78-86 376548-4 1979 By correlating thrombin-induced adherence of platelets to endothelial monolayers with PGI2 release (as measured by radioimmunoassay for 6-keto-prostaglandin FI1 alpha [6-keto-PGF1 alpha]), we have demonstrated an inverse relationship between platelet adherence and PGI2 levels. 6-Ketoprostaglandin F1 alpha 168-185 coagulation factor II, thrombin Homo sapiens 15-23 376548-5 1979 Untreated endothelial monolayers exposed to thrombin and platelets resulted in 4% platelet adherence and 107 nM 6-keto-PGF1 alpha. 6-Ketoprostaglandin F1 alpha 112-129 coagulation factor II, thrombin Homo sapiens 44-52 2521636-6 1989 To test this hypothesis, human endothelial cells labeled with [14C]arachidonic acid were stimulated with thrombin (2 units/ml, 10 min), resulting in the secretion of free arachidonic acid together with various 14C-labeled metabolites, mainly 6-keto-prostaglandin F1 alpha, the stable derivative of prostaglandin I2. 6-Ketoprostaglandin F1 alpha 242-271 coagulation factor II, thrombin Homo sapiens 105-113 3110148-7 1987 However, if the initial stimulation with thrombin was terminated by addition of D-Phe-Pro-Arg-chloromethyl ketone within 10-60 s, restimulation with a second dose of thrombin induced second rises in both IP3 and Ca2+i levels and additional 6-keto-PGF1 alpha production that were greatest when the initial thrombin stimulus was briefest. 6-Ketoprostaglandin F1 alpha 240-257 coagulation factor II, thrombin Homo sapiens 41-49 3110148-7 1987 However, if the initial stimulation with thrombin was terminated by addition of D-Phe-Pro-Arg-chloromethyl ketone within 10-60 s, restimulation with a second dose of thrombin induced second rises in both IP3 and Ca2+i levels and additional 6-keto-PGF1 alpha production that were greatest when the initial thrombin stimulus was briefest. 6-Ketoprostaglandin F1 alpha 240-257 coagulation factor II, thrombin Homo sapiens 166-174 3110148-7 1987 However, if the initial stimulation with thrombin was terminated by addition of D-Phe-Pro-Arg-chloromethyl ketone within 10-60 s, restimulation with a second dose of thrombin induced second rises in both IP3 and Ca2+i levels and additional 6-keto-PGF1 alpha production that were greatest when the initial thrombin stimulus was briefest. 6-Ketoprostaglandin F1 alpha 240-257 coagulation factor II, thrombin Homo sapiens 166-174 3099849-3 1987 Stimulation of the cells with human thrombin (2 U/ml) or calcium ionophore A23187 (5 microM) promoted the release into supernatants of arachidonic acid, 6-ketoprostaglandin F1 alpha, prostaglandins E2 and F2 alpha, in decreasing order of importance. 6-Ketoprostaglandin F1 alpha 153-181 coagulation factor II, thrombin Homo sapiens 36-44 6374960-3 1984 Stimulation with human thrombin (2 U/ml) promoted a rapid release of radioactive material into supernatants, which contained essentially 6-keto-prostaglandin F1 alpha and non-converted AA. 6-Ketoprostaglandin F1 alpha 137-166 coagulation factor II, thrombin Homo sapiens 23-31 6758553-4 1982 Washed platelet suspensions were induced to aggregate using thrombin and the supernatants stimulated the production of 6-keto PGF1 alpha by cultured endothelial cells. 6-Ketoprostaglandin F1 alpha 119-136 coagulation factor II, thrombin Homo sapiens 60-68 16467309-5 2006 Thrombin and peptide agonists of PAR-1 and PAR-2 increased luciferase activity in human umbilical vein endothelial cells infected with an NF-kappaB-dependent luciferase reporter adenovirus, and this, as well as PAR-induced 6-keto-PGF1alpha synthesis, was inhibited by co-infection with adenovirus encoding wild-type or mutated (Y42F) IkappaBalpha. 6-Ketoprostaglandin F1 alpha 223-239 coagulation factor II, thrombin Homo sapiens 0-8 16467309-6 2006 Thrombin- and SLIGKV-induced COX-2 expression and 6-keto-PGF1alpha generation were markedly attenuated by the NF-kappaB inhibitor PG490 and partially inhibited by the proteasome pathway inhibitor MG-132. 6-Ketoprostaglandin F1 alpha 50-66 coagulation factor II, thrombin Homo sapiens 0-8