PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32307979-6	2020	Subgroup analysis showed that the levels of beta-catenin, cyclinD1 and c-myc in the high-dose (>5muM) arsenic intervention group were lower than those in the control group, and the levels of beta-catenin and cyclinD1 in the high-dose (>5muM) arsenic intervention group were lower than those in the low-dose (<=5muM) arsenic intervention group (P<0.05, respectively).	Arsenic	102-109	cyclin D1	Homo sapiens	58-66	
12883267-8	2003	Arsenic increased expression of the P21 protein and decreased levels of cyclin A, cyclin B1 and cyclin D1, but expression of CDK2, CDK4, CDK6, and cyclin E were not affected.	Arsenic	0-7	cyclin D1	Homo sapiens	96-105	
34974760-2	2022	Meanwhile, compared with normal L-02 cells, arsenic-transformed malignant cells, L-02-As displayed more ROS and significantly higher Cyclin D1 expression as well as aerobic glycolysis.	Arsenic	44-51	cyclin D1	Homo sapiens	133-142	
32307979-6	2020	Subgroup analysis showed that the levels of beta-catenin, cyclinD1 and c-myc in the high-dose (>5muM) arsenic intervention group were lower than those in the control group, and the levels of beta-catenin and cyclinD1 in the high-dose (>5muM) arsenic intervention group were lower than those in the low-dose (<=5muM) arsenic intervention group (P<0.05, respectively).	Arsenic	102-109	cyclin D1	Homo sapiens	208-216	
29103775-0	2018	Cyclin D1 promoter -56 and -54bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen"s disease.	Arsenic	85-92	cyclin D1	Homo sapiens	0-9	
28444938-7	2017	In conclusion, arsenic induced proliferation in human uroepithelial cells after short and long term exposure to arsenite and JAK2/STAT3 signaling pathway might be pivotal in arsenite-induced proliferation by regulating cyclin D1, COX-2, PCNA, and BCL2.	Arsenic	15-22	cyclin D1	Homo sapiens	219-228	
23562784-0	2013	Regulation of cellular Cyclin D1 gene by arsenic is mediated through miR-2909.	Arsenic	41-48	cyclin D1	Homo sapiens	23-32	
21040761-0	2011	Effects of MEK and DNMT inhibitors on arsenic-treated human uroepithelial cells in relation to Cyclin-D1 and p16.	Arsenic	38-45	cyclin D1	Homo sapiens	95-104	
21040761-12	2011	Finally, these results indicated that Cyclin-D1 and p16 both might play important roles in carcinogenesis as a result of arsenic.	Arsenic	121-128	cyclin D1	Homo sapiens	38-47	
19168569-7	2009	Downstream of EGFR, arsenic exposure increased pERK and cyclin D1 levels.	Arsenic	20-27	cyclin D1	Homo sapiens	56-65	
18640142-1	2008	INTRODUCTION: Polymorphisms in p53, p21 and CCND1 could regulate the progression of the cell cycle and might increase the susceptibility to inorganic arsenic-related cancer risk.	Arsenic	150-157	cyclin D1	Homo sapiens	44-49	
27932253-0	2017	Regulation of cyclin D1 by arsenic and microRNA inhibits adipogenesis.	Arsenic	27-34	cyclin D1	Homo sapiens	14-23	
27932253-6	2017	Exposing hMSCs to arsenic increased abundance of miR-29b and cyclin D1 to promote proliferation over differentiation.	Arsenic	18-25	cyclin D1	Homo sapiens	61-70	
27932253-9	2017	Temporal regulation of cyclin D1 is critical for adipogenic differentiation, and the data suggest a paradigm where arsenic disruption of miR-29b regulatory pathways impairs adipogenic differentiation and ultimately adipose metabolic homeostasis.	Arsenic	115-122	cyclin D1	Homo sapiens	23-32	
26878773-5	2016	We also found that tBHQ relieved the G2/M phase arrest by arsenic exposure, which was associated with altering the expression of cell cycle regulators cyclin D1 and CDK4.	Arsenic	58-65	cyclin D1	Homo sapiens	151-160	
25868784-5	2015	Silibinin with 0.5 or 5 microM arsenic induced G1 or G2/M phase arrest, respectively, and decreased the protein levels of CDK2, -4, and -6 and cyclin D1, D3, and E and increased CDK inhibitors p21 and p27.	Arsenic	31-38	cyclin D1	Homo sapiens	143-152	
22102309-3	2011	Both epidemiological and experimental evidence indicates that arsenic and ultraviolet radiation act on signaling pathways that effect the expression of cyclin D1.	Arsenic	62-69	cyclin D1	Homo sapiens	152-161